EP0258637B1 - Ultrasonic pocket sprayer - Google Patents

Ultrasonic pocket sprayer Download PDF

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Publication number
EP0258637B1
EP0258637B1 EP87111004A EP87111004A EP0258637B1 EP 0258637 B1 EP0258637 B1 EP 0258637B1 EP 87111004 A EP87111004 A EP 87111004A EP 87111004 A EP87111004 A EP 87111004A EP 0258637 B1 EP0258637 B1 EP 0258637B1
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EP
European Patent Office
Prior art keywords
cartridge
housing portion
vibration system
ultrasonic
electronic circuit
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EP87111004A
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German (de)
French (fr)
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EP0258637A1 (en
Inventor
Wolf-Dietrich Dr. Drews
Martin Dipl.-Ing.(FH) Rüttel
Klaus Van Der Linden
Jürgen Friedrich
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Siemens AG
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Siemens AG
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Priority to AT87111004T priority Critical patent/ATE54071T1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0623—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn

Definitions

  • the invention relates to an ultrasonic pocket atomizer, in particular for atomizing medicinal products for inhalation purposes, with a removable and rechargeable battery pack, with a piezoelectric vibrating system, with an electronic circuit, with a power supply to the piezoelectric vibrating system, with a storage container, with metering option and with a feed for the liquid to be atomized to the vibration system and with a housing.
  • Ultrasonic atomizing devices are also suitable for atomizing liquids. From DE-PS 2 032 433 a device with a piezoelectric vibration system is known, with which sufficiently large vibration amplitudes can be achieved. With such atomizing devices, it is possible to produce very fine droplets with a relatively homogeneous distributor of the droplet size.
  • An ultrasonic atomizer device in the version as a hand-held device, with such a piezoelectric oscillation system with an excitation electronics, is known from DE-PS 2 239 950. But here, too, the aerosol is accelerated by an artificially generated air flow. In addition, this device only allows moderate distribution of the aerosol in the air flow and no metering of the same.
  • a medical inhalation device for the treatment of diseases of the respiratory tract is known.
  • low-voltage excitation electronics and a piezoelectric vibration system are arranged in a liquid-tight protective housing.
  • the sound transmitter is attached to the sound transmitter by means of a retaining ring in the area of a vibration node line.
  • This device is switched on via a position-dependent switch and can therefore only be operated in this position.
  • the housing is also designed as a liquid container. It is a peculiarity of this inhalation device that only a small percentage of the aerosol particles remaining in the suspension get into the bronchi and lungs. Sterile storage of the drug is not possible here.
  • French patent specification 2,444,504 discloses an ultrasonic nebulizing device suitable for medical use, in which no amount of liquid is sprayed onto a nebulizer element via a baffle by means of a pushbutton from a closed, depressible medicament container.
  • pressing the pushbutton also turns on the excitation electronics.
  • the device contains a replaceable battery set for supplying the excitation electronics. It is a peculiarity of this device that only a small percentage of the aerosol gets into the lungs. Also, the internal wiring of the device becomes contaminated with medication over time. Disinfection of all surfaces that come into contact with the drug is not possible with this device.
  • the invention is therefore to give up ', seeks to provide a portable in the pocket Ultrascnallzerstäubungs réelle which a predominantly suspendable and respirable Aeroso! generated and therefore also suitable for application before: drugs in the trachiobronchial space and in the lungs.
  • the application should be done without propellant gas and there should be no cold stimulus.
  • the readiness for use of the ultrasonic pocket atomizer should also be easy to check and, if necessary, quickly recoverable. All internal surfaces that come into contact with the medication should also be accessible for cleaning or disinfection.
  • the housing is divided into a lower housing part and an upper housing part and the piezoelectric vibrating system together with the rechargeable battery pack and the electronic circuit are installed in the lower housing part in a liquid-tight manner
  • the piezoelectric vibrating system looking out of the lower housing part with an atomizing plate ensures that no medication is present in the lower housing part the lower part containing the electronics long and that conversely from here no contamination of the surfaces of the upper housing part coming into contact with the medicament is possible.
  • the upper part of the housing contains a cartridge that is filled with the liquid to be atomized and is movably mounted, as well as a magnet that can be moved by the cartridge and actuates a switch in the lower part of the housing, it is possible to switch the electronics in the lower part of the housing on and off without creating a bridge the germs or medication can get from the upper part of the housing into the lower part of the housing and vice versa.
  • the maximum droplet size that is generated is in the range of less than 20 ⁇ m.
  • This idea is based on the knowledge that aerosol droplets that are larger than 20 ⁇ m are predominantly caught by the walls of the throat and mouth and only such small droplets with a good efficiency reach the bronchial space and the lungs through the respiratory tract .
  • the invention is based on the further finding that the operating frequency is to a very large extent responsible for the average droplet size, because when liquid is ejected, the subsequent retraction phase leads to a constriction and droplet formation at the rear and the higher the rate begins after the start of the spinning process Frequency is.
  • This ultrasonic pocket atomizer enables a low-noise application of substances without the use of a propellant gas and therefore also without cold stimulus.
  • the dosage of the substance to be atomized can be done with an accuracy of over 95%, which is very important especially with medicines.
