EP0480708A3 - Hydroxyalkylquinoline ether acids as leukotriene antagonists - Google Patents
Hydroxyalkylquinoline ether acids as leukotriene antagonists Download PDFInfo
- Publication number
- EP0480708A3 EP0480708A3 EP19910309289 EP91309289A EP0480708A3 EP 0480708 A3 EP0480708 A3 EP 0480708A3 EP 19910309289 EP19910309289 EP 19910309289 EP 91309289 A EP91309289 A EP 91309289A EP 0480708 A3 EP0480708 A3 EP 0480708A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- hydroxyalkylquinoline
- leukotriene antagonists
- ether acids
- compounds
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59688590A | 1990-10-12 | 1990-10-12 | |
US596885 | 1990-10-12 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0480708A2 EP0480708A2 (en) | 1992-04-15 |
EP0480708A3 true EP0480708A3 (en) | 1992-05-20 |
EP0480708B1 EP0480708B1 (en) | 1995-10-11 |
Family
ID=24389130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91309289A Expired - Lifetime EP0480708B1 (en) | 1990-10-12 | 1991-10-09 | Hydroxyalkylquinoline ether acids as leukotriene antagonists |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0480708B1 (en) |
JP (1) | JP2538154B2 (en) |
KR (1) | KR920008005A (en) |
CN (1) | CN1061594A (en) |
AT (1) | ATE128969T1 (en) |
AU (1) | AU639612B2 (en) |
CA (1) | CA2053208C (en) |
CS (1) | CS309491A3 (en) |
DE (1) | DE69113735T2 (en) |
ES (1) | ES2079586T3 (en) |
FI (1) | FI914795A (en) |
HU (1) | HUT61982A (en) |
IE (1) | IE913610A1 (en) |
IL (1) | IL99683A0 (en) |
MX (1) | MX9101556A (en) |
NO (1) | NO914003L (en) |
PT (1) | PT99211B (en) |
ZA (1) | ZA918115B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5506227A (en) * | 1992-04-13 | 1996-04-09 | Merck Frosst Canada, Inc. | Pyridine-substituted benzyl alcohols as leukotriene antagonists |
US5358955A (en) * | 1992-10-30 | 1994-10-25 | Abbott Laboratories | Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis |
US5438141A (en) * | 1993-05-21 | 1995-08-01 | Merck Frosst Canada, Inc. | Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists |
JPH09278653A (en) * | 1996-04-05 | 1997-10-28 | Santen Pharmaceut Co Ltd | Retinal disease-treating preparation |
WO1998008820A1 (en) * | 1996-08-26 | 1998-03-05 | Yamanouchi Pharmaceutical Co., Ltd. | Benzenesulfone compounds and salts thereof |
GB2356139A (en) * | 1999-11-15 | 2001-05-16 | Bayer Ag | Use of substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphonamides and cyanamides for the treatment of diseases |
EP1958936A1 (en) * | 2007-02-14 | 2008-08-20 | Inke, S.A. | Process for obtaining montelukast |
KR20140108627A (en) * | 2011-07-26 | 2014-09-12 | 썬 파마 어드밴스트 리서치 컴패니 리미티드 | Cysteinyl leukotriene antagonists |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0318093A2 (en) * | 1987-11-25 | 1989-05-31 | Merck Frosst Canada Inc. | Diarylquinoline diacids and their use as medicaments |
EP0349062A1 (en) * | 1988-06-27 | 1990-01-03 | Merck Frosst Canada Inc. | Quinoline ether alkanoic acid |
EP0399818A1 (en) * | 1989-05-24 | 1990-11-28 | Merck Frosst Canada Inc. | Diarylstyrylquinoline diacids |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62120365A (en) * | 1985-11-16 | 1987-06-01 | バイエル・アクチエンゲゼルシヤフト | Substituted benzyl ethers, manufacture and use |
IE59889B1 (en) * | 1986-02-14 | 1994-04-20 | Merck Frosst Canada Inc | 2-substituted quinoline dioic acids |
JPS62258369A (en) * | 1986-05-02 | 1987-11-10 | Nippon Soda Co Ltd | Quinazolinone derivative and production thereof |
EP0271287A3 (en) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Quinoline dioic acids and amides |
-
1991
- 1991-10-09 ES ES91309289T patent/ES2079586T3/en not_active Expired - Lifetime
- 1991-10-09 IL IL99683A patent/IL99683A0/en unknown
- 1991-10-09 AT AT91309289T patent/ATE128969T1/en not_active IP Right Cessation
- 1991-10-09 DE DE69113735T patent/DE69113735T2/en not_active Expired - Fee Related
- 1991-10-09 EP EP91309289A patent/EP0480708B1/en not_active Expired - Lifetime
- 1991-10-10 HU HU913218A patent/HUT61982A/en unknown
- 1991-10-10 CA CA002053208A patent/CA2053208C/en not_active Expired - Fee Related
- 1991-10-11 PT PT99211A patent/PT99211B/en not_active IP Right Cessation
- 1991-10-11 CN CN91111074A patent/CN1061594A/en active Pending
- 1991-10-11 AU AU85797/91A patent/AU639612B2/en not_active Ceased
- 1991-10-11 NO NO91914003A patent/NO914003L/en unknown
- 1991-10-11 CS CS913094A patent/CS309491A3/en unknown
