EP0399972A1 - Impeller for aseptic purposes - Google Patents

Impeller for aseptic purposes Download PDF

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Publication number
EP0399972A1
EP0399972A1 EP90850180A EP90850180A EP0399972A1 EP 0399972 A1 EP0399972 A1 EP 0399972A1 EP 90850180 A EP90850180 A EP 90850180A EP 90850180 A EP90850180 A EP 90850180A EP 0399972 A1 EP0399972 A1 EP 0399972A1
Authority
EP
European Patent Office
Prior art keywords
impeller
vessel
blade
rotation
cylindrical recess
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP90850180A
Other languages
German (de)
French (fr)
Other versions
EP0399972B1 (en
Inventor
Nils Arthun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
roplan International AB
Roplan International AB
Original Assignee
Steridose Systems AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20376064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0399972(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Steridose Systems AB filed Critical Steridose Systems AB
Publication of EP0399972A1 publication Critical patent/EP0399972A1/en
Application granted granted Critical
Publication of EP0399972B1 publication Critical patent/EP0399972B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4535—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a stud for supporting the stirring element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
    • B01F35/41—Mounting or supporting stirrer shafts or stirrer units on receptacles
    • B01F35/411—Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting only one extremity of the shaft
    • B01F35/4112—Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting only one extremity of the shaft at the bottom of the receptacle, e.g. by studs

Definitions

  • the object of the invention is thus to provide an impeller with a considerably greater self-cleaning capability so that sterilization with steam or other fluids can occur in a considerably shorter time.
  • the bearing means includes a stub-axle centrally located on an end wall of an inwardly extending cylindrical recess in the vessel's bottom wall.
  • the bearing- and drive means of the impeller are shown in figure 2 and include an inwardly-directed cylindrical recess 12 in the vessel wall 11, the recess being welded in such a way that no opening or inlets occur in this section of the tank wall.
  • the impeller 10 is rotatably supported by means of a bush 10a on a stub axle 13 which is centrally located on an end wall 14, which demarcates the cylindrical recess 12.
  • the impeller 10 is, like the vessel 11, principally manufac­tured from acidproof stainless steel, with a number of angled blades 15 and a central lifting ring 16.
  • the impeller presents a peripheral section 17 which surrounds the cylindrical recess 12 and contains a number of permanent magnets 18 which are inductively connected to a corresponding number of permanent magnets 19 which are located in a rotor 20.
  • This rotor is arranged to be driven in the direction of arrow 21 (see figure 1) by a (not shown) conventional electric motor, whereby the impeller 10 surrounding the recess is caused to rotate.
  • the passages and the orifices can be greater or fewer in number.
  • the device for driving the impeller can be diffe­rently designed.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Food-Manufacturing Devices (AREA)
  • Prostheses (AREA)
  • Thermally Insulated Containers For Foods (AREA)
  • Materials For Medical Uses (AREA)
  • Accessories For Mixers (AREA)

Abstract

An impeller for aseptic purposes which is rotatable by induc­tive drive means in a predetermined direction within a vessel for stirring and mixing sterile fluids. The impeller (10) comprises a plurality of radially extending stirring blades (15) on an outer surface of the impeller and bearing means on an inner surface of said impeller for rotatably mounting the impeller on the vessel wall. The impeller is further provided with through-flow passages which outwardly extend from the inside of the impeller in a direction away from an axis of rotation, through orifices (25, 26) which are situated on the outer sr-face of the impeller immediately adjacent each blade (15), seen in said direction of rotation, so that cleaning fluid can be sucked through the passages due to a low pressure region occurring behind each blade.

