EP0085045A4 - Procedes de preparation et d'utilisation de compositions intraveineuses nutritives. - Google Patents
Procedes de preparation et d'utilisation de compositions intraveineuses nutritives.Info
- Publication number
- EP0085045A4 EP0085045A4 EP19810902221 EP81902221A EP0085045A4 EP 0085045 A4 EP0085045 A4 EP 0085045A4 EP 19810902221 EP19810902221 EP 19810902221 EP 81902221 A EP81902221 A EP 81902221A EP 0085045 A4 EP0085045 A4 EP 0085045A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- nutrient
- sterile
- article
- nutrient composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2034—Separating means having separation clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7545—General characteristics of the apparatus with filters for solid matter, e.g. microaggregates
Definitions
- Patent 3,648,697 At the point of use, sterile water is mixed with the dry compositions, to form the solution at the site of use and obviate the storage and shipment of large quantities of water.
- the proposal to package and ship dry forms of parenteral compositions has not had commercial success.
- One of the major reasons for the lack of success has been the inability to produce at the site of use, an aqueous solution of the dry form, which will meet the stringent requirements of sterility, non-pyrogenieity and freedom from particulate matter. This has been due in part to a lack of a method which will provide the dry nutrient composition themselves in a state of acceptable sterility and purity.
- Even if sterile, pyrogen-free water is available at. the site of use for mixing with a dry form of the nutrient composition the product upon admixture generally has not been satisfactory, failing to meet standards.
- the method of the invention obviates a number of other problems associated with the prior art system of preparing parenteral nutrient solutions, which comprises sterilization by autoclaving.
- the parenteral solutions are packaged and then subjected to autoclaving to assure sterility.
- Autoclaving as a method of steriliza tion permits only certain nutrients to be present in the same solution during sterilization because of the chemical reactivity of these materials under autoclave conditions.
- amino acids and reducing sugars such as dextrose will combine in a Maillard reaction to form Amadori compounds which are potentially toxic and largely non-utilizable especially when infused intravenously.
- a further example of the limitation imposed by the prior art method of autoclave sterilization is encountered in regard to vitamins.
- the autoclave conditions are too severe for many vitamins such as, for example, thiamine, riboflavin, ascorbic acid and the like. These vitamins in particular are rapidly degraded to less than 10 percent of their initial activity when exposed to autoclave conditions and stored in aqueous solution, even for short periods of time.
- the dry-packaged products produced by the method of our invention greatly extend the flexible use of parenteral solutions in nutrient therapy.
- the method of our invention permits the safe, economic deliverability of simple and complex intravenous solutions at the patient's bedside.
- the invention comprises a method of preparing a stable, dry-packaged, sterile, pyrogen-free, nutrient composition for intravenous administration to a mammal, including a human, which comprises; providing the nutrient composition in a solid, form having a moisture content, which is not more than about 30 percent by weight of the solid form, provided that when the nutrient is an amino acid or carbohydrate, the moisture content does not exceed about 15 percent by weight and when the nutrient is a vitamin the moisture content does not exceed about 10 percent by weight, said form being readily dissolved in water at a temperature of circa 185°F to form an aqueous solution which will pass through a 5 micron filter by gravity at a rate of at least 1 liter per hour and the filtrate thereof will pass through a 0.22 micron filter by gravity at a rate of at least 1 liter per two hours; sealing the provided nutrient composition in a moisture-proof, microorganism-impermeable, ionizing ray permeable container adapted to receive and
- the method of the invention provides nutrient compositions in a dry-packaged form which may be admixed with sterile, pyrogen-free water suitable for parenteral use to obtain nutrient solution compositions acceptable for infusion into a human being, the compositions being solutions which are totally sterile, pyrogen-free, within acceptable limits of particulate matter and which contain nutrients, and other materials which have not been decomposed or degraded during the process of sterilization.
- the invention also comprises the storage stable, dry-packaged articles prepared by the method of the invention and the methods of their use to administer nutrients intravenously to mammals, including humans.
