EP0250547A1 - Composition pour le traitement de la maladie du periodonte - Google Patents

Composition pour le traitement de la maladie du periodonte

Info

Publication number
EP0250547A1
EP0250547A1 EP19870900483 EP87900483A EP0250547A1 EP 0250547 A1 EP0250547 A1 EP 0250547A1 EP 19870900483 EP19870900483 EP 19870900483 EP 87900483 A EP87900483 A EP 87900483A EP 0250547 A1 EP0250547 A1 EP 0250547A1
Authority
EP
European Patent Office
Prior art keywords
alkyldimethylbenzylammonium
periodontal disease
mouthwash
chlorides
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19870900483
Other languages
German (de)
English (en)
Inventor
Christian Schwabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micro-Map Inc
Original Assignee
Micro-Map Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro-Map Inc filed Critical Micro-Map Inc
Publication of EP0250547A1 publication Critical patent/EP0250547A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds

Definitions

  • composition for the treatment of periodontal disease Composition for the treatment of periodontal disease
  • This invention relates to a method and composition for the non-invasive treatment of periodontal disease, including periodontitis and related forms of gingival disease by topical application of alkyldimethylbenzylammonium chlorides.
  • Periodontal disease involves inflammation of gingival tissues in response to the actions of oral bacteria.
  • the gingiva appear red and swollen, and have a tendency to bleed when the teeth are brushed.
  • the attachment between the gums and the tooth may be broken. This creates a space, or periodontal pocket, between the tooth and gum which can serve as a center for enhanced microbial growth.
  • Such growth can lead to the formation of abscesses and bone loss in the alveolar crest.
  • the consequence of advanced periodontal disease is a loosening of the teeth and ultimately extraction is required.
  • Prophylactic measures can be taken to forestall the occurrence, or reoccurrence of periodontal disease.
  • Known prophylactic measures include the regular use of dental floss. Such measures are generally time consuming and involve a strict regimen of home care to be effective. For this reason, known prophylactic measures are rarely completely effective in preventing periodontal disease.
  • Anti-bacterial mouthwashes have been disclosed which are believed to be effective in the prevention or minimization of plaque.
  • some quaternary amines including benzethonium chloride. These preparations are not known to be effective, however, in the treatment of periodontal disease, and are of only limited effectiveness as a prophylactic measure.
  • an object of this invention to provide a method and composition for the treatment and prevention of periodontal disease.
  • Periodontal disease can be effectively treated by topical application of alkyldimethylbenzylammonium chlorides, where the alkyl groups are straight chains of from 12 to 18 carbon atoms.
  • alkyldimethylbenzylammonium chlorides leads to a reduction in the number of live microorganisms present in the oral cavity and to a reduction of gingival inflammation.
  • Treatment of extant inflammations is accomplished using a mouthwash containing from 0.1% to 0.2% of the alkyldimethylbenzylammonium chloride,
  • the mouthwash is preferably used twice daily, following lunch and after the last food of the day.
  • Toothpaste preparations containing alkyldimethylbenzylammonium chloride can be effectively used to prevent inflammation of the oral gingiva and periodontal disease.
  • the alkyldimethylbenzylammonium chloride is preferably incorporated into the toothpaste at a concentration of about 0.1%.
  • Alkyldimethylbenzylammonium chlorides are routinely available from drug stores and hospital supply companies for use in cold sterilization of surgical instruments. It has now been found that these compounds are effective in the treatment and prevention of periodontal disease.
  • alkyldimethylbenzylammonium chloride where the alkyl group is a straight chain of from 12 to 18 carbon atoms, is applied topically to the gingival tissues to treat and prevent periodontal disease.
  • Each of the alkyldimethylbenzylammonium chlorides is effective when used alone, and when used as a mixture.
  • the treatment involves application of an equimolar mixture of alkyldimethylbenzylammonium chlorides having an alkyl substituent of from 12 to 18 carbon atoms in length.
  • alkyldimethylbenzylammonium chloride is preferably applied as a mouthwash.
  • the alkyldimethylbenzylammonium chloride is dissolved in water to form a mouthwash capable of killing oral bacteria on contact.
  • the mouthwash contains from 0.1% to 0.2% alkyldimethylbenzylammonium chloride. higher concentrations are not required for therapeutic effectiveness, and are not recommended due to the bitter taste of the active ingredient.
  • a mouthwash according to this invention may also contain other ingredients conventionally included in mouthwash formulations, including flavorants, colorants, and astringents. It will also be understood that a mouthwash according to this invention can be formulated as a gel, as well as a liquid.
  • a mouthwash according to this invention is used regularly to treat periodontal disease until redness and swelling of the gums are alleviated.
  • the mouthwash is applied twice daily, following lunch and after the last food of the day.
  • a portion of the active ingredient adsorbs to the surface of the teeth, resulting in prolonged effectiveness.
  • Reduction of gingival inflammation generally results within one week of the onset of treatment, and in some cases may be effected with only a single application.
  • Alkyldimethylbenzylammonium chloride can be applied to the gums and teeth by simply swishing the mouthwash around in the oral cavity. Preferably, contact with the mouthwash is maintained for from 5 to 15 seconds.
  • the mouthwash may also be advantageously introduced into the lumen of a periodontal pocket or abscess using a blunt-needled syringe.
  • alkyldimethylbenzylammonium chloride may be applied either in a mouthwash or in a toothpaste.
  • a toothpaste according to this invention Preferably contains 0.1% alkyldimethylbenzylammonium chloride in an otherwise conventional toothpaste formulation. Such a toothpaste used regularly will effectively prevent the onset of periodontal disease. The following case studies will serve to illustrate the use and effectiveness of compositions according to this invention.
  • the patient diagnosed as having progressive periodontal symptoms was scheduled for periodontal treatment involving local surgical intervention.
  • the patient was given a mouthwash containing 0.2% alkyldimethylbenzylammonium chloride (40% C 12 ; 50% C 1 4 ; 10% C 16 ) according to this invention which was used once daily after the last meal for a period of one week prior to the scheduled appointment.
  • alkyldimethylbenzylammonium chloride as directed eliminated the need for any surgical intervention in the opinion of the periodontologist who had initially recommended surgery.
  • This patient had a periodontal abscess in the region of the upper left molar.
  • the patient was given a syringe with a blunt needle and advised to flush out the abscess with an 0.2% solution of alkyldimethylbenzylammonium chlorides (40% C 12 ; 50% C 14 ; 10% C 16 ).
  • the symptoms disappeared within one hour, and have not recur red af ter three months during which time a prophylactic amount of the compound was used occasionally in the form of an 0.2% mouthwash once every three days.
  • compositions according to this invention give excellent results when used in the treatment and prevention of periodontal disease. It will be understood, however, that in very advanced cases of periodontal disease surgical intervention may still be necessary. In these circumstances, compositions containing alkyldimethylbenzylammonium chloride are advantageously used to reduce gingival inflammation prior to surgery and as a prophylactic regimen following surgery.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

