EP0080835B1 - Pellets for oral administration to ruminants - Google Patents

Pellets for oral administration to ruminants Download PDF

Info

Publication number
EP0080835B1
EP0080835B1 EP82306145A EP82306145A EP0080835B1 EP 0080835 B1 EP0080835 B1 EP 0080835B1 EP 82306145 A EP82306145 A EP 82306145A EP 82306145 A EP82306145 A EP 82306145A EP 0080835 B1 EP0080835 B1 EP 0080835B1
Authority
EP
European Patent Office
Prior art keywords
pellet
active material
polymer
glass
phosphate compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP82306145A
Other languages
German (de)
French (fr)
Other versions
EP0080835A1 (en
Inventor
Cyril Francis Drake
Ronald Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adisseo France SAS
Original Assignee
AEC Societe de Chimie Organique and Biologique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AEC Societe de Chimie Organique and Biologique SA filed Critical AEC Societe de Chimie Organique and Biologique SA
Publication of EP0080835A1 publication Critical patent/EP0080835A1/en
Application granted granted Critical
Publication of EP0080835B1 publication Critical patent/EP0080835B1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0068—Rumen, e.g. rumen bolus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A23K40/35—Making capsules specially adapted for ruminants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/12—Silica-free oxide glass compositions
    • C03C3/16—Silica-free oxide glass compositions containing phosphorus
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0035—Compositions for glass with special properties for soluble glass for controlled release of a compound incorporated in said glass

Definitions

  • This invention relates to administering an active material in the form of pellets to ruminants.
  • a particularly important feed additive is the amino acid methionine (a-amino-y-methylthio-n butyric acid) which is essential to healthy growth.
  • This material cannot however, with present techniques, be utilised effectively by ruminant animals. Food eaten by a ruminant remains in the rumen, where it is exposed to natural bacterial action, for periods up to 24 hours after which it is passed through the remainder of the digestive system in about 1 hour. It has been found that if methionine is fed to a ruminant the material is substantially completely consumed by the rumen bacteria before it can be absorbed by the animal. It is difficult with present techniques to delay release of methionine from a feed additive until the material has reached the post-rumen part of the digestive system.
  • the object of the present invention is to minimise or to overcome this disadvantage.
  • a device for oral administration to a ruminant animal comprising an active material contained or incorporated in a carrier body, wherein said carrier body is relatively insoluble under the low acidity rumen conditions and is relatively soluble under the high acidity post-rumen conditions.
  • certain active materials for example methionine may be supplied e.g. to a ruminant animal in the form of a pellet or granules wherein the active material is contained in a composite material comprising a substantially insoluble food grade polymer and a water soluble particulate material.
  • the composition of the particulate material is chosen such that it is substantially insoluble in the near neutral (pH 6) conditions in the rumen but is highly soluble in the appreciably acid conditions (pH 2) pertaining in the post-rumen part of the alimentary canal.
  • the particulate material dissolves to provide a series of passageways through the polymeric material thus permitting the ingress of water.
  • Such a structure can be employed for the delayed and controlled dissolution of an active material that, prior to the dissolution of the particulate material and the consequent significant increase in the water penetrability of the polymer, is protected by the polymer from dissolution.
  • the soluble particulate material is a soluble glass composition or a mixture of such glass composition.
  • Water soluble glass compositions have the important property that their dissolution rate may be tailored to a desired value by minor composition adjustment thus providing for the manufacture of composite structures with a wide range of dissolution properties.
  • the glasses generally comprise phosphorous pentoxide, as the glass forming oxide of the glass together with one or more further oxides which provide the glass modifying constituents of the composition.
  • the dissolution rate, and the pH of solutions of such compositions are determined by the nature and proportion of the glass modifying oxide or oxides and by the overall molar ratio of glass modifier to glass former.
  • suitable glass compositions but by no means limiting are glasses of the general type where M 2 0 comprises one or more alkali-metal oxides, MO comprises one or more oxides selected from MgO, CaO, ZnO, FeO, CaO. Minor amounts of other glass-formers such as AI 2 0 3 and Si0 2 may be present.
  • the polymer may comprise a wide variety of materials. We prefer to employ cellulosic materials, but other materials may of course also be employed. Typical of such polymers, are polyenes, polyesters, polyamides, polysaccharides, natural gums and latexes, and mixtures and copolymers thereof.
  • the polymer matrix may be thermosetting of thermoplastic. Furthermore, in some applications, the polymer may be cross-linked in any of the known techniques.
  • the active material may be dispersed in the polymer-powdered glass composite, or a body comprising or containing the active material may be encapsulated in the polymer/glass composite.
  • a body comprising or containing the active material may be encapsulated in the polymer/glass composite.
  • the active material is granular and is formed into a body wherein the granules are cemented together by a composite comprising a polymer and a powdered water soluble glass.
  • the glass particles are significantly smaller than the active material granules so that the composite acts as a 'mortar' between the granules thus providing a coherent body.
  • the body may be formed e.g. by pressing, extraction or casting and may be subsequently comminuted.
  • the glass particles dissolve at a controlled rate to provide an array of interconnecting voids in the polymer.
  • the active material can then dissolve through these voids.
  • a pellet or granular material for oral consumption by a ruminant animal may be made by mixing a solid or liquid polymer with a finely divided glass composition and a granulated active material.
  • the active material is a liquid at ambient temperatures it may be absorbed on a solid carrier such as activated silica or bentonite clay. After thorough mixing has been effected the composition is formed into solid coherent bodies by pressing, extrusion or casting.
  • the major volume proportion may comprise active material.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)
  • Medicinal Preparation (AREA)

