EP0070777A1 - An improved drop counter - Google Patents

An improved drop counter Download PDF

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Publication number
EP0070777A1
EP0070777A1 EP82401334A EP82401334A EP0070777A1 EP 0070777 A1 EP0070777 A1 EP 0070777A1 EP 82401334 A EP82401334 A EP 82401334A EP 82401334 A EP82401334 A EP 82401334A EP 0070777 A1 EP0070777 A1 EP 0070777A1
Authority
EP
European Patent Office
Prior art keywords
channel
chamber
nipple
container
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP82401334A
Other languages
German (de)
English (en)
French (fr)
Inventor
Jean-Claude Paoletti
Jean-François Peccoux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratories Merck Sharp and Dohme Chibret SAS
Organon Pharma UK Ltd
Original Assignee
Laboratories Merck Sharp and Dohme Chibret SAS
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratories Merck Sharp and Dohme Chibret SAS, Merck Sharp and Dohme Ltd filed Critical Laboratories Merck Sharp and Dohme Chibret SAS
Publication of EP0070777A1 publication Critical patent/EP0070777A1/en
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers

Definitions

  • This invention relates to a drop counter device.
  • Drop counters are devices which are used very widely in the administration of medicaments, in particular collyria.
  • Collyria containing active principles are presently used to an increasing extent and they have a high pharmacological activity but are toxic and have secondary effects when the prescribed doses are not observed, in particular due to a faulty dropping action of the drop counter.
  • Drop counters which are presently used may be divided into two groups.
  • the first group comprises devices which have a tube surmounted by a nipple and are integral with a cap which is usually screwed onto the container.
  • the assembly of tube, nipple and cap has to be removed for use as a drop counter.
  • This type of device has numerous disadvantages. In particular, it is fairly burdensome because it requires the production and assembly of at least three distinct parts.
  • nipple-type drop counters are preferably used, in particular for administering collyria, these drop counters being tightly attached onto the opening of the container, which is usually a bottle containing the medicament in liquid form.
  • the liquid is ejected by the deformation of a hollow nipple which is pierced at the end by a hole. Direct pressure on the liquid generally results in a stream of liquid being ejected, not drops.
  • the size of the opening in the nipple is of the order of from 0.5 to 0.8 mm. Under these conditions, the risks of obturation as a result of one of the components of the mixture being deposited are quite considerable.
  • the present invention proposes a drop counter device in which the dropping action is improved. Moreover, in the device according to this invention, the presence of a chamber of determined volume allows a predetermined quantity of the product to be delivered by pressure on this chamber.
  • the device according to the present invention has the advantage that a delivery channel for the liquid may be used which is of a fairly large diameter, of the order of from 1 to 1.5 mm, which greatly reduces the risks of obturation.
  • the present invention proposes a drop counter device adapted to be positioned over the opening of a container holding a liquid, characterised in that the drop counter device consists of a nipple adapted to be tightly attached onto said opening and containing a substantially undeformable channel connecting the inside of the container to the outside thereof, the said nipple also containing a chamber, of which at least one wall is elastically deformable under pressure, the chamber being adjacent to said channel and in contact with the inside of the container,, and the said channel and said channel being separated by a wall which is substantially undeformable.
  • the largest dimension of the chamber preferably extends substantially parallel to the axis of the channel and the said chamber is completely situated in one of the half-spaces defined by a plane passing through the axis of the channel.
  • the nipple comprises two substantially flat parts which are positioned on both sides of the channel, one of these parts being positioned on the elastically deformable part of the chamber wall.
  • the volume of the chamber is calculated so that a complete pressure delivers a dose or a complete submultiple of a therapeutic dose of said medicament.
  • Another advantage of the device according to the present invention is that it may be moulded in a single piece from a supple and elastic material, such as, for example, natural rubber or synthetic rubber.
  • the channel is preferably in the shape of a truncated cone, the widest part of which is positioned towards the inside of the container.
  • the internal diameter of the channel at its end in contact with the exterior is preferably from O.b to 2 mm, especially from 1 to 1.5 mm.
  • the device according to the invention illustrated in Figures 1 to 3 comprises a base 1 surmounted by a body 2 and a head 3.
  • the base 1 which is substantially cylindrical in shape, has a cavity 4 inside, the cross section of which is similar to or smaller than the cross section of the opening of the bottle on which the base 1 is to be appliea.
  • This base 1 the external diameter of which is greater than that of the body 2, allows the device to be attached on to the bottle by means of one or.more connection elements which rest on the edge 5 and on a corresponding part of the bottle.
  • the said base 1 is surmounted by a body 2 and by a head 3 which are pierced along their vertical axis by a channel 6 which is in contact with the cavity 4 of the base and which issues outside through an outlet tube 7.
  • a chamber 8 is positioned on one side of the bony 2 of the device and it extends substantially parallel to the channel and is separated therefrom by a practically undeformable partition 9.
  • the chamber 8 is in contact with the hollow part 4 of the base.
  • the external wall 10 of said chamber 8 is thin so that it may be deformed simply by external pressure.
  • the part of the body 2 opposite the chamber 8 comprises a flat surface 11; likewise, the external face of the chamber is also flattened on a surface 12.
  • the deformable chamber only occupies a restricted part of the whole of the device and its volume is determined as a function of the characteristics of the liquid to be delivered, so that a complete pressure on the chamber only delivers a determined volume of liquid which preferably corresponds to a therapeutic dose or to a complete submultiple of the therapeutic dose.
  • the device as it has been described may be attached onto a bottle by any appropriate means and, in a variation of the device, it is possible for the base of the device to be provided with a circular groove to allow it to be directly and tightly attached onto a circular boss provided on the periphery of the opening of the bottle.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Level Indicators Using A Float (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
EP82401334A 1981-07-20 1982-07-16 An improved drop counter Withdrawn EP0070777A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8114083 1981-07-20
FR8114083A FR2509693B1 (fr) 1981-07-20 1981-07-20 Compte-gouttes perfectionne

