EP0258637A1 - Ultrasonic pocket sprayer - Google Patents

Ultrasonic pocket sprayer Download PDF

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Publication number
EP0258637A1
EP0258637A1 EP87111004A EP87111004A EP0258637A1 EP 0258637 A1 EP0258637 A1 EP 0258637A1 EP 87111004 A EP87111004 A EP 87111004A EP 87111004 A EP87111004 A EP 87111004A EP 0258637 A1 EP0258637 A1 EP 0258637A1
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EP
European Patent Office
Prior art keywords
ultrasonic
cartridge
pocket atomizer
ultrasonic pocket
atomizer according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP87111004A
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German (de)
French (fr)
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EP0258637B1 (en
Inventor
Wolf-Dietrich Dr. Drews
Martin Dipl.-Ing.(FH) Rüttel
Klaus Van Der Linden
Jürgen Friedrich
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Siemens AG
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Siemens AG
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Priority to AT87111004T priority Critical patent/ATE54071T1/en
Publication of EP0258637A1 publication Critical patent/EP0258637A1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0623—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn

Definitions

  • the invention relates to an ultrasonic pocket atomizer according to the preamble of patent claim 1.
  • Ultrasonic devices are also known for atomizing liquids. From DE-PS 20 32 433 devices with a piezoelectric vibration system are known, with which large vibration amplitudes can be achieved with comparatively little electrical energy. With such atomizing devices, it should be possible to produce very fine droplets with a relatively homogeneous distribution of the droplet size be.
  • the use of such piezoelectric vibration systems when using an electronic circuit and design as a hand-held device has become known from DE-PS 22 39 950.
  • the currently known ultrasound devices do not yet meet the requirements in terms of dimensions, weight, energy requirements and droplet size range, as well as exact drug dosages.
  • the metered dose aerosols currently used work with propellant gas, which is not desirable.
  • Inhalers are also known in which capsules filled with pharmaceutical powder are used and the powder of which is expelled via an air transport stream.
  • these inhalers cannot be filled with several single doses.
  • Another disadvantage of the metered dose aerosols working with propellant gas is that the high drug particle speed means that a certain proportion does not get into the lungs but, for example, into the esophagus.
  • the mechanical hand-held nebulizers have the particular disadvantage that a high expenditure of force is required to actuate the pump ball and the addition of preservatives to the medicament.
  • the object of the invention is to provide a device for the inhalation of active ingredients which enables the production of a suspended aerosol in which at least 50% of the droplets of the aerosol produced have a diameter of 20 microns and the majority of the droplets have a diameter in the range of 1 to 5 ⁇ m. It must also be possible to use the active ingredients in the trancheobronchial tree.
  • the application of the agent to be atomized must be possible without propellant gas and with precise dosing. A cold stimulus must not occur during application.
  • the aerosol should be suspended and if possible not have its own speed.
  • An ultrasonic pocket atomizer according to the invention enables low-noise application of substances without cold stimulus and without the use of a propellant gas.
  • the dosing of the substance to be atomized can be carried out with an accuracy of over 95% before atomization, which is very important in particular in the case of pharmaceuticals.
  • a suspended aerosol is generated in which at least 50% of the droplets of the aerosol produced have a diameter ⁇ 20 ⁇ m and the active ingredients can be used in the trancheobronchial tree.
  • the device according to the invention which can be operated in any position, is light, very handy and easy to accommodate and carry in the handbag or clothing.
  • the filling with the agent to be atomized takes place through easy replacement of cartridges.
  • the battery pack integrated in the lower part of the device is removable and rechargeable. Battery operation is possible and easy.
  • FIG. 2 being a longitudinal section of FIG. 1.
  • An ultrasonic pocket atomizer according to the invention consists of a piezoelectric vibration system 1 with an operating frequency in the range from 1 to 5 MHz, which is installed in the lower housing part 13 of the plastic housing in a liquid-tight manner.
  • Suitable plastics for this are, for example, acrylonitrile-butadiene-styrene copolymers (ABS).
  • ABS acrylonitrile-butadiene-styrene copolymers
  • the tightness is achieved by pouring the vibration system 1 into the holder 2 or by sealing with O-rings 28.
  • a particularly suitable casting compound is silicone rubber.
  • the vibrating system 1 is excited by an electronic circuit 3 to produce ultrasonic vibrations in the MHz range and atomizes the medicament 5 applied to the vibrating system 1 through the cartridge 4.
  • the electronic circuit is supplied with electrical energy via the rechargeable battery pack 6.
  • the device can be recharged with the integrated rechargeable battery by additionally routing the contacts 7 outwards in parallel.
  • the battery pack is removable, replaceable and rechargeable even without the device by means of a sliding device 8.
  • the dosing cartridge 4 filled with drug liquid is movably mounted in the upper housing part 9.
  • the button 10 moves Cartridge to the transducer.
  • a magnet 11 attached to the cartridge closes a switch 12 attached to the lower part 13 of the device.
  • the magnetic switch 11, 12 makes it possible to seal the lower housing part 13 in a liquid-tight manner with respect to the upper housing part 9.
  • the electronics are activated and the ultrasound atomizer is supplied with energy after an electronically specified period of time.
  • the time span is dimensioned such that there is sufficient time between actuation of the magnetic switch and the start of atomization.
  • the cartridge After closing the magnetic switch, the cartridge is moved forward, i.e. in the direction of the oscillation system, finally moves and strikes the thickened part of the body against a wall 14. Since the mechanical resistance of the plastic spring 15 is lower than the spring 21 integrated in the cartridge, the pressure on the cartridge by the operator continues to exert pressure on it only now slightly compressed and a precisely dosed amount of drug 5 is dispensed. By relieving the pressure on the cartridge, it moves back to its starting position. The quantity of medicament dispensed at the tip of the cartridge is stripped off on the atomizing plate 24 when it returns to the starting position and atomized after stripping.
  • the aerosol can be stored in the intake manifold 17 and is inhaled by the user.
  • the openings in the wall 18 are dimensioned such that sufficient air can be added to the intake manifold during the inhalation process.
  • the mouth of the user can enclose the intake manifold well.
  • the connector can be flush with one edge of the housing and the device dimensions can be kept small.
  • a cover 20 is provided for closing the intake manifold and is captively attached to the upper part of the device via a plastic film hinge 22.
  • the upper housing part 9 Since the upper housing part 9 is easily removable and inexpensive to produce, it can be discarded after the cartridge 4 filled with medication has been emptied. It is a very hygienic solution.
  • a transparent window 23 made of plastic is integrated on the upper part, which shows the amount of liquid still present. It allows you to monitor the level of the drug in the cartridge.
  • an electrical signal 25 indicates the state of charge of the rechargeable battery.
  • Suitable is e.g. a light emitting diode.
  • the outer contours of the device 26 are rounded, so that the user is inevitably given a corresponding location at which the device can be parked.
  • This storage container can be designed, for example, in such a way that the battery is simultaneously recharged during storage.
  • the integrated contacts are arranged asymmetrically with respect to the underside of the device, a specific position can even be specified in the storage container.
  • the upper housing part 9 is easily detachably connected to the lower housing part 13 by a snap-lock connection 16.
  • the device can also be designed so that, for example, the magnetic switch 11, 12 only triggers when the thickened part of the cartridge hits the wall.
  • Devices according to the invention are used with particular advantage for medical applications, in particular for asthmatics.
  • An application as a room and body spray device is also possible, as well as a humidifier.

