EP0110603A2 - Vorrichtung und Verfahren zum Schliessen von Kapseln - Google Patents

Vorrichtung und Verfahren zum Schliessen von Kapseln Download PDF

Info

Publication number
EP0110603A2
EP0110603A2 EP83306888A EP83306888A EP0110603A2 EP 0110603 A2 EP0110603 A2 EP 0110603A2 EP 83306888 A EP83306888 A EP 83306888A EP 83306888 A EP83306888 A EP 83306888A EP 0110603 A2 EP0110603 A2 EP 0110603A2
Authority
EP
European Patent Office
Prior art keywords
capsule
cap
sealing fluid
sealing
overlapping regions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP83306888A
Other languages
English (en)
French (fr)
Other versions
EP0110603A3 (de
Inventor
Fritz Wittwer
Louis Van Herle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of EP0110603A2 publication Critical patent/EP0110603A2/de
Publication of EP0110603A3 publication Critical patent/EP0110603A3/de
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/4895—Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
    • B29C65/54—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts
    • B29C65/542—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts by injection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
    • B29C65/54—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts
    • B29C65/546—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts by gravity, e.g. by pouring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
    • B29C65/54—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts
    • B29C65/548—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts by capillarity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/542—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining hollow covers or hollow bottoms to open ends of container bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/65—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles with a relative motion between the article and the welding tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7174—Capsules