  • 50% of the droplets of the aerosol generated have a diameter of less than 20 wm, which is ideal for transporting the active ingredients into the bronchial space and into the lungs.
  • the device according to the invention can be operated regardless of location, is very handy, can easily be accommodated in a pocket or in clothing. All surfaces that come into contact with the medication can be disinfected and hermetically separated from the lower part of the housing that contains the electronics. Filling with the agent to be atomized is done by simply changing cartridges.
  • the battery pack integrated in the lower part of the device is removable and rechargeable. Battery operation is possible and easy.
  • FIG. 2 being a longitudinal section of FIG. 1.
  • An ultrasonic pocket atomizer according to the invention consists of a piezoelectric vibration system 1 with an operating frequency in the range of 1 to 5 MHz, which is installed in the lower housing part 13 of the plastic housing in a liquid-tight manner.
  • Suitable plastics for this are, for example, acrylonitrile-butadiene-styrene copolymers (ABS).
  • ABS acrylonitrile-butadiene-styrene copolymers
  • the tightness is achieved by pouring the vibration system 1 into the holder 2 or by sealing with O-rings 28.
  • a particularly suitable casting compound is silicone rubber.
  • the vibrating system 1 is excited by an electronic circuit 3 to produce ultrasonic vibrations in the MHz range and atomizes the medicament 5 applied to the vibrating system 1 through the cartridge 4.
  • the electronic circuit is supplied with electrical energy via the rechargeable battery pack 6.
  • the device can be recharged with the integrated rechargeable battery by additionally routing the contacts 7 outwards in parallel.
  • the battery pack is removable, replaceable and rechargeable even without the device by means of a sliding device 8.
  • the dosing cartridge 4 filled with pharmaceutical liquid is movably mounted in the upper housing part 9.
  • the cartridge moves to the vibrator.
  • a magnet 11 attached to the cartridge closes a switch 12 attached to the lower part 13 of the device.
  • the magnetic switch 11, 12 makes it possible to - close the lower housing part 13 in a liquid-tight manner to the upper housing part 9.
  • the electronics are activated and the ultrasound atomizer is supplied with energy after an electronically specified period of time.
  • the time span is dimensioned such that there is sufficient time between actuation of the magnetic switch and the start of atomization.
  • the cartridge After closing the magnetic switch, the cartridge is moved forward, i.e. in the direction of the oscillation system, finally moves and strikes the thickened part of the body against a wall 14. Since the mechanical resistance of the plastic spring 15 is lower than the spring 21 integrated in the cartridge, the pressure on the cartridge by the operator continues to exert pressure on it only now slightly compressed and a precisely dosed amount of drug 5 is dispensed. By relieving the pressure on the cartridge, it moves back to its starting position. The quantity of medicament dispensed at the tip of the cartridge is stripped off on the atomizing plate 24 when it returns to the starting position and atomized after stripping.
  • the aerosol can be stored in the intake manifold 17 and is inhaled by the user.
  • the openings 18 present in the wall 14 are dimensioned such that sufficient air can be added to the intake manifold during the inhalation process.
  • the mouth of the user can enclose the intake manifold well.
  • the connector can be flush with one edge of the housing and the device dimensions can be kept small.
  • a cover 20 is provided, which un is captively attached to the upper part of the device via a plastic film hinge 22.
  • the upper housing part 9 Since the upper housing part 9 is easily removable and inexpensive to produce, it can be discarded after the cartridge 4 filled with medication has been emptied. It is a very hygienic solution.
  • a transparent window 23 made of plastic is integrated on the upper part, which shows the amount of liquid still present. It allows you to monitor the level of the drug in the cartridge.
  • an electrical signal 25 indicates the charge status of the rechargeable battery.
  • Suitable is e.g. a light emitting diode.
  • the outer contours of the device 26 are rounded, so that the user is inevitably given a corresponding location at which the device can be parked.
  • This storage container can be designed, for example, in such a way that the battery is simultaneously recharged during storage.
  • the integrated contacts are arranged asymmetrically with respect to the underside of the device, a specific position can even be specified in the storage container.
  • the upper housing part 9 is easily detachably connected to the lower housing part 13 by a snap-lock connection 16.
  • the device can also be designed so that, for example, the magnetic switch 11, 12 only triggers when the thickened part of the cartridge hits the wall.
  • Devices according to the invention are used with particular advantage for medical applications, in particular for asthmatics.
  • An application as a room and body spray device is also possible, as well as a humidifier.

Abstract

An ultrasonic pocket-size atomizer comprises a housing including a first portion and a second portion detachably connected thereto. A vibration generation mechanism is mounted liquid-tight in the first portion of the housing for generating an oscillation with a frequency between 1 and 5 Mhz. The vibration generation mechanism includes a piezoelectric assembly and an electronic circuit operatively connected to the assembly for energizing the assembly and causing the assembly to vibrate. A power source including a storage battery is removably and rechargeably disposed in the first portion of the housing for supplying electric current to the electronic circuit. A cartridge is provided for containing liquid to be atomized, the cartridge being movably disposed in the second portion of the housing. An activation mechanism is provided for automatically activating the electronic circuit upon motion of the movable section of the cartridge, the activation mechanism including a magnet attached to the movable section of the cartridge so as to move therewith. The activation mechanism further includes a switch operatively connected to the electronic circuit and operable by the magnet upon a shift in the position thereof during motion of the movable section of the cartridge.