Publications (1)

Publication Number Publication Date
EP0070777A1 true EP0070777A1 (en) 1983-01-26

Family

ID=9260668

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82401334A Withdrawn EP0070777A1 (en) 1981-07-20 1982-07-16 An improved drop counter

Country Status (7)

Country Link
EP (1) EP0070777A1 (enExample)
JP (1) JPS5826223A (enExample)
DK (1) DK326382A (enExample)
ES (1) ES274585Y (enExample)
FR (1) FR2509693B1 (enExample)
GR (1) GR77223B (enExample)
PT (1) PT75272B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63175727A (ja) * 1987-01-02 1988-07-20 ヘレナ　ラボラトリ−ズ　コ−ポレイシヨン 液体の計量分配の方法及び装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR659542A (fr) * 1927-09-15 1929-06-29 Capuchon servant d'instillateur et de compte-gouttes
DE824094C (de) * 1950-03-26 1951-12-10 Luise Benofsky Geb Herberger Tropfstoepsel
FR1100362A (fr) * 1954-03-01 1955-09-20 Centrale De Verreries Bouchon-aspirateur pour récipients contenant des liquides
FR1252753A (fr) * 1959-12-22 1961-02-03 Perfectionnements aux compte-gouttes, notamment pour flacons collyres
US3087656A (en) * 1961-03-31 1963-04-30 Dougherty Brothers Inc Squeeze cap for dispensing liquid in drop units
FR1333865A (fr) * 1962-06-19 1963-08-02 Anciens Etablissements E Rober Bouchon formant compte-gouttes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR659542A (fr) * 1927-09-15 1929-06-29 Capuchon servant d'instillateur et de compte-gouttes
DE824094C (de) * 1950-03-26 1951-12-10 Luise Benofsky Geb Herberger Tropfstoepsel
FR1100362A (fr) * 1954-03-01 1955-09-20 Centrale De Verreries Bouchon-aspirateur pour récipients contenant des liquides
FR1252753A (fr) * 1959-12-22 1961-02-03 Perfectionnements aux compte-gouttes, notamment pour flacons collyres
US3087656A (en) * 1961-03-31 1963-04-30 Dougherty Brothers Inc Squeeze cap for dispensing liquid in drop units
FR1333865A (fr) * 1962-06-19 1963-08-02 Anciens Etablissements E Rober Bouchon formant compte-gouttes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63175727A (ja) * 1987-01-02 1988-07-20 ヘレナ　ラボラトリ−ズ　コ−ポレイシヨン 液体の計量分配の方法及び装置

Also Published As

Publication number Publication date
JPS5826223A (ja) 1983-02-16
GR77223B (enExample) 1984-09-11
FR2509693A1 (fr) 1983-01-21
ES274585U (es) 1984-04-16
PT75272B (en) 1985-11-12
FR2509693B1 (fr) 1985-06-21
PT75272A (en) 1982-08-01
ES274585Y (es) 1984-12-01
DK326382A (da) 1983-01-21

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT BE CH DE GB IT LI LU NL SE

17P Request for examination filed

Effective date: 19830721

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19850115

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PAOLETTI, JEAN-CLAUDE

Inventor name: PECCOUX, JEAN-FRANCOIS