EP0487490B1 - Closure for sample vessels and method for its manufacture - Google Patents

Closure for sample vessels and method for its manufacture Download PDF

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Publication number
EP0487490B1
EP0487490B1 EP19910890275 EP91890275A EP0487490B1 EP 0487490 B1 EP0487490 B1 EP 0487490B1 EP 19910890275 EP19910890275 EP 19910890275 EP 91890275 A EP91890275 A EP 91890275A EP 0487490 B1 EP0487490 B1 EP 0487490B1
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EP
European Patent Office
Prior art keywords
channel
closure member
parts
member according
vessel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP19910890275
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German (de)
French (fr)
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EP0487490A3 (en
EP0487490A2 (en
Inventor
Johann Lacher
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Art Bickford & Co GmbH
Art Bickford and Co
Original Assignee
Art Bickford & Co GmbH
Art Bickford and Co
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Publication of EP0487490A2 publication Critical patent/EP0487490A2/en
Publication of EP0487490A3 publication Critical patent/EP0487490A3/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages

Definitions

  • the invention relates to a closure piece for vessels for samples, in particular for medical or technical tests, with a pouring channel arranged centrally, in particular in the axis of the vessel, and a separate, eccentrically arranged channel for a gaseous medium, in particular air, for connection to one Diluter, which two channels pass through the closure piece, the channel for the gaseous medium preferably having a riser pipe projecting into the interior of the vessel.
  • the invention further relates to a method for producing such a closure piece.
  • the primary vessels provided with the closure piece are seized in large numbers one after the other by a carrier of a sample distributor and subjected to the distribution process mentioned.
  • the vessel is firmly connected to the carrier, usually with the interposition of a seal.
  • contamination is often unavoidable, because when the sample vessel is transferred from a position in which the pouring channel is directed upwards to a position in which this channel points downwards, sample material enters the channel leading to the Diluter and remains there at least temporarily, even if this channel later carries compressed air.
  • the invention has for its object to avoid this disadvantage and to improve a closure piece of the type described above so that the risk of contamination of the contact surface with which the sample vessel is attached to the holder of the sample distributor is at least substantially reduced, if not with certainty is avoided.
  • the invention is based on the knowledge that the contamination mentioned is due to the fact that the channel for the diluter air passes straight through the closure piece in the known construction. It has been found that even a slight transverse extension of this channel significantly reduces the risk of contamination.
  • the solution of the aforementioned object according to the invention is that the inlet opening of the channel for the gaseous medium is offset relative to the outlet opening in the circumferential direction of the closure piece, a channel section adjoining the inlet opening having a channel section adjoining the outlet opening by an interior of the closure piece is connected transversely to these channel sections.
  • This transverse extension brakes the liquid (sample) which has penetrated into the diluter channel to such an extent that this sample can no longer reach the end face of the closure piece on the device side, that is to say to the contact surface on the vessel carrier, in particular if the aforementioned displacement reaches a maximum, i.e. Is 180 °.
  • the transverse channel section is an annular channel, which channel is preferably designed as a microchannel, in particular with an axial extension in the connecting piece of less than 0.05 mm.
  • a channel running in the circumferential direction is longer than a radial transverse channel, which favors the aforementioned braking of the liquid.
  • a channel running inside the closure piece could be created during manufacture by cores, which are later removed. In terms of production, however, it is simpler to design the closure piece in two parts within the scope of the invention, the two parts forming the transverse channel, in particular as an annular channel, between them in a connected position. It is particularly favorable if according to one Further development of the invention, the annular channel is limited in the radial direction by deformable sealing lips of at least one of the two parts. When the two parts are joined together to form the closure piece, these lips are squeezed and thus delimit the annular channel. In order to maintain this seal, it is recommended within the scope of the invention to connect the two parts to one another by a snap lock.
  • annular groove runs on the end face of the closure piece facing away from the vessel, which annular groove is connected to the channel for the gaseous medium.
  • This ring groove makes the closure piece regardless of the rotational position in which it is attached to the closure piece carrier.
  • the inventive method for producing the closure piece according to the invention is characterized in that the closure piece is injection molded or cast in two parts, of which one part has the pouring channel and the inlet opening of the channel for the gaseous medium, the other part the outlet opening for the gaseous medium Medium, and that a web connecting the two parts is injected or cast, which is then bent when the two parts are combined and, if necessary, is then removed.
  • this web forms a guarantee that the openings in the two parts of the channel to be connected to the diluter have the desired offset relative to one another.
  • FIG.1 shows a vertical section through the two parts of the closure piece in the separated state.
  • 2 shows the two parts combined and in the state placed on a sample vessel.
  • 3 shows an embodiment variant of FIG. 2.
  • FIG. 4 shows an embodiment similar to FIG. 2, in the state attached to a carrier for the sample vessel.
  • 5 shows in vertical section the two parts of the closure piece which are connected to one another during manufacture by a web, and
  • FIG. 6 is a view in the direction of the arrow VI in FIG. 5.
  • the closure piece 1 serves to close a vessel 2 (Fig. 2, 3), which is usually formed by a cylindrical glass tube, the bottom 3 of which is closed and which has an opening 4 at the top, which to be closed by the closure piece 1.
  • the closure piece 1 according to FIG. 1 is formed from two parts 5, 6, which can be firmly connected to one another, in particular by means of a snap closure, which will be described in more detail later.
  • the upper part 5 has a pouring pipe 7 which delimits a pouring channel 8 which passes through the part 5. This pouring channel 8 continues in part 6 and also passes through this part as a central opening.
  • the part 6 has a channel 9 which carries a gaseous medium, in particular air, which passes through the part 6 in the axial direction and for the most part runs in a riser pipe 10.
  • this channel 9 meets a microchannel designed as an annular channel 11, expediently with an axial dimension of less than 0.05 mm, in particular approximately 0.02 to 0.03 mm, which for the sake of clarity is exaggerated.