Description

Die Erfindung bezieht sich auf ein Ultraschall-Taschenzerstäubergerät, insbesindere zum Zerstäuben von Arzneimitteln für Inhalationszwecke, mit einem herausnehmbaren und wiederaufladbaren Akkusatz, mit einem piezoelektrischen Schwingsystem, mit einer Elektronikschaltung, mit einer Stromzuführung zum piezoelektrischen Schwingsystem, mit einem Vorratsbehälter, mit Dosiermöglichkeit und einer Zuführung für die zu zerstäubende Flüssigkeit zum Schwingsystem und mit einem Gehäuse.The invention relates to an ultrasonic pocket atomizer, in particular for atomizing medicinal products for inhalation purposes, with a removable and rechargeable battery pack, with a piezoelectric vibrating system, with an electronic circuit, with a power supply to the piezoelectric vibrating system, with a storage container, with metering option and with a feed for the liquid to be atomized to the vibration system and with a housing.

Bei Erkrankungen des Lungen- und Bronchialraums ist es vielfach wünschenswert, die Arzneimittel bzw. deren Wirkstoffe zu inhalieren. Am Markt sind Sprüh- und Spritzpistolen und mechanische Handverneblergeräte, mit welchen es möglich ist, das Medikament als Aerosol zu zerstäuben. Diese Geräte erzeugen keine besonders feine Verteilung des Aerosols und keine homogenen Gemische von Aerosol und Luft. Mechanische Handvernebler erfordern zudem einen hohen Kraftaufwand für die Betätigung des Pumpballes.In the case of diseases of the lungs and bronchial area, it is often desirable to inhale the drugs or their active ingredients. There are spray and spray guns and mechanical hand-held nebulizers on the market with which it is possible to atomize the drug as an aerosol. These devices do not produce a particularly fine distribution of the aerosol and no homogeneous mixtures of aerosol and air. Mechanical hand-held nebulizers also require a lot of force to actuate the pump ball.

Bekannte Aerosolsprühdosen haben den Nachteil, bei der Applikation einen Kältereiz zu erzeugen. Auch sind die Nebenwirkungen der Treibgase schädlich. Schließlich führt die sehr hohe Geschwindigkeit des Aerosols zu Schwierigkeiten bei der Koordination zwischen der Betätigung der Sprühdose und dem Inhalieren durch den Patienten. Dies gilt vor allem beim Einsatz zur Behandlung der Atemwege und der Lunge. Ganz allgemein führen die hohen Geschwindigkeiten der Arzneimittelpartikel, wie sie allen Geräten, die mit Treibgasen arbeiten, eigen sind, dazu, daß ein gewisser Anteil des Aerosols nicht in die Lunge gelangt, sondern beispielsweise in der Speiseröhre oder vorher schon an den Wänden der Mundhöhle hängen bleibt.Known aerosol spray cans have the disadvantage of generating a cold stimulus when applied. The side effects of the propellant gases are also harmful. Finally, the very high speed of the aerosol leads to difficulties in the coordination between the actuation of the spray can and the inhalation by the patient. This is especially true when used to treat the airways and lungs. In general, the high speeds of the drug particles, as they are common to all devices that work with propellant gases, mean that a certain proportion of the aerosol does not get into the lungs, but instead, for example, hangs in the esophagus or previously on the walls of the oral cavity remains.

Für die Zerstäubung von Flüssigkeiten sind auch Ultraschall-Zerstäubergeräte geeignet. So ist aus der DE-PS 2 032 433 ein Gerät mit einem piezoelektrischen Schwingsystem bekannt, mit dem sich hinreichend große Schwingungsamplituden erreichen erreichen lassen. Mit solchen Zerstäubergeräten ist eine Erzeugung von sehr feinen Tröpfchen mit relativ homogener Verteiler der Tröpfchengröße möglich. Ein Ultraschall-Zerstäubergerät, in der Ausführung als Handgerät, mit einem solchen piezoelektrischen Schwingsystem mit einer Anregungselektronik, ist aus der DE-PS 2 239 950 bekannt. Aber auch hier wird das Aerosol durch einen künstlich erzeugten Luftstrom beschleunigt. Darüber hinaus ist mit diesem Gerät nur eine mäßige Verteilung des Aerosols im Luftstrom und keine Dosierung desselben möglich.Ultrasonic atomizing devices are also suitable for atomizing liquids. From DE-PS 2 032 433 a device with a piezoelectric vibration system is known, with which sufficiently large vibration amplitudes can be achieved. With such atomizing devices, it is possible to produce very fine droplets with a relatively homogeneous distributor of the droplet size. An ultrasonic atomizer device, in the version as a hand-held device, with such a piezoelectric oscillation system with an excitation electronics, is known from DE-PS 2 239 950. But here, too, the aerosol is accelerated by an artificially generated air flow. In addition, this device only allows moderate distribution of the aerosol in the air flow and no metering of the same.