Definitions

  • This invention relates to a method of and apparatus for sealing capsules, using a jet to deposit sealing fluid and with a means for controlling the amount of sealing fluid deposited, and to a capsule sealed thereby.
  • the capsules sealed by the method and apparatus of the present invention are hard shell, telescopically joined capsules, having coaxial cap and body parts.
  • the capsules are made of gelatin or other hydrophilic polymer materials whose properties are pharmaceutically acceptable.
  • Capsules have a disadvantage when compared with other dosage forms, in that cap and body parts can be opened and rejoined without the disruption becoming externally visible. Therefore, the consumer has no real guarantee that the contents of a capsule have not been tampered with and that the contents will actually agree with the manufacturer's statement. Until now a reliable method of prevention against tampering with hard shell gelatin or other hydrophilic polymer material capsules has not been known.
  • Tamper-proof capsules have been recently developed which provide a total overlap by the cap side wall of the body side wall so as to impede gripping of the body closed end which makes separation of the two portions more difficult.
  • a method ofand apparatus for sealing capsules using a sealing fluid is disclosed.
  • the sealing fluid can be brought into contact with the overlapping region of the cap and body portions by: spraying the capsule with the sealing fluid; exposing the capsule to the sealing fluid in a steam chamber; or dipping the capsule in the sealing fluid.
  • the sealing fluid being directed to the overlap region and between the parts by capillary action.
  • the present invention discloses a method of sealing capsules in order to enhance tamper- proofing of capsules.
  • a method of sealing a capsule made from gelatin and/or another hydrophilic polymer, having hard shell coaxially aligned cap and body parts which are telescopically joined to define overlapping regions comprises depositing, at high-frequency from a jet, between the overlapping regions of the cap and body parts, droplets of a sealing fluid, to seal together the cap and body parts.
  • the jet employed in this aspect of the present invention may be of the pressure pulse jet nozzle type with accurate monitoring of droplet delivery and deflection.
  • the capsule is preferably axially aligned with the cap down so that the action of gravity and capillary action distribute the sealing fluid between the overlapping regions of the capsule parts.
  • the capsule may be axially aligned with the cap down so that the action of gravity and capillary action cause the sealing fluid injected into the overlapping region to quickly disperse between the overlapping capsule side walls.
  • the capillary action produces not only a relatively large sealing fluid dispersion area, but also a quick polymerization and drying which causes the immediate development of a firm seal at the overlapping seam of the capsule.
  • Surfactants can also be added to the sealing fluid to facilitate dispersion.
  • the sealing fluid employed in the present invention are cyanoacrylate-monomer, polyvinylalcohol solutions or polyvinylpyrollidone in water, or nitrocellulose in acetone or methylacetate and/or ethylacetate.
  • a hardshell gelatin or other hydrophilic polymer capsule comprising cap and body parts which have been telescopically joined with a wall of one part overlapping a wall of the other part, and sealed by a method according to the first aspect of the present invention.
  • the capsules of the second aspect of the present invention may be filled with one or more of the following: powder; a paste; tablets; pellets; granules or micro-capsules; a liquid; and a solid and a liquid.
  • an apparatus for sealing hard shell gelatin or other hydrophilic polymer capsules having coaxially aligned cap and body parts which are telescopically joined to define overlapping regions comprising:
  • a filled and telescopically joined capsule 1 is positioned by a holder (not shown) in an axially cap down position.
  • a sealing fluid 3 is delivered by pressure through a pressure pulse jet nozzle 2.
  • the nozzle 2 is pre-set to deposit the sealing fluid directly between the seam 4 of the overlapping capsule parts.
  • the sealing fluid is delivered through the nozzel 2 under pressure which is interrupted or pulsed so as to deliver the fluid as droplets 3 from the nozzle 2 at high-frequency of about 4 Hz.
  • the droplets are deposited on the capsule asspheroidal dots having a diameter between. about 0.03 to 0.4 mm. These droplets 3 run together so as to form a continuous film deposited on the seam 4.
  • Sealing may be performed with the capsule either in an axially cap down position or in an, axially body down position as the capillary forces between the overlap of body and cap are sufficient for the distribution of the sealing fluid between body and cap to form a seal therein.
  • the nozzle 2 is depositing droplets 3 on a capsule 1 which is axially cap down.
  • the nozzle 2 is at approximately a 45° angle to the axis of the capsule 1.
  • the capsule is oriented with the closed end of the cap downward and the open end of the cap upward to receive the body part.
  • the sealing fluid is deposited at the edge of the open end of the cap, and the sealing fluid flows downward by gravity and by capillary action between the cap and body side walls so as to form a tight seal therein.
  • FIG 2 shows the nozzle 2 depositing the droplets 3 on a capsule 1 which is axially cap down and is axially rotated so that the droplets 3 form a continuous seam 5 along the overlap between the side wall of the cap and the side wall of the body.
  • the sealing fluid flows downward by gravity and by capillary action between the overlap of the cap and body parts so as to form a tight bond and completely seal the seam between body and cap parts of the capsule 1.
  • FIG. 3 shows two nozzles 2 and 2', depositing droplets on spots 4 and 4' which are on opposite sides of the capsule 1 which is axially cap down and stationary. A two-spot sealing is obtained by this procedure.
  • Each nozzle can deliver between 1 and 10 microlitres of sealing fluid per capsule.
  • the nozzles can be adjusted to give the desired time period of exposure of each capsule to the sealing fluid and the time period can be varied to increase or decrease the amount of sealing fluid deposited, in order to conform to the configuration and size of each capsule.
  • the viscosity limitations are important and are dependent upon the apparatus, the method and the configuration of the capsule. Therefore, the viscosity must be determined for each specific case.
  • the viscosity normally ranges between 1.5 (or 2) and 20 c P ( mN s/m 2 )
  • cyanolite 101 R methyl- cyanoacrylate
  • the nozzle was directed at a 45° angle to the axis of the capsule which was in an axially cap down position. In this way, the sealing fluid was precisely injected into the seam and was quickly dispersed by capillary forces between the overlap of the cap and body parts.
  • the jet nozzle was kept dry by a constant flow of dry air at 25°C and 10% relative humidity. Because the capsule itself contains 12 to 16% water, the immediate polymerization of the fluid took place on the overlapping surfaces of the capsule walls without making any increase in temperature necessary.
  • the capsule parts could not be separated without destroying the capsules.
  • Example 2 In a similar manner to Example 1, a polyvinylpyrrolidone solution in water with a viscosity of 10 cP (mN s/m 2 ) was sprayed on the capsule seam. The application amount was 5 microlitres.
  • the capsule was bound together so tightly that a separation was impossible without destroying the capsule.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
EP83306888A 1982-11-23 1983-11-11 Vorrichtung und Verfahren zum Schliessen von Kapseln Withdrawn EP0110603A3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44400782A 1982-11-23 1982-11-23
US444007 1999-11-19

Publications (2)

Publication Number Publication Date
EP0110603A2 true EP0110603A2 (de) 1984-06-13
EP0110603A3 EP0110603A3 (de) 1985-05-29

Family

ID=23763102

Family Applications (1)

Application Number Title Priority Date Filing Date
EP83306888A Withdrawn EP0110603A3 (de) 1982-11-23 1983-11-11 Vorrichtung und Verfahren zum Schliessen von Kapseln

Country Status (2)

