EP0084557A4 - Behälter für kleine mengen von flüssigkeiten. - Google Patents
Behälter für kleine mengen von flüssigkeiten.Info
- Publication number
- EP0084557A4 EP0084557A4 EP19820902591 EP82902591A EP0084557A4 EP 0084557 A4 EP0084557 A4 EP 0084557A4 EP 19820902591 EP19820902591 EP 19820902591 EP 82902591 A EP82902591 A EP 82902591A EP 0084557 A4 EP0084557 A4 EP 0084557A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- housing
- receptacle
- cavity
- inches
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0854—Double walls
Definitions
- Biofluids are routinely analyzed in hospital clinical laboratories to aid in the diagnosis of disease and to provide critical information about a patient's well-being.
- the constituents of blood, lymph, urine, or products derived therefrom provide meaningful patient health information to a clinician or physician. Since physicians are becoming increasingly dependent on clinical
- the processing and manipulation steps generally include the eentrifugation of blood or filtration of biological fluids followed by serial dilutions and tr ⁇ insf er to a cuvette or sample container.
- Biological fluids such -as blood
- Conventional blood collection tubes used in many hospitals and clinics are elongated cylindrical containers having an opening at one
- ⁇ end fitted with a resilient stopper, and a rounded or flat bottom at the other end.
- the most common size of these blood collection tubes accommodates 30 10 milliliters of blood or other biological fluid.
- Illustrative of such blood collection tubes is the VACUTAINER* brand sold by Becton-Diekinson ( ⁇ Reg ⁇ istered Trademark of Becton-Diekinson).
- a phlembotomist first obt-ains a specimen of a patient's blood, appropriately labels the patient's specimen, and delivers the specimen to the clinical laboratory for analysis. The plasma or serum derived therefrom is processed and analyzed either manually, sem ⁇ - automat ⁇ cally, or automatically. In the majority of cases, the specimen must first be dispensed from the collection tube to a sample test tube or cuvette as described above.
- Certain automated chemical analyzers are capable of utilizing standard- sized conventional specimen containers as a means for introducing a patient's specimen into the analyzer.
- they are not equipped to handle specimen containers designed to hold small quantities of fluid. Therefore, one such instrument manufacturer requires that a separate sample cup be placed in the top of a standard-sized 10 milliliter collection tube for withdrawal of specimen and delivery to the analyzer.
- This creates several drawbacks for the rapid and reliable processing of a patient's specimen.
- One problem being the additional error-prone and time-consuming step of transferring the specimen from the specimen container to the sample cup, and another being the size requirements of the sample cups which contributes to significant evaporation of smaller fluid samples and which do not permit handling of small or micro quantities of fluid sample. Arrangements such as this are also prone to sample spillage due to dislodge ments of the sample cup from the top of the container.
- a container for holding a small quantity of liquid comprising an elongated housing having top and bottom end portions; and a fluid receptacle disposed at said top portion formed integral with said housing, the dimensions of said receptacle being substantially less than the dimensions of said housing.
- Figure 1 is a side plan view of a standard-sized sample container con ⁇ structed in accordance with the prior art
- Figure 2 is a side plan view of a container for small quantities of liquids constructed in accordance with an embodiment of the present invention
- Figure 3 is a partial, side sectional view of the container shown in ⁇ Figure 2 taken along line 3-3 thereof;
- Figure 4 is a top view of the container shown in Figure 2;
- Figure 5 is a side plan view of an alternate embodiment of a container for small quantities of liquids constructed in accordance with the present invention.
- Figure 6 is a partial, side sectional view of the container shown in
- Figure 7 is a top view of the container shown in Figure 5; Detailed Description of the Preferred Embodiment
- a micro-container has been developed in accordance with the present invention which overcomes the above-described problems associated with known containers designed for holding small sample volumes.
- the micro- container of the present invention is not only useful for storage of biological fluids in conventional test tube storage racks, but is also useful in storage racks especially designed for use in automated chemical analyzers since their overall dimensions are similar to those of standard blood collection tubes.
- the micro-containers of the present invention are easily handled by a laboratory technician, resulting in a rapid and reliable processing of fluid specimens for analysis.
- the preferred containers are cylindrical.
- the preferred micro-container of the present invention comprises an elongated cylindrical housing 10 having a top 12 and bottom 14 end portion and general dimensions similar to the standard sample collection tube 15 shown in Figure 1.