Description

  • The present invention relates to an impeller for aseptic purposes, rotatable by inductive drive means in a predetermined direction within a vessel for stirring and mixing sterile fluids, comprising a plurality of radially extending stirring blades located on an outer surface of the impeller and bearing means on an inner surface of said impeller for rotatably mounting the impeller on the vessel wall.
  • It is known to generate stirring motion in a fluid within a closed vessel by means of a magnetic coupling between an external drive unit and a completely separate internal impeller (see for example US 4209259). At the same time it is a recogni­zed problem to carry out cleaning and sterilizing of the vessel interior with the impeller. It has been proposed to provide the impeller with radial passages, which make it possible for cleaning fluid, for example water or overheated steam, to force its way in to the impeller's inner surfaces and flow over the bearing means.
  • However, a really effective sterilization is usually only achievable after a relatively prolonged cleaning cycle.
  • The object of the invention is thus to provide an impeller with a considerably greater self-cleaning capability so that sterilization with steam or other fluids can occur in a considerably shorter time.
  • This object is achieved according to the invention by an impeller which is characterized by through-flow passages which outwardly extend from the inside of the impeller in a direction away from the axis of rotation, to orifices situated on the outer surfaces of the impeller immediately adjacent each blade, seen in said direction of rotation, so that cleaning fluid can be sucked through the passages due to the low pressure region occurring behind each blade.
  • According to a preferred embodiment of the invention the bearing means includes a stub-axle centrally located on an end wall of an inwardly extending cylindrical recess in the vessel's bottom wall.
  • The cylindrical recess is appropriately surrounded by a peripheral section having a particular small clearance which permits the flow of cleaning fluid between the cylindrical recess and the peripheral section of the impeller.
  • The above-mentioned, and further characteristics of the in­vention will be described in more detail in the following, with reference to the attached drawings in which
    • Figure 1 shows a plan view of an impeller according to the invention,
    • Figure 2 is a partially sectioned side view of the impeller including its drive arrangement, and
    • Figure 3 is a section along line III-III in figure 1.
  • The impeller 10 shown in the drawing is located in a mixing vessel whose bottom wall 11 is shown in figure 2. The vessel is intended for use in a large process plant, for example for preparation of medicaments, and is provided with a number of inlets, outlets and regulating valves. Various sterile fluids are delivered to the vessel where they are mixed together by means of the impeller 10, after which the resulting mixture is drawn from the vessel.
  • The bearing- and drive means of the impeller are shown in figure 2 and include an inwardly-directed cylindrical recess 12 in the vessel wall 11, the recess being welded in such a way that no opening or inlets occur in this section of the tank wall. The impeller 10 is rotatably supported by means of a bush 10a on a stub axle 13 which is centrally located on an end wall 14, which demarcates the cylindrical recess 12.
  • The impeller 10 is, like the vessel 11, principally manufac­tured from acidproof stainless steel, with a number of angled blades 15 and a central lifting ring 16. The impeller presents a peripheral section 17 which surrounds the cylindrical recess 12 and contains a number of permanent magnets 18 which are inductively connected to a corresponding number of permanent magnets 19 which are located in a rotor 20. This rotor is arranged to be driven in the direction of arrow 21 (see figure 1) by a (not shown) conventional electric motor, whereby the impeller 10 surrounding the recess is caused to rotate.
  • From figure 3 it can be seen that the impeller is provided with through- flow passages 22,23, which extend from within the impeller 10 in a direction away from the axis of rotation 24 to orifices 25 resp. 26, situated on the outer surface of the impeller immediately adjacent each blade 15, seen in said direction of rotation. Through this arrangement, cleaning fluid will be sucked through the passages due to the low pressure region occurring behind each blade. In this way cleaning fluid can flow over the recess 12 and the stub axle 13 during rotation of the impeller, whereby the fluid can flow out from the impeller via the substantially radially directed passages 22, 23.
  • The invention is not restricted to above described example, but may be varied within the scope of the following claims. For example the passages and the orifices can be greater or fewer in number. The device for driving the impeller can be diffe­rently designed.

Claims (3)

1. An impeller for aseptic purposes, rotatable by inductive drive means (20) in a predetermined direction within a vessel (11) for stirring and mixing sterile fluids, comprising a plurality of radially extending stirring blades (15) located on an outer surface (10) of the impeller and bearing means (10a, 13) on an inner surface of said impeller for rotatably mounting the impeller on the vessel wall, characterized by through-flow passages (22, 23) which outwardly extend from the inside of the impeller (10) in a direction away from the axis of rotation (24), to orifices (25, 26) situated on the outer surface on the impeller immediately adjacent each blade, (15) seen in said direction of the rotation, so that cleaning fluid can be sucked through the passages (22, 23) due to the low pressure region occurring behind each blade.
2. Impeller according to claim 1, characterized in that the bearing means includes a stub axle (13) centrally located on an end wall (14) of an inwardly extending cylindrical recess (12) in the vessel's bottom wall (11).
3. Impeller according to claim 1 or 2, characterized by a peripheral section (17) which surrounds the cylindrical recess (12) with a particular small clearance, which permits the flow of cleaning fluid between the cylindrical recess (12) and the peripheral section (17) of the impeller.
EP90850180A 1989-05-26 1990-05-17 Impeller for aseptic purposes Expired - Lifetime EP0399972B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8901877A SE463750B (en) 1989-05-26 1989-05-26 MOVER FOR ASEPTIC PURPOSES, WHICH WILL BE PULLABLE IN A PRE-DETERMINED ROTATION DIRECTION THROUGH INDUCTIVE DRIVER INSIDE A TANK
SE8901877 1989-05-26

