GB2229374A - Two-compartment mixing and dispensing apparatus - Google Patents
Two-compartment mixing and dispensing apparatus Download PDFInfo
- Publication number
- GB2229374A GB2229374A GB8903665A GB8903665A GB2229374A GB 2229374 A GB2229374 A GB 2229374A GB 8903665 A GB8903665 A GB 8903665A GB 8903665 A GB8903665 A GB 8903665A GB 2229374 A GB2229374 A GB 2229374A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cylinder
- chamber
- duct
- plug
- seal means
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
- A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
Abstract
A dispensing apparatus comprises a first cylinder (2) defining a first chamber (18), a dispensing outlet (6) at a first end (3) of the first cylinder, a second cylinder (11) defining a second chamber (20) and slidably located in the first cylinder such that the first chamber is variable in volume by relative axial movement of the cylinders, a piston (19) slidably located in the second cylinder such that the volume of the second chamber is variable by movement of the piston relative to the second cylinder and seal means (17) operable to isolate the first and second chambers from one another wherein the seal means is disruptable to allow the contents of the respective chambers to mix prior to being dispensed through the dispensing outlet. A powdered drug and diluent may be stored in the separate chambers and mixed prior to dispensing. <IMAGE>
Description
"IMPROVEMENTS IN OR RELATING TO DISPENSING APPARATUS"
This invention relates to dispensing apparatus and in particular but not exclusively to apparatus for the nasal administration of drugs.
It is known to provide a drug in powder form and to mix the powder with a suitable diluent immediately prior to administration of the drug.
This is useful for example where a drug has an extended storage life when kept in freeze-dried form. It is an object of the present invention to provide dispensing apparatus suitable for storing the powder and diluent prior to use and facilitating mixing and dispensing of the drug in a convenient and cost effective manner.
According to the present invention there is disclosed dispensing apparatus comprising a first cylinder defining a first chamber, a dispensing outlet at a first end of the first cylinder, a second cylinder defining a second chamber and slidably located in the first cylinder such that the first chamber is variable in volume by relative axial movement of the cylinders, a piston slidably located in the second cylinder such that the volume of the second chamber is variable by movement of the piston relative to the second cylinder and seal means operable to isolate the first and second chambers from one another wherein the seal means is disruptable to allow the contents of the respective chambers to mix prior to being dispensed through the dispensing outlet.
The seal means may be disruptable by means responsive to an imbalance of the fluid pressures within the first and second chambers respectively.
The seal means may be disruptable by means responsive to excess fluid pressure within the second chamber resulting from the second chamber volume being reduced by piston movement relative to the second cylinder.
The seal means may comprise a ducted member of the second cylinder defining a duct communicating between the first and second chambers and a co-operating plug normally received within the ducted member so as to seal the duct, the plug being displaceable from a sealing position to a non-sealing position by fluid pressure to unseal the duct.
The apparatus may further comprise retaining means operable to limit travel of the plug relative to the ducted member after displacement from the sealing position.
The seal means may alternatively comprise a foil disc.
Advantageously the first end of the first cylinder may be closed by an end face defining an aperture comprising the dispensing outlet and wherein at least one groove communicating with the aperture is provided in the end face. This arrangement prevents the aperture from being blocked by a plug or seal disc for example in any of the above-mentioned arrangements.
Alternatively the seal means may comprise a frangible membrane normally sealing a ducted member of the second cylinder, the ducted member defining a duct communicating between the first and second chambers and defining a flow path therebetween after disruption of the seal means. The membrane may include a zone of weakness defining an open-ended tear line along which the membrane ruptures in response to an imbalance of fluid pressure.
In an alternative apparatus the seal means may comprise a precursive ducted portion of the second cylinder co-operable with a penetrable membrane normally closing the first cylinder, the seal means being disruptable by advancing the precursive ducted portion so as to penetrate the member such that a duct defined by the ducted portion communicates between the first and second chambers.
The apparatus may conveniently include a nasal applicator connected to the dispensing outlet. A spray nozzle may be provided at the outlet of the applicator where the product is to be dispensed in aerosol form.