Abstract

An ultrasonic pocket-size atomizer comprises a housing including a first portion and a second portion detachably connected thereto. A vibration generation mechanism is mounted liquid-tight in the first portion of the housing for generating an oscillation with a frequency between 1 and 5 Mhz. The vibration generation mechanism includes a piezoelectric assembly and an electronic circuit operatively connected to the assembly for energizing the assembly and causing the assembly to vibrate. A power source including a storage battery is removably and rechargeably disposed in the first portion of the housing for supplying electric current to the electronic circuit. A cartridge is provided for containing liquid to be atomized, the cartridge being movably disposed in the second portion of the housing. An activation mechanism is provided for automatically activating the electronic circuit upon motion of the movable section of the cartridge, the activation mechanism including a magnet attached to the movable section of the cartridge so as to move therewith. The activation mechanism further includes a switch operatively connected to the electronic circuit and operable by the magnet upon a shift in the position thereof during motion of the movable section of the cartridge.

Description

Die Erfindung betrifft ein Ultraschall-Taschenzerstäu­bergerät gemäß dem Oberbegriff des Patentanspru­ches 1.The invention relates to an ultrasonic pocket atomizer according to the preamble of patent claim 1.

Bei der Verabreichung von Arzneimitteln ist es vielfach wünschenswert, die Wirkstoffe zu inhalieren. Dies gilt vor allem für die Behandlung der Atemwege. Am Markt sind Sprüh- und Spritzpistolen und mechanische Hand­verneblergeräte, die von Hand zu betätigen sind. Sie erzeugen keine besonders feinen Verteilungen, keine homogenen Gemische und sie erfordern einen hohen Kraft­aufwand. Ein Nachteil bei der Applikation mittels der bekannten Aerosolsprühdosen (Dosieraerosolen) liegt insbesondere im auftretenden Kältereiz und in den schädlichen Nebenwirkungen der Treibgase und in der sehr hohen Geschwindigkeit des Aerosols und der damit schwierigen Koordination zwischen der Betätigung der Sprühdose und dem Inhalieren. Dies gilt vor allem bei einem Einsatz für die Behandlung der Atemwege.When administering drugs, it is often desirable to inhale the active ingredients. This is especially true for the treatment of the respiratory tract. There are spray and spray guns and mechanical hand-held nebulizers on the market that can be operated by hand. They do not produce particularly fine distributions, no homogeneous mixtures and they require a great deal of effort. A disadvantage of application by means of the known aerosol spray cans (metered dose aerosols) lies in particular in the cold stimulus that occurs and in the harmful side effects of the propellant gases and in the very high speed of the aerosol and the difficult coordination between the actuation of the spray can and the inhalation. This is especially true when used for the treatment of the respiratory tract.

Ferner sind zur Zerstäubung von Flüssigkeiten Ultra­schallgeräte bekannt. Aus der DE-PS 20 32 433 sind Geräte mit einem piezoelektrischen Schwingsystem be­kannt, mit dem sich große Schwingungsamplituden unter Aufwand von vergleichsweise geringer elektrischer Energie erreichen lassen. Mit solchen Zerstäuber­geräten soll eine Erzeugung sehr feiner Tröpfchen mit relativ homogener Verteilung der Tröpfchengröße möglich sein. Der Einsatz solcher piezoelektrischer Schwing­systeme bei Verwendung einer elektronischen Schaltung und Ausführung als Handgerät ist aus der DE-PS 22 39 950 bekanntgeworden.Ultrasonic devices are also known for atomizing liquids. From DE-PS 20 32 433 devices with a piezoelectric vibration system are known, with which large vibration amplitudes can be achieved with comparatively little electrical energy. With such atomizing devices, it should be possible to produce very fine droplets with a relatively homogeneous distribution of the droplet size be. The use of such piezoelectric vibration systems when using an electronic circuit and design as a hand-held device has become known from DE-PS 22 39 950.

Aus der DE-AS 25 37 765 sind auch medizinische Inhala­tionsgeräte zur Behandlung von Krankheiten der Atmungs­wege mit einem piezoelektrischen Schwingsystem bekannt mit einem flüssigkeitsdichten Schutzgehäuse, in das der Schallüberträger mittels eines Halteringes, der im Bereich einer Schwingungsknotenlinie am Schallüberträ­ger angeordnet ist und eine Niederspannungsanregungs­elektronik.From DE-AS 25 37 765 medical inhalation devices for the treatment of diseases of the respiratory tract with a piezoelectric vibration system are known with a liquid-tight protective housing into which the sound transmitter by means of a retaining ring, which is arranged in the region of a vibration node line on the sound transmitter, and low-voltage excitation electronics.

Für die Behandlung der Atemwege genügen die zur Zeit bekannten Ultraschallgeräte aber noch nicht den Forde­rungen an Abmessungen, Gewicht, Energiebedarf und Tröpfengrößenspektrum sowie an genauen Arzneimittel­dosierungen.For the treatment of the respiratory tract, the currently known ultrasound devices do not yet meet the requirements in terms of dimensions, weight, energy requirements and droplet size range, as well as exact drug dosages.

Die zur Zeit verwendeten Dosieraerosole arbeiten mit Treibgas, was nicht erwünscht ist. Es sind auch Inhala­toren bekannt, bei denen mit Arzneimittelpulver ge­füllte Kapseln verwendet werden und deren Pulver über einen Lufttransportstrom ausgestoßen wird. Diese Inha­latoren können jedoch nicht mit mehreren Einzeldosen gefüllt werden. Ein weiterer Nachteil der mit Treibgas arbeitenden Dosieraerosole ist, daß durch die hohe Arzneimittelpartikelgeschwindigkeit ein gewisser Anteil nicht in die Lunge, sondern beispielsweise in die Speiseröhre gelangt.The metered dose aerosols currently used work with propellant gas, which is not desirable. Inhalers are also known in which capsules filled with pharmaceutical powder are used and the powder of which is expelled via an air transport stream. However, these inhalers cannot be filled with several single doses. Another disadvantage of the metered dose aerosols working with propellant gas is that the high drug particle speed means that a certain proportion does not get into the lungs but, for example, into the esophagus.

Die mechanischen Handvernebler haben insbesondere den Nachteil, daß ein hoher Kraftaufwand für die Betätigung des Pumpballes erforderlich ist und der Zusatz von Konservierungsstoffen zum Arzneimittel.The mechanical hand-held nebulizers have the particular disadvantage that a high expenditure of force is required to actuate the pump ball and the addition of preservatives to the medicament.

Aufgabe der Erfindung ist es, für die Inhalation von Wirkstoffen ein Gerät zu schaffen, das die Erzeugung eines schwebfähigen Aerosols ermöglicht, bei dem mindestens 50 % der erzeugten Tröpfchen des Aerosols einen Durchmesser von 20 µm besitzen und der Haupt­anteil der Tröpfchen einen Durchmesser im Bereich von 1 bis 5 µm hat. Die Nutzung der Wirkstoffe muß auch noch im Trancheobronchialbaum möglich sein. Die Applikation des zu zerstäubenden Mittels muß ohne Treibgas und mit genauer Dosierung möglich sein. Ein Kältereiz darf bei der Applikation nicht auftreten. Wie bereits erwähnt, soll das Aerosol schwebfähig sein und möglichst keine Eigengeschwindigkeit besitzen.The object of the invention is to provide a device for the inhalation of active ingredients which enables the production of a suspended aerosol in which at least 50% of the droplets of the aerosol produced have a diameter of 20 microns and the majority of the droplets have a diameter in the range of 1 to 5 µm. It must also be possible to use the active ingredients in the trancheobronchial tree. The application of the agent to be atomized must be possible without propellant gas and with precise dosing. A cold stimulus must not occur during application. As already mentioned, the aerosol should be suspended and if possible not have its own speed.