Country Link
EP (1) EP0110603A3 (de)
JP (1) JPS59105455A (de)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2172570A (en) * 1985-03-21 1986-09-24 Warner Lambert Co Method for sealing capsules
GB2187703A (en) * 1986-03-12 1987-09-16 Warner Lambert Co Process for filling and sealing a vessel
DE3718320A1 (de) * 1986-06-02 1987-12-03 Warner Lambert Co Verfahren zum versiegeln von hartgelatinekapseln und dabei verwendete vorrichtung
EP0360765A1 (de) * 1988-09-19 1990-03-28 Massimo Marchesini Verfahren zur beiderseitigen Verbindung von Kappe und Kapselkörper einer Steckkapsel für den Einschluss von Medikamenten und Vorrichtung zu deren Herstellung
US5188688A (en) * 1990-07-20 1993-02-23 Minnesota Mining And Manufacturing Company Method of sealing a gelatin capsule
EP1459725A1 (de) * 2003-03-21 2004-09-22 Warner-Lambert Company LLC Vorrichtung und Verfahren zum Versiegeln von Kapseln
WO2005084609A1 (en) * 2004-02-27 2005-09-15 I.M.A. Industria Macchine Automatiche S.P.A. A method and related capsule filling machine for producing sealed capsules
WO2005084608A1 (en) * 2004-02-27 2005-09-15 I.M.A. Industria Macchine Automatiche S.P.A. A capsule filling machine and method for producing sealed capsules
WO2005121225A1 (en) * 2003-05-03 2005-12-22 Reckitt Benckiser (Uk) Limited Composition for sealing pvoh
EP2111837A1 (de) * 2007-02-15 2009-10-28 Qualicaps Co., Ltd. Banddichtung für hartkapseln mit eingekapseltem peg
US8181425B2 (en) 2006-08-04 2012-05-22 Capsugel Belgium Apparatus for sealing capsules

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2936493A (en) * 1955-06-16 1960-05-17 Scherer Corp R P Method of making plastic capsules
US3025652A (en) * 1960-08-09 1962-03-20 American Cyanamid Co Sealing hard shell capsules
US3159546A (en) * 1962-10-12 1964-12-01 F G Okie Inc Capsule sealing composition
US3200556A (en) * 1962-10-12 1965-08-17 Hartnett Co R W Capsule sealing method and apparatus
GB2070553A (en) * 1980-02-29 1981-09-09 Automatisme & Technique Process and apparatus for filling and sealing hard gelatin capsules
EP0110500A1 (de) * 1982-10-29 1984-06-13 Warner-Lambert Company Fälschungssichere Kapseln
EP0116744A1 (de) * 1982-12-20 1984-08-29 Warner-Lambert Company Vorrichtung und Verfahren zum Versiegeln von Kapseln
EP0116743A1 (de) * 1983-02-18 1984-08-29 Warner-Lambert Company Vorrichtung und Verfahren zum Versiegeln von Kapseln

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2936493A (en) * 1955-06-16 1960-05-17 Scherer Corp R P Method of making plastic capsules
US3025652A (en) * 1960-08-09 1962-03-20 American Cyanamid Co Sealing hard shell capsules
US3159546A (en) * 1962-10-12 1964-12-01 F G Okie Inc Capsule sealing composition
US3200556A (en) * 1962-10-12 1965-08-17 Hartnett Co R W Capsule sealing method and apparatus
GB2070553A (en) * 1980-02-29 1981-09-09 Automatisme & Technique Process and apparatus for filling and sealing hard gelatin capsules
EP0110500A1 (de) * 1982-10-29 1984-06-13 Warner-Lambert Company Fälschungssichere Kapseln
EP0116744A1 (de) * 1982-12-20 1984-08-29 Warner-Lambert Company Vorrichtung und Verfahren zum Versiegeln von Kapseln
EP0116743A1 (de) * 1983-02-18 1984-08-29 Warner-Lambert Company Vorrichtung und Verfahren zum Versiegeln von Kapseln