Conveniently a first product in powder form is contained within the first chamber and a diluent product is contained in the second chamber.
Particular embodiments of the present invention will now be described by way of example only and with reference to the accompanying drawings of which:
Figure 1 is a longitudinal section of apparatus in accordance with the present invention and having seal means comprising a displaceable plug;
Figure 2 is a longitudinal section of an alternative apparatus having a displaceable plug with plug retaining means;
Figure 3 is a longitudinal section of a further alternative device wherein the seal means comprises a frangible membrane;
Figure 4 is a longitudinal section of a further alternative device in which the seal means comprises a foil disc; and
Figure 5 is a longitudinal section of a further alternative device wherein the seal means comprises a penetrable membrane.
In Figure 1 a dispensing apparatus 1 comprises a first cylinder 2 of a transparent plastics material having a first end 3 closed by an end wall 4. An aperture 5 is formed in the end wall and communicates with a tubular dispensing outlet 6. Radially extending grooves 27 are provided in the end wall 4 which grooves communicate with the aperture 5. A nasal applicator 7 is fitted to the dispensing outlet 6 and is shaped to be suitable for nasal insertion and includes a flared outlet aperture 8 to the dispensing outlet 6. The nasal applicator 7 is adapted for dispensing a jet of solution directed into the nasal cavity of the user.
The first cylinder 2 has an open second end 9 at which is formed an annular handle 10 which projects radially outward from the cylinder.
A second cylinder 11 of a transparent plastics material is slidably received within the first cylinder so as to project from the second end 9.
The second cylinder 11 has a first end 12 directed towards the first end 3 of the first cylinder 2 and a ducted member 13 of smaller external radius than the second cylinder 11 projects axially from the first end 12. A duct 14 is defined by the ducted member 13 and an elastomeric annular sealing member 15 is located between the ducted member 13 and the internal surface 16 of the first cylinder 2. The duct 3 is plugged by a frictionally retained plug 17 having a cylindrical portion 70 normally sealing the duct and a ribbed portion having axially extending ribs 71.
The plug 17 is shown in its normal sealing position and also by chain dot in its non sealing position in which the ribbed portion continues to frictionally retain the plug relative to the ducted member 13 whilst defining flow paths through the duct 2 by means of axially extending channels lying between the ribs 71. A first chamber 18 is defined by the first cylinder 2 and bounded axially at one end by the end wall 4 and at its other end by the combination of the ducted member 13, the plug 17 and the elastomeric member 15.
An elastomeric piston 19 is located within the second cylinder 11 and is normally axially spaced from the ducted member 13 so as to define a sealed second chamber 20 within the second cylinder. A piston rod 21 is connected to the piston 19 and extends axially so as to project beyond the open end 22 of the second cylinder 11. A second handle 23 is provided at the open end 22 of the second cylinder and projects radially outwardly therefrom.
The piston rod 21 is of cruciform cross-section and terminates in a disc 24 at its outermost end with respect to the second cylinder 2.
A quantity of a freeze dried powder product 25 is contained within the first chamber 18 and the second chamber 20 is filled with a diluent 26.
In use the dispensing apparatus 1 is stored with a seal (not shown) being applied to the dispensing outlet 6. Immediately prior to use the seal is broken and the nasal applicator 7 fitted over the dispensing outlet 6. The user holds the apparatus with thumb resting against the disc 24 and fingers holding the second handle 23 and squeezes so as to urge the piston 21 into the second cylinder 11. The diluent 26 within the second chamber 20 is compressed by this action and the increased fluid pressure within the second chamber 20 results in a net axial force being applied to the plug 17 in a direction towards the first end 3. Once this net force is sufficient to overcome the frictional retaining forces between the plug 17 and the ducted member 13 the plug 17 is displaced from its sealing position to its non-sealing position. A flow path is then opened through the duct 14 and diluent 26 enters the first chamber to be mixed with the powder product 25.
Mixing can be promoted by shaking the apparatus 1 at this stage and the resulting solution is then ready to be dispensed. The dispensing operation requires that the user applies squeezing motion between the first handle 10 and the disc 24 of the piston 19. Once the piston 19 has been fully depressed relative to the second cylinder 11, further squeezing motion results in the second cylinder moving in unison with the piston relative to the first cylinder 2 thereby reducing the volume of the first chamber 18 such that the solution is dispensed through the dispensing outlet 6 and the nasal applicator 7.