Diese Aufgabe wird durch ein Ultraschall-Taschenzer­stäubergerät gelöst, das entsprechend dem Kennzeichen des Patentanspruches 1 ausgebildet ist.This object is achieved by an ultrasonic pocket atomizer which is designed in accordance with the characterizing part of patent claim 1.

Weitere Ausgestaltungen und Weiterbildungen der Erfin­dung gehen aus den Unteransprüchen hervor.Further refinements and developments of the invention emerge from the subclaims.

Ein Ultraschall-Taschenzerstäubergerät gemäß der Er­findung ermöglicht eine geräuscharme Applikation von Stoffen ohne Kältereiz und ohne Anwendung eines Treib­gases. Die Dosierung des zu zerstäubenden Stoffes kann vor der Zerstäubung mit einer Genauigkeit von über 95 % erfolgen, was insbesondere bei Arzneimitteln sehr wich­tig ist. Es wird ein schwebfähiges Aerosol erzeugt, bei dem mindestens 50 % der erzeugten Tröpfchen des Aero­sols einen Durchmesser < 20 µm besitzen und eine Nutzung der Wirkstoffe im Trancheobronchialbaum möglich ist. Schließlich ist das erfindungsgemäße Gerät, das lageunabhängig betrieben werden kann, leicht, sehr handlich und leicht in der Handtasche oder in der Bekleidung unterzubringen und mitzuführen. Die Auffül­lung mit dem zu zerstäubenden Mittel erfolgt durch einfaches Auswechseln von Kartuschen. Der im Geräte­unterteil integrierte Akkusatz ist herausnehmbar und wieder aufladbar. Der Batteriebetrieb ist möglich und einfach.An ultrasonic pocket atomizer according to the invention enables low-noise application of substances without cold stimulus and without the use of a propellant gas. The dosing of the substance to be atomized can be carried out with an accuracy of over 95% before atomization, which is very important in particular in the case of pharmaceuticals. A suspended aerosol is generated in which at least 50% of the droplets of the aerosol produced have a diameter <20 µm and the active ingredients can be used in the trancheobronchial tree. Finally, the device according to the invention, which can be operated in any position, is light, very handy and easy to accommodate and carry in the handbag or clothing. The filling with the agent to be atomized takes place through easy replacement of cartridges. The battery pack integrated in the lower part of the device is removable and rechargeable. Battery operation is possible and easy.

Im folgenden wird die Erfindung anhand der Figuren 1 und 2 näher beschrieben, wobei Figur 2 ein Längs­schnitt von Figur 1 ist.The invention is described in more detail below with reference to FIGS. 1 and 2, FIG. 2 being a longitudinal section of FIG. 1.

Ein Ultraschall-Taschenzerstäubergerät gemäß der Er­findung besteht aus einem piezoelektrischen Schwing­system 1 mit einer Betriebsfrequenz im Bereich von 1 bis 5 MHz, das flüssigkeitsdicht in das Gehäuseunter­teil 13 des Kunststoffgehäuses eingebaut ist. Geeignete Kunststoffe hierfür sind beispielsweise Acrylnitril-­Butadien-Styrol-Copolymere (ABS). Die Dichtheit wird erreicht durch Eingießen des Schwingsystems 1 in die Halterung 2 oder aber durch Abdichtung mit O-Ringen 28. Eine besonders geeignete Vergußmasse ist Silikon­kautschuk.An ultrasonic pocket atomizer according to the invention consists of a piezoelectric vibration system 1 with an operating frequency in the range from 1 to 5 MHz, which is installed in the lower housing part 13 of the plastic housing in a liquid-tight manner. Suitable plastics for this are, for example, acrylonitrile-butadiene-styrene copolymers (ABS). The tightness is achieved by pouring the vibration system 1 into the holder 2 or by sealing with O-rings 28. A particularly suitable casting compound is silicone rubber.

Das Schwingsystem 1 wird durch eine Elektronikschaltung 3 zu Ultraschallschwingungen im MHz-Bereich angeregt und zerstäubt das durch die Kartusche 4 auf das Schwingsystem 1 aufgebrachte Arzneimittel 5. Die Elektronikschaltung wird über den wiederaufladbaren Akkusatz 6 mit elektrischer Energie versorgt. Durch eine zusätzliche parallele Herausführung der Kontakte 7 nach außen kann das Gerät mit dem integrierten Akku nachgeladen werden. Durch eine Schiebevorrichtung 8 ist der Akkusatz herausnehmbar austauschbar und auch ohne das Gerät nachladbar.The vibrating system 1 is excited by an electronic circuit 3 to produce ultrasonic vibrations in the MHz range and atomizes the medicament 5 applied to the vibrating system 1 through the cartridge 4. The electronic circuit is supplied with electrical energy via the rechargeable battery pack 6. The device can be recharged with the integrated rechargeable battery by additionally routing the contacts 7 outwards in parallel. The battery pack is removable, replaceable and rechargeable even without the device by means of a sliding device 8.

Die mit Arzneimittelflüssigkeit gefüllte Dosierkar­tusche 4 ist in dem Gehäuseoberteil 9 bewegbar gela­gert. Durch Druck auf den Knopf 10 bewegt sich die Kartusche zum Schwinger. Gleichzeitig schließt ein an der Kartusche angebrachter Magnet 11 einen am Unter­teil 13 des Gerätes angebrachten Schalter 12. Durch den Magnetschalter 11, 12 ist es möglich, das Gehäuseunter­teil 13 flüssigkeitsdicht zum Gehäuseoberteil 9 abzu­schließen.The dosing cartridge 4 filled with drug liquid is movably mounted in the upper housing part 9. The button 10 moves Cartridge to the transducer. At the same time, a magnet 11 attached to the cartridge closes a switch 12 attached to the lower part 13 of the device. The magnetic switch 11, 12 makes it possible to seal the lower housing part 13 in a liquid-tight manner with respect to the upper housing part 9.

Durch Schließen des Schalters wird die Elektronik akti­viert und nach einer elektronisch vorgegebenen Zeit­spanne wird der Ultraschallzerstäuber mit Energie ver­sorgt.When the switch is closed, the electronics are activated and the ultrasound atomizer is supplied with energy after an electronically specified period of time.

Die Zeitspanne ist so bemessen, daß ausreichend Zeit verbleibt zwischen dem Betätigen des Magnetschalters und dem Zerstäubungsbeginn. Nach dem Schließen des Magnetschalters wird die Kartusche weiter nach vorne, d.h. in Richtung Schwingsystem, bewegt und stößt schließlich mit dem verdickten Teil des Körpers gegen eine Wand 14. Da der mechanische Widerstand der Kunst­stofffeder 15 geringer ist als der in der Kartusche integrierten Feder 21, wird die Kartusche durch den weiter auf ihr lastenden Druck durch den Bedienenden erst jetzt etwas zusammengedrückt und eine genau do­sierte Arzneimittelmenge 5 wird abgegeben. Durch Ent­lastung der Kartusche fährt sie in ihre Ausgangsposi­tion wieder zurück. Die an der Kartuschenspitze abge­gebene Arzneimittelmenge wird beim Zurückgehen in die Ausgangsposition an dem Zerstäuberteller 24 abgestreift und nach dem Abstreifen zerstäubt.The time span is dimensioned such that there is sufficient time between actuation of the magnetic switch and the start of atomization. After closing the magnetic switch, the cartridge is moved forward, i.e. in the direction of the oscillation system, finally moves and strikes the thickened part of the body against a wall 14. Since the mechanical resistance of the plastic spring 15 is lower than the spring 21 integrated in the cartridge, the pressure on the cartridge by the operator continues to exert pressure on it only now slightly compressed and a precisely dosed amount of drug 5 is dispensed. By relieving the pressure on the cartridge, it moves back to its starting position. The quantity of medicament dispensed at the tip of the cartridge is stripped off on the atomizing plate 24 when it returns to the starting position and atomized after stripping.