Publications (2)

Publication Number Publication Date
EP0399972A1 true EP0399972A1 (en) 1990-11-28
EP0399972B1 EP0399972B1 (en) 1993-04-21

Family

ID=20376064

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90850180A Expired - Lifetime EP0399972B1 (en) 1989-05-26 1990-05-17 Impeller for aseptic purposes

Country Status (8)

Country Link
EP (1) EP0399972B1 (en)
AT (1) ATE88374T1 (en)
DE (1) DE69001388T2 (en)
DK (1) DK0399972T3 (en)
ES (1) ES2041522T3 (en)
FI (1) FI92475C (en)
NO (1) NO169326C (en)
SE (1) SE463750B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590473A1 (en) * 1992-10-01 1994-04-06 Mavag Verfahrenstechnik Ag Impeller for stirring sterile liquids
DE4232934A1 (en) * 1992-10-01 1994-04-07 Mavag Verfahrenstechnik Ag Alt Double impeller for stirring sterile liquids
US5533803A (en) * 1992-10-01 1996-07-09 Mavag Verfahrenstechnik Ag Magnetic stirring apparatus with contactless coupling between stirring shaft and stirring tool
US5758965A (en) * 1996-12-05 1998-06-02 General Signal Corporation Mixer system
US5779359A (en) * 1996-12-05 1998-07-14 General Signal Corporation Mixer having exposed clean-in-place bearing assemblies
US6065865A (en) * 1998-06-05 2000-05-23 Mixel Magnetically driven agitator with magnetic rotation detector
US6206562B1 (en) * 1998-01-28 2001-03-27 Mixel Agitator with adjustable magnetic drive coupling
CN100340329C (en) * 2004-10-29 2007-10-03 中国石油化工股份有限公司 Self air feeding type gas liquid mixing blade
WO2008088371A2 (en) * 2006-06-16 2008-07-24 Xcellerex, Inc. Gas delivery configurations, foam control systems, and bag molding methods and articles for collapsible bag vessels and bioreactors
EP2196688A2 (en) 2005-07-29 2010-06-16 zeta AG Bioprocess Systems Magnetic stirrer
GB2440474B (en) * 2005-04-05 2011-01-05 Per-Olof K Andersson Ultraclean magnetic mixer
AT518668B1 (en) * 2017-01-25 2017-12-15 Zeta Biopharma Gmbh Agitator for a stirred tank

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3659700T3 (en) * 2018-11-29 2022-06-13 Alfa Laval Corp Ab MAGNETICALLY COUPLED LIQUID MIXER
CN111167295A (en) * 2020-01-15 2020-05-19 邓智超 Acid gas purification device for underground engineering construction
CN116510596B (en) * 2023-06-29 2023-09-29 中科圣杰(深圳)科技集团有限公司 Aseptic material workstation of throwing

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138167A (en) * 1963-06-18 1964-06-23 Sprout Waldron & Co Inc Mixer for feeds and the like
DE2511717A1 (en) * 1974-03-21 1975-09-25 Paul Raess Propellor for liquid manure prepn. - consists of two flights with aeration holes
EP0053759A2 (en) * 1980-12-10 1982-06-16 Friedrich Walter Dr. Herfeld Mixing apparatus and process for cleaning the same
EP0148738A1 (en) * 1983-12-08 1985-07-17 Boliden Aktiebolag Process and device for distribution of water purification chemicals