Durch die DE-AS 2 537 765 ist ein medizinisches Inhalationsgerät zur Behandlung von Krankheiten der Atemwege bekannt. Bei diesem Gerät ist eine Niederspannungsanregungselektronik und ein piezoelektrisches Schwingsystem in einem flüssigkeitsdichten Schutzgehäuse angeordnet. Dabei ist der Schallüberträger mittels eines Halterings im Bereich einer Schwingungsknotenlinie am Schallüberträger befestigt. Dieses Gerät wird über einen lageabhängigen Schalter eingeschaltet und läßt sich daher nur in dieser Lage betreiben. Beim Betrieb dieses Inhalationsgerätes fallen die schwereren Aerosolpartikel schwerkraftbedingt nach unten aus dem Aerosol heraus und in das Innere des Gehäuses, wo sie aufgefangen und wieder zurückgeführt werden. Das Gehäuse ist hierzu zugleich als Flüssigkeitsbehälter ausgebildet. Es ist eine Eigenart dieses Inhalationsgeräts, daß auch von dem in der Schwebe verbleibenden Aerosolpartikeln nur ein kleiner Prozentsatz in die Bronchien und in die Lunge gelangt. Eine sterile Aufbewahrung des Medikaments ist hier nicht möglich.From DE-AS 2 537 765 a medical inhalation device for the treatment of diseases of the respiratory tract is known. In this device, low-voltage excitation electronics and a piezoelectric vibration system are arranged in a liquid-tight protective housing. The sound transmitter is attached to the sound transmitter by means of a retaining ring in the area of a vibration node line. This device is switched on via a position-dependent switch and can therefore only be operated in this position. When this inhalation device is operated, the heavier aerosol particles fall down out of the aerosol due to gravity and into the interior of the housing, where they are collected and returned. For this purpose, the housing is also designed as a liquid container. It is a peculiarity of this inhalation device that only a small percentage of the aerosol particles remaining in the suspension get into the bronchi and lungs. Sterile storage of the drug is not possible here.

Schließlich ist durch die französische Patentschrift 2 444 504 ein für die medizinische Anwendung geeignetes Ultraschallzerstäubungsgerät bekannt, bei dem mittels einer Drucktaste aus einem geschlossenen eindrückbaren Medikamentenbehälter eine keine Flüssigkeitsmenge über ein Ablenkblech auf ein Zerstäuberelement aufgespritzt wird. Bei diesem Gerät wird mit dem Betätigen der Drucktaste zugleich auch die Anregungselektronik eingeschaltet. Das Gerät enthält einen auswechselbaren Batteriesatz für die Versorgung der Anregungselektronik. Es ist eine Eigenart dieses Gerätes, daß auch hier nur ein geringer Prozentsatz des Aerosols in die Lunge gelangt. Auch wird die innere Verdrahtung des Geräts mit der Zeit von Medikamenten verunreinigt. Eine Desinfizierung aller mit dem Medikament in Berührung kommenden Oberflächen ist bei diesem Gerät nicht möglich.Finally, French patent specification 2,444,504 discloses an ultrasonic nebulizing device suitable for medical use, in which no amount of liquid is sprayed onto a nebulizer element via a baffle by means of a pushbutton from a closed, depressible medicament container. In this device, pressing the pushbutton also turns on the excitation electronics. The device contains a replaceable battery set for supplying the excitation electronics. It is a peculiarity of this device that only a small percentage of the aerosol gets into the lungs. Also, the internal wiring of the device becomes contaminated with medication over time. Disinfection of all surfaces that come into contact with the drug is not possible with this device.

Für die Behandlung der Atemwege genügen alle diese zur Zeit bekannten Ultraschallgeräte aber noch nicht. Insbesondere hinsichtlich des Tröpfchengrößenspektrums sowie der genauen Arzneimitteldosierung, aber auch hinsichtlich Einsatzbereitschaft und Handhabung sind Verbesserungen wünschenswert.However, all of these currently known ultrasound devices are not yet sufficient for the treatment of the respiratory tract. Improvements are particularly desirable with regard to the droplet size spectrum and the exact dosage of medication, but also with regard to readiness for use and handling.

Der Erfindung liegt daher die Aufgab', zugrunde, ein in der Tasche tragbares Ultrascnallzerstäubungsgerät zu schaffen, welches eine überwiegend schwebfähiges und lungengängiges Aeroso! erzeugt und daher auch für die Applikation vor: Arzneimitteln im Trachiobronchialraum und in der Lunge geeignet ist. Die Applikation sollte ohne Treibgas erfolgen und es sollte kein Kältereiz auftreten. Für den medizinischen Einsatz sollten darüber hinaus die Einsatzbereitschaft des Ultraschall-Taschenzerstäubungsgerätes leicht überprüfbar und gegebenenfalls schnell wiederherstellbar sein. Auch sollten alle mit dem Medikament in Berührung kommenden inneren Oberflächen einer Reinigung bzw. Desinfektion zugänglich sein.The invention is therefore to give up ', seeks to provide a portable in the pocket Ultrascnallzerstäubungsgerät which a predominantly suspendable and respirable Aeroso! generated and therefore also suitable for application before: drugs in the trachiobronchial space and in the lungs. The application should be done without propellant gas and there should be no cold stimulus. For medical use, the readiness for use of the ultrasonic pocket atomizer should also be easy to check and, if necessary, quickly recoverable. All internal surfaces that come into contact with the medication should also be accessible for cleaning or disinfection.