- pyrogen-free means a material which will provide a negative reaction in the wellknown limulus test for the detection of pyrogens and which meets the requirements of the well-known rabbit test as described in the United States Pharmacopia, supra.
- ionizing-ray means ionizing radiation.
- ionizing radiation means radiation possessing an energy at least sufficient to produce ions or to break chemical bonds and thus includes also radiations such as
- the term "nutrient” is employed in its usually accept ed sense as meaning a substance that nourishes; a food material. It includes within its scope sugars, minerals, vitamins, amino acids, protein hydrolyzates, oligopeptides, keto and hydroxy analogues of amino acids, starches and gelatins and the like used for plasma expansion.
- drug is employed in its usually accepted sense as meaning a therapeutic agent and it includes antibiotics, anti-coagulant, anti-arrhythmia drugs, and cancer chemotherapeutic agents and the like.
- Figure 1 is a plane view of a packaged nutrient composition prepared according to the method of the invention, together with means for intravenous administration to a mammal.
- Figure 2 is an isometric view of another embodiment packaged nutrient form of the invention.
- Figure 3 is a cross-sectional view along lines 3-3 of Figure 2.
- Figure 4 is a partial view of the embodiment package seen in Figure 3, but unfolded.
- the 1 liter solution if it has passed the initial filter test is then passed through a 0.22 micron filter by gravity. If the filtrate passes through the 0.22 micron filter within a period of 2 hours, it is an indication that the starting nutrient composition is preferred for further processing by the method of the invention.
- the nutrient material provided for treatment by the method of the invention should also passthe USP XIX test for non-pyrogenicity.
- the initially provided nutrient compositions will have as low a bioburden as possible, i.e.; they preferably have low bacterial contamination.
- the initially provided nutrient compositions are then hermetically sealed in a moisture-proof, microorganism impermeable, ionizing ray-permeable container adapted to receive and dispense sterile, pyrogen-free fluids.
- the nutrient compositions are sealed in pouches, multiple containers such as overwraps or similar containers made of non-metallic materials which will effectively exclude infiltration of microorganisms, gas, vapor and moisture over a time period of several years.
- containers such as overwraps or similar containers made of non-metallic materials which will effectively exclude infiltration of microorganisms, gas, vapor and moisture over a time period of several years.
- packaging materials are commercially available in numerous forms of polymeric films, including laminates of 2 or more films.
- the pouches may be constructed of polyethylene, polypropylene, polyethyleneterephthalate, polyvinyl chloride and like polymeric films for forming hermetically sealed pouches.
- the containers should be initially provided in clean, particulate free condition and they may be pre-sterilized to some extent employing conventional techniques such as ultra-violet radiation and the like.
- the dosage employed for sterilizing the sealed in nutrient compositions is within the range of from about 1 to about 3 megarads, most preferably circa 2.5 megarads.
- the dosage of ionizing rays may be varied to some extent particularly depending on the moisture level of the material for irradiation.
- Irradiation as described about may also be carried out advantageously in the absence of oxidizing agents, i.e.; in an atmosphere having an oxygen concentration which is reduced to such a degree that the quantity of oxygen molecules present is sufficient to react during irradiation with the nutrient compositions and their packaging materials.
- the reduction of the oxygen presence can be obtained by packaging the nutrient compositions under and in the presence of an inert gaseous atmosphere such as nitrogen or by the use of partial vacuum packing.
- gamma radiation produced by cobalt 60 is a preferred ionizing ray for employment in the method of the invention.
- Gamma radiation produced by cobalt 60 has a high penetrating ability and obviates the need for concern about the thickness of the nutrient composition to be penetrated.
- a dry-package 10 which comprises a polymeric film, hermetically sealed pouch 12 containing a nutrient composition such as, for example, dextrose powder 14.
- the pouch 12 also contains at one end between dextrose powder 14 and an outlet conduit 16 a 10 micron particulate screen 18.
- An inlet conduit 20 communicates with the interior of the pouch 12 when ball valve 22 is open.
- the pouch 12 with.its contained dextrose powder 14 was hermetically sealed under vacuum conditions and irradiated with gamma radiation according to the above described method of the invention.
