EP0293421A1 - Systeme de support circulatoire biventriculaiare implantable - Google Patents

Systeme de support circulatoire biventriculaiare implantable

Info

Publication number
EP0293421A1
EP0293421A1 EP87907894A EP87907894A EP0293421A1 EP 0293421 A1 EP0293421 A1 EP 0293421A1 EP 87907894 A EP87907894 A EP 87907894A EP 87907894 A EP87907894 A EP 87907894A EP 0293421 A1 EP0293421 A1 EP 0293421A1
Authority
EP
European Patent Office
Prior art keywords
sac
pumping
patient
fluid
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87907894A
Other languages
German (de)
English (en)
Other versions
EP0293421A4 (fr
Inventor
Phillip Jay Miller
Jal Sohrab Jassawalla
Michael J. Conley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novacor Medical Corp
Original Assignee
Novacor Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novacor Medical Corp filed Critical Novacor Medical Corp
Publication of EP0293421A1 publication Critical patent/EP0293421A1/fr
Publication of EP0293421A4 publication Critical patent/EP0293421A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/424—Details relating to driving for positive displacement blood pumps
    • A61M60/427—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being hydraulic or pneumatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
    • A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
    • A61M60/183—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices drawing blood from both ventricles, e.g. bi-ventricular assist devices [BiVAD]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/424—Details relating to driving for positive displacement blood pumps
    • A61M60/457—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being magnetic
    • A61M60/459—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being magnetic generated by permanent magnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/424—Details relating to driving for positive displacement blood pumps
    • A61M60/457—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being magnetic
    • A61M60/462—Electromagnetic force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/835—Constructional details other than related to driving of positive displacement blood pumps
    • A61M60/837—Aspects of flexible displacement members, e.g. shapes or materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/869—Compliance chambers containing a gas or liquid other than blood to compensate volume variations of a blood chamber