- the clinician is .able to conveniently grasp the micro-container by its elongated housing portion 10 as he or she would a conventional container.
- the elongated housing also provides an adequate area for positioning of labels or other means of identification . on the container to facilitate positive sample identification in an automated clinical analyzer.
- the elongated cylindrical housing acts as a permanent support for the micro-container such that tipping of the container and subsequent spillage of precious sample is avoided.
- the receptacle 18 Disposed at the top end portion 12 of the elongated cylindrical housing 10 is a fluid receptacle 18, for holding small quantities of liquid.
- the receptacle 18 comprises and open-topped enclosure member 20 projecting upwardly from the top 12 of the housing 10.
- the receptacle includes an upstanding cylindrical wall portion 22 extending from the top 12 of said housing 10, and a curved, preferably concave bottom portion 24 adjacent
- enclosure member 20 has an inner volume of approximately 0.6 cubic centimeters to approximately 1.2 cubic centimeters.
- the wall portion 22 of enclosure member 20 is preferably high enough to contain small amounts of sample at the bottom-most portion thereof and still have enough head space to avoid spillage or evaportion of said sample. In one use of the present invention, this head space is also necessary for determining the meniscus level of the fluid contained therein.
- the liquid volume size of enclosure member 20 will be less than 1 milliliter.
- the fluid receptacle 18 comprises a cavity 26 formed within and integral with the top end 12 of the cylindrical housing 10.
- the cavity 26 includes a cylindrical wall portion 28 depending downwardly into the housing 10 and extending from a horizontal top wall portion 30 of said housing, and a curved, preferably concave bottom portion 32 adjacent to and integral with the bottom of portion of said cylindrical cavity.
- the dimensions of the cavity are substantially less than the dimensions of said housing and preferably the cross-sectional area of the cavity is substantially smaller than that of the housing.
- the depth of the cavity walls 28 can be increased substantially more than the height of the wall portion 22 of enclosure member 20 of the alternate embodiment described above since the overall height of the container need not be changed.
- An additional advantage of the embodiment in Figures 5 and 6 of present invention is that the shoulder region 34 between the receptacle and housing as shown in Figures 2 and 3 is eliminated. Although this would not affect the use of the containers in most procedures, it has been found that the embodiment shown in Figures 5 and 6 is more ideally suited for use in automated chemical analyzers such as described in co-pending application Serial Number , filed July , 1981.
- a level-sensing device is disclosed which controls the elevation of the liquid level 36 in the sample containers to a predetermined height. The elevation of the containers to this predetermined height facilitates the dispensing of the sample from the container to the cuvettes in the chemical analyzer.
- the micro-container shown in Figures 2-4 has an additional interface or shoulder 34 between the open-topped enclosure 20 and the cylindrical housing 10 which may produce a false signal by deflecting the path of the light beam to the optical means.
- This potential problem can been eliminated with the use of the micro-container shown in Figures 5-7 since this additional interface or shoulder 35 is eliminated.
- this shoulder may also interf er with the mechanical handling of the micro-container by the automated instru ⁇ ment.
- the micro-containers of the present invention may be formed by injection molding of polystyrene or other suitable plastics, although other non-plastic materials are also suitable for forming the micro- containers.
- the container of one embodiment of the present invention must be capable of transmitting light, and preferably has a polished upper portion 40 so as to efficiently transmit light without scattering thereof.
- the overall dimensions of the micro-container permit it to be used in auto- mated clinical analyzers which are designed to employ conventional blood . - collection tubes, and the smaller cross-sectional dimension of the receptacle prevents evaporation of fluid due to currents of air passing thereover.
- the receptacle should preferably have su ficient depth to minimize the con ⁇ vention of air, and in keeping with the micro-sample requirements, the diameter of the receptacle should be substantially smaller than that of the housing to insure an adequate fluid height for dispensing of specimen therefrom.
- the overall diameter of housing 10 is about 0.625 inches, and it has a height of about 4.0 inches.
- the horizontal wall portion 30 of the housing has a length of 0.188 inches, and the corresponding diameter of fluid receptacle 18 is about 0.250 inches.