- sterile, pyrogen-free, water is introduced through the conduit 20, passed valve 22 via a sterile connector 24 device which may be attached to a source of sterile, pyrogen-free, water.
- a sterile connector 24 device which may be attached to a source of sterile, pyrogen-free, water.
- ball valve 22 closes and the dextrose powder 14 may be dissolved by kneading or gently shaking the pouch 12.
- Indicia may be printed on the surface of pouch 12 as shown in Figure 1, to provide an indication of volume of water introduced into the pouch 12.
- the pouch 12 may be hung up through the aperture 26 and roller clamp 28 opened to permit flow of the solution from the interior of pouch 12 through screen 18 and into the conduit 16.
- Conduit 16 may be interrupted with a drip chamber 30 and additional in-line filters such as a 0.22 micron filter 32.
- the conduit 16 may also include a "Y" type of medication injection port 34.
- An adapter and needle 36 may be fitted to the open end of conduit 16 and upon insertion of the needle 36 into a mammalian vein, the solution of dextrose is dispensed therein, controlled by clamp 28.
- an injection port 38 may be provided for mixing medications with the dissolved dextrose powder 14
- the entire pouch 12 with its preassembled conduit 16, adapter and needle 36 and other components as described above are provided in a single, hermetically sealed, bacteria-impermeable outer package wherein all parts have been sterilized by ionizing radiation as described above.
- the operator need only open the outer sterile package, remove the pouch 12 with its attached ancillary components, transfer sterile, pyrogen-free water to the interior of pouch 12 using sterile technique, affect the solution of the dextrose powder 14, make an intravenous entry of the patient with needle 36 and administer the dissolved nutrient solution employing sterile technique and conventional procedure.
- the different classes of nutritional compositions be maintained separate from each other until dissolution in aqueous medium is desired.
- amino acids and dextrose mixed together for any significant period of time will produce Maillard reactions even at moderate moisture levels and room temperature. This ultimately shortens the shelf life for the packaged, mixed nutritional composition.
- some nutritional compositions must be maintained at moisture contents differing from contents for other nutritional compositions.
- minerals are generally very hygroscopic, drawing under normal ambient conditions as much as 20 to 30 percent moisture.
- salts are also hydrates, which would tend to bring water into the interior of the hermetically sealed container.
- such minerals are segregated from the normally drier amino acids and/or dextrose materials.
- the pouch 50 comprises a polymeric film pouch quite similar to the pouch 12 previously described.
- the pouch 50 is folded once at its midsection to form a fold line 52 and secured with a "U" member54.
- Construction details of the pouch 50 may be observed by viewing Figure 3, a cross-sectional view along lines 3-3 of Figure 2.
- the fold secures pouch 50 to provide the two interior chambers 56,58 and the fold is secured by the dividing clamp member 54.
- Pyrogen - representative samples are subjected to a limulus test for chemical detection of pyrogen. If positive for pyrogen by limulus, the lot is rejected. If the sample is not positive or is slightly positive for pyrogen, the sample is further tested by the rabbit test as outlined in United States Pharmacopia, XIX. If the temperatures are zero or are elevated, but under 1oC. for each of the three rabbits, the sample is accepted and passed for further processing. If the sum of temperatures in the three rabbits is higher than 3°C.,the lot is rejected. Sterility - representative samples if irradiated materials are tested by standard techniques for total plate count. Those samples that are found to be negative are then serially diluted on slant tubes in accordance with the techniques recommended in United States Pharmacopia, XIX, for sterility.
- Dextrose integrity Dextrose (pure samples) are compared with treated (irradiated) samples by means of optical rotation for gross differences and silyl ester derivatives are examined by gas-liquid chromatography for degradation products.
- Packages 12, 14 and 16 were tested for presence of particulate matter as described above and found to be free of particulate matter.
- Example 2 The procedure of Example 1, supra., was repeated except that the dextrose powder had a moisture content of 0.4 percent. The test results are shown in Table 2, below.
- Packages 4 , 6 and 8 were tested for particulate matter and found to be free of such matter.