  • this ring channel 11 a part 5 penetrating, in the axial direction extends channel 12, the inlet opening 13 of this channel is offset relative to the outlet opening 14 of the channel 9 with respect to the central axis 25 by 180 °.
  • the part 5 has a position notch 15 on an annular projection 16 projecting in the axial direction, into which position notch 15 a corresponding projection 17 of the other part 6 engages. Since the position notch 15 is offset by 180 ° relative to the channel 12, this latching means an analog offset of the two channels 9, 12.
  • the channels 9, 12 serve for supplying and removing air into and from the vessel 2 by means of a diluter.
  • the part 5 has on its end face 19 facing away from the part 6 an annular groove 20 into which the channel 12 opens with its inlet opening 13.
  • the closure piece 1 is independent of its rotational position in relation to the transport carriage with which the vessel 2 is transported during the sample distribution.
  • Fig.2 shows the closure piece 1 in the state attached to the vessel 2.
  • the closure piece 1 or its part 6 encompasses the upper edge of the vessel 2 with a sealing bell 21, which is provided on its inner circumference with a plurality of sealing lips 22.
  • Such training is particularly suitable for pure serum vessels or serum vessels with separating gel.
  • the vessel 2 there is a blood cake 23 with a separating gel, the fill level 24 of the blood sample leaves an air space 25 above.
  • the two parts 5, 6 of the closure piece 1 are pressed together, the projection 17 engaging in the position notch 15.
  • the annular channel 11 is delimited by the mutually facing end faces of the two parts 5, 6 and runs concentrically to the longitudinal axis 25 of the vessel 2.
  • the upper part 5 has on its end face 19 an outwardly facing flange 26 which is used to engage tendons, in particular tension claws 28 of a turnbuckle 27 (Fig.4), serve. These clamping claws 28 engage - distributed in the circumferential direction of the flange 26 - on the flange 26 and thereby tighten the closure piece 1 together with the vessel 2 attached to it on a support 29 of a sample distributor.
  • This carrier 29 can be pivoted about a horizontal axis on a transport carriage of the sample distributor, not shown, so that the pouring tube 7 can be brought into a downward-pointing position, a vacuum prevailing in the diluter line 18 so that the sample in the vessel 2 is retained is and can not flow through the pouring spout 7. As soon as the pouring position has been reached, the vacuum is replaced by excess pressure and a part of the sample in the vessel 2 is thus expelled through the pouring pipe 7.
  • the clamping claws 28 are movable in the axial direction of the sample vessel 2 by a drive, not shown, and can additionally be pivoted outwards or inwards, so that the flange 26 can be gripped or released.
  • the shape of the closure piece 1 shown in FIG. 4 differs from that of FIG. 2 only slightly by a different shape of the pouring tube 7, which has an enlargement 31 of the diameter of the pouring channel 8 at its mouth 30. This results in a drop centering due to the cross-sectional enlargement of the channel 8, i.e. at the end of the sample delivery, the residual drop retracts in this extension 31, so that no drop is lost unintentionally, even if the device is subjected to vibrations, for example when it is transported to the next delivery position.
  • the lower part 6 has on the inner surface of its sealing bell Sealing lips 22 with a pointed, approximately triangular cross section, whereas the sealing lips 22 according to FIG. 1 have a rounded cross section. Which of the cross-sectional shapes is selected depends on the area of application at hand.
  • annular channel 11 is not formed by an annular groove on the bottom surface of the upper part 5 (as in the embodiment according to FIGS. 1 and 2), but instead is laterally limited by deformable sealing lips 32 (see also FIG. 5).
  • these sealing lips 32 which have a triangular profile, are permanently deformed and thereby seal the annular channel 11 from the inside and outside.
  • a circumferential bead 33 of the lower part 6 engages in a circumferential groove 34 on the inner jacket of the upper part 5, so that the two parts 5, 6 are fastened to one another by a connection in the manner of a snap lock 35 (FIG. 4) are.
  • the vessel 2 is gripped by the closure piece 1 on its outer jacket.
  • the closure piece 1 can also be inserted into the opening 4 of the vessel 2 in the manner of a stopper, with a sleeve 39 lying inside the vessel 2 instead of the sealing bell 21 (FIG. 2) passing over part of it
  • the circumference merges into the riser pipe 10 and is provided on the outer jacket with sealing lips 22.
  • the closure piece 1 expediently consists of synthetic plastic material, although in principle other materials, for example rubber, can also be used. Injection-moldable materials are particularly suitable for manufacturing reasons. It can then, as shown in FIG. 5, be connected to the lower part 6 by a thin, flexible web 40 during manufacture by injection molding. After removal from the mold, this web 40 forms a guide, which, even in the case of mechanical production, ensures that the two openings 13, 14 are offset from one another by 180 ° with respect to the central axis when the two parts 5, 6 from the one in FIG shown demolding position in the shown in Figure 4 Connection position are brought without the web 40 is destroyed. After securing the connection of the parts 5, 6 by the snap lock 35, the web 40 can be removed. However, if desired, it can also remain and then offers a loop adhering to the closure piece 1, which can be advantageous in special cases.
  • the aforementioned two-part design of the closure piece and the production of the two parts 5, 6 in separate molded parts also offers the possibility of a simple transition to different vessel shapes during manufacture.
  • the upper part 5 can be produced unchanged for the changed vessel shape, whereas the shaped part for the lower part 6 is shaped in accordance with the respective vessel 2 present.
  • unusual tube shapes e.g. with a square cross-section, easy to grasp. Only the connection point of the two parts 5, 6 must of course correspond to one another in order to be able to connect the two parts securely to one another.

Description

Die Erfindung bezieht sich auf ein Verschlußstück für Gefäße für Probengut, insbesondere für medizinische oder technische Tests, mit einem mittig, insbesondere in der Gefäßachse, angeordneten Ausgußkanal und einem davon getrennten, exzentrisch angeordneten Kanal für ein gasförmiges Medium, insbesondere Luft, zum Anschluß an einen Diluter, welche beiden Kanäle das Verschlußstück durchsetzen, wobei vorzugsweise der Kanal für das gasförmige Medium ein in das Innere des Gefäßes ragendes Steigrohr aufweist. Weiters bezieht sich die Erfindung auf ein Verfahren zur Herstellung eines solchen Verschlußstückes.The invention relates to a closure piece for vessels for samples, in particular for medical or technical tests, with a pouring channel arranged centrally, in particular in the axis of the vessel, and a separate, eccentrically arranged channel for a gaseous medium, in particular air, for connection to one Diluter, which two channels pass through the closure piece, the channel for the gaseous medium preferably having a riser pipe projecting into the interior of the vessel. The invention further relates to a method for producing such a closure piece.