An alternative device 30 is shown in Figure 2. Corresponding reference numerals have been used in Figure 2 in respect of corresponding components where this is appropriate.
The apparatus of Figure 2 differs from the apparatus 1 of Figure 1 in that the plug 17 of Figure -1 is replaced by an alternative plug 31 which comprises a tubular portion 32 received as a frictional fit within the duct 14, the tubular portion having a closed end portion 33 to which is connected a filament 34 extending axially into the second chamber 20 and terminating in an enlarged head 35. The head 35 is dimensioned such that it will not pass through the duct 14. The head 35, the filament 34 and the tubular portion 32 are integrally formed of a plastics material. The dispensing outlet 6 is provided with a tapered outer surface 36 suitable for mating with a Luer connector. The apparatus 30 may thereby be connected to any other suitable dispensing apparatus components.
In use the first and second chambers 18 and 20 are sealed from one another by means of the plug 31 co-operating with the ducted member 13. To dispense a product the same procedure is followed as described above with reference to Figure 1. The plug 31 is displaced from its sealing position in the duct 14 by excess fluid pressure provided by compression of the diluent 26 and when so displaced the tubular portion 32 drops into the first chamber 18. The head 35 however is prevented from leaving the second chamber 20 by its size and hence the tubular portion 32 is held captive in this non-sealing position in proximity with the ducted member 13 by the connecting filament 34 which extends through the duct 14. The length of the filament 34 is chosen such that the tubular portion 32 is able to move axially sufficiently to disrupt sealing.
The plug 31 is then less likely to obstruct passage of fluid through the aperture 5.
A further alternative apparatus 40 is shown in
Figure 3 where corresponding reference numerals to those used in Figures 1 and 2 are used where appropriate in respect of corresponding components.
In the alternative apparatus 40 the first and second chambers 18 and 20 are sealed from one another by means of a frangible membrane 41 which is formed integrally with the ducted member 13 and of a plastics material.
The frangible membrane 41 extends so as to close the leading end 42 of the ducted member 13 so that diluent 26 is held separate from the powder product 25. The frangible membrane 41 is peripherally scored by a groove 43 which defines an open-ended tear line extending part way around the circumference of the membrane. During the dispensing operation (which corresponds so far as operator movements are concerned to the operation as described with reference to Figures 1 and 2) the excess fluid pressure generated by compression of the diluent 26 causes the frangible membrane to tear along the groove 43 which serves as an inbuilt zone of weakness. The membrane 41 remains attached to the ducted member 13 by virtue of the groove 43 being open-ended such that a retaining portion 44 remains untorn and prevents the membrane from breaking loose and from thereby obstructing the aperture 5.The apparatus 40 includes a modified nasal applicator 47 in which an outer sleeve 46 is received on an inner stem 45, a dispensing flowpath being provided by indentations moulded onto the sleeve and including an integrally formed spray nozzle. This arrangement directs an aerosol spray of the solution into the nasal cavity of the user.
A further alternative apparatus 50 is shown in
Figure 4 where corresponding reference numerals to those used in preceding Figures are used where appropriate for corresponding components.
The apparatus 50 of Figure 4 includes a foil disc 51 which is bonded to the leading end 42 of the ducted member 13 so as to seal the duct 14 and isolate the respective contents of the first and second chambers 18 and 19.
During a dispensing operation as described above with reference to the preceding Figures the excess fluid pressure generated within the second chamber 20 causes the foil disc 51 to rupture or become at least partially separated from the ducted member 13 thereby admitting diluent to the first chamber 18.
The foil disc 51 comprises a thin film of aluminium which is adhesively bonded to the ducting member 13.
A further alternative apparatus 60 is shown in
Figure 5 where reference numerals corresponding to
Figures 1 to 4 are used where appropriate in respect of corresponding components.