- drugs and like medications may be included with the nutrient compositions prepared by the method of the invention; admixed therewith if compatible or segregated in a separate pouch of the container of Figure 2 if it is desired to maintain separate until use.
- Representative of such drugs are antibiotics, antifungals and the like.
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1981/001061 WO1983000430A1 (fr) | 1981-08-07 | 1981-08-07 | Procedes de preparation et d'utilisation de compositions intraveineuses nutritives |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0085045A1 EP0085045A1 (fr) | 1983-08-10 |
EP0085045A4 true EP0085045A4 (fr) | 1984-08-20 |
Family
ID=22161357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19810902221 Withdrawn EP0085045A4 (fr) | 1981-08-07 | 1981-08-07 | Procedes de preparation et d'utilisation de compositions intraveineuses nutritives. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0085045A4 (fr) |
JP (1) | JPS58501226A (fr) |
DE (1) | DE3152571A1 (fr) |
DK (1) | DK283882A (fr) |
GB (1) | GB2120529B (fr) |
NL (1) | NL8120305A (fr) |
WO (1) | WO1983000430A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1214872B (it) * | 1984-04-06 | 1990-01-18 | Mariano Feriani | Sacca contenente due o piu'sostanze per infusione ad uso medicale, poste in scomparti separati, comprendente mezzi atti a consentire la miscelazione di tali sostanze solo al momento dell'uso. |
DE3622237A1 (de) * | 1986-07-02 | 1988-01-07 | Ruhland Nachf Gmbh Dr | Packung mit einem darin enthaltenen, mit einem nicht sterilisierbaren wirkstoff beladenen wirkstofftraeger und verfahren zu deren herstellung |
IT1226287B (it) * | 1988-07-22 | 1990-12-27 | Alberto Torre | Aminoacidi liofilizzati per uso iniettabile in sacche di plastica |
FR2639915B1 (fr) * | 1988-12-01 | 1991-04-19 | Liot Sa | Emballage pour produits d'oeuf concentre |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH364073A (fr) * | 1961-02-14 | 1962-08-31 | Vifor Sa | Récipient mélangeur |
US4265760A (en) * | 1979-02-26 | 1981-05-05 | Becton Dickinson & Company | Device for dilution and delivery of in vivo chemicals |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3648697A (en) * | 1969-08-01 | 1972-03-14 | Gardner Newell J | Intravenous feeding container and method of preparing the same |
US3740557A (en) * | 1970-05-27 | 1973-06-19 | D Kaushansky | Gamma-irradiation apparatus for granular materials of biological origin |
US4282863A (en) * | 1978-07-20 | 1981-08-11 | Beigler Myron A | Methods of preparing and using intravenous nutrient compositions |
-
1981
- 1981-08-07 EP EP19810902221 patent/EP0085045A4/fr not_active Withdrawn
- 1981-08-07 JP JP50278781A patent/JPS58501226A/ja active Pending
- 1981-08-07 WO PCT/US1981/001061 patent/WO1983000430A1/fr not_active Application Discontinuation
- 1981-08-07 DE DE19813152571 patent/DE3152571A1/de not_active Withdrawn
- 1981-08-07 GB GB8227101A patent/GB2120529B/en not_active Expired
- 1981-08-07 NL NL8120305A patent/NL8120305A/nl not_active Application Discontinuation
-
1982
- 1982-06-24 DK DK283882A patent/DK283882A/da not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH364073A (fr) * | 1961-02-14 | 1962-08-31 | Vifor Sa | Récipient mélangeur |
US4265760A (en) * | 1979-02-26 | 1981-05-05 | Becton Dickinson & Company | Device for dilution and delivery of in vivo chemicals |
Non-Patent Citations (5)
Title |
---|
CHEMICAL ABSTRACTS, vol. 72, 1970, page 259, no. 114849a, Columbus, Ohio, US; D. OPLETAL: "Radiation sterilization of poly(vinyl chloride) and polyethylene materials" & CESK. FARM. 1969, 18(10) 532-4 * |
