EP0536322A1 - PROTEINE 2$g(a) INFLAMMATOIRE PRODUITE PAR LES MACROPHAGES HUMAINS - Google Patents

PROTEINE 2$g(a) INFLAMMATOIRE PRODUITE PAR LES MACROPHAGES HUMAINS

Info

Publication number
EP0536322A1
EP0536322A1 EP91913839A EP91913839A EP0536322A1 EP 0536322 A1 EP0536322 A1 EP 0536322A1 EP 91913839 A EP91913839 A EP 91913839A EP 91913839 A EP91913839 A EP 91913839A EP 0536322 A1 EP0536322 A1 EP 0536322A1
Authority
EP
European Patent Office
Prior art keywords
mip
dna
polypeptide
sequence
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP91913839A
Other languages
German (de)
English (en)
Inventor
Patricia Tekamp-Olson
Carol Ann Gallegos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of EP0536322A1 publication Critical patent/EP0536322A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Une tentative d'identification de l'homologue humain de la protéine 2 inflammatoire produite par les macrophages murins a eu pour résultat inattendu non pas une mais deux séquences potentielles, respectivement appelées hu-MIP-2alpha et hu-MIP-beta. Le fait d'utiliser les séquences d'ADN ainsi que des systèmes de recombinaison de l'invention permet d'obtenir hu-MIP-2alpha, un des deux homologues humains de MIP-2 murine, sensiblement exempts d'une autre protéine humaine. L'invention concerne également des anticorps réagissant avec des polypeptides de hu-MIP-2alpha ainsi que des méthodes de dosage immunologique permettant de déterminer hu-MIP-2alpha, ainsi que des sondes de nucléotide destinées à détecter des séquences de nucléotide codant hu-MIP-2alpha dans des échantillons biologiques.
EP91913839A 1990-06-22 1991-06-24 PROTEINE 2$g(a) INFLAMMATOIRE PRODUITE PAR LES MACROPHAGES HUMAINS Withdrawn EP0536322A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54189790A 1990-06-22 1990-06-22
US541897 1990-06-22
US71519491A 1991-06-19 1991-06-19
US715194 1991-06-19

Publications (1)

Publication Number Publication Date
EP0536322A1 true EP0536322A1 (fr) 1993-04-14

Family

ID=27066835

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91913839A Withdrawn EP0536322A1 (fr) 1990-06-22 1991-06-24 PROTEINE 2$g(a) INFLAMMATOIRE PRODUITE PAR LES MACROPHAGES HUMAINS

Country Status (7)

Country Link
EP (1) EP0536322A1 (fr)
JP (1) JPH06501381A (fr)
CA (1) CA2086091A1 (fr)
IE (1) IE66226B1 (fr)
PT (1) PT98072B (fr)
SG (1) SG52674A1 (fr)
WO (1) WO1992000327A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145676A (en) * 1981-09-08 1992-09-08 The Rockefeller University Method and agents for promoting wound healing
EP0909817A1 (fr) * 1990-09-28 1999-04-21 Chiron Corporation Utilisations des gènes codant pour GRO et des protéines
ES2210255T3 (es) 1993-06-08 2004-07-01 Smithkline Beecham Corporation Metodos para mejorar la actividad biologica de quimiocinas.
US6447766B1 (en) 1993-06-08 2002-09-10 Smithkline Beecham Corporation Method of mobilizing hematopoietic stem cells
US6811773B1 (en) 1993-12-22 2004-11-02 Human Genome Sciences, Inc. Human monocyte colony inhibitory factor (M-CIF) polypeptides
US6488925B2 (en) 1993-12-22 2002-12-03 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polypeptides
US5504003A (en) * 1994-03-08 1996-04-02 Human Genome Sciences, Inc. Macrophage inflammatory protein-3 and -4
US6451562B1 (en) 1993-12-22 2002-09-17 Human Genome Sciences, Inc. Polypeptides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) polynucleotides
US6001606A (en) * 1994-03-08 1999-12-14 Human Genome Sciences, Inc. Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
WO1995023865A1 (fr) * 1994-03-03 1995-09-08 Genentech, Inc. Anticorps monoclonaux anti-il-8 pour le traitement des troubles
US5874080A (en) * 1994-03-03 1999-02-23 Genentech, Inc. Anti-IL-8 monoclonal antibodies for treatment of asthma
US6495129B1 (en) 1994-03-08 2002-12-17 Human Genome Sciences, Inc. Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
US5981231A (en) 1996-06-17 1999-11-09 Human Genome Sciences, Inc. Polynucleotides encoding chemokine β-15
KR100425016B1 (ko) * 2001-02-07 2004-03-27 주식회사 삼양사 용혈성 및 색소번짐 방지성이 우수한 폴리글리콜산 방사용처리제

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623698B2 (en) * 1988-09-02 1992-05-21 Chiron Corporation Macrophage-derived inflammatory mediator (mip-2)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9200327A1 *

Also Published As

Publication number Publication date
IE912192A1 (en) 1992-01-01
SG52674A1 (en) 1998-09-28
JPH06501381A (ja) 1994-02-17
IE66226B1 (en) 1995-12-13
CA2086091A1 (fr) 1991-12-23
WO1992000327A1 (fr) 1992-01-09
PT98072A (pt) 1992-03-31
PT98072B (pt) 1998-11-30

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19930427

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