Die Aufgabe wird durch die Merkmale des Anspruchs 1 gelöst. Weitere Ausgestaltungen der Erfindung sind den Ansprüchen 1 bis 10 zu entnehmen.The object is solved by the features of claim 1. Further refinements of the invention can be found in claims 1 to 10.

Dadurch, daß das Gehäuse in ein Gehäuseunterteil und ein Gehäuseoberteil aufgeteilt ist und das piezoelektrsiche Schwingsystem zusammen mit dem aufladbaren Akkusatz und der Elektronikschaltung im Gehäuseunterteil flüssigkeitsdicht eingebaut sind, wobei das piezoelektrische Schwingsystem mit einem Zerstäuberteller aus dem Gehäuseunterteil hervorschaut, ist sichergestellt, daß kein Medikament in das die Elektronik enthaltende Unterteil gelangen kann und daß umgekehrt von hier auch keine Verunreinigungen der mit dem Medikament in Berührung kommenden Oberflächen des Gehäuseoberteils möglich ist. Weil das Gehäuseoberteil eine mit der zu zerstäubenden Flüssigkeit gefüllte und bewegbar gelagerte Kartusche sowie einen von der Kartusche bewegbaren Magneten enthält, der ein Schalter im Gehäuseunterteil betätigt, wird es möglich, die Elektronik im Gehäuseunterteil ein- und auszuschalten ohne daß dabei eine Brücke entsteht, durch die Keime oder Medikamente vom Gehäuseoberteil in das Gehäuseunterteil und umgekehrt gelangen können. Infolge der Auslegung der Elektronikschaltung auf eine Betriebsfrequenz von 1 bis 5 MHz wird sichergestellt, daß das Maximum der Tröpfchengröße, die dabei erzeugt wird, im Bereich kleiner als 20 µm liegt. Diesem Gedanken liegt die Erkenntnis zugrunde, daß Aerosoltröpfchen, die größer als 20 µm sind, in überwiegendem Maße von den Wänden des Rachens und Mundes aufgefangen werden und nur eben solch kleinere Tröpfchen mit einem guten Wirkungsgrad durch die Atmungswege bis in den Bronchialraum und die Lunge gelangen. Der Erfindung liegt die weitere Erkenntnis zugrunde, daß die Betriebsfrequenz in ganz wesentlichem Maße für die durchschnittliche Tröpfchengröße verantwortlich ist, weil beim Abschleudem von Flüssigkeit die nachfolgende Rückziehphase zu einer rückwärtigen Einschnürung und Tröpfchenbildung führt und diese umso früher nach dem Beginn des Abschleudervorgangs einsetzt je höher die Frequenz ist.The fact that the housing is divided into a lower housing part and an upper housing part and the piezoelectric vibrating system together with the rechargeable battery pack and the electronic circuit are installed in the lower housing part in a liquid-tight manner, the piezoelectric vibrating system looking out of the lower housing part with an atomizing plate ensures that no medication is present in the lower housing part the lower part containing the electronics long and that conversely from here no contamination of the surfaces of the upper housing part coming into contact with the medicament is possible. Because the upper part of the housing contains a cartridge that is filled with the liquid to be atomized and is movably mounted, as well as a magnet that can be moved by the cartridge and actuates a switch in the lower part of the housing, it is possible to switch the electronics in the lower part of the housing on and off without creating a bridge the germs or medication can get from the upper part of the housing into the lower part of the housing and vice versa. As a result of the design of the electronic circuit for an operating frequency of 1 to 5 MHz, it is ensured that the maximum droplet size that is generated is in the range of less than 20 μm. This idea is based on the knowledge that aerosol droplets that are larger than 20 µm are predominantly caught by the walls of the throat and mouth and only such small droplets with a good efficiency reach the bronchial space and the lungs through the respiratory tract . The invention is based on the further finding that the operating frequency is to a very large extent responsible for the average droplet size, because when liquid is ejected, the subsequent retraction phase leads to a constriction and droplet formation at the rear and the higher the rate begins after the start of the spinning process Frequency is.

Dieses Ultraschall-Taschenzerstäubergerät ermöglicht eine geräuscharme Applikation von Stoffen ohne Anwendung eines Treibgases und daher auch ohne Kältereiz. Die Dosierung des zu zerstäubenden Stoffes kann mit einer Genauigkeit von über 95% erfolgen, was insbesondere bei Arzneimitteln sehr wichtig ist. 50% der erzeugten Tröpfchen des Aerosols haben dabei einen Durchmesser von kleiner als 20 wm, welcher optimal für einen Transport der Wirkstoffe in den Bronchialraum und in die Lunge ist. Das erfindungsgemäße Gerät ist lageunabhängig betreibbar, sehr handlich, leicht in der Tasche oder in der Bekleidung unterzubringen. Alle mit dem Medikament in Berührung kommenden Oberflächen sind desinfizierbar und von dem die Elektronik enthaltenen Gehäuseunterteil hermetisch abgetrennt. Die Auffüllung mit dem zu zerstäubenden Mittel erfolgt durch einfaches Auswechseln von Kartuschen. Der im Geräteunterteil integrierte Akkusatz ist herausnehmbar und wieder aufladbar. Der Batteriebetrieb ist möglich und einfach.This ultrasonic pocket atomizer enables a low-noise application of substances without the use of a propellant gas and therefore also without cold stimulus. The dosage of the substance to be atomized can be done with an accuracy of over 95%, which is very important especially with medicines. 50% of the droplets of the aerosol generated have a diameter of less than 20 wm, which is ideal for transporting the active ingredients into the bronchial space and into the lungs. The device according to the invention can be operated regardless of location, is very handy, can easily be accommodated in a pocket or in clothing. All surfaces that come into contact with the medication can be disinfected and hermetically separated from the lower part of the housing that contains the electronics. Filling with the agent to be atomized is done by simply changing cartridges. The battery pack integrated in the lower part of the device is removable and rechargeable. Battery operation is possible and easy.

