MY107767A - Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists - Google Patents

Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists

Info

Publication number
MY107767A
MY107767A MYPI93000558A MYPI19930558A MY107767A MY 107767 A MY107767 A MY 107767A MY PI93000558 A MYPI93000558 A MY PI93000558A MY PI19930558 A MYPI19930558 A MY PI19930558A MY 107767 A MY107767 A MY 107767A
Authority
MY
Malaysia
Prior art keywords
fluorinated
leukotriene antagonists
hydroxyalkylquinoline
acids
compounds
Prior art date
Application number
MYPI93000558A
Inventor
Labelle Marc
Zamboni Robert
Guay Daniel
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/866,690 external-priority patent/US5270324A/en
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of MY107767A publication Critical patent/MY107767A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Abstract

COMPOUNDS HAVING THE FORMULA 1: ARE LEUKOTRIENE ANTAGONISTS AND INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. THESE COMPOUNDS ARE USEFUL AS ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, AND CYTOPROTECTIVE AGENTS. THEY ARE ALSO USEFUL IN TREATING ANGINA, CEREBRAL SPASM, GLOMERULAR NEPHRITIS, HEPATITIS, ENDOTOXEMIA, UVEITIS, AND ALLOGRAFT REJECTION.
MYPI93000558A 1992-04-10 1993-04-01 Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists MY107767A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/866,690 US5270324A (en) 1992-04-10 1992-04-10 Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists

Publications (1)

Publication Number Publication Date
MY107767A true MY107767A (en) 1996-06-15

Family

ID=25348177

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI93000558A MY107767A (en) 1992-04-10 1993-04-01 Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists

Country Status (4)

Country Link
KR (1) KR950700884A (en)
MY (1) MY107767A (en)
RO (1) RO115954B1 (en)
RU (1) RU2143426C1 (en)

Also Published As

Publication number Publication date
RU94045911A (en) 1996-08-10
KR950700884A (en) 1995-02-20
RO115954B1 (en) 2000-08-30
RU2143426C1 (en) 1999-12-27

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