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2172570A (en) * 1985-03-21 1986-09-24 Warner Lambert Co Method for sealing capsules
GB2172570B (en) * 1985-03-21 1989-06-21 Warner Lambert Co Hard gelatin capsules.
GB2187703A (en) * 1986-03-12 1987-09-16 Warner Lambert Co Process for filling and sealing a vessel
GB2187703B (en) * 1986-03-12 1990-10-24 Warner Lambert Co Process for filling and sealing a non-locking capsule,capsules made by that process and apparatus for use in that process
DE3718320A1 (de) * 1986-06-02 1987-12-03 Warner Lambert Co Verfahren zum versiegeln von hartgelatinekapseln und dabei verwendete vorrichtung
DE3718320C2 (de) * 1986-06-02 2002-05-29 Warner Lambert Co Verfahren zum Versiegeln von Hartgelatinekapseln und dabei verwendete Vorrichtung
GB2191986A (en) * 1986-06-02 1987-12-31 Warner Lambert Co Method of sealing hard gelatin capsules
GB2191986B (en) * 1986-06-02 1990-03-28 Warner Lambert Co Method of sealing hard gelatin capsules
EP0360765A1 (de) * 1988-09-19 1990-03-28 Massimo Marchesini Verfahren zur beiderseitigen Verbindung von Kappe und Kapselkörper einer Steckkapsel für den Einschluss von Medikamenten und Vorrichtung zu deren Herstellung
US5188688A (en) * 1990-07-20 1993-02-23 Minnesota Mining And Manufacturing Company Method of sealing a gelatin capsule
AU2004222469B2 (en) * 2003-03-21 2009-10-01 Warner-Lambert Company Llc Apparatus for and method of sealing capsules
EP1459725A1 (de) * 2003-03-21 2004-09-22 Warner-Lambert Company LLC Vorrichtung und Verfahren zum Versiegeln von Kapseln
WO2004082563A1 (en) * 2003-03-21 2004-09-30 Warner-Lambert Company Llc Apparatus for and method of sealing capsules
US7645407B2 (en) 2003-03-21 2010-01-12 Warner-Lambert Company Llc Method of sealing a hard shell capsule
US8491298B2 (en) 2003-03-21 2013-07-23 Capsugel Belgium Nv Apparatus for sealing a pharmaceutically acceptable hard shell capsule
JP2006520616A (ja) * 2003-03-21 2006-09-14 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー カプセルを密封する装置及び方法
EA007670B1 (ru) * 2003-03-21 2006-12-29 Варнер-Ламберт Компани Ллси Устройство для герметизации и способ герметизации капсул
WO2005121225A1 (en) * 2003-05-03 2005-12-22 Reckitt Benckiser (Uk) Limited Composition for sealing pvoh
WO2005084609A1 (en) * 2004-02-27 2005-09-15 I.M.A. Industria Macchine Automatiche S.P.A. A method and related capsule filling machine for producing sealed capsules
WO2005084608A1 (en) * 2004-02-27 2005-09-15 I.M.A. Industria Macchine Automatiche S.P.A. A capsule filling machine and method for producing sealed capsules
US8181425B2 (en) 2006-08-04 2012-05-22 Capsugel Belgium Apparatus for sealing capsules
EP2111837A1 (de) * 2007-02-15 2009-10-28 Qualicaps Co., Ltd. Banddichtung für hartkapseln mit eingekapseltem peg
EP2111837A4 (de) * 2007-02-15 2011-04-06 Qualicaps Co Ltd Banddichtung für hartkapseln mit eingekapseltem peg
EP2402006A1 (de) * 2007-02-15 2012-01-04 Qualicaps Co., Ltd. Bandabdichtung für mit PEG gefüllte Hartkapsel
US9314966B2 (en) * 2007-02-15 2016-04-19 Qualicaps Co., Ltd. Bandseal for PEG-filled hard capsule
US9925719B2 (en) 2007-02-15 2018-03-27 Qualicaps Co., Ltd. Bandseal for PEG-filled hard capsule

Also Published As

Publication number Publication date
EP0110603A3 (de) 1985-05-29
JPS59105455A (ja) 1984-06-18

Similar Documents

Publication Publication Date Title
EP0110603A2 (de) Vorrichtung und Verfahren zum Schliessen von Kapseln
CA1252441A (en) Method for sealing capsules
EP0785822B1 (de) Methode zur herstellung von nahtlosen kapseln
CA2307160A1 (en) Application method for at least two different media and dispenser therefor
US4543138A (en) Capsule-sealing method and apparatus
US5100028A (en) Pressure-rupturable container seal having a fluid flow directing shield
JPH09222075A (ja) 流動物用排出装置
EP0112183A2 (de) Verfahren zum Anbringen einer Versiegelung auf einer Kapsel
US4724019A (en) Method and apparatus for sealing capsules
EP0116743A1 (de) Vorrichtung und Verfahren zum Versiegeln von Kapseln
US6082356A (en) Device for pre-dosing of a powdery product for a product dispenser
PT726765E (pt) Dispositivo e metodo para a preparacao de formas solidas com libertacao controlada do ingrediente activo
US3788561A (en) Apparatus for employing seals to closures for containers
CA2301258A1 (en) Dispensing package and method for making the same
EP0116744A1 (de) Vorrichtung und Verfahren zum Versiegeln von Kapseln
EP0078761A3 (de) Behälter mit unter Druck aufreissbarer naht zur Abgabe des Inhalts
US4820364A (en) Method for sealing capsules
EP0806371B1 (de) Flasche zum getrennten Aufbewaren von Substanzen welche vor dem Ausgeben gemischt werden müssen
US3232493A (en) Pressurized dispensing package
US2930384A (en) Method of dispensing neutralizing solution
US4556325A (en) Compartmentalized dynamic mixing apparatus
CA2514246C (en) Apparatus for and method of sealing capsules
NO984285L (no) Dyser for pyrofor infrar°de lokkebluss
JP2002255768A (ja) ２つの製品を即時に混合するための装置
GB2229374A (en) Two-compartment mixing and dispensing apparatus

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19860130

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WITTWER, FRITZ

Inventor name: VAN HERLE, LOUIS