In the alternative apparatus 60 the first and second chambers 18 and 20 are initially isolated by means of an elastomeric membrane 61 in the form of a cylindrical block which fits within the first cylinder 2 so as to form a complete seal circumferentially around the internal surface 16 thereof.
A thin precursive ducted member 62 projects from the second cylinder 11 and is initially received within a recess 63 formed in the membrane 61 so as to extend partially therethrough. In order to admit diluent 26 to the first chamber 2 the second cylinder 11 is advanced towards the first end 3 such that the ducted member 62 penetrates completely through the membrane 61.
In use a user initially squeezes together the first handle 10 and the second handle 23 such that the second cylinder 11 is moved relative to the first cylinder 2 in a direction towards the first end 3.
The precursive ducted member 62 is forced into penetrating engagement with the membrane 61 and once penetration is complete a connecting flow path between the first and second chambers 18 and 20 is established through the duct 64 defined by the ducted member 62. Diluent is transferred to the first chamber 18 by advancing the piston 19 by the user applying squeezing action between the disc 24 and the handle 23. After shaking the resultant solution can then be dispensed by advancing the piston further by applying squeezing action between the handle 10 and the disc 24.
Once the piston 19 has been fully depressed relative to the second cylinder 11, further squeezing motion results in the second cylinder moving in unison with the piston relative to the first cylinder 2 thereby reducing the volume of the first chamber 18. During this movement of the second cylinder 11 the membrane 61 slides axially in unison with the second cylinder and provides a sliding seal between the ducted member 62 and the internal surface 16 of the first cylinder 2. The solution is thereby pressurised such that the solution is dispensed through the dispensing outlet 6.
Apparatus in accordance with the present invention may be used for applications other than nasal administration and in particular any of the disclosed embodiments may be modified to include either a nasal applicator or a Luer connector or other connecting device suitable for connection to a drug delivery system.
Alternative materials may be used for components of the apparatus and the cylinders may for example be made of glass or alternatively a non transparent plastics material.
Claims (17)
1. Dispensing apparatus comprising a first cylinder defining a first chamber, a dispensing outlet at a first end of the first cylinder, a second cylinder defining a second chamber and slidably located in the first cylinder such that the first chamber is variable in volume by relative axial movement of the cylinders, a piston slidably located in the second cylinder such that the volume of the second chamber is variable by movement of the piston relative to the second cylinder and seal means operable to isolate the first and second chambers from one another wherein the seal means is disruptable to allow the contents of the respective chambers to mix prior to being dispensed through the dispensing outlet.
2. Apparatus as claimed in claim 1 wherein the seal means is disruptable by means responsive to an imbalance of the fluid pressures within the first and second chambers respectively.
3. Apparatus as claimed in claim 2 wherein the seal means is disruptable by means responsive to excess fluid pressure within the second chamber resulting from the second chamber volume being reduced by piston movement relative to the second cylinder.
4. Apparatus as claimed in claim 3 wherein the seal means comprises a ducted member of the second cylinder defining a duct communicating between the first and second chambers, and a co-operating plug normally received within the ducted member so as to seal the duct, the plug being displaceable from a sealing position to a non-sealing position by fluid pressure to unseal the duct.
5. Apparatus as claimed in claim 4 further comprising retaining means operable to limit travel of the plug relative to the ducted member after displacement from the sealing position.
6. Apparatus as claimed in claim 5 wherein the retaining means comprises an enlarged head portion of the plug connected to a duct sealing portion of the plug by a filament, the head portion being located in the second chamber and dimensioned such that it cannot pass through the duct.
7. Apparatus as claimed in claim 5 wherein the retaining means comprises a ribbed portion of the plug connected to a sealing portion of the plug, which ribbed portion defines a plurality of axially extending ribs defining channels therebetween, whereby in the non-sealing position of the plug the ribbed portion is frictionally retained in the duct by contact between the ribs and the ducted member and in which position a flow path through the duct is defined by the channels.
8. Apparatus as claimed in claim 3 wherein the seal means comprises a foil disc.
9. Apparatus as claimed in any of claims 3 to 8 wherein the first end of the first cylinder is closed by an end face defining an aperture comprising the dispensing outlet and wherein at least one groove communicating with the aperture is provided in the end face.
