Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/24—Phosphorous; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

• This invention relates to oral compositions, more particularly compositions for combating dental caries.
• fluorine-containing compounds in dentifrices as anti-caries agents, and it has been established that these compounds are effective to reduce the incidence of dental caries.
• Those compounds most commonly used today are sodium fluoride and sodium monofluorophosphate.
• fluorine-containing anti-caries agents are stannous fluoride, amine fluorides and other fluoride-ion sources e.g. as described in U.S. patent 4,684,518 (Parran et al.).
• dentifrices can be formulated comprising particulate hydroxyapatite and a fluorine-containing anti-caries agent, particularly sodium fluoride or sodium monofluorophosphate in which these ingredients are compatible to a surprising extent. Although there is some loss of available fluoride upon storage, these dentifrices remain particularly suitable against dental caries.
• a fluorine-containing anti-caries agent particularly sodium fluoride or sodium monofluorophosphate
• EP-A-0 342 380 discloses toothpastes which comprise hydroxyapatite and a fluoride. According to column 2, lines 30-38, when the pH of such a toothpaste is adjusted to 8.8, there is a certain reduction of fluoride loss, but that reduction is completely insatisfactory to resolve the problem of fluoride loss.
• the hydroxyapatite abrasive is used in a particle size giving satisfactory cleaning without being harmful to the tooth surface when used in appropriate amounts in dentifrices of the invention.
• the amount of the hydroxyapatite present in oral compositions of this invention will range from 1-50%, usually from 2% to 20%, preferably 3 to 15%, by weight of the oral composition. It desirably has an average particle size of from 1 to 15 ⁇ m, usually from 2-10 and preferably 3 to 10 ⁇ m.
• Preferred particulate hydroxyapatites for use in sodium -fluoride- or sodium monofluorophosphate-containing dentifrices of this invention are synthetic hydroxyapatites of high purity consisting of at least 92% of Ca10(PO4)6(OH)2. The remainder will comprise mainly bound water (typically 6% maximum) and a minor amount of calcium carbonate (typically 2% maximum).
• a process for the preparation of hydroxyapatites is described in GB-A-1 586 915 (British Charcoals & Macdonalds).
• a highly pure synthetic hydroxyapatite available commercially is that sold under the trade name CAPTAL by British Charcoals & Macdonalds of Greenock, Scotland. This contains about 97% Ca10(PO4)6(OH)2. The remaining 3% is mostly bound water with approximately 0.3% calcium carbonate.
• the sodium monofluorophosphate will generally be present in the dentifrices of this invention in at amount sufficient to provide from 50ppm to 5000ppm F, especially from 200ppm to 1500ppm and more especially from 500ppm to 1500ppm.
• the oral composition of this invention will, of course, also contain other ingredients commonly used to formulate such products, depending on the form of the oral product.
• the product will comprise an humectant-containing liquid phase and a binder or thickener which acts to maintain the particulate solid abrasive in stable suspension in the liquid phase.
• a surfactant and a flavouring agent are also usual ingredients of commercially acceptable dentifrices.
• Humectants commonly used are glycerol and sorbitol syrup (usually comprising an approximately 70% solution). However, other humectants are known to those in the art including propylene glycol, lactitol, and hydrogenated corn syrup. The amount of humectant will generally range from 10 to 85% by weight of the dentifrice.
• the liquid phase can be aqueous or nonaqueous.
• binding or thickening agents have been indicated for use in dentifrices, preferred ones being sodium carboxymethylcellulose and xanthan gum.
• Others include natural gum binders such as gum tragacanth, gum karaya and gum arabic, Irish moss, alginates and carrageenans.
• Silica thickening agents include the silica aerogels and various precipitated silicas. Mixtures of binders may be used.
• the amount of binder included in a dentifrice is generally between 0.1 and 10% by weight.
• surfactant it is usual to include a surfactant in a dentifrice and again the literature discloses a wide variety of suitable materials.
• Surfactants which have found wide use in practice are sodium lauryl sulphate, sodium dodecylbenzene sulphonate and sodium lauroylsarcosinate.
• Other anionic surfactants may be used as well as other types such cationic, amphoteric and non-ionic surfactants.
• Surfactants are usually present in an amount of from 0.5 to 5% by weight of the dentifrice.
• Flavours that are usually used in dentifrices are those based on oils of spearmint and peppermint. Examples of other flavouring materials used are menthol, clove, wintergreen, eucalyptus and aniseed. An amount of from 0.1% to 5% by weight is a suitable amount of flavour to incorporate in a dentifrice.
• the oral compositions of the invention may also comprise a proportion of a supplementary abrasive agent such as silica, alumina, hydrated alumina, calcium carbonate, anhydrous dicalcium phosphate, dicalcium phosphate dihydrate and water-insoluble sodium metaphosphate.
• a supplementary abrasive agent such as silica, alumina, hydrated alumina, calcium carbonate, anhydrous dicalcium phosphate, dicalcium phosphate dihydrate and water-insoluble sodium metaphosphate.
• the oral composition of the invention may include a wide variety of optional ingredients. These include an anti-plaque agent such as an antimicrobial compound for example chlorhexidine or 2,4,4'-trichloro-2'-hydroxy-diphenyl ether, or a zinc salt (see EP-A-161 898); an anti-tartar ingredient such as a condensed phosphate e.g.
• the invention also relates to a method of combating dental caries which consists in applying to the teeth, such as by brushing, an oral composition according to the invention.
• Model systems were made comprising 10% Captal 3 (average particle size 8 ⁇ m (microns)) and 0.76% sodium monofluorophosphate (SMFP), the balance being water.
• Captal 3 average particle size 8 ⁇ m (microns)
• SMFP sodium monofluorophosphate
• WEF water extractable fluoride

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Birds (AREA)
• Inorganic Chemistry (AREA)
• Epidemiology (AREA)
• Chemical & Material Sciences (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Cosmetics (AREA)
• Medicinal Preparation (AREA)

Priority Applications (1)

Applications Claiming Priority (2)

Publications (2)

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Family Applications (1)

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• 1989
  • 1989-11-30 GB GB898927073A patent/GB8927073D0/en active Pending
• 1990
  • 1990-11-23 AT AT90203098T patent/ATE92751T1/de not_active IP Right Cessation
  • 1990-11-23 DE DE90203098T patent/DE69002738T2/de not_active Expired - Fee Related
  • 1990-11-23 ES ES90203098T patent/ES2058764T3/es not_active Expired - Lifetime
  • 1990-11-23 EP EP90203098A patent/EP0431672B1/en not_active Expired - Lifetime
  • 1990-11-26 AU AU66915/90A patent/AU624752B2/en not_active Ceased
  • 1990-11-27 CA CA002030714A patent/CA2030714A1/en not_active Abandoned
  • 1990-11-29 IN IN311/BOM/90A patent/IN171074B/en unknown
  • 1990-11-29 BR BR909006062A patent/BR9006062A/pt not_active Application Discontinuation
  • 1990-11-30 US US07/620,502 patent/US5112599A/en not_active Expired - Fee Related
  • 1990-11-30 ZA ZA909644A patent/ZA909644B/xx unknown
  • 1990-11-30 JP JP2341199A patent/JPH03193726A/ja active Pending

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