Das Aerosol kann in dem Ansaugstutzen 17 gespeichert werden und wird durch den Benutzer eingeatmet.The aerosol can be stored in the intake manifold 17 and is inhaled by the user.

Die in der Wand 18 vorhandenen Öffnungen sind so bemes­sen, daß in dem Ansaugstutzen während des Einatmungs­vorgangs ausreichend Luft nachgeführt werden kann.The openings in the wall 18 are dimensioned such that sufficient air can be added to the intake manifold during the inhalation process.

Mit der speziellen Kontur des Ansaugstutzens 19 ist es möglich, daß der Mund des Benutzers den Ansaug­stutzen gut umschließen kann. Dabei kann der Stutzen an einer Kante des Gehäuses bündig abschließen und die Geräteabmessungen können gering gehalten werden.With the special contour of the intake manifold 19, it is possible that the mouth of the user can enclose the intake manifold well. The connector can be flush with one edge of the housing and the device dimensions can be kept small.

Aus hygienischen Gründen soll der Ansaugstutzen nach dem Inhalationsvorgang wieder verschlossen werden. Für das Verschließen des Ansaugstutzens ist ein Deckel 20 vorgesehen, der unverlierbar über ein Kunststoff-Film-­Scharnier 22 an dem Geräteoberteil befestigt ist.For hygienic reasons, the intake port should be closed again after the inhalation process. A cover 20 is provided for closing the intake manifold and is captively attached to the upper part of the device via a plastic film hinge 22.

Da das Gehäuseoberteil 9 leicht entfernbar und kostengünstig herstellbar ist, kann es nach dem Ent­leeren der mit Arzneimittel gefüllten Kartusche 4 ver­worfen werden. Es ist eine sehr hygienische Lösung.Since the upper housing part 9 is easily removable and inexpensive to produce, it can be discarded after the cartridge 4 filled with medication has been emptied. It is a very hygienic solution.

Für den Benutzer ist es wichtig, die noch in der Kartu­sche befindliche Arzneimittelmenge zu kennen. Dafür ist an dem Oberteil ein durchsichtiges Fenster 23 aus Kunststoff integriert, das die noch vorhandene Flüssig­keitsmenge zeigt. Es ermöglicht den Füllstand des Arzneimittels in der Kartusche zu beobachten.It is important for the user to know the amount of medication that is still in the cartridge. For this purpose, a transparent window 23 made of plastic is integrated on the upper part, which shows the amount of liquid still present. It allows you to monitor the level of the drug in the cartridge.

Da der für das Zerstäuben erforderliche Energievorrat in den Akkus nicht mit der Anzahl der Arzneimitteldosen in der Kartusche übereinstimmt, zeigt ein elektri­sches Signal 25 den Ladezustand des Akkus an. Geeignet ist z.B. eine Leuchtdiode.Since the energy supply required for atomization in the rechargeable batteries does not match the number of drug doses in the cartridge, an electrical signal 25 indicates the state of charge of the rechargeable battery. Suitable is e.g. a light emitting diode.

Leuchtet beim Betätigen des Gerätes diese Diode erst­malig nicht mehr, wird dem Benutzer angezeigt, daß der Akkusatz bald nachgeladen werden muß. Der Energieinhalt des Akkus ist jedenfalls noch so hoch, daß noch einige weitere Inhalationsvorgängen möglich sind. Dieses ist erforderlich, da gegebenenfalls der Akku nicht sofort nachgeladen werden kann und trotzdem der Bedarf für eine Inhalation besteht.If this diode no longer lights up when the device is operated, the user is informed that the battery pack must be recharged soon. In any case, the energy content of the battery is still so high that a few more inhalation processes are possible. This is necessary because the battery may not can be recharged immediately and there is still a need for inhalation.

Die äußeren Konturen des Gerätes 26 sind abgerundet, damit dem Benutzer zwangsläufig ein entsprechender Ort vorgegeben wird, an dem das Gerät abgestellt werden kann. Dieser Aufbewahrungsbehälter kann beispielsweise so ausgeführt werden, daß beim Aufbewahren gleichzeitig der Akku nachgeladen wird.The outer contours of the device 26 are rounded, so that the user is inevitably given a corresponding location at which the device can be parked. This storage container can be designed, for example, in such a way that the battery is simultaneously recharged during storage.

Da die integrierten Kontakte asymmetrisch bezüglich der Geräteunterseite angeordnet sind, kann sogar eine be­stimmte Lage im Aufbewahrungsbehälter vorgegeben werden.Since the integrated contacts are arranged asymmetrically with respect to the underside of the device, a specific position can even be specified in the storage container.

Das Gehäuseoberteil 9 ist mit dem Gehäuseunterteil 13 durch eine Schnapp-Rastverbindung 16 leicht trennbar verbunden.The upper housing part 9 is easily detachably connected to the lower housing part 13 by a snap-lock connection 16.

Das Gerät kann auch so ausgeführt werden, daß bei­spielsweise der Magnetschalter 11, 12 erst beim An­stoßen des verdickten Teils der Kartusche gegen die Wand auslöst.The device can also be designed so that, for example, the magnetic switch 11, 12 only triggers when the thickened part of the cartridge hits the wall.

Geräte gemäß der Erfindung werden mit besonderem Vor­teil für medizinische Applikationen insbesondere bei Asthmatikern eingesetzt. Eine Anwendung als Raum- und Körperspraygerät ist aber ebenfalls möglich, sowie als Luftbefeuchter.Devices according to the invention are used with particular advantage for medical applications, in particular for asthmatics. An application as a room and body spray device is also possible, as well as a humidifier.

Claims (13)

