EP0028411B1 - Stopfen für Fläschchen - Google Patents

Stopfen für Fläschchen Download PDF

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Publication number
EP0028411B1
EP0028411B1 EP80106715A EP80106715A EP0028411B1 EP 0028411 B1 EP0028411 B1 EP 0028411B1 EP 80106715 A EP80106715 A EP 80106715A EP 80106715 A EP80106715 A EP 80106715A EP 0028411 B1 EP0028411 B1 EP 0028411B1
Authority
EP
European Patent Office
Prior art keywords
cap
inner cap
flange
stopper
rubber plug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP80106715A
Other languages
English (en)
French (fr)
Other versions
EP0028411A1 (de
Inventor
Hisatomi Fukuoka
Seizou Sunago
Kiyonori Okada
Shinji Nakashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to AT80106715T priority Critical patent/ATE5958T1/de
Publication of EP0028411A1 publication Critical patent/EP0028411A1/de
Application granted granted Critical
Publication of EP0028411B1 publication Critical patent/EP0028411B1/de
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/241—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with freeze-drying means

Definitions

  • This invention relates to a stopper for vials, and more particularly to a stopper for sealing off a vial by a simplified procedure without necessitating the step of crimping an aluminum cap.
  • US-A-3 587 897 discloses a container closure comprising a cap of a cuplike form adapted to hold a stopper or liner in place in a container, said cap having a top including inner and outer portions. While the outer portion, i.e. a cover member may be made of a pliable material, such as plastic, the inner portion, i.e. the closure for holding the stopper in place has a generally cuplike form and is made out of sheet material such as aluminum.
  • DE-A-2 405 169 describes a dropping dispenser to be fixed to a bottle by the user of the bottle.
  • This dropping dispenser comprises two elements, i.e. an inner dropping insert to be introduced into the bottle opening and an outer cup for sealing the opening of the dropping insert.
  • a stopper for vials is known as well, which comprises an aluminum outer cap for holding the stopper in place.
  • Such so-called “flip-off caps” of aluminum are widely used for vials containing pharmaceutical preparations, especially powders or the like for preparing injection solutions.
  • Such raps are costly since they are made of aluminum and, moreover, have the drawback of requiring a cumbersome vial closing process because the aluminum cap must be fitted to the vial by crimping after the vial has been sealed with a rubber plug pressed against the flange of the vial.
  • Subject matter of this invention therefore is a stopper for a vial having a flange at its opening portion comprising a rubber plug having a top plate fittable to the flange in pressing contact therewith, an inner cap for receiving the rubber plug and having an upper wall formed with a hole in its center and an outer cap made of a flexible plastic fittable over the inner caps (as known from US-A-3587897), which is characterized in that the side wall of the inner cap comprises at least one projection on the inner peripheral surface thereof, the projection being fittable to the lower face of the flange with the top plate of the rubber plug held between the upper wall of the inner cap and the flange and at least one projection engageable with the top plate of the rubber plug on the inner surface of the inner cap side wall at its upper end; in that the outer cap has a side wall provided on its inner peripheral surface with a projection engageable with the outer peripheral surface of the inner cap side wall; and in that the inner cap is made of a flexible plastic.
  • the stopper of this invention comprises an outer cap 1, an inner cap 2 and a rubber plug 3.
  • the outer cap 1 includes an upper wall 1 a and a side wall 1 b integral therewith and formed with a projection 4 on its inner peripheral surface.
  • the projection 4 is engageable with the outer periphery of the side wall 2b of the inner cap 2 to hold the outer cap 1 thereon.
  • the inner cap 2 includes an upper wall 2a integral with the above-mentioned side wall 2b.
  • the upper wall 2a is formed in its center with a hole 5 for permitting an injection needle to penetrate the rubber plug 3.
  • Formed on the inner peripheral surface of the side wall 2b are two projections 6 which are fittable to the lower face of the flange 11 a of a vial 11 with the top plate 3a of the rubber plug 3 positioned between the upper wall 2a and the flange 11 a.
  • Four projections 7 are provided on the inner surface of the side wall 2b at its upper end for engaging the top plate 3a of the rubber plug 3 to retain the plug 3 in the inner cap 2.
  • the rubber plug 3 which is a rubber stopper heretofore used for vials, comprises the above-mentioned top plate 3a serving as a packing, and two legs 3b. Each of the legs has on its outer surface a projection 8 engageable with the opening portion of the vial 11.
  • the outer cap 1 and the inner cap 2 are made of a flexible plastic, which is preferably polypropylene, polyethylene, polycarbonate or the like.
  • the projection 4 on the outer cap 1 and the projections 6 and 7 on the inner cap 2 are not limitative in their arrangement but can be provided as desired insofar as they are serviceable as contemplated.
  • the projections 6 on the inner cap 2 may be in the form of a continuous projection extending over the entire inner periphery of the inner cap side wall 2b like the projection 4 on the outer cap 1, or may be in the form of dots resembling the projections 7 on the inner cap 2.
  • the stopper of this invention will be used in the following manner, for example, for a vial 11 for containing a freeze-dried preparation for injection.
  • the inner cap 2 is fitted in the outer cap 1 in engagement with the projection 4, with the rubber plug 3 engaged with the projections 7 on the inner cap 2.
  • the stopper is then placed on the vial 11 containing an aqueous solution S of the preparation so that the projections 8 on the rubber plug 3 bear on the opening portion of the vial 11 as seen in Fig. 7.
  • the projections 6 on the inner cap 2 strike the upper edge of the flange 11 a on the vial 11, thereby forcing the side wall 2b of the inner cap 2 radially outward at its lower portion, and thereafter come into fitting engagement with the lower face of the flange 11 a, whereupon the inner cap side wall 2b restores itself.
  • the vial 11 containing the powder P is completely sealed off as shown in Fig. 8.
  • the vial stopper of this invention for which no aluminum material is used, can be manufactured at a low cost.
  • the stopper is easy to use since it seals off the vial completely when simply pressed on. Because the sealing step can be performed subsequent to freeze-drying within a freeze-drying chamber in a continuous operation, the stopper is very useful for providing pharmaceutical products free from foreign matter and having an extremely low water content and a high quality.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (2)

