EP0228067A3 - Seamless soft capsule - Google Patents

Seamless soft capsule Download PDF

Info

Publication number
EP0228067A3
EP0228067A3 EP86117918A EP86117918A EP0228067A3 EP 0228067 A3 EP0228067 A3 EP 0228067A3 EP 86117918 A EP86117918 A EP 86117918A EP 86117918 A EP86117918 A EP 86117918A EP 0228067 A3 EP0228067 A3 EP 0228067A3
Authority
EP
European Patent Office
Prior art keywords
stream
composite jet
film
forming
soft capsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP86117918A
Other versions
EP0228067B1 (en
EP0228067A2 (en
Inventor
Tadashi Kosaka
Kazuki Omata
Tatsuo Hashimoto
Teruaki Yamazaki
Kazuo Hayashi
Tomiya Hosoi
Kenichi Ikuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Priority to AT86117918T priority Critical patent/ATE67401T1/en
Publication of EP0228067A2 publication Critical patent/EP0228067A2/en
Publication of EP0228067A3 publication Critical patent/EP0228067A3/en
Application granted granted Critical
Publication of EP0228067B1 publication Critical patent/EP0228067B1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Rigid Containers With Two Or More Constituent Elements (AREA)
  • Wrappers (AREA)

Abstract

A soft capsule composed of a plurality of cells coalesced to each other and filling substances encapsulated in the individual cells, the wall of at least one of the cells being formed of a material different from a material forming the wall of at least one of the other cells, and said capsule being seamless. The soft capsule can be produced by (a) preparing a plurality of composite jet streams each consisting of a stream of a film-forming liquid substance for forming a cell wall and within said stream of a film-forming liquid substance a single stream, or a plurality of independent streams, of a filling substance having flowability, the film-forming liquid subtance in at least one of the composite jet streams being different from the film-forming liquid substance in at least one of the other composite jet streams, (b) advancing the plurality of composite jet streams in closely spaced relationship into and through a stream of a liquid medium substantially incapable of dissolving the film-forming liquid substance in the flowing direction of the liquid medium stream, (c) coalescing the adjacent composite jet streams to each other to form a single composite jet stream in the liquid medium stream, (d) cutting the single composite jet stream to a predetermined length successively from its leading end in the liquid medium stream, and (e) solidifying the cell walls of the resulting soft capsule.
EP86117918A 1985-12-26 1986-12-23 Seamless soft capsule Expired EP0228067B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT86117918T ATE67401T1 (en) 1985-12-26 1986-12-23 SOFT SEAMLESS CAPSULES.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP297182/85 1985-12-26
JP29718285 1985-12-26

Publications (3)

Publication Number Publication Date
EP0228067A2 EP0228067A2 (en) 1987-07-08
EP0228067A3 true EP0228067A3 (en) 1988-06-01
EP0228067B1 EP0228067B1 (en) 1991-09-18

Family

ID=17843233

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86117918A Expired EP0228067B1 (en) 1985-12-26 1986-12-23 Seamless soft capsule

Country Status (6)

Country Link
EP (1) EP0228067B1 (en)
JP (1) JPH06104193B2 (en)
AT (1) ATE67401T1 (en)
DE (1) DE3681572D1 (en)
ES (1) ES2024418B3 (en)
GR (1) GR3002754T3 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
CA2109085C (en) * 1991-04-25 2003-03-11 Keith E. Dionne Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
GB2338896B (en) * 1998-07-02 2003-05-21 Reckitt & Colmann Prod Ltd Chewable Capsules
AU773800B2 (en) 1999-07-30 2004-06-10 Capsugel Belgium Nv Multi-component pharmaceutical dosage form
CN1109627C (en) * 2000-01-26 2003-05-28 依钟康 Soft capsule for packing different material and its production equipment and method
US7883721B2 (en) 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
GB0102342D0 (en) 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US7670612B2 (en) 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
US20050214361A1 (en) * 2002-05-09 2005-09-29 Chugai Seiyaku Kabushiki Kaisha Photostabilized soft capsule
US7025911B2 (en) 2002-09-13 2006-04-11 Freund Corporation Manufacturing method for oral quick-dissolving seamless capsule
JP2004105282A (en) * 2002-09-13 2004-04-08 Freunt Ind Co Ltd Method for producing seamless capsule immediately melting in buccal cavity
ES2665464T3 (en) * 2003-03-28 2018-04-25 Sigmoid Pharma Limited Solid oral dosage form containing seamless microcapsules
TW200526274A (en) 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
WO2005044174A1 (en) * 2003-11-07 2005-05-19 Freund Corporation Seamless capsule manufacturing method, seamless capsule manufacturing device, and seamless capsule
TW201240679A (en) 2004-03-12 2012-10-16 Capsugel Belgium Nv Pharmaceutical formulations
US20070134493A1 (en) * 2005-12-08 2007-06-14 Kanji Meghpara Compositions and capsules with stable hydrophilic layers
JP5183104B2 (en) * 2006-06-19 2013-04-17 森下仁丹株式会社 Multiple soft capsules for bad breath removal
US20090297455A1 (en) * 2006-08-09 2009-12-03 Koninklijke Philips Electronics N.V. Device for and a method of activating a physiologically effective substance by ultrasonic waves, and a capsule
JP2009119148A (en) * 2007-11-16 2009-06-04 Freunt Ind Co Ltd Apparatus and method for producing multi-color seamless capsule
ES2629377T3 (en) * 2011-11-16 2017-08-09 Morishita Jintan Co., Ltd. Insect pest repellent
JP6091679B1 (en) * 2016-03-29 2017-03-08 株式会社松風 Droplet generator

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0116311A1 (en) * 1983-01-17 1984-08-22 Morishita Jintan Co., Ltd. Double soft capsules and production thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60109520A (en) * 1983-11-16 1985-06-15 Fujisawa Pharmaceut Co Ltd Multilocular soft capsule agent
JPS61151119A (en) * 1984-12-24 1986-07-09 Taisho Pharmaceut Co Ltd Seamless capsule

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0116311A1 (en) * 1983-01-17 1984-08-22 Morishita Jintan Co., Ltd. Double soft capsules and production thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN, Band 10, Nr. 350 (C-387)[2406], 26th November 1985; & JP-A-61 151 119 (TAISHO PHARMACEUT CO. LTD.) 09-07-1986 *
PATENT ABSTRACTS OF JAPAN, vol. 9, no. 254 (C-308)[1977], 11th October 1985; & JP-A-60 109 520 (FUJISAWA YAKUHIN KOGYO) 15-06-1985 *

Also Published As

Publication number Publication date
GR3002754T3 (en) 1993-01-25
EP0228067B1 (en) 1991-09-18
EP0228067A2 (en) 1987-07-08
DE3681572D1 (en) 1991-10-24
ATE67401T1 (en) 1991-10-15
JPH06104193B2 (en) 1994-12-21
JPS62234542A (en) 1987-10-14
ES2024418B3 (en) 1992-03-01

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