Description

  • This invention relates to administering an active material in the form of pellets to ruminants.
  • Domesticated animals, for example pigs and poultry, are often supplied with feed additives to encourage growth and/or to maintain the animal in a healthy condition. A particularly important feed additive is the amino acid methionine (a-amino-y-methylthio-n butyric acid) which is essential to healthy growth. This material cannot however, with present techniques, be utilised effectively by ruminant animals. Food eaten by a ruminant remains in the rumen, where it is exposed to natural bacterial action, for periods up to 24 hours after which it is passed through the remainder of the digestive system in about 1 hour. It has been found that if methionine is fed to a ruminant the material is substantially completely consumed by the rumen bacteria before it can be absorbed by the animal. It is difficult with present techniques to delay release of methionine from a feed additive until the material has reached the post-rumen part of the digestive system.
  • The object of the present invention is to minimise or to overcome this disadvantage.
  • According to one aspect of the invention there is provided a device for oral administration to a ruminant animal and comprising an active material contained or incorporated in a carrier body, wherein said carrier body is relatively insoluble under the low acidity rumen conditions and is relatively soluble under the high acidity post-rumen conditions.
  • It is known from DE-A-2838309 that certain active materials, for example methionine may be supplied e.g. to a ruminant animal in the form of a pellet or granules wherein the active material is contained in a composite material comprising a substantially insoluble food grade polymer and a water soluble particulate material. The composition of the particulate material is chosen such that it is substantially insoluble in the near neutral (pH 6) conditions in the rumen but is highly soluble in the appreciably acid conditions (pH 2) pertaining in the post-rumen part of the alimentary canal. I
  • When the structure is immersed in an aqueous medium the particulate material dissolves to provide a series of passageways through the polymeric material thus permitting the ingress of water. Such a structure can be employed for the delayed and controlled dissolution of an active material that, prior to the dissolution of the particulate material and the consequent significant increase in the water penetrability of the polymer, is protected by the polymer from dissolution.
  • We have found that advantageously the soluble particulate material is a soluble glass composition or a mixture of such glass composition. Water soluble glass compositions have the important property that their dissolution rate may be tailored to a desired value by minor composition adjustment thus providing for the manufacture of composite structures with a wide range of dissolution properties.
  • We employ phosphate glasses for this purpose as such materials are relatively non-toxic and also relatively simple to prepare. Furthermore, the techniques for controlling the dissolution rate of these glass systems are well understood. The glasses generally comprise phosphorous pentoxide, as the glass forming oxide of the glass together with one or more further oxides which provide the glass modifying constituents of the composition. The dissolution rate, and the pH of solutions of such compositions are determined by the nature and proportion of the glass modifying oxide or oxides and by the overall molar ratio of glass modifier to glass former.
  • We have also found that the presence of certain metal oxides, for example oxides of most two or three valent metals, reduces the dissolution rate of a glass composition whilst the presence of other metal oxides, in particular alkali metal oxides, increase the dissolution rate. Thus, by suitable adjustment of the ratio of glass-formers to glass modifiers and the proportions of these two types of oxides any desired dissolution rate can be obtained. The techniques of glass dissolution rate and solution pH control are more fully described in European Patent Application No. 80302902.4 published under No. 24891. Moreover, the relative solution rate of the glass at different pHs is determined by the glass composition. Typical of suitable glass compositions, but by no means limiting are glasses of the general type
    Figure imgb0001
    where M20 comprises one or more alkali-metal oxides, MO comprises one or more oxides selected from MgO, CaO, ZnO, FeO, CaO. Minor amounts of other glass-formers such as AI203 and Si02 may be present.
  • Two typical glass compositions are:
    Figure imgb0002
  • which has dissolution rates at pH2 and pH6 in the ratio 3:1 and:
    Figure imgb0003
  • which has dissolution rates at pH2 and pH6 in the ratio 12:1.
  • The polymer may comprise a wide variety of materials. We prefer to employ cellulosic materials, but other materials may of course also be employed. Typical of such polymers, are polyenes, polyesters, polyamides, polysaccharides, natural gums and latexes, and mixtures and copolymers thereof. The polymer matrix may be thermosetting of thermoplastic. Furthermore, in some applications, the polymer may be cross-linked in any of the known techniques.
  • The active material may be dispersed in the polymer-powdered glass composite, or a body comprising or containing the active material may be encapsulated in the polymer/glass composite. When the device is administered to a ruminant animal it remains in the rumen for a period of up to 24 hours during which time substantially no dissolution of the glass takes place. The device is then passed to the post-rumen wherein the relatively acid conditions pertaining therein cause rapid dissolution of the glass permitting consequent release of the active material.
  • In a particularly advantageous arrangement the active material is granular and is formed into a body wherein the granules are cemented together by a composite comprising a polymer and a powdered water soluble glass. The glass particles are significantly smaller than the active material granules so that the composite acts as a 'mortar' between the granules thus providing a coherent body. The body may be formed e.g. by pressing, extraction or casting and may be subsequently comminuted.
  • When such a body is immersed in an aqueous medium of suitable pH the glass particles dissolve at a controlled rate to provide an array of interconnecting voids in the polymer. The active material can then dissolve through these voids.
  • Typically a pellet or granular material for oral consumption by a ruminant animal may be made by mixing a solid or liquid polymer with a finely divided glass composition and a granulated active material. Where the active material is a liquid at ambient temperatures it may be absorbed on a solid carrier such as activated silica or bentonite clay. After thorough mixing has been effected the composition is formed into solid coherent bodies by pressing, extrusion or casting. In such a pellet or granular material the major volume proportion may comprise active material.