- the length of the downwardly depending cylindrical wall portion 28 of the cavity is about 1.3 inches.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Devices For Use In Laboratory Experiments (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28498081A | 1981-07-20 | 1981-07-20 | |
US284980 | 1981-07-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0084557A1 EP0084557A1 (de) | 1983-08-03 |
EP0084557A4 true EP0084557A4 (de) | 1985-09-16 |
Family
ID=23092261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19820902591 Withdrawn EP0084557A4 (de) | 1981-07-20 | 1982-07-19 | Behälter für kleine mengen von flüssigkeiten. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0084557A4 (de) |
JP (1) | JPS58501146A (de) |
ES (1) | ES275137Y (de) |
WO (1) | WO1983000386A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758409A (en) * | 1986-07-10 | 1988-07-19 | Techicon Instruments Corporation | Microsample cup |
DE8808738U1 (de) * | 1988-07-07 | 1988-09-01 | Diekmann, Stephan, Dr., 3400 Göttingen | Gefäß zur Druchführung von Reaktionen bei erhöhter Temperatur |
US4980129A (en) * | 1989-12-22 | 1990-12-25 | Eastman Kodak Company | Kit of collection vessels of uniform outside dimensions, different volumes |
US6436349B1 (en) | 1991-03-04 | 2002-08-20 | Bayer Corporation | Fluid handling apparatus for an automated analyzer |
CA2384523C (en) * | 1991-03-04 | 2007-01-09 | Bayer Corporation | Automated analyzer |
FR2688888B1 (fr) * | 1992-03-23 | 1994-07-01 | Boy Sa Inst Jacques | Dispositif destine notamment a la mise en óoeuvre de microtechniques d'analyse. |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2252750A (en) * | 1938-08-08 | 1941-08-19 | Walter M Basch | Transparent double walled jar for testing liquids |
US3493306A (en) * | 1965-03-25 | 1970-02-03 | Peter Mayer | Cell for photometric and/or spectrophotometric measurements |
US3811326A (en) * | 1972-02-10 | 1974-05-21 | V Sokol | Disposable dilution system |
US4172670A (en) * | 1977-06-27 | 1979-10-30 | Welker Robert H | Liquid sample collection apparatus |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2302830A (en) * | 1940-10-30 | 1942-11-24 | Sol A Axelrad | Microscope test slide |
US3807955A (en) * | 1971-04-15 | 1974-04-30 | Becton Dickinson Co | Serum/plasma isolator cup |
US3942717A (en) * | 1973-02-09 | 1976-03-09 | Robison William O | Specimen container |
JPS5246778Y2 (de) * | 1975-01-29 | 1977-10-24 | ||
DE2508527C2 (de) * | 1975-02-27 | 1978-11-09 | Walter Sarstedt Kunststoff-Spritzgusswerk, 5223 Nuembrecht | Küvette für optische Untersuchungen von Flüssigkeiten |
-
1982
- 1982-07-19 JP JP50255882A patent/JPS58501146A/ja active Pending
- 1982-07-19 ES ES1982275137U patent/ES275137Y/es not_active Expired
- 1982-07-19 WO PCT/US1982/000980 patent/WO1983000386A1/en not_active Application Discontinuation
- 1982-07-19 EP EP19820902591 patent/EP0084557A4/de not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2252750A (en) * | 1938-08-08 | 1941-08-19 | Walter M Basch | Transparent double walled jar for testing liquids |
US3493306A (en) * | 1965-03-25 | 1970-02-03 | Peter Mayer | Cell for photometric and/or spectrophotometric measurements |
US3811326A (en) * | 1972-02-10 | 1974-05-21 | V Sokol | Disposable dilution system |
US4172670A (en) * | 1977-06-27 | 1979-10-30 | Welker Robert H | Liquid sample collection apparatus |
Non-Patent Citations (1)
Title |
---|
See also references of WO8300386A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPS58501146A (ja) | 1983-07-14 |
EP0084557A1 (de) | 1983-08-03 |
ES275137U (es) | 1984-02-01 |
WO1983000386A1 (en) | 1983-02-03 |
ES275137Y (es) | 1984-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Designated state(s): CH DE FR GB LI |
|
17P | Request for examination filed |
Effective date: 19830621 |
|
RBV | Designated contracting states (corrected) |
Designated state(s): CH DE FR GB LI |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19870202 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HSEI, PAUL K. Inventor name: LISTON, MAX D. |