1. Ultraschall-Taschenzerstäubergerät, insbesondere zum Zerstäuben von Arzneimitteln für Inhalationszwecke mit einem mit einer elektrischen Stromquelle verbundenen piezoelektrischen Schwingsystem, einer Zuführung zum piezoelektrischen Schwingsystem, einem Vorratsbehälter mit Dosiervorrichtung und Zuführungen für die zu zer­stäubende Flüssigkeit, die in einem Schutzgehäuse an­geordnet sind, gekennzeichnet durch ein im Gehäuseunterteil (13) flüssigkeitsdicht einge­brachtes piezoelektrisches Schwingsystem (1) mit einer Betriebsfrequenz im Bereich von 1 bis 5 MHz, das durch eine Elektronikschaltung (3) zu Ultraschallschwingungen im Bereich vom 1-5 MHz angeregt wird und einer mit der zu zerstäubenden Flüssigkeit (5) gefüllten, in dem Gehäuseoberteil (9) bewegbar gelagerten Kartusche (4), die sich in Richtung zum Schwinger bewegt und einen Magneten (11) aufweist, der einen Schalter (12) am Gehäuseunterteil (13) betätigt und daß im Geräteunter­teil (13) ein herausnehmbarer und wieder aufladbarer Akkusatz (6) integriert ist.1. Ultrasonic pocket atomizer, in particular for atomizing medicinal products for inhalation purposes with a piezoelectric vibrating system connected to an electrical power source, a feed to the piezoelectric vibrating system, a storage container with metering device and feeds for the liquid to be atomized, which are arranged in a protective housing, characterized by a piezoelectric vibrating system (1), which is incorporated in the lower part of the housing in a liquid-tight manner and has an operating frequency in the range of 1 to 5 MHz, which is excited by an electronic circuit (3) to produce ultrasonic vibrations in the range of 1-5 MHz and one with the liquid to be atomized ( 5) filled, in the upper housing part (9) movably mounted cartridge (4) which moves in the direction of the oscillator and has a magnet (11) which actuates a switch (12) on the lower housing part (13) and that in the lower part (13 ) a removable and rechargeable Battery pack (6) is integrated. 2. Ultraschall-Taschenzerstäubergerät nach Patentan­spruch 1, dadurch gekennzeichnet, daß das Gehäuseoberteil (9) mit dem Gehäuseunterteil (13) durch einen Schnapp-Rastverschluß (16) verbunden ist.2. Ultrasonic pocket atomizer according to claim 1, characterized in that the upper housing part (9) with the lower housing part (13) is connected by a snap lock (16). 3. Ultraschall-Taschenzerstäubergerät nach Patentan­spruch 1, dadurch gekennzeichnet, daß das piezoelektrische Schwingsystem (1) mit Silikon­kautschuk in die Halterung (2) eingegossen ist.3. Ultrasonic pocket atomizer according to claim 1, characterized in that the piezoelectric vibration system (1) with silicone rubber is poured into the holder (2). 4. Ultraschall-Taschenzerstäubergerät nach Patentan­spruch 1, dadurch gekennzeichnet, daß das piezoelektrische Schwingsystem (1) in einer spritzgegossenen Halterung (2) aus elastischem Kunst­stoff angeordnet ist.4. Ultrasonic pocket atomizer according to claim 1, characterized in that the piezoelectric vibration system (1) is arranged in an injection-molded holder (2) made of elastic plastic. 5. Ultraschall-Taschenzerstäubergerät nach Patentan­spruch 1, dadurch gekennzeichnet, daß das piezoelektrische Schwingsystem (1) mit 0-Ringen (28) abgedichtet ist.5. Ultrasonic pocket atomizer according to claim 1, characterized in that the piezoelectric vibration system (1) is sealed with 0-rings (28). 6. Ultraschall-Taschenzerstäubergerät nach einem der vorangegangenen Ansprüche, dadurch ge­kennzeichnet, daß ein Schwingsystem ge­mäß Patentanmeldung P 36 16 713.4 (VPA 86 P 3180 DE) verwendet ist.6. Ultrasonic pocket atomizer according to one of the preceding claims, characterized in that a vibration system according to patent application P 36 16 713.4 (VPA 86 P 3180 DE) is used. 7. Ultraschall-Taschenzerstäubergerät nach Patentan­spruch 1 bis 6, dadurch gekenn­zeichnet, daß die Kartusche (4) durch Druck auf den Knopf (10) bewegbar ist.7. Ultrasonic pocket atomizer according to claim 1 to 6, characterized in that the cartridge (4) can be moved by pressing the button (10). 8. Ultraschall-Taschenzerstäubergerät nach einem der vorangegangenen Ansprüche, dadurch ge­kennzeichnet, daß die Kartusche (4) ein Ventil gemäß Patentanmeldung P 36 08 621.5 (VPA 86 P 3088 DE) aufweist.8. Ultrasonic pocket atomizer device according to one of the preceding claims, characterized in that the cartridge (4) has a valve according to patent application P 36 08 621.5 (VPA 86 P 3088 DE). 9. Ultraschall-Taschenzerstäubergerät nach Patentan­spruch 1, dadurch gekennzeich­net, daß das Gehäuseoberteil (9) ein durchsichtiges Fenster (23) aufweist.9. Ultrasonic pocket atomizer device according to claim 1, characterized in that the upper housing part (9) has a transparent window (23). 10. Ultraschall-Taschenzerstäubergerät nach einem der Ansprüche 1 bis 9, dadurch gekenn­zeichnet, daß der wiederaufladbare, aus dem Geräteunterteil (13) herausnehmbare Akku (6), des­sen Ladezustand ein elektronisches Signal anzeigt, mit einer Elektronikschaltung (3) verbunden ist.10. Ultrasonic pocket atomizer according to one of claims 1 to 9, characterized in that the rechargeable, from the removable device (13) removable battery (6), the charge of which indicates an electronic signal, is connected to an electronic circuit (3). 11. Ultraschall-Taschenzerstäubergerät, nach einem der vorangegangenen Ansprüche 1 bis 10, gekenn­zeichnet durch einen Erregerkreis für das Schwingsystem gemäß Patentanmeldung P 36 25 461.4 (VPA 86 P 3253 DE).11. Ultrasonic Taschenzerstäubergerät, according to any one of the preceding claims 1 to 10, characterized by an energizing circuit for the oscillating system in accordance with patent application P 36 25 461.4 (VPA 86 P 3253 US). 12. Ultraschall-Taschenzerstäubergerät nach einem der vorangegangenen Ansprüche 1 bis 11, dadurch gekennzeichnet, daß als elektronisches Signal eine Leuchtdiode (25) dient.12. Ultrasonic pocket atomizer according to one of the preceding claims 1 to 11, characterized in that a light-emitting diode (25) is used as the electronic signal. 13. Ultraschall-Taschenzerstäubergerät nach einem der vorangegangenen Ansprüche 1 bis 11, dadurch gekennzeichnet, daß als elektronisches Signal ein akkustisches Signal dient.13. Ultrasonic pocket atomizer according to one of the preceding claims 1 to 11, characterized in that an acoustic signal is used as the electronic signal.
EP87111004A 1986-08-11 1987-07-29 Ultrasonic pocket sprayer Expired - Lifetime EP0258637B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT87111004T ATE54071T1 (en) 1986-08-11 1987-07-29 ULTRASONIC POCKET ATOMIZER.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863627222 DE3627222A1 (en) 1986-08-11 1986-08-11 ULTRASONIC POCKET SPRAYER
DE3627222 1986-08-11

Publications (2)

Publication Number Publication Date
EP0258637A1 true EP0258637A1 (en) 1988-03-09
EP0258637B1 EP0258637B1 (en) 1990-06-27

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EP87111004A Expired - Lifetime EP0258637B1 (en) 1986-08-11 1987-07-29 Ultrasonic pocket sprayer

Country Status (7)