Claims (7)

1. A pellet for oral administration to a ruminant animal comprising an active material contained or incorporated in a carrier body consisting of a polymer selected from the group of cellulosic materials, polyenes, polyester, polyamides, polysaccharides, natural gums and latexes, and mixtures and copolymers thereof and a phosphate compound characterised in that the phosphate compound is a water soluble phosphate glass or a mixture of such glasses which is substantially insoluble under the pH conditions pertaining in the rumen but is soluble under the pH conditions pertaining in the post-rumen.
2. A pellet according to claim 1 characterised in that the glasses generally comprises phosphorous pentoxide with one or more further oxides.
3. A pellet as claimed in claim 1 or 2 characterised in that the active material is methionine.
, 4. A pellet as claimed in claim 1 or 2 characterised in that the active material is a liquid absorbed onto activated silica or a bentonite clay.
5. A method of making a ruminant feed additive pellet, as claimed in claim 1 or-2, said method including, mixing the active material with a powdered phosphate compound and a polymer, and pressing, moulding, extruding or casting the mixture to form a coherent composite.
6. A method of making a ruminant feed additive pellet as claimed in claim 1 or 2, said method including coating an active material with a composite material comprising a powdered phosphate compound and a polymer.
7. A method of treating a ruminant animal, said method including administering to the animal a feed additive pellet as claimed in claim 1 or 2.
EP82306145A 1981-11-18 1982-11-18 Pellets for oral administration to ruminants Expired EP0080835B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08134751A GB2109665B (en) 1981-11-18 1981-11-18 Composite animal feed additives
GB8134751 1981-11-18