Im folgenden wird die Erfindung anhand der Figuren 1 und 2 näher beschrieben, wobei Figur 2 ein Längsschnitt von Figur 1 ist.The invention is described in more detail below with reference to FIGS. 1 and 2, FIG. 2 being a longitudinal section of FIG. 1.

Ein Ultraschall-Taschenzerstäubergerät gemäß der Erfindung besteht aus einem piezoelektrischen Schwingsystem 1 mit einer Betriebsfrequenz im Bereich von 1 bis 5 MHz, das flüssigkeitsdicht in das Gehäuseunterteil 13 des Kunststoffgehäuses eingebaut ist. Geeignete Kunststoffe hierfür sind beispielsweise Acrylnitril-Butadien-Styrol-Copolymere (ABS). Die Dichtheit wird erreicht durch Eingießen des Schwingsystems 1 in die Halterung 2 oder aber durch Abdichtung mit O-Ringen 28. Eine besonders geeignete Vergußmasse ist Silikonkautschuk.An ultrasonic pocket atomizer according to the invention consists of a piezoelectric vibration system 1 with an operating frequency in the range of 1 to 5 MHz, which is installed in the lower housing part 13 of the plastic housing in a liquid-tight manner. Suitable plastics for this are, for example, acrylonitrile-butadiene-styrene copolymers (ABS). The tightness is achieved by pouring the vibration system 1 into the holder 2 or by sealing with O-rings 28. A particularly suitable casting compound is silicone rubber.

Das Schwingsystem 1 wird durch eine Elektronikschaltung 3 zu Ultraschallschwingungen im MHz-Bereich angeregt und zerstäubt das durch die Kartusche 4 auf das Schwingsystem 1 aufgebrachte Arzneimittel 5. Die Elektronikschaltung wird über den wiederaufladbaren Akkusatz 6 mit elektrischer Energie versorgt. Durch eine zusätzliche parallele Herausführung der Kontakte 7 nach außen kann das Gerät mit dem integrierten Akku nachgeladen werden. Durch eine Schiebevorrichtung 8 ist der Akkusatz herausnehmbar austauschbar und auch ohne das Gerät nachladbar.The vibrating system 1 is excited by an electronic circuit 3 to produce ultrasonic vibrations in the MHz range and atomizes the medicament 5 applied to the vibrating system 1 through the cartridge 4. The electronic circuit is supplied with electrical energy via the rechargeable battery pack 6. The device can be recharged with the integrated rechargeable battery by additionally routing the contacts 7 outwards in parallel. The battery pack is removable, replaceable and rechargeable even without the device by means of a sliding device 8.

Die mit Arzneimittelflüssigkeit gefüllte Dosierkartusche 4 ist in dem Gehäuseoberteil 9 bewegbar gelagert. Durch Druck auf den Knopf 10 bewegt sich die Kartusche zum Schwinger. Gleichzeitig schließt ein an der Kartusche angebrachter Magnet 11 einen am Unterteil 13 des Gerätes angebrachten Schalter 12. Durch den Magnetschalter 11, 12 ist es möglich,- das Gehäuseunterteil 13 flüssigkeitsdicht zum Gehäuseoberteil 9 abzuschließen.The dosing cartridge 4 filled with pharmaceutical liquid is movably mounted in the upper housing part 9. By pressing button 10, the cartridge moves to the vibrator. At the same time, a magnet 11 attached to the cartridge closes a switch 12 attached to the lower part 13 of the device. The magnetic switch 11, 12 makes it possible to - close the lower housing part 13 in a liquid-tight manner to the upper housing part 9.

Durch Schließen des Schalters wird die Elektronik aktiviert und nach einer elektronisch vorgegebenen Zeitspanne wird der Ultraschallzerstäuber mit Energie versorgt.When the switch is closed, the electronics are activated and the ultrasound atomizer is supplied with energy after an electronically specified period of time.

