EP0069005B2 - Installation de lyophilisation à double série d'étagères - Google Patents

Installation de lyophilisation à double série d'étagères Download PDF

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Publication number
EP0069005B2
EP0069005B2 EP82401135A EP82401135A EP0069005B2 EP 0069005 B2 EP0069005 B2 EP 0069005B2 EP 82401135 A EP82401135 A EP 82401135A EP 82401135 A EP82401135 A EP 82401135A EP 0069005 B2 EP0069005 B2 EP 0069005B2
Authority
EP
European Patent Office
Prior art keywords
series
racks
casing
frame
installation according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP82401135A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0069005A1 (fr
EP0069005B1 (fr
Inventor
Michel Baron
Philippe Larrat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Usifroid SA
Original Assignee
Usifroid SA
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Publication date
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Application filed by Usifroid SA filed Critical Usifroid SA
Priority to AT82401135T priority Critical patent/ATE8707T1/de
Publication of EP0069005A1 publication Critical patent/EP0069005A1/fr
Publication of EP0069005B1 publication Critical patent/EP0069005B1/fr
Application granted granted Critical
Publication of EP0069005B2 publication Critical patent/EP0069005B2/fr
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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • lyophilization is a process for removing water from the structure of organic or mineral substances, in particular food products, pharmaceuticals, etc. and which essentially consists of a freezing operation then a sublimation operation under vacuum .
  • the lyophilisation installations currently known comprise either (FR-A-2,198,611) two separate compartments: one dedicated to freezing, the other to sublimation, the latter being able to be put under vacuum, or, in the case of installations of the aforementioned type, a single compartment in which the two freezing and sublimation operations are carried out and which can, for this second operation, be put under vacuum.
  • the present invention aims to overcome the above-mentioned drawbacks and for this purpose proposes a freeze-drying installation of the aforementioned type in which the above-mentioned shelves form two separate series, namely a first series of freezing shelves provided only with means of cooling to a temperature below 0 ° C and a second series of sublimation shelves provided only with heating means at a temperature above 0 0 C, in that a transfer device is provided for passing the trays from the shelves of the first series to those of the second series, and in that means are provided to put the entire enclosure under vacuum during sublimation.
  • Each series of shelves thus remains at a constant or substantially constant temperature, for example - 40 ° C. for the first series and +40 ° C. for the second series, which eliminates the loss of energy and time, the device for transfer, ensuring the movement of the trays, allowing the freezing and sublimation to be carried out successively.
  • the shelves of one series are coplanar with the shelves of the other series and the aforementioned transfer device is provided for driving the trays by sliding them from one shelf to another. This gives a very simple configuration and very reliable operation of the installation.
  • the aforementioned enclosure is provided, between the two series of shelves, with a set of retractable shutters forming a thermal barrier between said series.
  • This set of retractable shutters stops the radiation and convection between the two series of shelves and thus ensures a better thermal efficiency of the installation, while allowing the free sliding of the trays.
  • the installation essentially comprises an enclosure or tank 10 of generally parallelepipedal shape, capable of being placed under vacuum and closed, at its two opposite ends, by doors 11, 12 each provided with 'a window 11a, 12a allowing visual control of the products being processed.
  • enclosure 10 Inside the enclosure 10 are mounted two series of superimposed shelves or plates 20 and 30 intended to receive bins B containing the products to be lyophilized, as well as a transfer device 40 for passing the bins B from the shelves from the 20 series to the 30 series.
  • the superimposed shelves 20a, 20b, 20c ... and 30a, 30b, 30c ... of the series 20 and 30 are provided with known cooling and heating means, constituted for example by coils (not shown), in which circulates a cooling fluid and a heating fluid respectively.
