EP0277995A1 - Implant en biomateriaux ayant une surface a charge positive nette - Google Patents

Implant en biomateriaux ayant une surface a charge positive nette

Info

Publication number
EP0277995A1
EP0277995A1 EP87905705A EP87905705A EP0277995A1 EP 0277995 A1 EP0277995 A1 EP 0277995A1 EP 87905705 A EP87905705 A EP 87905705A EP 87905705 A EP87905705 A EP 87905705A EP 0277995 A1 EP0277995 A1 EP 0277995A1
Authority
EP
European Patent Office
Prior art keywords
implant
compound
biomaterial
amino groups
biomaterial implant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87905705A
Other languages
German (de)
English (en)
Other versions
EP0277995A4 (fr
Inventor
Gershon Golomb
Robert J. Levy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Original Assignee
Childrens Medical Center Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center Corp filed Critical Childrens Medical Center Corp
Publication of EP0277995A1 publication Critical patent/EP0277995A1/fr
Publication of EP0277995A4 publication Critical patent/EP0277995A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo

Definitions

  • the biomaterial implants of the invention are prepared by contacting a conventionally fabricated biomaterial implant with the compound in a suitable aqueous buffer solution, e.g., HEPES, to allow the compound to penetrate into the tissue.
  • a suitable aqueous buffer solution e.g., HEPES
  • the pH of the buffer solution is between 7.0 and 8.0.
  • the implants are then contacted with a buffered solution of glutaraldehyde.
  • the implant can be reduced with sodium borohydride following glutaraldehyde treatment.

Abstract

Un implant en biomatériaux, dérivés de préférence de tissus animaux traités au glutaraldéhyde, est lié par covalence à un composé qui donne une charge positive nette à l'implant. L'implant est de préférence traité avec un acide polyaminé ayant des groupes amino libres afin de donner la charge positive nette à la surface de l'implant.
EP19870905705 1986-08-20 1987-08-20 Implant en biomateriaux ayant une surface a charge positive nette. Withdrawn EP0277995A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89836186A 1986-08-20 1986-08-20
US898361 1986-08-20

Publications (2)

Publication Number Publication Date
EP0277995A1 true EP0277995A1 (fr) 1988-08-17
EP0277995A4 EP0277995A4 (fr) 1989-11-07

Family

ID=25409340

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870905705 Withdrawn EP0277995A4 (fr) 1986-08-20 1987-08-20 Implant en biomateriaux ayant une surface a charge positive nette.

Country Status (4)

Country Link
EP (1) EP0277995A4 (fr)
JP (1) JPH01500730A (fr)
IL (1) IL83592A0 (fr)
WO (1) WO1988001155A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2772087B2 (ja) * 1988-02-03 1998-07-02 バイオメディカル・デザイン・インコーポレーテッド 補綴材のカルシウム沈着の防止
US5480963A (en) * 1994-07-22 1996-01-02 United States Surgical Corporation Absorbable copolymers derived from tricarboxylic acids and surgical articles made therefrom
US6193749B1 (en) 1996-02-05 2001-02-27 St. Jude Medical, Inc. Calcification-resistant biomaterials
US6302909B1 (en) 1996-07-31 2001-10-16 St. Jude Medical, Inc. Calcification-resistant biomaterials
AU1848997A (en) * 1996-02-05 1997-08-22 St. Jude Medical Inc. Calcification-resistant biomaterials
US6254635B1 (en) 1998-02-02 2001-07-03 St. Jude Medical, Inc. Calcification-resistant medical articles
US6391538B1 (en) 2000-02-09 2002-05-21 The Children's Hospital Of Philadelphia Stabilization of implantable bioprosthetic tissue
US7167746B2 (en) 2004-07-12 2007-01-23 Ats Medical, Inc. Anti-coagulation and demineralization system for conductive medical devices
US9844667B2 (en) 2006-04-12 2017-12-19 Medtronic Ats Medical Inc. System for conditioning surfaces in vivo
US8653632B2 (en) 2007-03-28 2014-02-18 Medtronic Ats Medical Inc. System and method for conditioning implantable medical devices
WO2008121814A1 (fr) 2007-03-28 2008-10-09 Ats Medical, Inc. Procédé pour inhiber l'interaction des plaquettes avec les surfaces de biomatériaux
CN111569152A (zh) * 2020-05-28 2020-08-25 四川大学 一种兼具抗凝血和抗钙化性能的生物瓣膜及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0065827A1 (fr) * 1981-04-30 1982-12-01 McNeilab, Inc. Tissu pour implantation résistant à la calcification
EP0103947A2 (fr) * 1982-08-25 1984-03-28 McNeilab, Inc. Procédé pour empêcher la minéralisation de tissu naturel lors de l'implantation
EP0174737A2 (fr) * 1984-08-14 1986-03-19 Mayo Foundation Traitement de tissu collagénique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4378224A (en) * 1980-09-19 1983-03-29 Nimni Marcel E Coating for bioprosthetic device and method of making same
US4521564A (en) * 1984-02-10 1985-06-04 Warner-Lambert Company Covalent bonded antithrombogenic polyurethane material

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0065827A1 (fr) * 1981-04-30 1982-12-01 McNeilab, Inc. Tissu pour implantation résistant à la calcification
EP0103947A2 (fr) * 1982-08-25 1984-03-28 McNeilab, Inc. Procédé pour empêcher la minéralisation de tissu naturel lors de l'implantation
EP0174737A2 (fr) * 1984-08-14 1986-03-19 Mayo Foundation Traitement de tissu collagénique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8801155A1 *

Also Published As

Publication number Publication date
EP0277995A4 (fr) 1989-11-07
JPH01500730A (ja) 1989-03-16
IL83592A0 (en) 1988-01-31
WO1988001155A1 (fr) 1988-02-25

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