Publications (2)

Publication Number Publication Date
EP0080835A1 EP0080835A1 (en) 1983-06-08
EP0080835B1 true EP0080835B1 (en) 1986-07-02

Family

ID=10525973

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82306145A Expired EP0080835B1 (en) 1981-11-18 1982-11-18 Pellets for oral administration to ruminants

Country Status (5)

Country Link
US (1) US4473545A (en)
EP (1) EP0080835B1 (en)
JP (1) JPS58169445A (en)
DE (1) DE3271899D1 (en)
GB (1) GB2109665B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2111388A (en) * 1981-11-18 1983-07-06 Standard Telephones Cables Ltd Composite materials
GB2139868B (en) * 1983-05-16 1987-04-23 Vaasanmylly Oy Feedstuff for ruminants and a process for its production
GB2146531B (en) * 1983-09-15 1987-04-29 Stc Plc Controlled release system
GB8331661D0 (en) * 1983-11-26 1984-01-04 Standard Telephones Cables Ltd Water soluble glass composition
FR2575039B1 (en) * 1984-12-20 1990-01-19 Aec Chim Organ Biolog COMPOSITIONS FOR COATING FOOD ADDITIVES FOR RUMINANTS AND FOOD ADDITIVES THEREFOR
GB8508173D0 (en) * 1985-03-28 1985-05-01 Standard Telephones Cables Ltd Controlled delivery device
US4659541A (en) * 1985-05-01 1987-04-21 Westinghouse Electric Corp. Nuclear fuel rod support grid with improved multiple dimple arrangement
US4670248A (en) * 1985-08-15 1987-06-02 International Minerals & Chemical Corp. Olivine bolus
US4808412A (en) * 1987-06-11 1989-02-28 Eastman Kodak Company Rumen-stable compositions
GB8917063D0 (en) * 1989-07-26 1989-09-13 Pilkington Controlled Release Composite bolus manufacture and use
US5165946A (en) * 1990-03-07 1992-11-24 Engelhard Corporation Animal feed additive and method for inactivating mycotoxins present in animal feeds
FR2785807B1 (en) * 1998-11-13 2000-12-15 D Aquitaine Cie Chim FOOD SUPPLEMENT FORMULATION, FOOD COMPOSITION COMPRISING SAME
BRPI0518845A2 (en) 2004-12-06 2008-12-09 Sage Biosciences Inc Method for increasing resistance to ruminal inactivation of a strain of gram-positive lysine-producing bacteria, feed supplementation of protected lysine in the rumen, and methods for increasing the metabolically available lysine content of a feedstuff for ruminants, and in vitro for to evaluate the resistance of a strain of lysine-producing bacteria to in vivo rumen inactivation
EP2724670B1 (en) 2012-10-26 2015-06-17 Pekka Kankfelt Detecting altered pH levels of rumens
DE102021131457A1 (en) 2021-11-30 2023-06-01 Farmerscent GmbH Crude fiber crust pellets, animal feed containing them and corresponding processes and uses

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2023547A1 (en) * 1970-05-14 1971-12-02 Deutsche Gold- U. Silber-Scheideanstalt, Vormals Roessler, 6000 Frankfurt Compound feed additives containing amino acids for feeding ruminants
EG10802A (en) * 1971-02-19 1976-10-31 Bayer Ag A process for embeding veterinary substances and their protection against the influence of the gastric juice of the rumen
NO133648C (en) * 1971-03-17 1976-06-09 Rumen Chemie Ag
GB1440217A (en) * 1973-09-26 1976-06-23 Ici Ltd Compositions
SE418749B (en) * 1977-04-04 1981-06-22 Ewos Ab FILM TRANSMISSION POLICIES FOR FEED LIFE AND MEDICINAL PRODUCTS AND PH-DEPENDENT SOLUBILITY CHARACTERISTICS IN Aqueous media AND PROCEDURE FOR THEIR PREPARATION
US4181708A (en) * 1977-09-02 1980-01-01 Eastman Kodak Company Rumen-stable pellets
US4196187A (en) * 1977-09-02 1980-04-01 Eastman Kodak Company Rumen-stable pellets
FR2401619A1 (en) * 1977-09-02 1979-03-30 Eastman Kodak Co PROCESS FOR PREPARING INDEGRADABLE GRANULES IN THE PANSE DES RUMINANTS
US4181709A (en) * 1977-09-02 1980-01-01 Eastman Kodak Company Rumen-stable pellets
US4181710A (en) * 1977-09-02 1980-01-01 Eastman Kodak Company Rumen-stable pellets
US4177255A (en) * 1977-09-02 1979-12-04 Eastman Kodak Company Rumen-stable pellets
DE2807132C2 (en) * 1978-02-20 1983-11-03 Battelle-Institut E.V., 6000 Frankfurt Implantable pharmaceutical depot
US4199561A (en) * 1979-02-26 1980-04-22 The Dow Chemical Company Coated nutrients and medicaments for veterinary use
US4256785A (en) * 1979-07-25 1981-03-17 Eastman Kodak Company Pellet coating process