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US (1) US4877989A (en)
EP (1) EP0258637B1 (en)
JP (1) JP2540462B2 (en)
AT (1) ATE54071T1 (en)
CA (1) CA1313098C (en)
DE (2) DE3627222A1 (en)
ES (1) ES2015558B3 (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373237A1 (en) * 1988-12-13 1990-06-20 Siemens Aktiengesellschaft Pocket inhaler device
EP0373419A2 (en) * 1988-12-12 1990-06-20 Siemens Aktiengesellschaft Battery changer for a medical appliance
FR2705911A1 (en) * 1993-06-02 1994-12-09 Oreal Piezoelectric nebulization device.
DE4431019A1 (en) * 1994-08-31 1996-03-07 Siemens Ag Ultrasound atomiser head for medical use
GB2265845B (en) * 1991-11-12 1996-05-01 Medix Ltd A nebuliser and nebuliser control system
US5836521A (en) * 1995-03-09 1998-11-17 Dysekompagniet I/S Valve device with impact member and solenoid for atomizing a liquid
US5950619A (en) * 1995-03-14 1999-09-14 Siemens Aktiengesellschaft Ultrasonic atomizer device with removable precision dosating unit
US5970974A (en) * 1995-03-14 1999-10-26 Siemens Aktiengesellschaft Dosating unit for an ultrasonic atomizer device
EP1389064A2 (en) * 2001-01-26 2004-02-18 Yoni Iger Method and apparatus for the delivery of substances to biological components
WO2007120565A1 (en) * 2006-04-11 2007-10-25 S.C. Johnson & Son, Inc. Electronic aerosol device
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Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02170613A (en) * 1988-12-23 1990-07-02 Hitachi Ltd Automatic equalizer
US5269327A (en) * 1989-12-01 1993-12-14 Philip Morris Incorporated Electrical smoking article
US5224498A (en) * 1989-12-01 1993-07-06 Philip Morris Incorporated Electrically-powered heating element
US5093894A (en) * 1989-12-01 1992-03-03 Philip Morris Incorporated Electrically-powered linear heating element
US5060671A (en) * 1989-12-01 1991-10-29 Philip Morris Incorporated Flavor generating article
US5095921A (en) * 1990-11-19 1992-03-17 Philip Morris Incorporated Flavor generating article
US5179966A (en) * 1990-11-19 1993-01-19 Philip Morris Incorporated Flavor generating article
US5665262A (en) * 1991-03-11 1997-09-09 Philip Morris Incorporated Tubular heater for use in an electrical smoking article
US5249586A (en) * 1991-03-11 1993-10-05 Philip Morris Incorporated Electrical smoking
US5388594A (en) * 1991-03-11 1995-02-14 Philip Morris Incorporated Electrical smoking system for delivering flavors and method for making same
US5573692A (en) * 1991-03-11 1996-11-12 Philip Morris Incorporated Platinum heater for electrical smoking article having ohmic contact
US5505214A (en) * 1991-03-11 1996-04-09 Philip Morris Incorporated Electrical smoking article and method for making same
US5121541A (en) * 1991-11-12 1992-06-16 Patrakis Strati G Electric razor with built-in mister
US5666976A (en) * 1992-09-11 1997-09-16 Philip Morris Incorporated Cigarette and method of manufacturing cigarette for electrical smoking system
US5692525A (en) * 1992-09-11 1997-12-02 Philip Morris Incorporated Cigarette for electrical smoking system
TW245766B (en) * 1992-09-11 1995-04-21 Philip Morris Prod
GB2272389B (en) * 1992-11-04 1996-07-24 Bespak Plc Dispensing apparatus
US5452711A (en) * 1992-12-24 1995-09-26 Exar Corporation Small form factor atomizer
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5558085A (en) * 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US6098620A (en) * 1993-01-29 2000-08-08 Aradigm Corporation Device for aerosolizing narcotics
US5672581A (en) * 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5743250A (en) * 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5915378A (en) * 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5934272A (en) * 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5819726A (en) * 1993-01-29 1998-10-13 Aradigm Corporation Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease
US5724957A (en) * 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5873358A (en) * 1993-01-29 1999-02-23 Aradigm Corporation Method of maintaining a diabetic patient's blood glucose level in a desired range
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US5970973A (en) * 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US6012450A (en) * 1993-01-29 2000-01-11 Aradigm Corporation Intrapulmonary delivery of hematopoietic drug
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5709202A (en) * 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5666977A (en) * 1993-06-10 1997-09-16 Philip Morris Incorporated Electrical smoking article using liquid tobacco flavor medium delivery system
CH686872A5 (en) * 1993-08-09 1996-07-31 Disetronic Ag Medical Inhalationsgeraet.
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US6782886B2 (en) * 1995-04-05 2004-08-31 Aerogen, Inc. Metering pumps for an aerosolizer
US6014970A (en) * 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6085740A (en) 1996-02-21 2000-07-11 Aerogen, Inc. Liquid dispensing apparatus and methods
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
US20040237961A1 (en) * 1995-06-08 2004-12-02 Snow John Medlin Inhalation actuated device for use with metered dose inhalers (MDIs)
US6357442B1 (en) 1995-06-08 2002-03-19 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIS)
IT1277427B1 (en) * 1995-08-03 1997-11-10 Miat Spa ULTRASONIC AEROSOL APPARATUS
US5649554A (en) * 1995-10-16 1997-07-22 Philip Morris Incorporated Electrical lighter with a rotatable tobacco supply
US5743251A (en) * 1996-05-15 1998-04-28 Philip Morris Incorporated Aerosol and a method and apparatus for generating an aerosol
IT1283125B1 (en) * 1996-06-12 1998-04-07 Miat Spa WATERPROOF AEROSOL APPLIANCE
JP3386050B2 (en) * 1997-10-06 2003-03-10 オムロン株式会社 Spraying equipment
US6234167B1 (en) * 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6196218B1 (en) * 1999-02-24 2001-03-06 Ponwell Enterprises Ltd Piezo inhaler
US6293474B1 (en) 1999-03-08 2001-09-25 S. C. Johnson & Son, Inc. Delivery system for dispensing volatiles
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
US6962151B1 (en) * 1999-11-05 2005-11-08 Pari GmbH Spezialisten für effektive Inhalation Inhalation nebulizer
US6883516B2 (en) 2000-04-27 2005-04-26 Chrysalis Technologies Incorporated Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution
MY136453A (en) 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
US6748944B1 (en) * 2000-05-03 2004-06-15 Dellavecchia Michael Anthony Ultrasonic dosage device and method
US7100600B2 (en) 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US6948491B2 (en) 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US6543443B1 (en) 2000-07-12 2003-04-08 Aerogen, Inc. Methods and devices for nebulizing fluids
US6435175B1 (en) * 2000-08-29 2002-08-20 Sensormedics Corporation Pulmonary drug delivery device
US6964647B1 (en) 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US6450419B1 (en) 2000-10-27 2002-09-17 S.C. Johnson & Son, Inc. Self contained liquid atomizer assembly
US6601581B1 (en) * 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6761729B2 (en) 2000-12-22 2004-07-13 Advanced Medicalapplications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US6533803B2 (en) 2000-12-22 2003-03-18 Advanced Medical Applications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US7914470B2 (en) 2001-01-12 2011-03-29 Celleration, Inc. Ultrasonic method and device for wound treatment
US6569099B1 (en) 2001-01-12 2003-05-27 Eilaz Babaev Ultrasonic method and device for wound treatment
US8235919B2 (en) 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US6960173B2 (en) 2001-01-30 2005-11-01 Eilaz Babaev Ultrasound wound treatment method and device using standing waves
US6546927B2 (en) 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
WO2002074372A2 (en) 2001-03-15 2002-09-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nebulizer having cooling chamber
US6550472B2 (en) 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
US6478754B1 (en) 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
US6554201B2 (en) 2001-05-02 2003-04-29 Aerogen, Inc. Insert molded aerosol generator and methods
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US6994083B2 (en) 2001-12-21 2006-02-07 Trudell Medical International Nebulizer apparatus and method
US6543701B1 (en) * 2001-12-21 2003-04-08 Tung-Huang Ho Pocket-type ultrasonic atomizer structure
WO2003057291A1 (en) 2002-01-07 2003-07-17 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
EP1474196B1 (en) 2002-01-15 2016-08-17 Novartis AG Methods and systems for operating an aerosol generator
US7677411B2 (en) 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6889690B2 (en) 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US7118010B2 (en) * 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US6985798B2 (en) * 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
AU2003256253A1 (en) 2002-05-20 2003-12-02 Aerogen, Inc. Aerosol for medical treatment and methods
US6843430B2 (en) * 2002-05-24 2005-01-18 S. C. Johnson & Son, Inc. Low leakage liquid atomization device
JP2006507110A (en) 2002-06-27 2006-03-02 オリエル・セラピューティクス，インコーポレイテッド Apparatus, system and related methods for processing, dispensing and / or evaluating non-pharmaceutical dry powders
TW562704B (en) * 2002-11-12 2003-11-21 Purzer Pharmaceutical Co Ltd Ultrasonic atomizer device for generating high contents of sub-micron atomized droplets
CA2526362C (en) 2003-05-20 2012-10-09 James F. Collins Ophthalmic drug delivery system
US8012136B2 (en) 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
JP4411901B2 (en) * 2003-08-11 2010-02-10 セイコーエプソン株式会社 Atomizer
US7367334B2 (en) 2003-08-27 2008-05-06 Philip Morris Usa Inc. Fluid vaporizing device having controlled temperature profile heater/capillary tube
DE10345950A1 (en) * 2003-10-02 2005-05-19 Pari GmbH Spezialisten für effektive Inhalation Inhalation therapy device with valve
US7095653B2 (en) * 2003-10-08 2006-08-22 Micron Technology, Inc. Common wordline flash array architecture
US7451761B2 (en) 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7377277B2 (en) 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7723899B2 (en) 2004-02-03 2010-05-25 S.C. Johnson & Son, Inc. Active material and light emitting device
US7538473B2 (en) * 2004-02-03 2009-05-26 S.C. Johnson & Son, Inc. Drive circuits and methods for ultrasonic piezoelectric actuators
AU2005262940B2 (en) * 2004-04-02 2010-07-01 Creare Incorporated Aerosol delivery systems and methods
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
US8061562B2 (en) * 2004-10-12 2011-11-22 S.C. Johnson & Son, Inc. Compact spray device
ES2319235T3 (en) 2004-10-12 2009-05-05 S.C. JOHNSON &amp; SON, INC. METHOD OF OPERATION OF A DISTRIBUTION UNIT.
GB0503098D0 (en) * 2005-02-15 2005-03-23 Reckitt Benckiser Uk Ltd Spray device
EP1848648B1 (en) * 2005-02-15 2009-05-13 Reckitt Benckiser (UK) LIMITED Seal assembly for a pressurised container
GB0503095D0 (en) * 2005-02-15 2005-03-23 Reckitt Benckiser Uk Ltd Holder
CN101208123B (en) 2005-05-25 2012-09-19 亚罗擎公司 Vibration systems and methods
US7785277B2 (en) 2005-06-23 2010-08-31 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7713218B2 (en) 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US9101949B2 (en) 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US7896539B2 (en) 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US7928814B2 (en) * 2006-01-04 2011-04-19 Thomson Licensing Apparatus and method for signal level control
FR2898468B1 (en) * 2006-03-15 2008-06-06 Lvmh Rech PIEZOELECTRIC ELEMENT SPRAY DEVICE AND USE THEREOF IN COSMETOLOGY AND PERFUMERY.
US20080183200A1 (en) * 2006-06-07 2008-07-31 Bacoustics Llc Method of selective and contained ultrasound debridement
US8562547B2 (en) * 2006-06-07 2013-10-22 Eliaz Babaev Method for debriding wounds
US7431704B2 (en) 2006-06-07 2008-10-07 Bacoustics, Llc Apparatus and method for the treatment of tissue with ultrasound energy by direct contact
WO2008024923A2 (en) * 2006-08-25 2008-02-28 Eilaz Babaev Portable ultrasound device for the treatment of wounds
GB0623052D0 (en) * 2006-11-18 2006-12-27 Reckitt Benckiser Uk Ltd An assembly
US8491521B2 (en) 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
US20080245892A1 (en) * 2007-04-09 2008-10-09 Ping Huang Decay prevention structure of a heat dissipating board of a humidifier
US8590743B2 (en) * 2007-05-10 2013-11-26 S.C. Johnson & Son, Inc. Actuator cap for a spray device
US7780095B2 (en) * 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US7753285B2 (en) * 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US8469244B2 (en) 2007-08-16 2013-06-25 S.C. Johnson & Son, Inc. Overcap and system for spraying a fluid
US8381951B2 (en) 2007-08-16 2013-02-26 S.C. Johnson & Son, Inc. Overcap for a spray device
US8556122B2 (en) 2007-08-16 2013-10-15 S.C. Johnson & Son, Inc. Apparatus for control of a volatile material dispenser
WO2009103063A2 (en) * 2008-02-15 2009-08-20 Tsi Incorporated An automated qualitative mask fit tester
EP2100525A1 (en) 2008-03-14 2009-09-16 Philip Morris Products S.A. Electrically heated aerosol generating system and method
US8387827B2 (en) 2008-03-24 2013-03-05 S.C. Johnson & Son, Inc. Volatile material dispenser
EP2110034A1 (en) 2008-04-17 2009-10-21 Philip Morris Products S.A. An electrically heated smoking system
US7891580B2 (en) * 2008-04-30 2011-02-22 S.C. Johnson & Son, Inc. High volume atomizer for common consumer spray products
EP2113178A1 (en) 2008-04-30 2009-11-04 Philip Morris Products S.A. An electrically heated smoking system having a liquid storage portion
WO2009155245A1 (en) 2008-06-17 2009-12-23 Davicon Corporation Liquid dispensing apparatus using a passive liquid metering method
EP2253233A1 (en) 2009-05-21 2010-11-24 Philip Morris Products S.A. An electrically heated smoking system
DE102009026500B3 (en) * 2009-05-27 2011-02-24 Miwe Michael Wenz Gmbh proofer
US8459499B2 (en) 2009-10-26 2013-06-11 S.C. Johnson & Son, Inc. Dispensers and functional operation and timing control improvements for dispensers
EP2319334A1 (en) 2009-10-27 2011-05-11 Philip Morris Products S.A. A smoking system having a liquid storage portion
EP2327318A1 (en) 2009-11-27 2011-06-01 Philip Morris Products S.A. An electrically heated smoking system with internal or external heater
US20110232321A1 (en) * 2010-03-24 2011-09-29 Whirlpool Corporation Atomization of food preservation solution
US20110232312A1 (en) * 2010-03-24 2011-09-29 Whirlpool Corporation Flexible wick as water delivery system
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
JP2013531548A (en) 2010-07-15 2013-08-08 コリンシアン オフサルミック，インコーポレイティド Method and system for performing teletherapy and remote monitoring
JP5964826B2 (en) 2010-07-15 2016-08-03 アイノビア，インコーポレイティド Drop generation device
ES2787254T3 (en) 2010-07-15 2020-10-15 Eyenovia Inc Supply of ophthalmic drugs
US8781307B2 (en) 2010-08-16 2014-07-15 Michael Buzzetti Variable voltage portable vaporizer
EP2790620A1 (en) 2011-12-12 2014-10-22 Corinthian Ophthalmic, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use
US9282772B2 (en) 2012-01-31 2016-03-15 Altria Client Services Llc Electronic vaping device
US9108782B2 (en) 2012-10-15 2015-08-18 S.C. Johnson & Son, Inc. Dispensing systems with improved sensing capabilities
US9282803B2 (en) * 2013-10-03 2016-03-15 Donald John Ciervo Ultrasonic cosmetic applicator
US9597702B1 (en) * 2013-10-03 2017-03-21 Sonaer, Inc. Ultrasonic cosmetic applicator
US11224767B2 (en) 2013-11-26 2022-01-18 Sanuwave Health, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
US10220109B2 (en) 2014-04-18 2019-03-05 Todd H. Becker Pest control system and method
WO2015161250A1 (en) 2014-04-18 2015-10-22 Conroy Thomas A Diffusion management system
KR102650737B1 (en) * 2015-10-30 2024-03-26 존슨 앤드 존슨 컨수머 인코포레이티드 Sterile Aerosol Misting Device
JP6911025B2 (en) 2015-10-30 2021-07-28 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｃｏｎｓｕｍｅｒ Ｉｎｃ． Unit dose sterile aerosol mist sprayer
CA3003438C (en) 2015-10-30 2024-01-02 Johnson & Johnson Consumer Inc. Aseptic aerosol misting device
RU2728719C2 (en) 2015-10-30 2020-07-30 Джонсон энд Джонсон Консьюмер Инк. Aseptic aerosol fogger
WO2017118553A1 (en) 2016-01-07 2017-07-13 Philip Morris Products S.A. Aerosol-generating device with sealed compartment
US11325149B2 (en) 2016-01-23 2022-05-10 William Tan Ultrasonic atomizer and cartridge for the dispersal of a liquid
CN105876873B (en) * 2016-06-30 2018-12-07 湖南中烟工业有限责任公司 A kind of combined type ultrasonic atomizer and its atomization method, electronic cigarette
AU2017306411B2 (en) 2016-08-03 2022-03-31 Scentbridge Holdings, Llc Method and system of a networked scent diffusion device
WO2018031693A1 (en) * 2016-08-09 2018-02-15 Cashman Kathryn Ampoule for inhalant device
KR102643190B1 (en) 2017-06-10 2024-03-04 아이노비아 인코포레이티드 Devices for handling fluids and delivering fluids to the eye
CA3180786A1 (en) 2020-06-01 2021-05-28 Imad Lahoud An infectious disease screening system
JP2023527574A (en) 2020-06-01 2023-06-29 シャヒーン イノベーションズ ホールディング リミテッド Infectious disease test device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2308584A1 (en) * 1970-06-30 1974-08-29 Siemens Ag PIEZOELECTRIC VIBRATION SYSTEM FOR LIQUID ATOMIZATION
US3896280A (en) * 1974-03-13 1975-07-22 Us Army Valve position indicator
DE2831553A1 (en) * 1978-07-18 1980-01-31 Siemens Ag Fine droplets prodn. by ultrasonic atomisation - using bipolar resonator attached to HF source of proportions to give droplets in 5 micron range
FR2431038A1 (en) * 1978-07-11 1980-02-08 Plessey Handel Investment Ag VIBRATORY ATOMIZER, PARTICULARLY FOR SUPPLYING AN EXPLOSION ENGINE
FR2444504A1 (en) * 1978-12-19 1980-07-18 Bosch Siemens Hausgeraete LIQUID ATOMIZER, PARTICULARLY INHALATION APPARATUS