  • the lines between these coils and the necessary sources of cooling and heating fluids (not shown) have been indicated at 21, 22 and 31, 32.
  • the shelves 20a, 20b, 20c ... and 30a, 30b, 30c are further provided with side edges 23a, 23b, 23c and 33a, 33b, 33c ... allows both the guidance of the tanks B during their translation.
  • the temperatures of the refrigerant and heating fluids must be respectively less than and greater than 0 ° C. so as to allow the freezing of the aqueous substances contained in the products to be lyophilized, then the sublimation, under vacuum, of these aqueous substances. These temperatures can be, for example, -40 ° C and + 40 ° C.
  • each shelf 20a, 20b, 20c ... of the series of cold shelves 20 is coplanar with a shelf 30a, 30b, 30c ... of the series of hot shelves 30.
  • the transfer device generally designated by 40, comprises a frame 41 movable in translation in one direction and in the other in the enclosure 10 and on which is articulated a pushing member of the tanks 42 and a mechanism 43 to drive said frame in translation.
  • the frame 41 is formed of two identical side cheeks 410 provided with support rollers 411 which roll on horizontal rails 15 fixed on the internal walls of the enclosure 10 and pressure rollers 413 bearing on the side walls of said enclosure.
  • the cheeks 410 are also provided with racks 415 for the translational drive of the frame 41.
  • the pushing member of the trays 42 comprises a set of horizontal bars 420 fixed on two uprights 421 articulated, by means of links 422, on the frame 41.
  • Each upright 421 is provided, at its lower part, with a roller 423 cooperating with a fixed ramp or cam 13 mounted on the enclosure.
  • the profile of the ramp 13 is provided for controlling the positioning of the member 42 relative to the frame 41 so that the bars 420 occupy either a low position allowing the placing of the trays B on the shelves 20a, 20b, etc. .. ( Figure 2 and solid lines in Figure 5), or a high position so as to engage said bins B and drive them in translation, shelves of the series 20 on those of the series 30 ( Figure 4 and dashes of the figure 5).
  • the ramp 13 is provided, for this purpose, in the vicinity of its left end (looking at Figure 2) with a sharply inclined portion 13a.
  • the mechanism 43 for translational drive of the frame 41 comprises two shafts 430 mounted vertically and rotatably in the enclosure 10, each shaft 430 being provided with two series of grooves 431 intended to mesh with the racks 415 mounted on the two lateral cheeks 410 of said frame 41 (see FIG. 5).
  • the rotation drive of each shaft 430 is provided by the same electric motor 432 located outside the enclosure, by means of a right angle gear 433, of a transmission of any known type, indicated in 434 provided so that the two shafts 430 rotate in synchronism and in opposite directions and of a pinion 435 keyed to the upper part of said shaft 430, which crosses the wall of the enclosure 10.
  • a seal 436 ensuring vacuum sealing is provided for this purpose.
  • rollers 16 and 17 In the enclosure 10, and integral with the latter, are mounted upper and lower guide rollers 16 and 17 respectively which ensure a rectilinear movement of the frame 41 by opposing the lateral thrust exerted on said frame at the racks.
  • the rollers 16 are supported on the internal faces of the upper part of the cheeks 410 while the rollers 17 are supported on angles 414 fixed to the lower part of the cheeks 410.
  • the installation operates as follows: after bringing the shelves 20 to the predetermined negative temperature, the tanks B are placed in position, manually or automatically, on said shelves in order to obtain the freezing of the products. Then, as soon as said freezing temperature is obtained, the chamber is placed under vacuum and sublimation is carried out by passing the tanks B from the cold plates 20 to the hot plates 30. For this, the engine 432 is started. which, by means of the shafts 430, drives in translation, from left to right while looking at FIGS. 2 and 4, the frame 41.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
  • Warehouses Or Storage Devices (AREA)
  • Holders For Apparel And Elements Relating To Apparel (AREA)
  • Handcart (AREA)
EP82401135A 1981-07-01 1982-06-22 Installation de lyophilisation à double série d'étagères Expired EP0069005B2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82401135T ATE8707T1 (de) 1981-07-01 1982-06-22 Lyophilisierungsanlage mit zwei nebeneinanderstehenden regalgestellen.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8112926 1981-07-01
FR8112926A FR2508993A1 (fr) 1981-07-01 1981-07-01 Installation de lyophilisation a double serie d'etageres