Auf zahlreichen Anwendungsgebieten, insbesondere auf medizinisch-technischem Gebiet oder für Laboruntersuchungen aller Art, bei welchen Probengut aus einem Gefäß in vorbestimmten Mengen verteilt werden muß, ist es bekannt, Verschlußstücke der oben angeführten Art einzusetzen (EP-B 48 452). Mittels des Diluters kann Luft aus dem das Probengut enthaltenden Gefäß abgesaugt werden, so daß das Gefäß mit nach unten gerichtetem Ausgußkanal von Sekundärgefäß zu Sekundärgefäß transportiert werden kann, ohne daß Probengut verlorengeht. Über dem jeweiligen Sekundärgefäß wird Unterdruck im Primärgefäß mittels des Diluters weggenommen und Druck dem Primärgefäß oberhalb des Probengutes zugeführt, so daß Probengut durch den Ausgußkanal austreten und in das Sekundärgefäß fallen kann. Dauer und Höhe des zugeführten Druckes bestimmen die abzugebende Probengutmenge. In der Regel werden die mit dem Verschlußstück versehenen Primärgefäße nacheinander in großer Zahl von einem Träger eines Probenverteilers erfaßt und dem erwähnten Verteilvorgang unterworfen. Das Gefäß wird hiebei mit dem Träger fest verbunden, zumeist unter Zwischenschaltung einer Dichtung. Insbesondere auf medizinischen Gebiet ist es erwünscht, die Anlagefläche des Trägers des Probenverteilers, an welcher das Verschlußstück im befestigten Zustand anliegt, frei von Kontaminierungen zu halten, da ansonsten Querinfektionen nicht zu vermeiden sind. Es hat sich jedoch gezeigt, daß eine solche Kontaminierung oft nicht zu vermeiden ist, denn beim Überführen des Probengefäßes aus einer Lage, in welcher der Ausgußkanal nach oben gerichtet ist, in eine Lage, in welcher dieser Kanal nach unten weist, tritt Probengut in den zum Diluter führenden Kanal ein und verbleibt dort zumindest zeitweise, auch wenn dieser Kanal später Druckluft führt. Durch Anordnung eines Steigrohres, welches verhältnismäßig weit in das Probengefäß hineinreicht, läßt sich dieser Nachteil zwar mildern, aber nicht völlig beheben.In numerous fields of application, in particular in the medical-technical field or for laboratory tests of all kinds, in which sample material from a vessel has to be distributed in predetermined quantities, it is known to use closure pieces of the type mentioned above (EP-B 48 452). By means of the diluter, air can be sucked out of the vessel containing the sample material, so that the vessel can be transported from the secondary vessel to the secondary vessel with the pouring channel directed downward, without the sample material being lost. Above the respective secondary vessel, negative pressure in the primary vessel is removed by means of the diluter and pressure is fed to the primary vessel above the sample material, so that sample material can exit through the pouring channel and fall into the secondary vessel. The duration and level of the pressure supplied determine the amount of sample to be dispensed. As a rule, the primary vessels provided with the closure piece are seized in large numbers one after the other by a carrier of a sample distributor and subjected to the distribution process mentioned. The vessel is firmly connected to the carrier, usually with the interposition of a seal. In the medical field in particular, it is desirable to keep the contact surface of the carrier of the sample distributor, against which the closure piece rests when fastened, free of contamination, since otherwise cross-infections cannot be avoided. However, it has been shown that such contamination is often unavoidable, because when the sample vessel is transferred from a position in which the pouring channel is directed upwards to a position in which this channel points downwards, sample material enters the channel leading to the Diluter and remains there at least temporarily, even if this channel later carries compressed air. By Arrangement of a riser pipe, which extends relatively far into the sample vessel, can alleviate this disadvantage, but not completely eliminate it.

Die Erfindung setzt sich zur Aufgabe, diesen Nachteil zu vermeiden und ein Verschlußstück der eingangs geschilderten Art so zu verbessern, daß die Gefahr einer Kontaminierung der Kontaktfläche, mit welcher das Probengefäß an der Halterung des Probenverteilers befestigt wird, zumindest wesentlich herabgesetzt, wenn nicht mit Sicherheit vermieden ist. Die Erfindung geht hiebei von der Erkenntnis aus, daß die erwähnte Kontaminierung darauf zurückzuführen ist, daß der Kanal für die Diluterluft das Verschlußstück bei der bekannten Konstruktion geradlinig durchsetzt. Es wurde gefunden, daß schon eine geringe Quererstreckung dieses Kanals die Gefahr einer Kontaminierung wesentlich herabsetzt. Davon ausgehend, besteht die erfindungsgemäße Lösung der zuvor erwähnten Aufgabe darin, daß die Einlaßöffnung des Kanals für das gasförmige Medium relativ zur Auslaßöffnung in Umfangsrichtung des Verschlußstückes versetzt ist, wobei ein an die Einlaßöffnung anschließender Kanalabschnitt mit einem an die Auslaßöffnung anschließenden Kanalabschnitt durch einen im Inneren des Verschlußstückes quer zu diesen Kanalabschnitten verlaufenden Kanalabschnitt verbunden ist. Dadurch ergibt sich die bereits erwähnte Quererstreckung des zum Diluter führenden Kanales. Diese Quererstreckung bremst die in den Diluterkanal eingedrungene Flüssigkeit (Probe) so weit, daß diese Probe nicht mehr zur geräteseitigen Stirnfläche des Verschlüßstückes, also zur Anlagefläche an dem Gefäßträger gelangen kann, insbesondere wenn die erwähnte Versetzung ein Maximum erreicht, d.h. 180° beträgt.The invention has for its object to avoid this disadvantage and to improve a closure piece of the type described above so that the risk of contamination of the contact surface with which the sample vessel is attached to the holder of the sample distributor is at least substantially reduced, if not with certainty is avoided. The invention is based on the knowledge that the contamination mentioned is due to the fact that the channel for the diluter air passes straight through the closure piece in the known construction. It has been found that even a slight transverse extension of this channel significantly reduces the risk of contamination. Proceeding from this, the solution of the aforementioned object according to the invention is that the inlet opening of the channel for the gaseous medium is offset relative to the outlet opening in the circumferential direction of the closure piece, a channel section adjoining the inlet opening having a channel section adjoining the outlet opening by an interior of the closure piece is connected transversely to these channel sections. This results in the aforementioned transverse extension of the channel leading to the diluter. This transverse extension brakes the liquid (sample) which has penetrated into the diluter channel to such an extent that this sample can no longer reach the end face of the closure piece on the device side, that is to say to the contact surface on the vessel carrier, in particular if the aforementioned displacement reaches a maximum, i.e. Is 180 °.