Definitions

  • This invention relates generally to cardiovascular circulatory systems. More particularly, the invention relates to a totally implantable circulatory system which provides both left ventricular pumping for systemic circulation and coordinated right ventricular pumping for pulmonary circulation.
  • the system may be used as an assist system to operate along with the patients own heart, or may be used as a total replacement for the patient's ventricular functions.
  • the pump described in the foregoing patent is implanted in a patient in the abdominal cavity and is connected such that, upon contraction or systole of the left ventricle, it receives blood therefrom and thereby fills. Upon cessation of systole, the pump contracts to expel its contents into the arterial system of the patient. As such, the pump takes over the load of the ventricle from which it receives blood, either partially or completely, thereby relieving the ventricle.
  • a major advantage of the type of pump just described is in its relatively low power requirements.
  • the device is powered through a totally implantable power supply containing rechargeable batteries, which can be recharged by power transmitted transcutaneously through a so-called belt-skin transformer system.
  • a so-called belt-skin transformer system is described in U.S. Patent No. 4,143,661, assigned to the assignee of the present invention.
  • the left ventricular assist system approach described above has been successful in assuming up to the full load imposed on the left ventricle, the right ventricle remains only indirectly assisted (only under circumstances of normal pulmonary ventricular resistance) . This may be satisfactory in situations in which the right ventricle is not significantly impaired.
  • the installation of a similar assist system for the right ventricle is very difficult or impossible due to limitations in body cavity volume.
  • Another object of the invention is to provide an improved biventricular circulatory support system which has relatively low power requirements.
  • FIGURE 1 is a full section view of a biventricular circulatory system constructed in accordance with the invention at the start of left ventricular ejection and right ventricular filling;
  • FIGURE 2 is a full section view similar to FIGURE 1, showing the system at the. start of left ventricular filling and right ventricular ejection;
  • FIGURE 3 is a partial cross sectional view taken from the right end of FIGURE 2;
  • FIGURE 4 is a plot of ejection force vs. displacement for the left ventricular potion and the right ventricular portion of the device of FIGURES 1-3 without magnetic alteration of the right ventricular portion;
  • FIGURE 5 is a plot similar to FIGURE 4 but illustrating the conditions with magnetic alteration of the right ventricular portion.
  • the biventricular circulatory support system of the invention includes first pumping means for assuming at least a part of the pumping load of the patient's left ventricle.
  • the first pumping means is adapted for connection to the systemic arterial circulation of the patient and is responsive to electrical signals applied thereto to contract and pump blood.
  • a second pumping means for assuming at least a part of the pumping load of the patient's right ventricle is also implanted.
  • the second pumping means is adapted for connection to the pulmonary arterial circulation of the patient.
  • a control system applies electrical signals to the first pumping means.
  • the first and second pumping means are encapsulated in a common volume such that contraction of the first pumping means allows expansion of the second pumping means and such that expansion of the first pumping means allows contraction of the second pumping means.
  • a blood pump in the form of a biventricular assist device is depicted.
  • the device is adapted for implantation within the body (not shown) of a patient.
  • the device is preferably of the type shown and described in U.S. Patent No. 4,565,497.
  • the system also includes an implanted module, not shown, that includes electronic power shaping and control components and a standby storage battery.
  • the system is preferably powered and charged via a belt skin transformer with associated implanted and external power supplies, controllers, and other components, not shown.
  • a belt skin transformer with associated implanted and external power supplies, controllers, and other components, not shown.
  • Such a transformer and other elements may be constructed in accordance with those described in U.S. Patent No. 4,143,661 and U.S. Patent Application Serial No. 757,786, filed July 22, 1985.
  • the transformer can be used to communicate data and reprogram internal elements.
  • the system includes a pump 10, which is for the purpose of supporting left ventricular circulation (systemic) , and a pump 110 for supporting right ventricular circulation (pulmonary) , both of which are to be implanted in a human patient.
  • the device 10 includes an enclosure or sac 11 defining a pumping chamber 13.
  • Opposed pusher plates 15, 17 are disposed on opposites sides of the enclosure 11 and in contact therewith. Movement of the plates toward one another acts to compress the flexible enclosure and force the 5 contents of the chamber out through a suitable outlet duct 16. Movement of the plates away from one another acts to permit the Chamber 13 to fill through an inlet duct 18. Greater detail of this pump chamber configuration is given in the U.S. Patent No. 10 4,557,673.
  • An annular support 19 surrounds the flexible enclosure 11 to position it with respect to the remaining portions of the pump, including the actuator mechanism.
  • a pair of opposed beam springs 27 and 33 are used.
  • Opposed posts 21 and 23, extend from the plates 15 and 17 respectively.
  • the post 21 is pivotlly connected to the end of the beam spring 27 by a pin 29.
  • the post 23 is pivotally connected to the end of the beam spring 33 by a pivot pin 35.
  • the end of beam spring 27 opposite the post 21 is secured to a support 39.
  • the end of the beam spring 33 opposite the post 23 is secured to a support 45.
  • the springs 27 and 33 extend through 5 slots, not shown, formed in the solenoid assemblies.
  • Each of the supports 39 and 45, respectively, is provided with a pair of arms 49 and 51, respectively, extending therefrom coextensively with the corresponding beam springs 27 and 33.