10. Apparatus as claimed in claim 2 wherein the seal means comprises a frangible membrane normally sealing a ducted member of the second cylinder, the ducted member defining a duct communicating between the first and second chambers and defining a flow path therebetween after disruption of the seal means.
11. Apparatus as claimed in claim 10 wherein the membrane includes a zone of weakness defining an open-ended tear line along which the membrane ruptures in response to an imbalance of fluid pressure.
12. Apparatus as claimed in claim 1 wherein the seal means comprises a precursive ducted portion of the second cylinder co-operable with a penetrable membrane normally closing the first cylinder, the seal means being disruptable by advancing the precursive ducted portion so as to penetrate the member such that a duct defined by the ducted portion communicates between the first and second chambers.
13. Apparatus as claimed in any preceding claim comprising a nasal applicator connected to the dispensing outlet.
14. Apparatus as claimed in any of claims 1 to 12 comprising a luer connector being connected to the dispensing outlet.
15. Apparatus as claimed in any of claims 1 to 13 comprising a spray nozzle connected to the dispensing outlet for dispensing a fluid product in aerosol form.
16. Apparatus as claimed in any preceding claim wherein the first chamber contains a first product in powder form and the second chamber contains a diluent product.
17. Apparatus substantially as hereinbefore described with reference to and as shown in any of the accompanying drawings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8903665A GB2229374B (en) | 1989-02-17 | 1989-02-17 | Improvements in or relating to dispensing apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8903665A GB2229374B (en) | 1989-02-17 | 1989-02-17 | Improvements in or relating to dispensing apparatus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8903665D0 GB8903665D0 (en) | 1989-04-05 |
| GB2229374A true GB2229374A (en) | 1990-09-26 |
| GB2229374B GB2229374B (en) | 1993-04-21 |
Family
ID=10651881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8903665A Expired - Fee Related GB2229374B (en) | 1989-02-17 | 1989-02-17 | Improvements in or relating to dispensing apparatus |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2229374B (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137528A (en) * | 1990-11-26 | 1992-08-11 | Crose Virginia W | Ampoule for administering a liquid local anaesthetic |
| EP0511183A1 (en) * | 1991-04-25 | 1992-10-28 | Kabi Pharmacia AB | Injection container |
| US5211285A (en) * | 1992-03-19 | 1993-05-18 | Habley Medical Technology Corporation | Telescoping, pharmaceutical mixing container |
| EP0588148A1 (en) * | 1992-09-16 | 1994-03-23 | Becton, Dickinson and Company | Syringe having needle isolation features |
| US5372586A (en) * | 1993-10-20 | 1994-12-13 | Habley Medical Technology Corp. | Telescoping pharmaceutical storage and mixing syringe |
| US5520657A (en) * | 1993-08-09 | 1996-05-28 | Sellers; Jackie | Method and device for vessel location cannulation utilizing a unique needle and syringe device |
| US5630800A (en) * | 1993-11-08 | 1997-05-20 | Ferring Arzneimettel Gmbh | Injection syringe for the missing and application of injection substances |
| EP0974373A1 (en) * | 1998-07-20 | 2000-01-26 | Jaime Luis Szapiro Melamed | Syringe with two variable volume chambers for containing and administering mixtures of products provided separately |
| WO2000029051A1 (en) * | 1998-11-13 | 2000-05-25 | B.F. Elettromeccanica S.R.L. | Disposable syringe for the automatic mixing of a first and a second component |
| US8382704B2 (en) * | 2006-12-29 | 2013-02-26 | Medrad, Inc. | Systems and methods of delivering a dilated slurry to a patient |
| EP2620124A1 (en) * | 2012-01-27 | 2013-07-31 | Hubert De Backer NV | Injection syringe |