Die Zeitspanne ist so bemessen, daß ausreichend Zeit verbleibt zwischen dem Betätigen des Magnetschalters und dem Zerstäubungsbeginn. Nach dem Schließen des Magnetschalters wird die Kartusche weiter nach vorne, d.h. in Richtung Schwingsystem, bewegt und stößt schließlich mit dem verdickten Teil des Körpers gegen eine Wand 14. Da der mechanische Widerstand der Kunststofffeder 15 geringer ist als der in der Kartusche integrierten Feder 21, wird die Kartusche durch den weiter auf ihr lastenden Druck durch den Bedienenden erst jetzt etwas zusammengedrückt und eine genau dosierte Arzneimittelmenge 5 wird abgegeben. Durch Entlastung der Kartusche fährt sie in ihre Ausgangsposition wieder zurück. Die an der Kartuschenspitze abgegebene Arzneimittelmenge wird beim Zurückgehen in die Ausgangsposition an dem Zerstäuberteller 24 abgestreift und nach dem Abstreifen zerstäubt.The time span is dimensioned such that there is sufficient time between actuation of the magnetic switch and the start of atomization. After closing the magnetic switch, the cartridge is moved forward, i.e. in the direction of the oscillation system, finally moves and strikes the thickened part of the body against a wall 14. Since the mechanical resistance of the plastic spring 15 is lower than the spring 21 integrated in the cartridge, the pressure on the cartridge by the operator continues to exert pressure on it only now slightly compressed and a precisely dosed amount of drug 5 is dispensed. By relieving the pressure on the cartridge, it moves back to its starting position. The quantity of medicament dispensed at the tip of the cartridge is stripped off on the atomizing plate 24 when it returns to the starting position and atomized after stripping.

Das Aerosol kann in dem Ansaugstutzen 17 gespeichert werden und wird durch den Benutzer eingeatmet.The aerosol can be stored in the intake manifold 17 and is inhaled by the user.

Die in der Wand 14 vorhandenen Offnungen 18 sind so bemessen, daß in dem Ansaugstutzen während des Einatmungsvorgangs ausreichend Luft nachgeführt werden kann.The openings 18 present in the wall 14 are dimensioned such that sufficient air can be added to the intake manifold during the inhalation process.

Mit der speziellen Kontur des Ansaugstutzens 19 ist es möglich, daß der Mund des Benutzers den Ansaugstutzen gut umschließen kann. Dabei kann der Stutzen an einer Kante des Gehäuses bündig abschließen und die Geräteabmessungen können gering gehalten werden.With the special contour of the intake manifold 19, it is possible that the mouth of the user can enclose the intake manifold well. The connector can be flush with one edge of the housing and the device dimensions can be kept small.

Aus hygienischen Gründen soll der Ansaugstutzen nach dem Inhalationsvorgang wieder verschlossen werden. Für das Verschließen des Ansaugstutzens ist ein Deckel 20 vorgesehen, der unverlierbar über ein Kunststoff-Film-Scharnier 22 an dem Geräteoberteil befestigt ist.For hygienic reasons, the intake port should be closed again after the inhalation process. For closing the intake manifold, a cover 20 is provided, which un is captively attached to the upper part of the device via a plastic film hinge 22.

Da das Gehäuseoberteil 9 leicht entfernbar und kostengünstig herstellbar ist, kann es nach dem Entleeren der mit Arzneimittel gefüllten Kartusche 4 verworfen werden. Es ist eine sehr hygienische Lösung.Since the upper housing part 9 is easily removable and inexpensive to produce, it can be discarded after the cartridge 4 filled with medication has been emptied. It is a very hygienic solution.

Für den Benutzer ist es wichtig, die noch in der Kartusche befindliche Arzneimittelmenge zu kennen. Dafür ist an dem Oberteil ein durchsichtiges Fenster 23 aus Kunststoff integriert, das die noch vorhandene Flüssigkeitsmenge zeigt. Es ermöglicht den Füllstand des Arzneimittels in der Kartusche zu beobachten.It is important for the user to know the amount of medication that is still in the cartridge. For this purpose, a transparent window 23 made of plastic is integrated on the upper part, which shows the amount of liquid still present. It allows you to monitor the level of the drug in the cartridge.

Da der für das Zerstäuben erforderliche Energievorrat in den Akkus nicht mit der Anzahl der Arzneimitteldosen in der Kartusche übereinstimmt, zeigt ein elektrisches Signal 25 den Ladezustand des Akkus an. Geeignet ist z.B. eine Leuchtdiode.Since the energy supply in the rechargeable batteries required for atomization does not match the number of drug doses in the cartridge, an electrical signal 25 indicates the charge status of the rechargeable battery. Suitable is e.g. a light emitting diode.

Leuchtet beim Betätigen des Gerätes diese Diode erstmalig nicht mehr, wird dem Benutzer angezeigt, daß der Akkusatz bald nachgeladen werden muß. Der Energieinhalt des Akkus ist jedenfalls noch so hoch, daß noch einige weitere Inhalationsvorgängen möglich sind. Dieses ist erforderlich, da gegebenenfalls der Akku nicht sofort nachgeladen werden kann und trotzdem der Bedarf für eine Inhalation besteht.If this diode no longer lights up when the device is operated, the user is informed that the battery pack must be recharged soon. In any case, the energy content of the battery is still so high that a few more inhalation processes are possible. This is necessary because the battery may not be able to be recharged immediately and there is still a need for inhalation.

Die äußeren Konturen des Gerätes 26 sind abgerundet, damit dem Benutzer zwangsläufig ein entsprechender Ort vorgegeben wird, an dem das Gerät abgestellt werden kann. Dieser Aufbewahrungsbehälter kann beispielsweise so ausgeführt werden, daß beim Aufbewahren gleichzeitig der Akku nachgeladen wird.The outer contours of the device 26 are rounded, so that the user is inevitably given a corresponding location at which the device can be parked. This storage container can be designed, for example, in such a way that the battery is simultaneously recharged during storage.