Gemäß einer bevorzugten Ausführungsform der Erfindung ist der quer verlaufende Kanalabschnitt ein Ringkanal, welcher Kanal vorzugsweise als Mikrokanal, insbesondere mit einer axialen Erstreckung im Vorschlußstück von weniger als 0,05 mm, ausgebildet ist. Ein in Umfangsrichtung verlaufender Kanal ist länger als ein radialer Querkanal, was die erwähnte Bremsung der Flüssigkeit begünstigt. Die Ausbildung als Mikrokanal, insbesondere mit den erwähnten Abmessungen, hat sich als besonders wirksam erwiesen und vermeidet eine Kontaminierung der Kontaktfläche völlig.According to a preferred embodiment of the invention, the transverse channel section is an annular channel, which channel is preferably designed as a microchannel, in particular with an axial extension in the connecting piece of less than 0.05 mm. A channel running in the circumferential direction is longer than a radial transverse channel, which favors the aforementioned braking of the liquid. The training as a microchannel, in particular with the dimensions mentioned, has proven to be particularly effective and completely prevents contamination of the contact surface.

Ein im Inneren des Verschlußstückes verlaufender Kanal könnte bei der Herstellung durch Kerne erzeugt werden, welche später entfernt werden. Herstellungsmäßig einfacher ist es jedoch, das Verschlußstück im Rahmen der Erfindung zweiteilig auszubilden, wobei die beiden Teile in miteinander verbundener Lage den Querkanal, insbesondere als Ringkanal, zwischen sich bilden. Besonders günstig ist es hiebei, wenn gemäß einer Weiterbildung der Erfindung der Ringkanal in radialer Richtung durch verformbare Dichtlippen zumindest des einen der beiden Teile begrenzt ist. Bei der Zusammenfügung der beiden Teile zum Verschlußstück werden diese Lippen verquetscht und begrenzen derart dichtend den Ringkanal. Um diese Dichtung aufrecht zu erhalten, empfiehlt es sich hiebei im Rahmen der Erfindung, die beiden Teile durch einen Schnappverschluß miteinander zu verbinden.A channel running inside the closure piece could be created during manufacture by cores, which are later removed. In terms of production, however, it is simpler to design the closure piece in two parts within the scope of the invention, the two parts forming the transverse channel, in particular as an annular channel, between them in a connected position. It is particularly favorable if according to one Further development of the invention, the annular channel is limited in the radial direction by deformable sealing lips of at least one of the two parts. When the two parts are joined together to form the closure piece, these lips are squeezed and thus delimit the annular channel. In order to maintain this seal, it is recommended within the scope of the invention to connect the two parts to one another by a snap lock.

Gemäß einer bevorzugten Ausführungsform der Erfindung verläuft eine Ringnut an der vom Gefäß abgewendeten Stirnfläche des Verschlußstückes, welche Ringnut mit dem Kanal für das gasförmige Medium in Verbindung steht. Diese Ringnut macht das Verschlußstück unabhängig davon, in welcher Drehstellung es am Verschlußstückträger befestigt wird.According to a preferred embodiment of the invention, an annular groove runs on the end face of the closure piece facing away from the vessel, which annular groove is connected to the channel for the gaseous medium. This ring groove makes the closure piece regardless of the rotational position in which it is attached to the closure piece carrier.

Das erfindungsgemäße Verfahren zur Herstellung des erfindungsgemäßen Verschlußstückes ist dadurch gekennzeichnet, daß das Verschlußstück in zwei Teilen gespritzt oder gegossen wird, von welchen Teilen das eine Teil den Ausgußkanal sowie die Einlaßöffnung des Kanales für das gasförmige Medium aufweist, das andere Teil die Auslaßöffnung für das gasförmige Medium, und daß ein die beiden Teile verbindender Steg mitgespritzt oder mitgegossen wird, welcher anschließend bei der Vereinigung der beiden Teile gebogen und gegebenenfalls danach entfernt wird. Dieser Steg bildet bei der Vereinigung der beiden Teile eine Gewähr dafür, daß die in den beiden Teilen vorgesehenen Öffnungen des an den Diluter anzuschließenden Kanales die gewünschte Versetzung relativ zueinander aufweisen.The inventive method for producing the closure piece according to the invention is characterized in that the closure piece is injection molded or cast in two parts, of which one part has the pouring channel and the inlet opening of the channel for the gaseous medium, the other part the outlet opening for the gaseous medium Medium, and that a web connecting the two parts is injected or cast, which is then bent when the two parts are combined and, if necessary, is then removed. When the two parts are combined, this web forms a guarantee that the openings in the two parts of the channel to be connected to the diluter have the desired offset relative to one another.