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387607A (en) * 1964-02-10 1968-06-11 Vilbiss Co Apparatus for inhalation therapy
US3561444A (en) * 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3828773A (en) * 1972-09-22 1974-08-13 Theratron Corp Nebulizing apparatus and system
US3989042A (en) * 1974-06-06 1976-11-02 Tdk Electronics Company, Limited Oscillator-exciting system for ultrasonic liquid nebulizer
DE2557958B2 (en) * 1975-12-22 1981-01-29 Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart Piezoelectric ultrasonic liquid atomizer
US4109863A (en) * 1977-08-17 1978-08-29 The United States Of America As Represented By The United States Department Of Energy Apparatus for ultrasonic nebulization
DE7917568U1 (en) * 1979-06-19 1979-09-20 Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart INHALATION DEVICE
FR2507087B1 (en) * 1981-06-06 1986-06-27 Rowenta Werke Gmbh ULTRASONIC INHALER
US4583056A (en) * 1984-09-13 1986-04-15 Matsushita Seiko Co., Ltd. Apparatus having printed circuit pattern for suppressing radio interference
EP0212352B1 (en) * 1985-08-09 1989-09-27 Siemens Aktiengesellschaft Ultrasonic generator
US4757227A (en) * 1986-03-24 1988-07-12 Intersonics Incorporated Transducer for producing sound of very high intensity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2308584A1 (en) * 1970-06-30 1974-08-29 Siemens Ag PIEZOELECTRIC VIBRATION SYSTEM FOR LIQUID ATOMIZATION
US3896280A (en) * 1974-03-13 1975-07-22 Us Army Valve position indicator
FR2431038A1 (en) * 1978-07-11 1980-02-08 Plessey Handel Investment Ag VIBRATORY ATOMIZER, PARTICULARLY FOR SUPPLYING AN EXPLOSION ENGINE
DE2831553A1 (en) * 1978-07-18 1980-01-31 Siemens Ag Fine droplets prodn. by ultrasonic atomisation - using bipolar resonator attached to HF source of proportions to give droplets in 5 micron range
FR2444504A1 (en) * 1978-12-19 1980-07-18 Bosch Siemens Hausgeraete LIQUID ATOMIZER, PARTICULARLY INHALATION APPARATUS

