EP0111529A1

EP0111529A1 - Medicament pour le traitement des affections neoplasiques

Info

Publication number: EP0111529A1
Application number: EP83901948A
Authority: EP
Inventors: Mihai Danila
Original assignee: INTREPRINDEREA DE MEDICAMENTE' BIOFARM'
Current assignee: INTREPRINDEREA DE MEDICAMENTE' BIOFARM'
Priority date: 1982-06-16
Filing date: 1983-05-26
Publication date: 1984-06-27
Also published as: RO81783B1; DD210843A5; IT8321614A0; RO81783A3; WO1984000005A1; DE3366025D1; CA1203167A; EP0111529B1; IT1161934B; IL68896A0

Abstract

Médicament pour le traitement des affections néoplasiques présenté comme un ensemble de trois types de médicament où l'hydroquinone et le métol avec ou sans double sulfate d'aluminium et de potassium sont mélangés dans des capsules operculées, le nitrate d'uranyle étant dissous dans une infusion de Corydalis marchaliana, contenant du bleu de méthylène, et, en vue d'intensifier son action sur le tissu musculaire, une teinture végétale alcoolique obtenue à partir de la Potentilla reptans, de l'Helleborus niger et de la Medicago sativa est utilisée comme adjuvant au traitement.

Description

Medioino for the Treatment of Neoplazic Disease

Technical Field

This invention rεfers to a meâicine used for the tratment of socie neoplazic diseases, for acute leukemia, for the Hodgkin disease, for the Eahler disease and for the thrombocytopenic purple.

Background Art

At présent, différent methods are used (surgery, raâiotherapy and some chemical substances useful for the various stages of the disease) as treatment méthods for différent cancer forms.

The main groups of thia type of medicines are the hormones, the alkylation agents as for instance isoyparites, ethyleniminss, esther of the methanolsulphonic acid and antimetabolic agents as the antagoniste of the folie acid, of purine and pyrimidins and of emino-acids.

Dérivâtives of elanine, nitrozourea, hydroxiurea are also used as wëll as dérivâtives of glutamic acid

(aminoglutamic and benzoyl glutamic acids a.s.o) and various nctural products (colchicina and vincristina).

Lately, the canceu immunotherapy has been tried, but some of the methods hâve not a specific character, while others, althpugh they hâve a spécifie character, were not thoroughly tested, their reεults were not notewolthy and were given up.

Disclosure of Invention

Acoording to the présent invention, the medicine broadens the séries of therapeutical products used in the thepapy of the neoplazic cisease, the highly efficient medicine conoisting of a set of three drug types in which hydroquinone and motolo with or without double aluminium and potassium sulphate are mixed at a ratio of 50:1 in operculated capsules, the uranyl nitrate being dissolved at a ratio of 1g to 100 g solution of Cordalis merchaliana infusion which contains 0.01 ml. 1% metjylene blue solution, and in order to intensify its effect on the tumours of muscular tissue, a 40% alcoholic vegetal tincture is used as a treatment aid being obtained from Herba Potentilla reptans, Eadix Helleborus niger and Herba Medicago sativa according to the association ratio of the alcbholate of dry plants of 10:3:3, in the case of the eolostasis hepatitis it is associated with a decoction, of Herba Helicrisium arenaria.

According to the invention the medicine has the following advantages.

- a high effieiency as compared to the known antineoplazic medicines determining the resorption of the neoplazic formations and creating a general good condition of the diseased.

- may be used in the postsurgieal therapy.

- it is not toxic.

- it is well tolerated at any age.

Best Mode of Carrying Out

Here is en exemple of the obtaining of the medicine.

The medicine is presented as a set of three drug types as follows: a) Operculated capsules containing 0.5g hydroquinone and O.ol g metole (C₁₇) or operculated capsules containing 0.5g hydroquinone, 0.01g metole and O.o2 double aluminium and potassium sulphate. b) Uranyl nitrate 1% solution of aoueous infusion of Coridalis marchaliana, infusion which contains 0.010 ml. 1% solution of methylene blue (UFO₈ solution). c)Alcoholic vegetal tincture 40% obtained by extraction from Potentilla reptans, Helleborus niger and Medicago sativa, a 10:3:3 rotio of weight association of dry plants during the extraction (Hbp solution).

The operculoted capsules containing a C₁₇ or V composition are prepared according to the ordinary phar maceutical technology.

The Corydalis marchaliana infusion is obtained of 0.200 g of dry plant in 100 ml.of water, and in this cold infusion 1% mrthylrne blue id added, and the uranyl nitrate is dissolved.