Weitere Kennzeichen und Vorteile der Erfindung ergeben sich aus der Beschreibung von Ausführungsbeispielen, welche in der Zeichnung schematisch dargestellt sind. Fig.1 zeigt einen Vertikalschnitt durch die beiden Teile des Verschlußstückes im voneinander getrennten Zustand. Fig.2 zeigt die beiden Teile miteinander vereinigt und im auf ein Probengefäß aufgesetzten Zustand. Fig.3 zeigt eine Ausführungsvariante zu Fig.2. Fig.4 zeigt eine Ausführungsform ähnlich zu Fig.2, im an einem Träger für das Probengefäß befestigten Zustand. Fig.5 zeigt im Vertikalschnitt die beiden bei der Herstellung durch einen Steg miteinander verbundenen Teile des Verschlußstückes und Fig.6 ist eine Ansicht in Richtung des Pfeiles VI der Fig.5.Further characteristics and advantages of the invention result from the description of exemplary embodiments, which are shown schematically in the drawing. Fig.1 shows a vertical section through the two parts of the closure piece in the separated state. 2 shows the two parts combined and in the state placed on a sample vessel. 3 shows an embodiment variant of FIG. 2. FIG. 4 shows an embodiment similar to FIG. 2, in the state attached to a carrier for the sample vessel. 5 shows in vertical section the two parts of the closure piece which are connected to one another during manufacture by a web, and FIG. 6 is a view in the direction of the arrow VI in FIG. 5.

Das Verschlußstück 1 dient zum Verschluß eines Gefäßes 2 (Fig.2,3), welches in der Regel von einem zylindrischen Glasröhrchen gebildet ist, dessen Boden 3 geschlossen ist und das oben eine Öffnung 4 hat, welche durch das Verschlußstück 1 verschlossen werden soll. Das Verschlußstück 1 gemäß Fig.1 ist aus zwei Teilen 5,6 gebildet, die miteinander fest verbindbar sind, insbesondere mittels eines Schnappverschlusses, der später noch näher beschrieben wird. Das obere Teil 5 hat ein Ausgußrohr 7, welches einen Ausgußkanal 8 begrenzt, der das Teil 5 durchsetzt. Dieser Ausgußkanal 8 setzt sich im Teil 6 fort und durchsetzt auch dieses Teil als mittige Öffnung. Exzentrisch zu diesem mittig angeordneten Ausgußkanal 8 hat der Teil 6 einen ein gasförmiges Medium, insbesondere Luft, führenden Kanal 9, welcher den Teil 6 in axialer Richtung durchsetzt und zum Großteil in einem Steigrohr 10 verläuft. Im zusammengesetzten Zustand der beiden Teile 5,6 trifft dieser Kanal 9 auf einen als Ringkanal 11 ausgebildeten Mikrokanal, zweckmäßig mit einer axialen Abmessung von weniger als 0,05 mm, insbesondere etwa 0,02 bis 0,03 mm, welcher der besseren Deutlichkeit halber übertrieben stark dargestellt ist. In diesen Ringkanal 11 mündet ein das Teil 5 durchsetzender, in axialer Richtung verlaufender Kanal 12, wobei die Einlaßöffnung 13 dieses Kanales relativ zur Auslaßöffnung 14 des Kanales 9 in Bezug auf die mittige Achse 25 um 180° versetzt ist. Hiebei wurde für "Einlaß" bzw. "Auslaß" jener Betriebszustand angenommen, bei welchem Luft von einem nicht dargestellten Diluter in das Innere des Gefäßes zugeführt wird; bei Absaugung von Luft aus dem Gefäß 2 mittels des Diluters sind die Verhältnisse natürlich umgekehrt.The closure piece 1 serves to close a vessel 2 (Fig. 2, 3), which is usually formed by a cylindrical glass tube, the bottom 3 of which is closed and which has an opening 4 at the top, which to be closed by the closure piece 1. The closure piece 1 according to FIG. 1 is formed from two parts 5, 6, which can be firmly connected to one another, in particular by means of a snap closure, which will be described in more detail later. The upper part 5 has a pouring pipe 7 which delimits a pouring channel 8 which passes through the part 5. This pouring channel 8 continues in part 6 and also passes through this part as a central opening. Eccentric to this centrally arranged pouring channel 8, the part 6 has a channel 9 which carries a gaseous medium, in particular air, which passes through the part 6 in the axial direction and for the most part runs in a riser pipe 10. In the assembled state of the two parts 5, 6, this channel 9 meets a microchannel designed as an annular channel 11, expediently with an axial dimension of less than 0.05 mm, in particular approximately 0.02 to 0.03 mm, which for the sake of clarity is exaggerated. In this ring channel 11 a part 5 penetrating, in the axial direction extends channel 12, the inlet opening 13 of this channel is offset relative to the outlet opening 14 of the channel 9 with respect to the central axis 25 by 180 °. For "inlet" or "outlet", that operating state was assumed in which air is fed into the interior of the vessel from a diluter (not shown); when air is sucked out of the vessel 2 by means of the diluter, the situation is of course reversed.

Um die erwähnte Versetzung der Einlaßöffnung 13 in Bezug auf die Auslaßöffnung 14 zu sichern, hat das Teil 5 eine Positionskerbe 15 an einem in axialer Richtung vorstehenden ringförmigen Vorsprung 16, in welche Positionskerbe 15 ein entsprechender Vorsprung 17 des anderen Teiles 6 einrastet. Da die Positionskerbe 15 relativ zum Kanal 12 um 180° versetzt ist, bedeutet diese Einrastung eine analoge Versetzung der beiden Kanäle 9,12.In order to secure the aforementioned displacement of the inlet opening 13 with respect to the outlet opening 14, the part 5 has a position notch 15 on an annular projection 16 projecting in the axial direction, into which position notch 15 a corresponding projection 17 of the other part 6 engages. Since the position notch 15 is offset by 180 ° relative to the channel 12, this latching means an analog offset of the two channels 9, 12.

Wie bereits erwähnt, dienen die Kanäle 9,12 zur Zufuhr bzw. Abfuhr von Luft in das bzw. aus dem Gefäß 2 mittels eines Diluters. Um den Anschluß an die Diluterleitung 18 (Fig.4) zu sichern, hat das Teil 5 an seiner dem Teil 6 abgewendeten Stirnfläche 19 eine Ringnut 20, in welche der Kanal 12 mit seiner Einlaßöffnung 13 mündet. Dadurch wird das Verschlußstück 1 unabhängig von seiner Drehlage in Bezug auf den Transportwagen, mit welchem das Gefäß 2 bei der Probenverteilung transportiert wird.As already mentioned, the channels 9, 12 serve for supplying and removing air into and from the vessel 2 by means of a diluter. In order to secure the connection to the diluter line 18 (FIG. 4), the part 5 has on its end face 19 facing away from the part 6 an annular groove 20 into which the channel 12 opens with its inlet opening 13. As a result, the closure piece 1 is independent of its rotational position in relation to the transport carriage with which the vessel 2 is transported during the sample distribution.

Fig.2 zeigt das Verschlußstück 1 im am Gefäß 2 befestigten Zustand. Das Verschlußstück 1 bzw. sein Teil 6 umgreift hiebei den Oberrand des Gefäßes 2 mit einer Abdichtglocke 21, welche an ihrem Innenumfang mit mehreren Dichtlippen 22 versehen ist. Eine solche Ausbildung eignet sich insbesondere für reine Serumgefäße oder Serumgefäße mit Trenngel. Im Gefäß 2 befindet sich ein Blutkuchen 23 mit Trenngel, der Füllstandpegel 24 der Blutprobe läßt oberhalb noch einen Luftraum 25 frei. Die beiden Teile 5,6 des Verschlußstückes 1 sind miteinander zusammengepreßt, wobei der Vorsprung 17 in die Positionskerbe 15 eingreift. Der Ringkanal 11 wird durch die einander zugewendeten Stirnflächen der beiden Teile 5,6 begrenzt und verläuft konzentrisch zur Längsachse 25 des Gefäßes 2. Das obere Teil 5 hat an seiner Stirnfläche 19 einen nach außen weisenden Flansch 26, welcher zum Angriff von Spanngliedern, insbesondere Spannkrallen 28 eines Spannverschlusses 27 (Fig.4), dienen. Diese Spannkrallen 28 greifen - in Umfangsrichtung des Flansches 26 verteilt - am Flansch 26 an und spannen dadurch das Verschlußstück 1 samt dem daran hängenden Gefäß 2 an einem Träger 29 eines Probenverteilers fest. Dieser Träger 29 ist an einem nicht dargestellten Transportwagen des Probenverteilers um eine horizontale Achse schwenkbar, so daß das Ausgußrohr 7 in eine nach unten weisende Stellung gebracht werden kann, wobei in der Diluterleitung 18 ein Vakuum herrscht, so daß die im Gefäß 2 befindliche Probe zurückgehalten wird und nicht durch das Ausgußrohr 7 ausströmen kann. Sobald die Ausgießposition erreicht ist, wird das Vakuum durch Überdruck ersetzt und somit eine Teilmenge der im Gefäß 2 befindlichen Probe durch das Ausgußrohr 7 ausgestoßen.Fig.2 shows the closure piece 1 in the state attached to the vessel 2. The closure piece 1 or its part 6 encompasses the upper edge of the vessel 2 with a sealing bell 21, which is provided on its inner circumference with a plurality of sealing lips 22. Such training is particularly suitable for pure serum vessels or serum vessels with separating gel. In the vessel 2 there is a blood cake 23 with a separating gel, the fill level 24 of the blood sample leaves an air space 25 above. The two parts 5, 6 of the closure piece 1 are pressed together, the projection 17 engaging in the position notch 15. The annular channel 11 is delimited by the mutually facing end faces of the two parts 5, 6 and runs concentrically to the longitudinal axis 25 of the vessel 2. The upper part 5 has on its end face 19 an outwardly facing flange 26 which is used to engage tendons, in particular tension claws 28 of a turnbuckle 27 (Fig.4), serve. These clamping claws 28 engage - distributed in the circumferential direction of the flange 26 - on the flange 26 and thereby tighten the closure piece 1 together with the vessel 2 attached to it on a support 29 of a sample distributor. This carrier 29 can be pivoted about a horizontal axis on a transport carriage of the sample distributor, not shown, so that the pouring tube 7 can be brought into a downward-pointing position, a vacuum prevailing in the diluter line 18 so that the sample in the vessel 2 is retained is and can not flow through the pouring spout 7. As soon as the pouring position has been reached, the vacuum is replaced by excess pressure and a part of the sample in the vessel 2 is thus expelled through the pouring pipe 7.

Die Spannkrallen 28 sind durch einen nicht dargestellten Antrieb in Achsrichtung des Probengefäßes 2 beweglich und zusätzlich nach außen bzw. innen schwenkbar, so daß der Flansch 26 ergriffen bzw. freigegeben werden kann.The clamping claws 28 are movable in the axial direction of the sample vessel 2 by a drive, not shown, and can additionally be pivoted outwards or inwards, so that the flange 26 can be gripped or released.

Die in Fig.4 dargestellte Form des Verschlußstückes 1 unterscheidet sich von jener nach Fig.2 lediglich geringfügig durch eine abweichende Form des Ausgußrohres 7, welches an seiner Mündung 30 eine Erweiterung 31 des Durchmessers des Ausgußkanales 8 aufweist. Dies ergibt eine Tropfenzentrierung durch die Querschnittsvergrößerung des Kanales 8, d.h. bei Beendigung der Probenabgabe zieht sich der Resttropfen in diese Erweiterung 31 zurück, so daß kein Tropfen unbeabsichtigt verlorengeht, auch dann nicht, wenn das Gerät, etwa beim Weitertransport in die nächste Abgabeposition, Erschütterungen unterworfen wird.The shape of the closure piece 1 shown in FIG. 4 differs from that of FIG. 2 only slightly by a different shape of the pouring tube 7, which has an enlargement 31 of the diameter of the pouring channel 8 at its mouth 30. This results in a drop centering due to the cross-sectional enlargement of the channel 8, i.e. at the end of the sample delivery, the residual drop retracts in this extension 31, so that no drop is lost unintentionally, even if the device is subjected to vibrations, for example when it is transported to the next delivery position.

Ferner hat das untere Teil 6 an der Innenfläche seiner Abdichtglocke Dichtlippen 22 mit spitzem, etwa dreieckigem Querschnitt, wogegen die Dichtlippen 22 nach Fig.1 einen abgerundeten Querschnitt aufweisen. Welche der Querschnittsformen gewählt wird, hängt vom vorliegenden Anwendungsgebiet ab.Furthermore, the lower part 6 has on the inner surface of its sealing bell Sealing lips 22 with a pointed, approximately triangular cross section, whereas the sealing lips 22 according to FIG. 1 have a rounded cross section. Which of the cross-sectional shapes is selected depends on the area of application at hand.