| WO2024112625A1 (en) * | 2022-11-21 | 2024-05-30 | Becton, Dickinson And Company | Sequential drug delivery syringe |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1130593A (en) * | 1965-04-30 | 1968-10-16 | Novo Terapeutisk Labor As | Injection syringe with two coaxial cylindrical chambers |
| GB1263949A (en) * | 1968-05-28 | 1972-02-16 | Century Disposable Devices | Disposable syringe |
| GB1314234A (en) * | 1969-08-01 | 1973-04-18 | Dentaire Ivoclar Ets | Mixing containers for interreacting substances for preparing ready-for-use dental preparations |
| GB1334712A (en) * | 1970-05-19 | 1973-10-24 | Dentaire Ivoclar Ets | Receptacles having at least three chambers |
| GB2002241A (en) * | 1977-08-15 | 1979-02-21 | Abbott Lab | Two compartment syringe |
-
1989
- 1989-02-17 GB GB8903665A patent/GB2229374B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1130593A (en) * | 1965-04-30 | 1968-10-16 | Novo Terapeutisk Labor As | Injection syringe with two coaxial cylindrical chambers |
| GB1263949A (en) * | 1968-05-28 | 1972-02-16 | Century Disposable Devices | Disposable syringe |
| GB1314234A (en) * | 1969-08-01 | 1973-04-18 | Dentaire Ivoclar Ets | Mixing containers for interreacting substances for preparing ready-for-use dental preparations |
| GB1334712A (en) * | 1970-05-19 | 1973-10-24 | Dentaire Ivoclar Ets | Receptacles having at least three chambers |
| GB2002241A (en) * | 1977-08-15 | 1979-02-21 | Abbott Lab | Two compartment syringe |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137528A (en) * | 1990-11-26 | 1992-08-11 | Crose Virginia W | Ampoule for administering a liquid local anaesthetic |
| EP0511183A1 (en) * | 1991-04-25 | 1992-10-28 | Kabi Pharmacia AB | Injection container |
| WO1992019295A1 (en) * | 1991-04-25 | 1992-11-12 | Kabi Pharmacia Ab | Injection container |
| US5211285A (en) * | 1992-03-19 | 1993-05-18 | Habley Medical Technology Corporation | Telescoping, pharmaceutical mixing container |
| EP0588148A1 (en) * | 1992-09-16 | 1994-03-23 | Becton, Dickinson and Company | Syringe having needle isolation features |
| AU662240B2 (en) * | 1992-09-16 | 1995-08-24 | Becton Dickinson & Company | Syringe having needle isolation features |
| US6015401A (en) * | 1993-08-09 | 2000-01-18 | Brackett; Jacqueline Darlene | Methods for vessel cannulation |
| US5520657A (en) * | 1993-08-09 | 1996-05-28 | Sellers; Jackie | Method and device for vessel location cannulation utilizing a unique needle and syringe device |
| US5372586A (en) * | 1993-10-20 | 1994-12-13 | Habley Medical Technology Corp. | Telescoping pharmaceutical storage and mixing syringe |
| US5630800A (en) * | 1993-11-08 | 1997-05-20 | Ferring Arzneimettel Gmbh | Injection syringe for the missing and application of injection substances |
| EP0974373A1 (en) * | 1998-07-20 | 2000-01-26 | Jaime Luis Szapiro Melamed | Syringe with two variable volume chambers for containing and administering mixtures of products provided separately |
| WO2000029051A1 (en) * | 1998-11-13 | 2000-05-25 | B.F. Elettromeccanica S.R.L. | Disposable syringe for the automatic mixing of a first and a second component |
| US8382704B2 (en) * | 2006-12-29 | 2013-02-26 | Medrad, Inc. | Systems and methods of delivering a dilated slurry to a patient |
| US9814827B2 (en) | 2006-12-29 | 2017-11-14 | Bayer Healthcare Llc | Systems and methods of delivering a dilated slurry to a patient |
| EP2620124A1 (en) * | 2012-01-27 | 2013-07-31 | Hubert De Backer NV | Injection syringe |
| BE1020614A5 (en) * | 2012-01-27 | 2014-01-07 | Hubert De Backer Nv | SYRINGE. |
| WO2024112625A1 (en) * | 2022-11-21 | 2024-05-30 | Becton, Dickinson And Company | Sequential drug delivery syringe |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2229374B (en) | 1993-04-21 |
| GB8903665D0 (en) | 1989-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20010217 |