EP0234871A3 - Expression contrôlable des protéines recombinantes dans la levure - Google Patents

Expression contrôlable des protéines recombinantes dans la levure

Info

Publication number
EP0234871A3
EP0234871A3 EP87301443A EP87301443A EP0234871A3 EP 0234871 A3 EP0234871 A3 EP 0234871A3 EP 87301443 A EP87301443 A EP 87301443A EP 87301443 A EP87301443 A EP 87301443A EP 0234871 A3 EP0234871 A3 EP 0234871A3
Authority
EP
European Patent Office
Prior art keywords
yeast
expression
recombinant proteins
regulatable expression
epstein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87301443A
Other languages
German (de)
English (en)
Other versions
EP0234871A2 (fr
Inventor
Ronald W. Ellis
Kathryn J. Hofmann
Loren D. Schultz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0234871A2 publication Critical patent/EP0234871A2/fr
Publication of EP0234871A3 publication Critical patent/EP0234871A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP87301443A 1986-02-28 1987-02-19 Expression contrôlable des protéines recombinantes dans la levure Withdrawn EP0234871A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83550686A 1986-02-28 1986-02-28
US835506 1986-02-28

Publications (2)

Publication Number Publication Date
EP0234871A2 EP0234871A2 (fr) 1987-09-02
EP0234871A3 true EP0234871A3 (fr) 1988-10-12

Family

ID=25269678

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87301443A Withdrawn EP0234871A3 (fr) 1986-02-28 1987-02-19 Expression contrôlable des protéines recombinantes dans la levure

Country Status (2)

Country Link
EP (1) EP0234871A3 (fr)
JP (1) JPS62253384A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0234862A3 (fr) * 1986-02-28 1988-10-05 Merck & Co. Inc. Expression de protéines recombinantes dans la levure
CA1324969C (fr) 1988-05-06 1993-12-07 Jeffrey R. Shuster Expression a haut rendement de proteines dans la levure
DK2546340T3 (en) * 2010-02-09 2016-06-27 Univ Yamaguchi HØJEKSPRESSIONSPROMOTOR, ARISING FROM, Kluyveromyces marxianus

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0116201A1 (fr) * 1983-01-12 1984-08-22 Chiron Corporation Expression sécrétoire en eukaryotes
EP0123294A1 (fr) * 1983-04-22 1984-10-31 Amgen Inc. Vecteurs pour la transformation de la levure
EP0123289A2 (fr) * 1983-04-26 1984-10-31 Chiron Corporation Facteur-A et ses signaux de traitement
EP0123228A2 (fr) * 1983-04-25 1984-10-31 Chiron Corporation Synthèse à l'aide d'ADN hybride de facteurs de croissance mûrs du type insuline
EP0129073A1 (fr) * 1983-05-25 1984-12-27 Chiron Corporation Synthèse de l'ADN hybride de facteur mûr de déclenchement de l'hormone de croissance
EP0151079A2 (fr) * 1984-01-30 1985-08-07 University Of Chicago Vaccin contre le virus d'Epstein-Barr
EP0171000A2 (fr) * 1984-07-27 1986-02-12 Suntory Limited Procédé de préparation d'une protéine ou d'un peptide hétérologue et mûr
EP0173254A1 (fr) * 1984-08-23 1986-03-05 Hans Joachim Wolf Séquences d'ADN du génome d'EBV, molécules recombinantes d'ADN, procédés pour la production des antigènes relatifs à EBV, compositions diagnostiques et compositions pharmaceutiques contenant les dits antigènes
EP0234862A2 (fr) * 1986-02-28 1987-09-02 Merck & Co. Inc. Expression de protéines recombinantes dans la levure
EP0248637A2 (fr) * 1986-06-03 1987-12-09 Delta Biotechnology Limited Induction de l'expression de gènes régulée par le galactose dans la levure

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0116201A1 (fr) * 1983-01-12 1984-08-22 Chiron Corporation Expression sécrétoire en eukaryotes
EP0123294A1 (fr) * 1983-04-22 1984-10-31 Amgen Inc. Vecteurs pour la transformation de la levure
EP0123228A2 (fr) * 1983-04-25 1984-10-31 Chiron Corporation Synthèse à l'aide d'ADN hybride de facteurs de croissance mûrs du type insuline
EP0123289A2 (fr) * 1983-04-26 1984-10-31 Chiron Corporation Facteur-A et ses signaux de traitement
EP0129073A1 (fr) * 1983-05-25 1984-12-27 Chiron Corporation Synthèse de l'ADN hybride de facteur mûr de déclenchement de l'hormone de croissance
EP0151079A2 (fr) * 1984-01-30 1985-08-07 University Of Chicago Vaccin contre le virus d'Epstein-Barr
EP0171000A2 (fr) * 1984-07-27 1986-02-12 Suntory Limited Procédé de préparation d'une protéine ou d'un peptide hétérologue et mûr
EP0173254A1 (fr) * 1984-08-23 1986-03-05 Hans Joachim Wolf Séquences d'ADN du génome d'EBV, molécules recombinantes d'ADN, procédés pour la production des antigènes relatifs à EBV, compositions diagnostiques et compositions pharmaceutiques contenant les dits antigènes
EP0234862A2 (fr) * 1986-02-28 1987-09-02 Merck & Co. Inc. Expression de protéines recombinantes dans la levure
EP0248637A2 (fr) * 1986-06-03 1987-12-09 Delta Biotechnology Limited Induction de l'expression de gènes régulée par le galactose dans la levure

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, vol. 3, no. 12, September 1985, pages 377-416, Intercept Ltd; S.M. KINGSMAN et al.: "Heterologous gene expression in Saccharomyces cerevisiae" *
GENE, vol. 54, no. 1, 1987, pages 113-123, Elsevier Science Publishers B.V., Amsterdam, NL; L.D. SCHULTZ et al.: "Expression and secretion in yeast of a 400-kDa envelope glycoprotein derived from Epstein-Barr virus" *
JOURNAL OF VIROLOGY, vol. 54, no. 3, June 1985, pages 665-674, American Society for Microbiology; C. BEISEL et al.: "Two major outer envelope glycoproteins of Epstein-Barr virus are encoded by the same gene" *
PROC. NATL. ACAD. SCI. USA, vol. 79, December 1982, pages 7410-7414; L. GUARENTE et al.: "A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site" *
PROC. NATL. ACAD. SCI. USA, vol. 81, August 1984, pages 4642-4646; A.J. BRAKE et al.: "Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae" *

Also Published As

Publication number Publication date
EP0234871A2 (fr) 1987-09-02
JPS62253384A (ja) 1987-11-05

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Inventor name: SCHULTZ, LOREN D.

Inventor name: HOFMANN, KATHRYN J.

Inventor name: ELLIS, RONALD W.