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138167A (en) * 1963-06-18 1964-06-23 Sprout Waldron & Co Inc Mixer for feeds and the like
DE2511717A1 (en) * 1974-03-21 1975-09-25 Paul Raess Propellor for liquid manure prepn. - consists of two flights with aeration holes
EP0053759A2 (en) * 1980-12-10 1982-06-16 Friedrich Walter Dr. Herfeld Mixing apparatus and process for cleaning the same
EP0148738A1 (en) * 1983-12-08 1985-07-17 Boliden Aktiebolag Process and device for distribution of water purification chemicals

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590473A1 (en) * 1992-10-01 1994-04-06 Mavag Verfahrenstechnik Ag Impeller for stirring sterile liquids
DE4232936A1 (en) * 1992-10-01 1994-04-07 Mavag Verfahrenstechnik Ag Alt Impeller for stirring sterile liquids
DE4232934A1 (en) * 1992-10-01 1994-04-07 Mavag Verfahrenstechnik Ag Alt Double impeller for stirring sterile liquids
EP0599010A1 (en) * 1992-10-01 1994-06-01 Mavag Verfahrenstechnik Ag Double impeller for stirring sterile liquids.
US5393142A (en) * 1992-10-01 1995-02-28 Mavag Verfahrenstechnik Ag Impeller for stirring sterile liquids
US5407272A (en) * 1992-10-01 1995-04-18 Mavag Verfahrenstechnik Ag. Double impeller for stirring sterile liquids
US5533803A (en) * 1992-10-01 1996-07-09 Mavag Verfahrenstechnik Ag Magnetic stirring apparatus with contactless coupling between stirring shaft and stirring tool
US5758965A (en) * 1996-12-05 1998-06-02 General Signal Corporation Mixer system
US5779359A (en) * 1996-12-05 1998-07-14 General Signal Corporation Mixer having exposed clean-in-place bearing assemblies
US6206562B1 (en) * 1998-01-28 2001-03-27 Mixel Agitator with adjustable magnetic drive coupling
US6065865A (en) * 1998-06-05 2000-05-23 Mixel Magnetically driven agitator with magnetic rotation detector
CN100340329C (en) * 2004-10-29 2007-10-03 中国石油化工股份有限公司 Self air feeding type gas liquid mixing blade
GB2440474B (en) * 2005-04-05 2011-01-05 Per-Olof K Andersson Ultraclean magnetic mixer
EP2196688A2 (en) 2005-07-29 2010-06-16 zeta AG Bioprocess Systems Magnetic stirrer
US8128277B2 (en) 2005-07-29 2012-03-06 Zeta Biopharma Gmbh Magnetic agitator
WO2008088371A2 (en) * 2006-06-16 2008-07-24 Xcellerex, Inc. Gas delivery configurations, foam control systems, and bag molding methods and articles for collapsible bag vessels and bioreactors
WO2008088371A3 (en) * 2006-06-16 2009-04-09 Xcellerex Inc Gas delivery configurations, foam control systems, and bag molding methods and articles for collapsible bag vessels and bioreactors
US9908664B2 (en) 2006-06-16 2018-03-06 Ge Healthcare Bio-Sciences Corp. Method of forming a collapsible bag using a mold and mandrel
US11008138B2 (en) 2006-06-16 2021-05-18 Global Life Sciences Solutions Usa Llc Method of forming a collapsible bag using a mold and mandrel
US11312539B2 (en) 2006-06-16 2022-04-26 Global Life Sciences Solutions Usa Llc Method of forming a collapsible bag using a mold and mandrel
AT518668B1 (en) * 2017-01-25 2017-12-15 Zeta Biopharma Gmbh Agitator for a stirred tank
AT518668A4 (en) * 2017-01-25 2017-12-15 Zeta Biopharma Gmbh Agitator for a stirred tank

Also Published As

Publication number Publication date
NO169326B (en) 1992-03-02
NO169326C (en) 1992-06-10
NO902321L (en) 1990-11-27
FI92475B (en) 1994-08-15
SE8901877L (en) 1990-11-27
DE69001388D1 (en) 1993-05-27
ATE88374T1 (en) 1993-05-15
SE463750B (en) 1991-01-21
EP0399972B1 (en) 1993-04-21
NO902321D0 (en) 1990-05-25
ES2041522T3 (en) 1993-11-16
FI902451A0 (en) 1990-05-17
FI92475C (en) 1994-11-25
DK0399972T3 (en) 1993-08-09
DE69001388T2 (en) 1993-10-21
SE8901877D0 (en) 1989-05-26

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