Schließlich besteht bei der Ausführungsform nach Fig.4 eine Abweichung gegenüber jener nach Fig.2 darin, daß der Ringkanal 11 nicht von einer Ringnut an der Bodenfläche des oberen Teiles 5 gebildet ist (wie bei der Ausführungsform nach den Fig.1 und 2) sondern seitlich durch verformbare Dichtlippen 32 (siehe auch Fig.5) begrenzt ist. Beim Zusammenpressen des Oberteiles 5 mit dem Unterteil 6 werden diese Dichtlippen 32, welche ein Dreiecksprofil aufweisen, bleibend verformt und dichten dadurch den Ringkanal 11 nach außen und innen ab. Bei diesem Zusammenpressen der beiden Teile 5,6 rastet ein Umfangswulst 33 des Unterteiles 6 in eine Umfangsnut 34 am Innenmantel des Oberteiles 5 ein, so daß die beiden Teile 5,6 aneinander durch eine Verbindung nach Art eines Schnappverschlusses 35 (Fig.4) befestigt sind.Finally, in the embodiment according to FIG. 4, there is a deviation from that according to FIG. 2 in that the annular channel 11 is not formed by an annular groove on the bottom surface of the upper part 5 (as in the embodiment according to FIGS. 1 and 2), but instead is laterally limited by deformable sealing lips 32 (see also FIG. 5). When the upper part 5 is pressed together with the lower part 6, these sealing lips 32, which have a triangular profile, are permanently deformed and thereby seal the annular channel 11 from the inside and outside. During this pressing together of the two parts 5, 6, a circumferential bead 33 of the lower part 6 engages in a circumferential groove 34 on the inner jacket of the upper part 5, so that the two parts 5, 6 are fastened to one another by a connection in the manner of a snap lock 35 (FIG. 4) are.

Zweckmäßig befindet sich zwischen der Anlagefläche 36 (Fig.4) des Trägers 29 und der oberen Stirnfläche 19 des Oberteiles 5 eine an der Anlagefläche 36 befestigte Dichtung 37, welche mit einer Durchgangsöffnung 38 versehen ist, die mit der Diluterleitung 18 und der Ringnut 20 fluchtet.Appropriately, between the contact surface 36 (FIG. 4) of the carrier 29 and the upper end face 19 of the upper part 5 there is a seal 37 fastened to the contact surface 36, which is provided with a through opening 38 which is aligned with the diluter line 18 and the annular groove 20 .

Bei den bisher beschriebenen Ausführungsformen wird das Gefäß 2 vom Verschlußstück 1 an seinem Außenmantel ergriffen. Es kann jedoch auch, wie Fig.3 zeigt, das Verschlußstück 1 stopfenartig in die Öffnung 4 des Gefäßes 2 eingesetzt sein, wobei anstelle der Abdichtglocke 21 (Fig.2) eine innen am Gefäß 2 anliegende Hülse 39 tritt, die über einen Teil ihres Umfanges in das Steigrohr 10 übergeht und am Außenmantel mit Dichtlippen 22 versehen ist.In the embodiments described so far, the vessel 2 is gripped by the closure piece 1 on its outer jacket. However, as FIG. 3 shows, the closure piece 1 can also be inserted into the opening 4 of the vessel 2 in the manner of a stopper, with a sleeve 39 lying inside the vessel 2 instead of the sealing bell 21 (FIG. 2) passing over part of it The circumference merges into the riser pipe 10 and is provided on the outer jacket with sealing lips 22.

Zweckmäßig besteht das Verschlußstück 1 aus synthetischem Kunststoffmaterial, obwohl im Prinzip auch andere Materialien, z.B. Gummi, verwendbar sind. Besonders eignen sich spritzgußfähige Materialien aus Herstellungsgründen. Es kann dann, wie Fig.5 zeigt, bei der Herstellung durch Spritzgießen der Oberteil 5 in der Form mit dem Unterteil 6 durch einen dünnen, biegsamen Steg 40 verbunden sein. Nach dem Entformen bildet dieser Steg 40 eine Führung, welche es auch bei maschineller Fertigung sicherstellt, daß die beiden Öffnungen 13,14 gegeneinander um 180° in Bezug auf die Mittelachse versetzt sind, wenn die beiden Teile 5,6 aus der in Fig.5 dargestellten Entformposition in die in Fig.4 dargestellte Verbindungslage gebracht werden, ohne daß der Steg 40 zerstört wird. Nach Sicherung der Verbindung der Teile 5,6 durch den Schnappverschluß 35 kann der Steg 40 entfernt werden. Er kann jedoch - wenn dies gewünscht ist - auch verbleiben und bietet dann eine am Verschlußstück 1 anhaftende Schlaufe, die in Sonderfällen von Vorteil sein kann.The closure piece 1 expediently consists of synthetic plastic material, although in principle other materials, for example rubber, can also be used. Injection-moldable materials are particularly suitable for manufacturing reasons. It can then, as shown in FIG. 5, be connected to the lower part 6 by a thin, flexible web 40 during manufacture by injection molding. After removal from the mold, this web 40 forms a guide, which, even in the case of mechanical production, ensures that the two openings 13, 14 are offset from one another by 180 ° with respect to the central axis when the two parts 5, 6 from the one in FIG shown demolding position in the shown in Figure 4 Connection position are brought without the web 40 is destroyed. After securing the connection of the parts 5, 6 by the snap lock 35, the web 40 can be removed. However, if desired, it can also remain and then offers a loop adhering to the closure piece 1, which can be advantageous in special cases.

Die erwähnte Zweiteiligkeit des Verschlußstückes und die Herstellung der beiden Teile 5,6 in gesonderten Formteilen (Fig.5,6) bietet auch die Möglichkeit eines einfachen Überganges auf unterschiedliche Gefäßformen bei der Fertigung. In einem solchen Fall kann das Oberteil 5 unverändert für die geänderte Gefäßform hergestellt werden, wogegen das Formteil für den Unterteil 6 dem jeweils vorliegenden Gefäß 2 entsprechend geformt wird. Auf diese Weise sind auch unübliche Röhrchenformen, z.B. mit quadratischem Querschnitt, leicht erfaßbar. Lediglich die Verbindungsstelle der beiden Teile 5,6 muß natürlich einander entsprechen, um die beiden Teile sicher miteinander verbinden zu können.The aforementioned two-part design of the closure piece and the production of the two parts 5, 6 in separate molded parts (FIG. 5, 6) also offers the possibility of a simple transition to different vessel shapes during manufacture. In such a case, the upper part 5 can be produced unchanged for the changed vessel shape, whereas the shaped part for the lower part 6 is shaped in accordance with the respective vessel 2 present. In this way, unusual tube shapes, e.g. with a square cross-section, easy to grasp. Only the connection point of the two parts 5, 6 must of course correspond to one another in order to be able to connect the two parts securely to one another.

Claims (11)

  1. Closure member (1) for sample vessels (2), in particular for medical or technical tests, comprising a centrally, in particular in the vessel axis (25), disposed discharge channel (8) and a separately therefrom, excentrically disposed channel (9,11,12) for a gaseous medium, in particular air, for the connection to a diluter, which two channels (8,9,11,12) penetrate the closure member (1), wherein preferably the channel (9,11,12) for the gaseous medium comprises a riser pipe (10) extending into the interior of the vessel (2), characterized in that the inlet opening (13) of the channel (9,11,12) for the gaseous medium is displaced in peripheral direction of the closure member (1) with respect to its outlet opening (14), a channel section (12) connected to the inlet opening (13) being in communication with a channel section (9) connected to the outlet opening (14) by means of a channel section (11) extending transversely to these channel sections (9,12) in the interior of the closure member (1).
  2. Closure member according to claim 1, characterized in that the displacement amounts to 180°.
  3. Closure member according to claim 1 or 2, characterized in that the transversely extending channel section (11) is an annular channel which preferably is formed as a micro channel, in particular with an axial dimension in the closure member of less than 0.5 mm.
  4. Closure member according to claim 3, characterized in that it consists in a manner known per se of two parts (5,6) and that the two parts (5,6), in a position connected to each other, delimit between themselves the transversely extending channel section (11), in particular as an annular channel.
  5. Closure member according to claim 4, characterized in that the transversely extending channel section (11), formed as an annular channel, is confined in radial direction by deformable sealing lips (32) of at least one of the two parts (5,6).
  6. Closure member according to claim 4 or 5, characterized in that the two parts (5,6) are connectable to each other by a snap closure (35).
  7. Closure member according to any of claims 4 to 6, characterized in that on that part (5) which is more spaced apart from the vessel (2), a radially outward protruding flange (26) is provided for the catch of a fastening closure (27).
  8. Closure member according to any of claims 4 to 7, characterrized in that on that connection surface of the one part (5) that faces the other part (6), a positioning score (15) is provided into which engages a protrusion (17) of the other part (6).
  9. Closure member according to any of claims 1 to 8, characterized in that an annular groove (20) extends on its front surface (19) opposite to the vessel (2), which groove is in connection with the channel (9,11,12) for the gaseous medium.
  10. Closure member according to any of claims 1 to 9, characterized in that the discharge channel (8), which preferably is confined by a discharge tube (7), comprises an enlargement (31) at its mouth (30).
  11. Method for manufacturing a closure member according to any of claims 1 to 10, characterized in that it is injected or poured in two parts (5,6), from which parts the one part (5) comprises the discharge channel (8) as well as the inlet opening (13) of the channel (9,11,12) for the gaseous medium, the other part (6) the outlet opening (14) for the gaseous medium, and that a web (40) connecting the two parts (5,6) is injected our poured together, which subsequently is bent when joining the two parts (5,6) and, optionally, is removed thereafter.
EP19910890275 1990-11-20 1991-11-13 Closure for sample vessels and method for its manufacture Expired - Lifetime EP0487490B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT2356/90 1990-11-20
AT235690A AT399139B (en) 1990-11-20 1990-11-20 SEALING PIECE FOR VESSELS FOR SPECIMEN GOODS AND METHOD FOR THE PRODUCTION THEREOF

Publications (3)

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EP0487490A2 EP0487490A2 (en) 1992-05-27
EP0487490A3 EP0487490A3 (en) 1992-11-04
EP0487490B1 true EP0487490B1 (en) 1995-02-01

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AT (1) AT399139B (en)
DE (1) DE59104487D1 (en)

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US6160992A (en) * 1996-10-31 2000-12-12 Lucent Technologies Inc. Method and system for communicating with remote units in a communication system
US6312648B1 (en) * 1998-01-12 2001-11-06 The United States Of America As Represented By The Department Of Health And Human Services Applicator system
ITRM20040397A1 (en) * 2004-08-04 2004-11-04 Univ Roma DISPOSABLE DEVICE FOR ONE OR MORE INTRODUCTIONS, TREATMENT AND COLLECTIONS OF BIOLOGICAL MATERIAL FROM AT LEAST ONE OF THE SEPARATION PHASES, PRESENT INSIDE THE DEVICE, IN STERILITY CONDITIONS AND AT CONSTANT PRESSURE.
DE102007004227A1 (en) * 2007-01-27 2008-09-18 Bruker Biospin Ag Cap for NMR sample tube with internal sealing lip
DE102008023341A1 (en) * 2008-02-27 2009-06-25 Elm - Plastic Gmbh Pipette adapter for inserting into e.g. medicament containing bottle, has upwardly opened casing including crank with through opening at lower end, and inwardly opened casing including gaskets at outer side of inwardly opened casing
DE202008004471U1 (en) * 2008-04-01 2008-08-21 Rest, Georg Containers for securing, storing and transporting biological samples

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FR2185196A5 (en) * 1972-05-19 1973-12-28 Larrieu Jean
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WO2023192679A1 (en) * 2022-04-01 2023-10-05 Gill, Llc Locking sample cap

Also Published As

Publication number Publication date
EP0487490A3 (en) 1992-11-04
EP0487490A2 (en) 1992-05-27
ATA235690A (en) 1994-08-15
DE59104487D1 (en) 1995-03-16
AT399139B (en) 1995-03-27

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