La maladie du périodonte est traitée de manière efficace par application topique de chlorures d'alkyldiméthylbenzylammonium ayant en tant que groupe alkyle une chaîne droite de 12 à 18 atomes de carbone. L'agent thérapeutique préféré est un mélange équimolaire de ces composés. Le traitement peut être effectué en utilisant un collutoire contenant entre 0,1% et 0,2% de chlorure d'alkyldiméthylbenzylammonium. Des applications prophylactiques utilisant en particulier comme véhicule de la pâte dentifrice sont également efficaces.
EP19870900483 1985-12-13 1986-12-05 Composition pour le traitement de la maladie du periodonte Withdrawn EP0250547A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80849885A 1985-12-13 1985-12-13
US808498 1985-12-13

Publications (1)

Publication Number Publication Date
EP0250547A1 true EP0250547A1 (fr) 1988-01-07

Family

ID=25198946

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870900483 Withdrawn EP0250547A1 (fr) 1985-12-13 1986-12-05 Composition pour le traitement de la maladie du periodonte

Country Status (2)

Country Link
EP (1) EP0250547A1 (fr)
WO (1) WO1987003476A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5176901A (en) * 1991-04-10 1993-01-05 Smithkline Beecham Corporation Dental composition
US5994383A (en) * 1997-11-18 1999-11-30 Woodward Laboratories, Inc. Surfactant-based antimicrobial compositions and methods for using the same
US6479039B1 (en) 1999-07-13 2002-11-12 Woodward Laboratories, Inc. Antimicrobial artificial nail composition and methods for preparing and using same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021537A (en) * 1973-08-09 1977-05-03 Research Lab Products, Inc. Oral bactericidal compositions
DE2440802C2 (de) * 1974-08-26 1986-07-17 Blendax-Werke R. Schneider Gmbh & Co, 6500 Mainz Verwendung einer Zahn- und Mundpflegemittel-Kombination zur aufeinanderfolgenden Reinigung und Pflege von menschlichen Zähnen
GB1475251A (en) * 1975-01-15 1977-06-01 Colgate Palmolive Co Oral preparations
US4370314A (en) * 1975-12-08 1983-01-25 Colgate-Palmolive Company Oral composition containing antibacterial agent
GB1544536A (en) * 1975-12-12 1979-04-19 Colgate Palmolive Co Dentifrices
US4323551A (en) * 1981-02-19 1982-04-06 The Procter & Gamble Company Mouthwash compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8703476A1 *

Also Published As

Publication number Publication date
WO1987003476A1 (fr) 1987-06-18

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Inventor name: SCHWABE, CHRISTIAN