Also Published As

Publication number Publication date
GB2109665B (en) 1985-07-24
US4473545A (en) 1984-09-25
GB2109665A (en) 1983-06-08
JPH0370495B2 (en) 1991-11-07
JPS58169445A (en) 1983-10-05
DE3271899D1 (en) 1986-08-07
EP0080835A1 (en) 1983-06-08

Similar Documents

Publication Publication Date Title
EP0080835B1 (en) Pellets for oral administration to ruminants
US4407786A (en) Glass composition
CA1109793A (en) Animal feed supplement blocks
CN1057671C (en) Coated vitamin C preparation for animal feed, production and use thereof
NZ203769A (en) Feed additives for ruminants;granules and tablets
EP0147932B1 (en) Water soluble glass compositions
JPH09172979A (en) Feed additive for ruminant containing new compound salt of phosphoric acid and amino acid and antacid
GB2081703A (en) Controlled Release Glass
EP0781100A1 (en) Animal feedstuffs and additives
US4283227A (en) ZnO--SeO2 --R2 O soluble glass
US4662879A (en) Rumen bolus
WO1997024314A1 (en) Composite salt of phosphoric and amino acids with polyvalent metals and feed additive composition for ruminants
JPH0424977B2 (en)
US7105191B2 (en) Calcium supplement for animals and method for making same
JPS60153764A (en) Feed for fish farming and production thereof
KR880002185B1 (en) Process for producing mineral feed shaped pellet
CA1214061A (en) Feed additives for ruminants
JP3361364B2 (en) Ruminant feed additives and manufacturing method
JPS6338176B2 (en)
EP0025024B2 (en) A method of producing so-called lick stones
JPH01218558A (en) Feed additive for ruminant
GB2110086A (en) Subcutaneous implant
KR880002186B1 (en) Process for producing solid salt of feed
WO1999033341A1 (en) Substantially water-insoluble matrix containing bioactive substances for slow release
SU762844A1 (en) Method of preparing vitamine and mineral additive for feed

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): BE CH DE FR IT LI NL SE

17P Request for examination filed

Effective date: 19830620

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: A.E.C. - SOCIETE DE CHIMIE ORGANIQUE ET BIOLOGIQU

ITF It: translation for a ep patent filed

Owner name: BARZANO' E ZANARDO MILANO S.P.A.

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): BE CH DE FR IT LI NL SE

REF Corresponds to:

Ref document number: 3271899

Country of ref document: DE

Date of ref document: 19860807

ET Fr: translation filed
NLR4 Nl: receipt of corrected translation in the netherlands language at the initiative of the proprietor of the patent
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
REG Reference to a national code

Ref country code: FR

Ref legal event code: CD

Ref country code: FR

Ref legal event code: CA

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19911128

Year of fee payment: 10

ITTA It: last paid annual fee
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19911130

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 19911230

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 19921007

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19921028

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19921030

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Effective date: 19921130

Ref country code: CH

Effective date: 19921130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Effective date: 19930601

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee
REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Effective date: 19930803

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Effective date: 19931119

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Effective date: 19931130

BERE Be: lapsed

Owner name: AEC - SOC.DE CHIMIE ORGANIQUE ET BIOLOGIQUE

Effective date: 19931130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Effective date: 19940729

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

EUG Se: european patent has lapsed

Ref document number: 82306145.2

Effective date: 19940610