DE3681572D1 - SOFT SEAMLESS CAPSULES. - Google Patents

SOFT SEAMLESS CAPSULES.

Info

Publication number
DE3681572D1
DE3681572D1 DE8686117918T DE3681572T DE3681572D1 DE 3681572 D1 DE3681572 D1 DE 3681572D1 DE 8686117918 T DE8686117918 T DE 8686117918T DE 3681572 T DE3681572 T DE 3681572T DE 3681572 D1 DE3681572 D1 DE 3681572D1
Authority
DE
Germany
Prior art keywords
stream
composite jet
film
forming
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686117918T
Other languages
German (de)
Inventor
Tadashi Kosaka
Kazuki Omata
Tatsuo Hashimoto
Teruaki Yamazaki
Kazuo Hayashi
Tomiya Hosoi
Kenichi Ikuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3681572D1 publication Critical patent/DE3681572D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Rigid Containers With Two Or More Constituent Elements (AREA)
  • Wrappers (AREA)

Abstract

A soft capsule composed of a plurality of cells coalesced to each other and filling substances encapsulated in the individual cells, the wall of at least one of the cells being formed of a material different from a material forming the wall of at least one of the other cells, and said capsule being seamless. The soft capsule can be produced by (a) preparing a plurality of composite jet streams each consisting of a stream of a film-forming liquid substance for forming a cell wall and within said stream of a film-forming liquid substance a single stream, or a plurality of independent streams, of a filling substance having flowability, the film-forming liquid subtance in at least one of the composite jet streams being different from the film-forming liquid substance in at least one of the other composite jet streams, (b) advancing the plurality of composite jet streams in closely spaced relationship into and through a stream of a liquid medium substantially incapable of dissolving the film-forming liquid substance in the flowing direction of the liquid medium stream, (c) coalescing the adjacent composite jet streams to each other to form a single composite jet stream in the liquid medium stream, (d) cutting the single composite jet stream to a predetermined length successively from its leading end in the liquid medium stream, and (e) solidifying the cell walls of the resulting soft capsule.
DE8686117918T 1985-12-26 1986-12-23 SOFT SEAMLESS CAPSULES. Expired - Fee Related DE3681572D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29718285 1985-12-26

Publications (1)

Publication Number Publication Date
DE3681572D1 true DE3681572D1 (en) 1991-10-24

Family

ID=17843233

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686117918T Expired - Fee Related DE3681572D1 (en) 1985-12-26 1986-12-23 SOFT SEAMLESS CAPSULES.

Country Status (6)

Country Link
EP (1) EP0228067B1 (en)
JP (1) JPH06104193B2 (en)
AT (1) ATE67401T1 (en)
DE (1) DE3681572D1 (en)
ES (1) ES2024418B3 (en)
GR (1) GR3002754T3 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG47470A1 (en) * 1991-04-25 1998-04-17 Univ Brown Res Found Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
GB2338896B (en) 1998-07-02 2003-05-21 Reckitt & Colmann Prod Ltd Chewable Capsules
DK1204410T3 (en) 1999-07-30 2012-10-29 Capsugel Belgium Nv PHARMACEUTICAL DOSAGE FORM WITH MULTIPLE COMPONENTS
CN1109627C (en) * 2000-01-26 2003-05-28 依钟康 Soft capsule for packing different material and its production equipment and method
GB0102342D0 (en) 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US7883721B2 (en) 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
US7670612B2 (en) 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
WO2003094897A1 (en) * 2002-05-09 2003-11-20 Chugai Seiyaku Kabushiki Kaisha Photostabilized soft capsule
US7025911B2 (en) 2002-09-13 2006-04-11 Freund Corporation Manufacturing method for oral quick-dissolving seamless capsule
JP2004105282A (en) * 2002-09-13 2004-04-08 Freunt Ind Co Ltd Method for producing seamless capsule immediately melting in buccal cavity
ES2665464T3 (en) * 2003-03-28 2018-04-25 Sigmoid Pharma Limited Solid oral dosage form containing seamless microcapsules
TW200526274A (en) 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
WO2005044174A1 (en) * 2003-11-07 2005-05-19 Freund Corporation Seamless capsule manufacturing method, seamless capsule manufacturing device, and seamless capsule
TW201240679A (en) 2004-03-12 2012-10-16 Capsugel Belgium Nv Pharmaceutical formulations
US20070134493A1 (en) * 2005-12-08 2007-06-14 Kanji Meghpara Compositions and capsules with stable hydrophilic layers
JP5183104B2 (en) * 2006-06-19 2013-04-17 森下仁丹株式会社 Multiple soft capsules for bad breath removal
JP2010500091A (en) * 2006-08-09 2010-01-07 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Apparatus and method for activating physiologically effective substance by ultrasound and capsule
JP2009119148A (en) * 2007-11-16 2009-06-04 Freunt Ind Co Ltd Apparatus and method for producing multi-color seamless capsule
AU2012337700B2 (en) * 2011-11-16 2016-05-19 Morishita Jintan Co., Ltd. Insect pest repellant
JP6091679B1 (en) * 2016-03-29 2017-03-08 株式会社松風 Droplet generator

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59131355A (en) * 1983-01-17 1984-07-28 森下仁丹株式会社 Multiple soft capsule
JPS60109520A (en) * 1983-11-16 1985-06-15 Fujisawa Pharmaceut Co Ltd Multilocular soft capsule agent
JPS61151119A (en) * 1984-12-24 1986-07-09 Taisho Pharmaceut Co Ltd Seamless capsule

Also Published As

Publication number Publication date
EP0228067B1 (en) 1991-09-18
ATE67401T1 (en) 1991-10-15
ES2024418B3 (en) 1992-03-01
JPS62234542A (en) 1987-10-14
GR3002754T3 (en) 1993-01-25
EP0228067A3 (en) 1988-06-01
JPH06104193B2 (en) 1994-12-21
EP0228067A2 (en) 1987-07-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee