EP0388962A3 - Bmy-41950 antitumor antibiotic - Google Patents

Bmy-41950 antitumor antibiotic Download PDF

Info

Publication number
EP0388962A3
EP0388962A3 EP19900105446 EP90105446A EP0388962A3 EP 0388962 A3 EP0388962 A3 EP 0388962A3 EP 19900105446 EP19900105446 EP 19900105446 EP 90105446 A EP90105446 A EP 90105446A EP 0388962 A3 EP0388962 A3 EP 0388962A3
Authority
EP
European Patent Office
Prior art keywords
bmy
antitumor antibiotic
antibiotic
antitumor
atcc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19900105446
Other languages
German (de)
French (fr)
Other versions
EP0388962A2 (en
EP0388962B1 (en
Inventor
Daniel Schroeder
Kin Sing Lam
Jacqueline Mattei
Grace A. Hesler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP0388962A2 publication Critical patent/EP0388962A2/en
Publication of EP0388962A3 publication Critical patent/EP0388962A3/en
Application granted granted Critical
Publication of EP0388962B1 publication Critical patent/EP0388962B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/898—Streptomyces hygroscopicus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A new antitumor antibiotic designated BMY-41950 of formula (I) is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
EP90105446A 1989-03-23 1990-03-22 BMY-41950 antitumor antibiotic Expired - Lifetime EP0388962B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32792989A 1989-03-23 1989-03-23
US327929 1990-02-20
US07/482,364 US5015578A (en) 1989-03-23 1990-02-20 BMY-41950 antitumor antibiotic
US482364 2000-01-13

Publications (3)

Publication Number Publication Date
EP0388962A2 EP0388962A2 (en) 1990-09-26
EP0388962A3 true EP0388962A3 (en) 1991-01-16
EP0388962B1 EP0388962B1 (en) 1994-09-14

Family

ID=26986136

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90105446A Expired - Lifetime EP0388962B1 (en) 1989-03-23 1990-03-22 BMY-41950 antitumor antibiotic

Country Status (10)

Country Link
US (1) US5015578A (en)
EP (1) EP0388962B1 (en)
JP (1) JPH07624B2 (en)
AT (1) ATE111476T1 (en)
CY (1) CY1816A (en)
DE (1) DE69012384T2 (en)
DK (1) DK0388962T3 (en)
ES (1) ES2058645T3 (en)
HK (1) HK23695A (en)
SG (1) SG163194G (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242814A (en) * 1989-10-10 1993-09-07 Eli Lilly And Company Polyether antibiotic
US4973552A (en) * 1990-02-20 1990-11-27 Bristol-Meyers Squibb Company Staurosporine fermentation process
US5158938A (en) * 1990-03-06 1992-10-27 Bristol-Myers Squibb Company Rebeccamycin
US5478813A (en) * 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
ES2136103T3 (en) * 1992-06-22 1999-11-16 Kyowa Hakko Kogyo Kk PROCEDURE FOR THE PREPARATION OF STAUROSPORIN DERIVATIVES.
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) * 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2154698C (en) 1993-01-28 2010-02-23 Lawrence Leroy Kunz Therapeutic inhibitor of vascular smooth muscle cells
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
ES2388248T3 (en) 1997-03-31 2012-10-11 Boston Scientific Scimed Limited Dosage form comprising taxol in crystalline form
CO4940430A1 (en) * 1997-07-07 2000-07-24 Novartis Ag POLYCLIC COMPOUNDS CONTAINING HYDROGENATED STAUROSPORIN WITH CONVENIENT PHARMACOLOGICAL PROPERTIES AND AN INHIBITING EFFECT ON THE GROWTH OF TUMOR CELLS
US6284783B1 (en) 1999-06-09 2001-09-04 The Uab Research Foundation Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis
FR2801054B1 (en) * 1999-11-17 2003-06-13 Adir NOVEL DERIVATIVES OF 12,13- (PYRANOSYL) -INDOLO [2,3-A] PYRROLO [3,4-C] CARBAZOLE AND 12,13- (PYRANOSYL) -FURO [3,4-C] INDOLO [2,3 -A] CARBAZOLE, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7608420B2 (en) * 2003-04-22 2009-10-27 Lonza Ag Process for the recovery of staurosporine from a fermentation broth

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
EP0175284A2 (en) * 1984-09-17 1986-03-26 Schering Corporation Novel antibiotics, process for their preparation and pharmaceutical compositions containing them
EP0238011A2 (en) * 1986-03-20 1987-09-23 Kyowa Hakko Kogyo Co., Ltd. Polycyclic condensed amino sugar derivatives with anti-tumor and anti-bacterial activity, produced by streptomyces
EP0269025A2 (en) * 1986-11-21 1988-06-01 Bristol-Myers Squibb Company Rebeccamycin analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5373501A (en) * 1976-12-11 1978-06-30 Kitasato Inst Novel antibiotics amm2282 and process for preparing same
US4390546A (en) * 1981-12-07 1983-06-28 Merck & Co., Inc. Antiparasitic macrolide from a strain of Streptomyces hygroscopicus
DE3752123T2 (en) * 1987-03-09 1998-05-14 Kyowa Hakko Kogyo Kk DERIVATIVES OF THE PHYSIOLOGICALLY ACTIVE AGENT K-252

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
EP0175284A2 (en) * 1984-09-17 1986-03-26 Schering Corporation Novel antibiotics, process for their preparation and pharmaceutical compositions containing them
EP0238011A2 (en) * 1986-03-20 1987-09-23 Kyowa Hakko Kogyo Co., Ltd. Polycyclic condensed amino sugar derivatives with anti-tumor and anti-bacterial activity, produced by streptomyces
EP0269025A2 (en) * 1986-11-21 1988-06-01 Bristol-Myers Squibb Company Rebeccamycin analogs

Also Published As

Publication number Publication date
CY1816A (en) 1995-10-20
US5015578A (en) 1991-05-14
ES2058645T3 (en) 1994-11-01
EP0388962A2 (en) 1990-09-26
ATE111476T1 (en) 1994-09-15
EP0388962B1 (en) 1994-09-14
JPH03215428A (en) 1991-09-20
HK23695A (en) 1995-03-03
DE69012384T2 (en) 1995-02-16
JPH07624B2 (en) 1995-01-11
DK0388962T3 (en) 1994-10-17
SG163194G (en) 1995-04-28
DE69012384D1 (en) 1994-10-20

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