  • a projection 0 or preload stop 53 is provided on the spring 27 to engage the free end of the arm 49.
  • a preload stop 55 is provided on the spring 33 to engage the free end of the arm 51.
  • the beam springs 27 and 33 lie in a 5 plane such that the engaging points of the preload stops 53 and 55 project beyond that plane and. accordingly, preload the beam springs 27 and 33 in bending stress. The result is that each of the beam springs 27 and 33 is always stressed in bending by a minimum amount provided by the preload of the preload stops 53 and 55.
  • Each of the supports 39 and 45 is mounted to a frame 61 for pivotal movement about an axis through a pivot pin 57 and 59, respectively.
  • the support 39 pivots on the pin 57, so likewise does the adjacent section of the beam springs 27 moves pivotally about the axis.
  • the support 45 pivots on the axis of the pin 59, so likewise the adjacent end of the beam spring 33 pivots about the axis of the pin 59 with the support 45.
  • Each of the pins 57 and 59 is supported by the frame 61 which comprises a portion of the general frame (not shown) of the pump which includes the annular enclosure support 19.
  • solenoid means For the purpose of pivoting the beam springs about the axes of the pins 57 and 59, solenoid means are provided.
  • the solenoid means include a pair of solenoid assemblies 63 and 65 mounted, respectively, on supports 39, 45. Supports 39, 45 and attached solenoid assemblies 63, 65, respectively, each forms a unit pivotally mounted on the frame 61 via the pins 57 and 59. Energization of the coils solenoid assemblies by suitable control means, not shown, causes the ends of the solenoid assemblies to be attracted toward each other.
  • FIGURE 1 illustrates the apparatus in a condition in which the pump chamber 13 is full and the solenoid assemblies 63 and 65 are energized. In this condition, the arms 49 and 51 are swung closed to their closest condition, whereas the beam springs 27 and 33 are in the condition of greatest energy storage. In this condition, the preload bias provided to the springs by the arms 49 and 51 engaging the preload stops 53 and 55 removed.
  • the solenoid assemblies After closure to the position of FIGURE 1, the solenoid assemblies are held there by a relatively small latching current. If additional holding force is needed, a small permanent magnet may be used. The force of the latter may be overcome when necessary by a small reverse current in the solenoid coils. From the condition of FIGURE 1, the natural tendency for the beam springs 27 and 33 to relieve the stressed condition results in the plates 15 and 17 being moved toward each other, thus expelling the contents in the pump chamber 13. At the end of the pump stroke, shown in FIGURE 2, the beam springs have returned to their less stressed condition with the preload stops 53 and 55 abutting the arms 49 and 51. Once this has occurred, the solenoid assemblies are de-energized or unlatched.
  • the apparatus is returned to the sac-full condition as the result of blood filling the sac via the inlet duct 18.
  • the solenoid gap thus increases as the supports 39 and 45 pivot about the pivot pins 57 and 59, respectively, as the plates 15 and 17 push out the ends of the springs 27 and 33.
  • a suitable detector not shown, is provided to determine the time at which the rate of pump fill drops below a preselected threshold.
  • a microprocessor not shown, is programmed to resume the pumping function.
  • the inlet duct 18 may be adapted to connect to the left ventricle of the patient's heart.
  • the outlet may be adapted for connection to the patient's systemic circulation, such as by grafting onto the supraceliac aorta.
  • the connecting conduit may be of any suitable construction such as a woven Dacron (TM) tube, properly protected from kinking or compression, which may extend through the pericardial portion of the patient's diaphragm.
  • TM woven Dacron
  • Actual connection of the conduit to the left ventricle may be via a suitable cannula (not shown) inserted, via the apex, into the left ventricular cavity.
  • the outflow conduit may be of a suitable material, such as ° woven Dacron TM, and may be connected to the aorta at different locations, such as the supraceliac axis (or other systemic artery) by anastomosis routine to vascular surgery.
  • a suitable material such as ° woven Dacron TM
  • the sac 11 fills during ventricular systole by offering low resistance to the outflow from the left ventricle.
  • the pump Synchronized with systole, at, before, or after termination thereof, the pump begins an eject cycle in which it contracts to expel its contents into the 0 patient's circulatory system.
  • Energization signals are provided to the device from the implanted module (not shown) .
  • the right or pulmonary circulatory function although requiring approximately the same pumping 5 volume as the left ventricular function, does not have the same pumping load.
  • the present invention makes use of this fact in a way that requires only a 20% increase in the power requirements of the system from what would be required in a system designed solely for left 0 ventricular circulation.
  • Components of the right ventricular circulatory device 110 having function similar to those of the left ventricular circulatory device 10 have been given identical reference numbers in FIGURES 1 through 3, preceded by 1.
  • the right 5 ventricular circulatory device 110 includes an enclosure sac 111 defining a pumping chamber 113.
  • Opposed pusher plates 115 and 117 are disposed on opposite sides of the enclosure 111 and in contact therewith. Movement of plates toward one another acts to compress the flexible enclosure or sac and force the contents of the chamber out through the outlet duct
  • An annular support 119 surrounds the periphery of the enclosure or 111 to position it with respect to the remaining portions of the pump.
  • Bias springs 127 and 133 are provided which, in the illustrated embodiment, comprise a single
  • the present invention enables use of only a single energy converter or pump drive to drive both left and right ventricular devices.
  • the right ventricular circulatory device is "slaved" off the left ventriculatory circulatory device by encapsulating both devices in a common shell 71 which provides a common volume.