Publications (3)

Publication Number Publication Date
EP0069005A1 EP0069005A1 (fr) 1983-01-05
EP0069005B1 EP0069005B1 (fr) 1984-07-25
EP0069005B2 true EP0069005B2 (fr) 1989-07-19

Family

ID=9260069

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82401135A Expired EP0069005B2 (fr) 1981-07-01 1982-06-22 Installation de lyophilisation à double série d'étagères

Country Status (7)

Country Link
US (1) US4449305A (da)
EP (1) EP0069005B2 (da)
JP (1) JPS5849884A (da)
AT (1) ATE8707T1 (da)
CA (1) CA1189319A (da)
DE (1) DE3260464D1 (da)
FR (1) FR2508993A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745771A (en) * 1983-08-23 1988-05-24 Board Of Regents, The University Of Texas System Apparatus and method for cryopreparing biological tissue for ultrastructural analysis
US4676070A (en) * 1984-11-30 1987-06-30 The Board Of Regents, The University Of Texas Apparatus and method for cryopreparing biological tissue
US4742690A (en) * 1983-08-23 1988-05-10 Board Of Regents, The University Of Texas System Apparatus and method for cryopreparing biological tissue for ultrastructural analysis
US4624512A (en) * 1985-06-10 1986-11-25 Hull Corporation Processing cabinet with sub-door access
US5044165A (en) * 1986-12-03 1991-09-03 Board Of Regents, The University Of Texas Cryo-slammer
DE4000913A1 (de) * 1990-01-15 1991-09-12 Leybold Ag Verfahren und vorrichtung zum einfrieren eines der gefriertrocknung zu unterwerfenden produktes
US6122836A (en) * 1998-05-07 2000-09-26 S.P. Industries, Inc., The Virtis Division Freeze drying apparatus and method employing vapor flow monitoring and/or vacuum pressure control
JP3653239B2 (ja) * 2001-06-14 2005-05-25 共和真空技術株式会社 食品・薬品等の凍結乾燥装置
US7347004B1 (en) 2005-01-13 2008-03-25 Lyophilization Services Of New England, Inc. Freeze drying apparatus and method
GB0525115D0 (en) * 2005-12-09 2006-01-18 Oxford Biosensors Ltd Freeze drying of target substances
US9121637B2 (en) * 2013-06-25 2015-09-01 Millrock Technology Inc. Using surface heat flux measurement to monitor and control a freeze drying process
US10605527B2 (en) 2015-09-22 2020-03-31 Millrock Technology, Inc. Apparatus and method for developing freeze drying protocols using small batches of product
US10113797B2 (en) * 2016-09-09 2018-10-30 Sp Industries, Inc. Energy recovery in a freeze-drying system
CN107830689A (zh) * 2017-10-31 2018-03-23 山东华玫生物科技有限公司 一种玫瑰花产业化冻干生产系统及工艺
US11287185B1 (en) 2020-09-09 2022-03-29 Stay Fresh Technology, LLC Freeze drying with constant-pressure and constant-temperature phases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3242575A (en) * 1960-11-05 1966-03-29 Manaresi Alessandra Lyophilization apparatus
DE1198294B (de) * 1963-04-06 1965-08-05 Leybold Hochvakuum Anlagen Kontinuierlich arbeitende Gefriertrocknungs-kammer fuer Gueter in als ihre spaetere Verpackung dienenden Schalen
FR1398067A (fr) * 1964-03-25 1965-05-07 Bonnet Ets Perfectionnements apportés aux dispositifs de lyophilisation
FR1415793A (fr) * 1964-09-18 1965-10-29 Bonnet Ets Perfectionnements apportés aux dispositifs et aux procédés de lyophilisation
US3667135A (en) * 1970-12-24 1972-06-06 Horton John T Vibratory conveyor system
US3740860A (en) * 1972-07-31 1973-06-26 Smitherm Industries Freeze drying method and apparatus
JPS5432180A (en) * 1977-08-17 1979-03-09 Nitto Electric Ind Co Ltd Tubular membrane separator

Also Published As

Publication number Publication date
FR2508993B1 (da) 1983-11-04
ATE8707T1 (de) 1984-08-15
EP0069005A1 (fr) 1983-01-05
FR2508993A1 (fr) 1983-01-07
DE3260464D1 (en) 1984-08-30
JPS5849884A (ja) 1983-03-24
EP0069005B1 (fr) 1984-07-25
CA1189319A (fr) 1985-06-25
US4449305A (en) 1984-05-22

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