EP0029332A1 - Zahnreinigungszusammensetzungen - Google Patents

Zahnreinigungszusammensetzungen Download PDF

Info

Publication number
EP0029332A1
EP0029332A1 EP80304018A EP80304018A EP0029332A1 EP 0029332 A1 EP0029332 A1 EP 0029332A1 EP 80304018 A EP80304018 A EP 80304018A EP 80304018 A EP80304018 A EP 80304018A EP 0029332 A1 EP0029332 A1 EP 0029332A1
Authority
EP
European Patent Office
Prior art keywords
dentifrice composition
weight
dentifrice
composition according
teeth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP80304018A
Other languages
English (en)
French (fr)
Inventor
Hideki Aoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dental Chemical Co Ltd
Original Assignee
Dental Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP14701179A external-priority patent/JPS5673014A/ja
Priority claimed from JP14701279A external-priority patent/JPS5673015A/ja
Application filed by Dental Chemical Co Ltd filed Critical Dental Chemical Co Ltd
Publication of EP0029332A1 publication Critical patent/EP0029332A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof

Definitions

  • the invention relates to dentifrice compositions.
  • a dentifrice composition containing synthetic hydroxyapatite powder.
  • the composition is preferably neutral or weakly alkaline, the preferred maximum pH value being substantially 9.
  • the dentifrice composition of the present invention is effective in eliminating plaque (a colony of bacteria) from a tooth surface and also has some fortifying and remineralizing effect on the enamel coating of the tooth.
  • a conventional dentifrice contains, as a tooth-cleaning and abrading agent, a mineral, such as colloidal silica, etc. While these abrading agents are used to remove contaminants on teeth, it is essential that they do not harm the teeth.
  • the dentifrice composition of the present invention contains a suitable amount of synthetic hydroxyapatite powder which can remove plaque as well as substances contaminating the teeth very effectively.
  • synthetic hydroxyapatite has a hardness similar to that of the enamel portion of the tooth and can impart an appropriate abrading effect on the enamel portion during brushing of the teeth.
  • synthetic hydroxyapatite which, in preferred compositions has an average particle size of the hydroxyapatite powder of about 2p and a maximum particle size thereof 10p or less,has a large surface area and an excellent absorptivity.
  • the dentifrice composition may further contain 0.1 to 20% by weight of NaCl and/or KCl and 0.003 to 3% by weight of MgCl 2 , based on the weight of the composition.
  • the latter dentifrice composition of the present invention can deposit crystals of hydroxyapatite on the surfaces of the teeth more effectively than compositions without these chlorides.
  • the solubility of hydroxy- apatite in water is increased in the presence of the chlorides specified above.
  • hydroxyapatite is a salt which is only slightly soluble in water, the ion products of its ions (Ca ++ ), (HP0 4 ), etc., dissolved and ionised in water in the dentifrice, are small. This means that the ion products present for promoting coating of the surfaces of the teeth, i.e. depositing crystals of hydroxyapatite on the surfaces of the teeth, are small.
  • the dentifrice composition of the present invention may include various additives which are commonly employed in dentifrices and may further include, if desired,citric acid, lactic acid, acetic acid, pyrrolic acid, glutamine, proline, serine, glycine, etc.
  • Examples 1 to 7 and 11 to 17 respectively show formulations of the dentifrice compositions in accordance with the present invention in terms of parts by weight and Examples 8 to 10, 18 and 19 are to substantiate effects of the compositions of the present invention.
  • a 0.1% solution of Neutral Red was applied to the front teeth of each of three male adults A,B, and C (22 to 25 years old), who had been using conventional, commercially available dentifrices. Thereafter, a similar dyeing operation was conducted one day after they started to use the dentifrice of Example 1 and the plaque-stained areas before and after the change of the dentifrice were compared.
  • the stained area after the change was about 10% of the initial stained area and it was confirmed that the decontamination of the plaque areas was about 90%.
  • the decontamination of the plaque areas was about 50%.
  • An adult's permanent tooth was sliced in two using a prisma adamantinum to form a section having a thickness of about 200pm.
  • a saturated solution of hydroxyapatite was prepared by stirring hydroxyapatite'powder into distilled water in quantities equivalent to 1g hydroxyapatite per 100ml water.
  • the supernatant liquid was passed over the prepared tooth section at a flow rate of 0.6ml/min.
  • the section was observed continuously with the use of a polarization microscope and it was confirmed that the section became coated with material resembling apatite crystals to a thickenss of about 1 ⁇ m after 14 hours.
  • hydroxyapatite powder 1g was introduced into 100ml of distilled water at 37°C and NaCl and MgCl 2 were added in various concentrations.
  • the calcium ion concentrations of the respective solutions were measured and it was confirmed that the solubility of hydroxyapatite was increased by adding NaCl and MgCl 2 .
  • the calcium ion concentrations 10 days after the preparation of the solutions were as follows:
  • An adult's permanent tooth was sliced in two using a prisma adamantinum to prepare a section about 200 ⁇ m thick.
  • the enamel portion was removed to expose the dentine portion.
  • a saturated solution of hydroxyapatite in distilled water containing 0.001% of MgCl 2 and 0.9% of NaCl was passed over the prepared tooth-section at a flow rate 0.6ml/min.
  • the section was observed continuously with the use of a polarization microscope and it was confirmed that the surfaces of the section were coated all over with material resembling apatite- crystals to a thickness of about 5pm.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
EP80304018A 1979-11-15 1980-11-11 Zahnreinigungszusammensetzungen Withdrawn EP0029332A1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP147011/79 1979-11-15
JP14701179A JPS5673014A (en) 1979-11-15 1979-11-15 Toothpaste composition
JP14701279A JPS5673015A (en) 1979-11-15 1979-11-15 Toothpaste composition
JP147012/79 1979-11-15