  • the common shell includes two chambers 73, 75 inter-connected by a tube 77 of suitable length. This is to provide flexibility in the positioning of the two pumping devices within the patient.
  • a single chamber would also be within the scope of the invention. In either case, the volume enclosed by the shell within the chamber or chambers and, if present, inter-connecting tube, is filled with a fluid.
  • the force of the bias springs 127 and 133 is overcome, causing the pusher plates to move apart, allowing the sac to fill.
  • the energy converter has completed its ejection stroke expelling the contents of the left ventricular device sac 11 and resulting in the filling of the right ventricular device sac 111.
  • the solenoid de-energized the left ventricular device sac 11 is free to fill.
  • the bias springs in the right ventricular device since they are exerting an ejecting force on the pusher plates, begins -li ⁇
  • the ejection stroke of the right ventricular device As the coupling fluid is drawn from the left ventricular device chamber 73 back to the right ventricular device chamber 75, the left ventricular device fills at the same time the right ventricular device ejects.
  • the small permanent magnet pairs 136 and 138 are utilized on the right ventricular ⁇ evice 110 to pull on the right ventricular device springs 127 and 133, reducing their net ejection force. This force is readily overcome by the springs of the right ventricular device once left ventricular device fill begins.
  • the two devices opexate in synchronous counterpulsation with respect to each other, with the energy converter-driven ejection of the left ventricular device also providing the energy temporarily stored in the right ventricular device bias springs. It has been found that an increase in output of the energy converter of the left device of about twenty percent, over that necessary for the left ventricular device alone, will provide more than sufficient energy for the right ventricular device as well.
  • the output of the right ventricle is somewhat lower than that of the left ventricle due to differing systemic circulatory requirements.
  • This difference is accommodated, in accordance with the invention, by designing a certain amount of compliance into the encapsulation shell 71. This may be done by providing a compliant region or accumulator communicating with the interior of the shell, or by utilizing a shell material which provides the desired degree of compliance. With compliance of the appropriate magnitude, the difference in stroke volume between the left and right devices may be made to match the anticipated differential between the pulmonary and systemic flows.
  • the right ventricular device ejection is spring driven, its ejected volume on any stroke is responsive to both preload and after load in the pulmonary circulation. As the pulmonary artery pressure increases, the residual volume of the right ventricular device will increase and the right ventricular device output will drop accordingly. In the case where the device is used as an assist device, rather than a cardiac replacement device, as the right atrial pressure rises, the compliance of the coupling between the left and right devices allows some increased filling, of the right device sac, with resultant increase in ejected volume. In this manner the output of the right ventricular device automatically adjusts to the physiologic system.
  • the force/displacement characteristics of the right ventricular device bias springs may be seen by comparing the effective force profiles at each pusher plate as illustrated in FIGURES 4 and 5. It may be seen by comparing the two force profiles, the upper profiles being without the permanent magnets and the lower profile being with the permanent magnets 136, 138, the overall force profile can be tailored to provide optimum pumping action, while at the same time maximizing system efficiency and minimizing spring size and stress level. The presence of the magnets moves the equilibrium point to the right, as viewed in the curves or profiles, to provide more ejection for the left ventricular device.
  • the fluid head effects due to changes in patient orientation may become more pronounced.
  • the effect of head changes may be taken into account in designing the device as required in accordance with the placement of the device within the patient. This can be done by adjusting the bias springs to compensate for some or all of any additional loading caused by fluid head. It is preferred to design for nominal or average fluid head. Variations are readily accommodated by the device itself.
  • the encapsulation shell be a biocompatible material which is slightly compliant to allow for the slight differentiation between the flows in the left and right ventricular devices.
  • a titanium or fiber reinforced plastic or a relatively rigid polyurethane material are all suitable.
  • the preferred fluid within the encapsulating shell is a low vicosity silicon oil.
  • the fluid could also comprise a gas or a gas mixture designed to balance osmotic diffusion through the blood or pump sacs.
  • Another alternative would be a rigid shell material containing compressible gas. Air, freon, and mixtures thereof are all suitable, as are liquid-gas mixtures.
  • the device may be constructed as a ventricular assist system, or may be utilized as a total replacement for the left and right ventricles.
  • springs are required on both sacs.
  • bias springs may be dispensed within the right ventricular device. In such a case, the effect is that the left ventricular device assumes the entire load of the right ventricle.
  • the invention may totally unload the patients ventricles, or may be operated to only partially unload the patients ventricles.
  • the plurality of stops 140 are provided to engage the outer support ring.
  • other expedients may be employed as appropriate.
  • beam springs have been shown for the right ventricular device, other types of springs may be employed, such as coil or torsion springs.
  • the system of the invention provides an improved means for biventricular circulatory support.
  • the system combines a pair of mechanical type pumps for left and right ventricular action from a single energy converter.
  • the system is readily implantable within the normal adult human and is capable of being operated by a fully implanted control system.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)