1. Verschluß für eine Ampulle (11), die einen Flansch (11 a) in ihrem Offnungsbereich aufweist, mit einem Gummistopfen (3), der eine Kopfplatte (3a) besitzt, die in Druckkontakt an dem Flansch (1 1 a) befestigt werden kann, einer inneren Kappe (2) zur Aufnahme des Gummistopfens (3), die eine obere Wand (2a) mit einem Loch (5) in der Mitte aufweist, und einer über die innere Kappe passenden äußeren Kappe (1) aus einem flexiblen Kunststoff, dadurch gekennzeichnet, daß die Seitenwand (2b) der inneren Kappe (2) auf ihrer inneren Umfangsoberfläche mindestens einen Vorsprung (6), welcher Vorsprung (6) an der Unterseite des Flansches (11 a) befestigt werden kann, wobei die Kopfplatte (3a) des Gummistopfens (3) zwischen der oberen Wand (2a) der inneren Kappe (2) und dem Flansch (11a) festgehalten wird, und am oberen Ende der inneren Oberfläche der Seitenwand (2b) der inneren Kappe mindestens einen Vorsprung (7) aufweist, welcher in die Kopfplatte (3a) des Gummistopfens eingreift; daß die äußere Kappe (1) eine Seitenwand (1 b) aufweist, die an ihrer inneren Umfangsoberfläche mit einem Vorsprung (4) versehen ist, welcher in die äußere Umfangsoberfläche der Seitenwand (2b) der inneren Kappe eingreift; und daß die innere Kappe (2) aus einem flexiblen Kunststoff besteht.
2. Verschluß nach Anspruch 1, dadurch gekennzeichnet, daß die äußere Kappe (1) und die innere Kappe (2) aus Polypropylen, Polyethylen oder Polycarbonat bestehen.
EP80106715A 1979-11-01 1980-10-31 Stopfen für Fläschchen Expired EP0028411B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT80106715T ATE5958T1 (de) 1979-11-01 1980-10-31 Stopfen fuer flaeschchen.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP142612/79 1979-11-01
JP14261279A JPS5664961A (en) 1979-11-01 1979-11-01 Plug body for vial

Publications (2)

Publication Number Publication Date
EP0028411A1 EP0028411A1 (de) 1981-05-13
EP0028411B1 true EP0028411B1 (de) 1984-01-25

Family

ID=15319368

Family Applications (1)

Application Number Title Priority Date Filing Date
EP80106715A Expired EP0028411B1 (de) 1979-11-01 1980-10-31 Stopfen für Fläschchen

Country Status (5)