The Hbp vegetal tincture is obtained by the maceration of the chopped dry plants, at the above ratios, in one liter of ethylic alcohol 40%, for 20 days. After the maceration, the supernatant liquid is decanted thus contituting the Hbp vegetal tincture.

According to the invention, generally one C₁₇ or V capsule is taken daily with an infusion of Coride lis marchaliana, (25 ml.pt least), and, in the case of the tumours or musculcr tissue with another 5 ml.of Hbp alcoholic vegetal tincture diluted in 25 ml. of water or Coridalis infusion, 2-3 times a day for 1-6 months after which 1 drop of UFO₈ solution per 10 kg.of body is recomended for 1-2 months also associated with the Hbp alcoholic vegetal tincture. According to the invention, the total cure is of 6-10 months. In the case of the underponderal disessed, the C_{1 7} or V capsules will be taken intermittently once in two days.

In the case of the cancer of the digestive tract end its annexes, it is highly efficient to administer operculated capsules, dissolved in 25 ml. Coridalis marchaliana infusion, daily, in the morning, before broakfast, associated with 5-10 ml. Hbp diluted in 25 ml. water, at lunch end dinner.

The treatment necessarily lests 6 months- 1 year. In the case of the system neoplazia (Hodkin lymphogranulomatosis, lymphatic leukemia, Kahier disease thrombocytopenia, malignant reticolosis) the V operculsted capsules are highly efficient. In these cases the presence of tho potash alum and sodium alum is necescary because the potash ion represents an exogenio contribution to the prostetic group of the mitochondrial enzymes. The V operculated capsules also are recomeended for the treatment of the agressive ehronic hepatitis intermittently, once in two days.

In the case of the hepatitis with cholostasis, the Herba Helicrisium arenarium decoction is recommended at a ratio of 0.5g-1g dry plant in 250 ml. of water, as a treatment aid with cholesteric and cholagogic effects which is taken in the morning, before brenkfast, periodically for seven days.

For the treatment of miastenia gravis the highly efficient V operculated capsules are recommended, in which the double aluminium and potassium sulphate is of 0.04 g for an operculated capsule daily, the cure consisting in one capsule daily.

For the treatment of the ovarian and thyroid cancers the C₁₇ operculated capsules and the UFO₈ solution will be administered in alternating cures of 4-5 months, both of them per os. The same treatment is recommended for the lungs cancer.

Also, in the case of the thyroid, ovarian, lungs cancers and in the case of ganglioneuroma, the UFO₈ solution will be administered per os, 1 drop per 10 kg. of body, in 50 ml of water or Coridalis infusion, in the monrning, before breakfast. The rhythm of the cure is of 5 days with a pause of two days, for 5-6 months.

For the treatment of the Kaposi angiosarcomatosis C₁₇ operculated capsules are administered per os associated with local wet dressings soaked with UFO₈. The U FO ₈ solution may be used in local applications, as an intrapleural and intraperitoneal treatment in the case of the corcinomatous pleuresy and peritonitis, determining a quick resorption of the carcinomotous liquid. In this case the UFO₈ solution will be sterili zed after a dilution with distilled water at a ratio of 1:5. During this treatment the diseased will take C₁₇ operculated capsules per os, one capsule daily. For the treatment of the herpetic keratitis and of the cutaneous and genital herpes, the daily local application of the UFO₈ solution or the daily ocular instillations for 1-2 months proved to be very efficient.

In all the above mentioned situations, the Hbp vegetal tincture together with the other drugs in the composition of the medicine have, according to the invetion, an immunologie influence on the organism. Thus, in the case of chronic obstructive bronchopathy, of obliterating arteritis and of diabetic retina unsticking, only the use of this tincture can regulate the metabolism of lipids and hydrocarbonates.

Claims

Claim

Lledicine for the treatment of the ncoplazic disease characterized by the fact that it is presented as a set of three drug types in which hydroquinone and metole with or without double aluminium and potassium sulphate are associated at a ratio of 50:1 in operculated capsules, the uranyl nitrate being dissolved at a ratio of 1g in 100 g solution of Coridalis marchaliana solution which contains 0.01 ml. methylene blue 1 % solution, and in order to intensify its effect in the case of tumours or muscular tissue a 40% alcoholic vegetal tincture obtained from Herba Potentilla reptans, Hadix Helleborus niger and Herba Hedicago sativa is used as a treatment aid, having an association ratio of the dry plants at extraction of 10:3:3, in the case of hepctitis with cholostasis a decoctum of Herba Helicrisium arenaria is associated.