Abstract

Système de support circulatoire biventriculaire dans lequel une première pompe (10) se charge de la circulation ventriculaire gauche (systèmique) et une deuxième pompe (110) se charge de la circulation ventriculaire droite (pulmonaire). Les deux pompes sont implantées dans un patient et chaque pompe est enfermée dans un sac (11, 111) définissant une chambre de pompage (13, 113). Les sacs (11, 111) sont reliés par un conduit ou tube (77) pour former un volume commun (13, 113, 77), de sorte que la contraction de la première pompe permet l'expansion de la deuxième, et que l'expansion de la première pompe permet la contraction de la deuxième.
EP19870907894 1986-11-14 1987-11-12 Systeme de support circulatoire biventriculaiare implantable. Withdrawn EP0293421A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93134086A 1986-11-14 1986-11-14
US931340 1986-11-14

Publications (2)

Publication Number Publication Date
EP0293421A1 true EP0293421A1 (fr) 1988-12-07
EP0293421A4 EP0293421A4 (fr) 1989-02-23

Family

ID=25460629

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870907894 Withdrawn EP0293421A4 (fr) 1986-11-14 1987-11-12 Systeme de support circulatoire biventriculaiare implantable.

Country Status (5)

Country Link
EP (1) EP0293421A4 (fr)
JP (1) JPH01501371A (fr)
AU (1) AU8328487A (fr)
BR (1) BR8707532A (fr)
WO (1) WO1988003394A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89954A0 (en) * 1989-04-13 1989-12-15 Afikim S A E Liquid sampling apparatus

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1501024A (fr) * 1966-09-15 1967-11-10 Nouvelle pompe sanguine implantable
DE2337497A1 (de) * 1972-09-07 1974-04-18 Kurpanek W H Kuenstliches herz
WO1984002164A1 (fr) * 1982-12-03 1984-06-07 Novacor Medical Corp Dispositif d'actionnement d'une pompe
WO1985002339A1 (fr) * 1983-12-02 1985-06-06 Strimling Walter W Pompe cardiaque implantable
EP0146445A2 (fr) * 1983-11-18 1985-06-26 AEROSPATIALE Société Nationale Industrielle Prothèse cardiaque totale comportant deux pompes découplées associées en une unité fonctionnellement indissociable, et valves électrocommandées pour une telle prothèse

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2470593A2 (fr) * 1979-01-22 1981-06-12 Lapeyre Didier Nouvelle prothese cardiaque totale
SE8401779L (sv) * 1984-03-30 1985-10-01 Astra Tech Ab Dubbelpump, avsedd som hjertprotes eller liknande

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1501024A (fr) * 1966-09-15 1967-11-10 Nouvelle pompe sanguine implantable
DE2337497A1 (de) * 1972-09-07 1974-04-18 Kurpanek W H Kuenstliches herz
WO1984002164A1 (fr) * 1982-12-03 1984-06-07 Novacor Medical Corp Dispositif d'actionnement d'une pompe
EP0146445A2 (fr) * 1983-11-18 1985-06-26 AEROSPATIALE Société Nationale Industrielle Prothèse cardiaque totale comportant deux pompes découplées associées en une unité fonctionnellement indissociable, et valves électrocommandées pour une telle prothèse
WO1985002339A1 (fr) * 1983-12-02 1985-06-06 Strimling Walter W Pompe cardiaque implantable

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8803394A1 *

Also Published As

Publication number Publication date
AU8328487A (en) 1988-06-01
EP0293421A4 (fr) 1989-02-23
JPH01501371A (ja) 1989-05-18
BR8707532A (pt) 1989-02-21
WO1988003394A1 (fr) 1988-05-19

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