- 1991-10-11 ZA ZA918115A patent/ZA918115B/en unknown
- 1991-10-11 FI FI914795A patent/FI914795A/en not_active Application Discontinuation
- 1991-10-11 MX MX9101556A patent/MX9101556A/en unknown
- 1991-10-12 KR KR1019910017952A patent/KR920008005A/en not_active Application Discontinuation
- 1991-10-14 JP JP3331108A patent/JP2538154B2/en not_active Expired - Lifetime
- 1991-10-16 IE IE361091A patent/IE913610A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0318093A2 (en) * | 1987-11-25 | 1989-05-31 | Merck Frosst Canada Inc. | Diarylquinoline diacids and their use as medicaments |
EP0349062A1 (en) * | 1988-06-27 | 1990-01-03 | Merck Frosst Canada Inc. | Quinoline ether alkanoic acid |
EP0399818A1 (en) * | 1989-05-24 | 1990-11-28 | Merck Frosst Canada Inc. | Diarylstyrylquinoline diacids |
Also Published As
Publication number | Publication date |
---|---|
NO914003D0 (en) | 1991-10-11 |
IL99683A0 (en) | 1992-08-18 |
PT99211B (en) | 1999-04-30 |
CA2053208A1 (en) | 1992-04-13 |
DE69113735D1 (en) | 1995-11-16 |
NO914003L (en) | 1992-04-13 |
DE69113735T2 (en) | 1996-06-13 |
CA2053208C (en) | 2003-04-15 |
ES2079586T3 (en) | 1996-01-16 |
CS309491A3 (en) | 1992-04-15 |
AU639612B2 (en) | 1993-07-29 |
IE913610A1 (en) | 1992-04-22 |
FI914795A0 (en) | 1991-10-11 |
CN1061594A (en) | 1992-06-03 |
JPH05105664A (en) | 1993-04-27 |
KR920008005A (en) | 1992-05-27 |
AU8579791A (en) | 1992-04-16 |
ZA918115B (en) | 1992-08-26 |
MX9101556A (en) | 1994-01-31 |
EP0480708B1 (en) | 1995-10-11 |
EP0480708A2 (en) | 1992-04-15 |
HU913218D0 (en) | 1992-01-28 |
ATE128969T1 (en) | 1995-10-15 |
PT99211A (en) | 1992-09-30 |
FI914795A (en) | 1992-04-13 |
JP2538154B2 (en) | 1996-09-25 |
HUT61982A (en) | 1993-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY2094B1 (en) | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists | |
ZA932533B (en) | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists | |
EP0480708A3 (en) | Hydroxyalkylquinoline ether acids as leukotriene antagonists | |
MY107767A (en) | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE |
|
AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE |
|
17P | Request for examination filed |
Effective date: 19921014 |
|
17Q | First examination report despatched |
Effective date: 19930518 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 19951011 Ref country code: LI Effective date: 19951011 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 19951011 Ref country code: DK Effective date: 19951011 Ref country code: CH Effective date: 19951011 Ref country code: BE Effective date: 19951011 Ref country code: AT Effective date: 19951011 |
|
REF | Corresponds to: |
Ref document number: 128969 Country of ref document: AT Date of ref document: 19951015 Kind code of ref document: T |
|
REF | Corresponds to: |
Ref document number: 69113735 Country of ref document: DE Date of ref document: 19951116 |
|
ITF | It: translation for a ep patent filed |
Owner name: SOCIETA' ITALIANA BREVETTI S.P.A. |
|
ET | Fr: translation filed | ||
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Effective date: 19960111 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2079586 Country of ref document: ES Kind code of ref document: T3 |
|
NLV1 | Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act | ||
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed | ||
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 19961031 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: CD Ref country code: FR Ref legal event code: CA |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: 732E |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20000928 Year of fee payment: 10 Ref country code: FR Payment date: 20000928 Year of fee payment: 10 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: ES Payment date: 20001018 Year of fee payment: 10 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20001127 Year of fee payment: 10 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20011009 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20011010 |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: IF02 |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20011009 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20020628 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20020702 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20021113 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED. Effective date: 20051009 |