Da die integrierten Kontakte asymmetrisch bezüglich der Geräteunterseite angeordnet sind, kann sogar eine bestimmte Lage im Aufbewahrungsbehälter vorgegeben werden.Since the integrated contacts are arranged asymmetrically with respect to the underside of the device, a specific position can even be specified in the storage container.

Das Gehäuseoberteil 9 ist mit dem Gehäuseunterteil 13 durch eine Schnapp-Rastverbindung 16 leicht trennbar verbunden.The upper housing part 9 is easily detachably connected to the lower housing part 13 by a snap-lock connection 16.

Das Gerät kann auch so ausgeführt werden, daß beispielsweise der Magnetschalter 11, 12 erst beim Anstoßen des verdickten Teils der Kartusche gegen die Wand auslöst.The device can also be designed so that, for example, the magnetic switch 11, 12 only triggers when the thickened part of the cartridge hits the wall.

Geräte gemäß der Erfindung werden mit besonderem Vorteil für medizinische Applikationen insbesondere bei Asthmatikern eingesetzt. Eine Anwendung als Raum- und Körperspraygerät ist aber ebenfalls möglich, sowie als Luftbefeuchter.Devices according to the invention are used with particular advantage for medical applications, in particular for asthmatics. An application as a room and body spray device is also possible, as well as a humidifier.

Claims (10)

1. Ultrasonic pocket sprayer (26), in particular for spraying medication for inhalation purposes, having a storage battery (6) which can be removed and recharged, a piezo electric vibration system (1), an electronic circuit (3), a current supply to the piezo electric vibration system, a storage container (4) having a dosing possibility and supply to the vibration system for the liquid (5) to be sprayed, and a housing (9, 13), characterised in that the housing is divided into a lower housing portion (13) and an upper housing portion (9), the piezolectric vibration system (1) built into the lower housing portion in fluid- tight manner together with the rechargeable storage battery (6) and the electronic circuit (3), with the piezoelectric vibration system projecting out of the lower housing portion with its sprayer disc (24), the upper housing portion (9) contains a cartridge (4) filled with the liquid to be sprayed and movably mounted in the upper housing portion (9), and a magnet (11) which can be moved with the cartridge, this magnet activating a switch (12) in the lower housing portion (13) whereby the piezoelectric vibration system is excited by the electronic circuit with an operating frequency in the range of from 1 to 5 MHz.
2. Ultrasonic pocket sprayer according to claim 1, characterised in that the upper housing portion (9) is attached to the lower housing portion (13) by a snap-in detent lock (16).
3. Ultrasonic pocket sprayer according to claim 1, characterised in that the piezo-electric vibration system (1) is cast into the mounting means (2) with silicone rubber.
4. Ultrasonic pocket sprayer according to claim 1, characterised in that the piezo-electric vibration system (1) is arranged in an injection-moulded mounting means (2) of resilient plastics material.
5. Ultrasonic pocket sprayer according to claim 1, characterised in that the piezo electric vibration system (1) is sealed with O-rings (28).
6. Ultrasonic pocket sprayer according to claims 1 to 5, characterised in that the cartridge (4) can be moved by pressure on the button (10).
7. Ultrasonic pocket sprayer according to claim 1, characterised in that the upper housing portion (9) has a transparent window (23).
8. Ultrasonic pocket sprayer according to one of claims 1 to 7, characterised in that the rechargeable storage battery (6) which can be taken out of the lower portion (13) of the device and whose charge state is indicated by an electronic signal, is connected to an electronic circuit (3).
9. Ultrasonic pocket sprayer according to one of the preceding claims 1 to 8, characterised in that a lightemitting diode (25) is used as the electronic signal.
10. Ultrasonic pocket sprayer according to one of the preceding claims, characterised in that an acoustic signal is used as the electronic signal.
EP87111004A 1986-08-11 1987-07-29 Ultrasonic pocket sprayer Expired - Lifetime EP0258637B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT87111004T ATE54071T1 (en) 1986-08-11 1987-07-29 ULTRASONIC POCKET ATOMIZER.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863627222 DE3627222A1 (en) 1986-08-11 1986-08-11 ULTRASONIC POCKET SPRAYER
DE3627222 1986-08-11

Publications (2)

Publication Number Publication Date
EP0258637A1 EP0258637A1 (en) 1988-03-09
EP0258637B1 true EP0258637B1 (en) 1990-06-27

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EP87111004A Expired - Lifetime EP0258637B1 (en) 1986-08-11 1987-07-29 Ultrasonic pocket sprayer

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US (1) US4877989A (en)
EP (1) EP0258637B1 (en)
JP (1) JP2540462B2 (en)
AT (1) ATE54071T1 (en)
CA (1) CA1313098C (en)
DE (2) DE3627222A1 (en)
ES (1) ES2015558B3 (en)

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ATE54071T1 (en) 1990-07-15
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EP0258637A1 (en) 1988-03-09
ES2015558B3 (en) 1990-09-01
JPS6349271A (en) 1988-03-02
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US4877989A (en) 1989-10-31
DE3763372D1 (en) 1990-08-02

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