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373419A2 (en) * 1988-12-12 1990-06-20 Siemens Aktiengesellschaft Battery changer for a medical appliance
EP0373419A3 (en) * 1988-12-12 1991-07-10 Siemens Aktiengesellschaft Battery changer for a medical appliance
US5089763A (en) * 1988-12-12 1992-02-18 Siemens Aktiengesellschaft Battery charging unit for a medical appliance
EP0373237A1 (en) * 1988-12-13 1990-06-20 Siemens Aktiengesellschaft Pocket inhaler device
US5134993A (en) * 1988-12-13 1992-08-04 Siemens Aktiengesellschaft Inhalator device, in particular a pocket inhalator
GB2265845B (en) * 1991-11-12 1996-05-01 Medix Ltd A nebuliser and nebuliser control system
US5551416A (en) * 1991-11-12 1996-09-03 Medix Limited Nebuliser and nebuliser control system
EP0628356A1 (en) * 1993-06-02 1994-12-14 L'oreal Piezoelectrical nebuliser
FR2705911A1 (en) * 1993-06-02 1994-12-09 Oreal Piezoelectric nebulization device.
US5529055A (en) * 1993-06-02 1996-06-25 L'oreal Piezoelectric nebulizing apparatus
DE4431019A1 (en) * 1994-08-31 1996-03-07 Siemens Ag Ultrasound atomiser head for medical use
US5836521A (en) * 1995-03-09 1998-11-17 Dysekompagniet I/S Valve device with impact member and solenoid for atomizing a liquid
US5950619A (en) * 1995-03-14 1999-09-14 Siemens Aktiengesellschaft Ultrasonic atomizer device with removable precision dosating unit
US5970974A (en) * 1995-03-14 1999-10-26 Siemens Aktiengesellschaft Dosating unit for an ultrasonic atomizer device
EP1389064A2 (en) * 2001-01-26 2004-02-18 Yoni Iger Method and apparatus for the delivery of substances to biological components
EP1389064B1 (en) * 2001-01-26 2010-08-04 Yoni Iger Apparatus for the delivery of substances to biological components
WO2007120565A1 (en) * 2006-04-11 2007-10-25 S.C. Johnson & Son, Inc. Electronic aerosol device
US11589610B2 (en) 2019-12-15 2023-02-28 Shaheen Innovations Holding Limited Nicotine delivery device having a mist generator device and a driver device
US11730899B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Mist inhaler devices
US11602165B2 (en) 2019-12-15 2023-03-14 Shaheen Innovations Holding Limited Nicotine delivery device having a mist generator device and a driver device
US11944121B2 (en) 2019-12-15 2024-04-02 Shaheen Innovations Holding Limited Ultrasonic mist inhaler with capillary element
US11660406B2 (en) 2019-12-15 2023-05-30 Shaheen Innovations Holding Limited Mist inhaler devices
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US11744963B2 (en) 2019-12-15 2023-09-05 Shaheen Innovations Holding Limited Mist inhaler devices
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CA1313098C (en) 1993-01-26
ATE54071T1 (en) 1990-07-15
JPS6349271A (en) 1988-03-02
US4877989A (en) 1989-10-31
JP2540462B2 (en) 1996-10-02
DE3627222A1 (en) 1988-02-18
ES2015558B3 (en) 1990-09-01
DE3763372D1 (en) 1990-08-02
EP0258637B1 (en) 1990-06-27

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