Country Link
EP (1) EP0028411B1 (de)
JP (1) JPS5664961A (de)
AT (1) ATE5958T1 (de)
DE (1) DE3066308D1 (de)
ES (1) ES265665Y (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2516480B1 (fr) * 1981-11-13 1986-03-07 Lyonnaise Bouchage Moyens de bouchage d'un recipient contenant des produits a injecter
US4554125A (en) * 1983-03-17 1985-11-19 Schering Corporation Method of making a stopper for a sterile fluid container
US4465200A (en) * 1983-06-06 1984-08-14 Becton, Dickinson And Company Low contamination closure for blood collection tubes
JPS6096260U (ja) * 1983-12-05 1985-07-01 第一製薬株式会社 薬用壜の蓋
JPS61178344U (de) * 1985-04-24 1986-11-07
US4697717A (en) * 1986-08-18 1987-10-06 Becton, Dickinson And Company Rubber/plastic stopper composite with mechanical adhesive joints
JPS63180556U (de) * 1987-05-12 1988-11-22
WO1991011259A1 (en) * 1990-01-26 1991-08-08 Mallinckrodt, Inc. Sanitary sampling system
CA2067691C (en) * 1991-05-13 1995-12-12 James A. Burns Stopper-shield combination closure
US5823379A (en) * 1993-10-20 1998-10-20 Amersham International Plc Sealed container for hazardous material
DE69611722T2 (de) 1995-10-18 2001-05-10 Daikyo Seiko Ltd Kunststoffkappe und Verfahren zu ihrer Herstellung
US5718348A (en) * 1996-09-12 1998-02-17 Comar, Inc. Overcap assembly for gear finish vial
GB2312207B (en) * 1996-10-25 1998-08-26 Massmould Holdings Plug closure assembly
US20060134354A1 (en) * 2004-12-16 2006-06-22 Walters Jay M Calibration vial stopper with improved security features
US7543188B2 (en) * 2005-06-29 2009-06-02 Oracle International Corp. Browser based remote control of functional testing tool
FR2912384B1 (fr) * 2007-02-09 2009-04-10 Biocorp Rech Et Dev Sa Dispositif de bouchage pour un recipient, recipient equipe d'un tel dispositif et procede de fermeture d'un lot de tel recipient
JP5479029B2 (ja) * 2009-10-30 2014-04-23 株式会社大協精工 バイアル用のゴム栓（ｂ）とプラスチック製キャップ（ｃ）との組み合わせ
JP5683129B2 (ja) * 2010-04-30 2015-03-11 大和特殊硝子株式会社 バイアル用栓体とこれに用いるシール部材
FI20116059A (fi) 2011-10-28 2013-04-29 Thermo Fisher Scientific Oy Reagenssipullo, järjestelmä, menetelmä ja laite suljinkorkkien ja vastaavien käsittelemiseksi
WO2019125223A1 (ru) * 2017-12-21 2019-06-27 Акционерное общество "Елатомский приборный завод" Пробирка вакуумная

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1949902A (en) * 1930-11-05 1934-03-06 Owens Illinois Glass Co Bottle closure
US3092278A (en) * 1957-09-20 1963-06-04 Astra Apotekarnes Kem Fab Cap for a container for an injection liquid
US3073471A (en) * 1960-03-17 1963-01-15 Aluminum Co Of America Closure device for sealed packages
US3746196A (en) * 1971-01-29 1973-07-17 Green Cross Corp Coated plastic container for liquid medicine
BE794248A (fr) * 1972-02-22 1973-05-16 Baxter Laboratories Inc Perfectionnements apportes aux fermetures steriles pour bouteilles ou flacons a solution
US3888377A (en) * 1973-05-30 1975-06-10 Reinhard Stadler Closure cap for an infusion flask
DE2361350B1 (de) * 1973-12-08 1975-05-28 Matthias Faensen, Kleinmetallwarenfabrikation, 5190 Stolberg Verschluß für pharmazeutische Flaschen
DE2405169A1 (de) * 1974-02-04 1975-08-07 Sanner Kg Friedr Tropfeinsatz
NL7707814A (nl) * 1976-08-03 1978-02-07 Abbott Lab Plastic houders.
US4211333A (en) * 1978-06-05 1980-07-08 Merck & Co., Inc. Tamperproof container

Also Published As

Publication number Publication date
EP0028411A1 (de) 1981-05-13
ES265665U (es) 1983-02-01
DE3066308D1 (en) 1984-03-01
ATE5958T1 (de) 1984-02-15
ES265665Y (es) 1983-07-16
JPS5664961A (en) 1981-06-02

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