CHEMICAL ABSTRACTS, vol. 78, 1973, page 287, no. 164068q, Columbus, Ohio, US; T. OBA et al.: "Radiosterilization of medical products. IV. Effects of gamma-radiation on the physical and chemical properties of disposable infusion assemblies" & EISEI SHIKENJO HOKOKU 1972, (90), 15-20 * |
HAGERS HANDBUCH DER PHARMAZEUTISCHEN PRAXIS, vol. VII, 4th edition, 1971, pages 375-376, Springer-Verlag, Berlin, DE; * |
HAGERS HANDBUCH DER PHARMAZEUTISCHEN PRAXIS, vol. VII, 4th edition, 1971, pages 375-376, Springer-Verlag, Berlin, DE; Page, 375, "Infusionsgeräte" - page 376, before "Reinigung der Behälter und Verschlüsse" * |
See also references of WO8300430A1 * |
Also Published As
Publication number | Publication date |
---|---|
GB2120529B (en) | 1985-05-01 |
WO1983000430A1 (fr) | 1983-02-17 |
EP0085045A1 (fr) | 1983-08-10 |
DE3152571A1 (de) | 1983-07-28 |
NL8120305A (nl) | 1983-05-02 |
JPS58501226A (ja) | 1983-07-28 |
GB2120529A (en) | 1983-12-07 |
DK283882A (da) | 1983-02-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4282863A (en) | Methods of preparing and using intravenous nutrient compositions | |
US3774036A (en) | Generation of a supply of radionuclide | |
US5362442A (en) | Method for sterilizing products with gamma radiation | |
Gopal | Radiation sterilization of pharmaceuticals and polymers | |
Moroff et al. | The irradiation of blood and blood components to prevent graft-versus-host disease: technical issues and guidelines | |
US4999375A (en) | Psoralen reagent compositions for extracorporeal treatment of blood | |
EP0776649A2 (fr) | Récipient médical comportant de solution électrolytique | |
JPH04500472A (ja) | 無菌製品およびそのような無菌製品の滅菌および組立て方法 | |
EP0522111B1 (fr) | Systeme permettant d'elaborer une solution parenterale en un site donne et loin d'un milieu sterile | |
US3749556A (en) | Radiopharmaceutical generator kit | |
CN102470185A (zh) | 二级包装中的预装填容器的表面消毒 | |
BR112014026334B1 (pt) | Forma de dosagem de infusão de gencitabina e conjunto que compreende a mesma | |
EP0085045A4 (fr) | Procedes de preparation et d'utilisation de compositions intraveineuses nutritives. | |
WO1998008481A9 (fr) | PROCEDE ET APPAREILLAGE DESTINES A PRODUIRE DU Bi-212 ET UNE UTILISATION DE CEUX-CI | |
KAKEMI et al. | Interaction of parabens and other pharmaceutical adjuvants with plastic containers | |
IE910985A1 (en) | Sterile or specific pathogen free environment products | |
JPH04500817A (ja) | 栄養組成物およびその調製方法 | |
Mehta et al. | Physicochemical stability of space medicines | |
Butler et al. | Effects of Oxygen on the Inactivation of Enzymes by Ionizing Radiations: II. Solid Trypsin and Deoxyribonuclease | |
Levinson et al. | Detection of particles in intravenous fluids using scanning electron microscopy | |
CA1082593A (fr) | Sterilisation en phase vapeur a basse temperature et conservation de produits injectables ayant une action biologique | |
Dine et al. | Effects of PVC bags sterilization process on the 5-fluorouracil stability | |
EP3973950A1 (fr) | Formulation de nutrition parentérale contenant de la vitamine b12 | |
Stokes et al. | Particulate contamination and stability of three additives in 0.9% sodium chloride injection in plastic and glass large-volume containers | |
KooRNHOF et al. | Enhancement of microbiological safety levels of aseptically admixed total parenteral nutrition solutions through low‐dose gamma irradiation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19830414 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): FR |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19870302 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: BEIGLER, MYRON A. Inventor name: KOURY, AMIN J. |