Publications (1)

Publication Number Publication Date
EP0029332A1 true EP0029332A1 (de) 1981-05-27

Family

ID=26477693

Family Applications (1)

Application Number Title Priority Date Filing Date
EP80304018A Withdrawn EP0029332A1 (de) 1979-11-15 1980-11-11 Zahnreinigungszusammensetzungen

Country Status (1)

Country Link
EP (1) EP0029332A1 (de)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344832A1 (de) * 1988-05-19 1989-12-06 Unilever N.V. Orale Präparate
EP0346957A1 (de) * 1988-05-19 1989-12-20 Unilever N.V. Orale Präparate
US4913894A (en) * 1987-09-11 1990-04-03 Colgate-Palmolive Company Appetite suppressant dentifrice
US4935225A (en) * 1987-09-11 1990-06-19 Curtis John P Appetite suppresant dentifrice
US5130122A (en) * 1989-01-27 1992-07-14 Medicontrol Corporation Oral cavity and dental microemulsion products
US5185153A (en) * 1990-10-04 1993-02-09 The Research Foundation Of The State University Of New York Agents effecting the lysis of oral bacteria
EP0786245A1 (de) * 1996-01-24 1997-07-30 Sangi Co., Ltd. Submikrometrischer Hydroxyapatit enthaltende Dentalzusammensetzungen
WO2013034421A3 (en) * 2011-09-08 2014-01-16 Unilever N.V. Tooth remineralizing dentifrice
CN104257517B (zh) * 2014-09-22 2017-11-17 片仔癀（上海）生物科技研发有限公司 一种改性羟基磷灰石及其制备方法与用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE295749C (de) *
FR1343753A (fr) * 1962-10-12 1963-11-22 Composition dermophile pour l'hygiène corporelle et son utilisation à l'état pour ou comme support pour d'autres substances cosmétiques telles que sérums, laits, crèmes de soin, produits capillaires, dentifrices et tous autres articles de soin et d'hygiène
FR1434455A (fr) * 1964-03-20 1966-04-08 Warner Lambert Pharmaceutical Composition dentifrice perfectionnée
GB1090340A (en) * 1964-03-20 1967-11-08 Warner Lambert Pharmaceutical Dentrifice composition
FR2092609A1 (en) * 1970-06-01 1972-01-28 Dubois Prevost Raoul Dental enamel maturation - encouraged by confection contg natural complex of calcium, carbon and phosphorus
FR2255051A1 (en) * 1973-12-03 1975-07-18 Dangelmajer Charles Fluorosilicate contg. dentifrice - prevents formation of plaque and tartar and avoids caries and peridontitis

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE295749C (de) *
FR1343753A (fr) * 1962-10-12 1963-11-22 Composition dermophile pour l'hygiène corporelle et son utilisation à l'état pour ou comme support pour d'autres substances cosmétiques telles que sérums, laits, crèmes de soin, produits capillaires, dentifrices et tous autres articles de soin et d'hygiène
FR1434455A (fr) * 1964-03-20 1966-04-08 Warner Lambert Pharmaceutical Composition dentifrice perfectionnée
GB1090340A (en) * 1964-03-20 1967-11-08 Warner Lambert Pharmaceutical Dentrifice composition
FR2092609A1 (en) * 1970-06-01 1972-01-28 Dubois Prevost Raoul Dental enamel maturation - encouraged by confection contg natural complex of calcium, carbon and phosphorus
FR2255051A1 (en) * 1973-12-03 1975-07-18 Dangelmajer Charles Fluorosilicate contg. dentifrice - prevents formation of plaque and tartar and avoids caries and peridontitis

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4913894A (en) * 1987-09-11 1990-04-03 Colgate-Palmolive Company Appetite suppressant dentifrice
US4935225A (en) * 1987-09-11 1990-06-19 Curtis John P Appetite suppresant dentifrice
EP0344832A1 (de) * 1988-05-19 1989-12-06 Unilever N.V. Orale Präparate
EP0346957A1 (de) * 1988-05-19 1989-12-20 Unilever N.V. Orale Präparate
US4933171A (en) * 1988-05-19 1990-06-12 Unilever Patent Holdings B.V. Oral compositions
AU615746B2 (en) * 1988-05-19 1991-10-10 Unilever Plc Oral compositions
US5130122A (en) * 1989-01-27 1992-07-14 Medicontrol Corporation Oral cavity and dental microemulsion products
US5185153A (en) * 1990-10-04 1993-02-09 The Research Foundation Of The State University Of New York Agents effecting the lysis of oral bacteria
EP0786245A1 (de) * 1996-01-24 1997-07-30 Sangi Co., Ltd. Submikrometrischer Hydroxyapatit enthaltende Dentalzusammensetzungen
US5833959A (en) * 1996-01-24 1998-11-10 Sangi Co., Ltd. Compositions for dental tissue
WO2013034421A3 (en) * 2011-09-08 2014-01-16 Unilever N.V. Tooth remineralizing dentifrice
CN104257517B (zh) * 2014-09-22 2017-11-17 片仔癀（上海）生物科技研发有限公司 一种改性羟基磷灰石及其制备方法与用途

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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AK Designated contracting states

Designated state(s): DE FR GB

17P Request for examination filed

Effective date: 19811019

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19821215

RIN1 Information on inventor provided before grant (corrected)

Inventor name: AOKI, HIDEKI