EP0021940B1 - Nouveaux dérivés aminés du benzothiazole, leur procédé de préparation et leur application en thérapeutique - Google Patents

Nouveaux dérivés aminés du benzothiazole, leur procédé de préparation et leur application en thérapeutique Download PDF

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Publication number
EP0021940B1
EP0021940B1 EP80400831A EP80400831A EP0021940B1 EP 0021940 B1 EP0021940 B1 EP 0021940B1 EP 80400831 A EP80400831 A EP 80400831A EP 80400831 A EP80400831 A EP 80400831A EP 0021940 B1 EP0021940 B1 EP 0021940B1
Authority
EP
European Patent Office
Prior art keywords
formula
thiazole
benzo
tetrahydro
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP80400831A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0021940A1 (fr
Inventor
Jacques Georges Maillard
Pierre Paul André Delaunay
Jacky Marcel Gérard Legeai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Jacques Logeais SA
Original Assignee
Laboratoires Jacques Logeais SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Jacques Logeais SA filed Critical Laboratoires Jacques Logeais SA
Publication of EP0021940A1 publication Critical patent/EP0021940A1/fr
Application granted granted Critical
Publication of EP0021940B1 publication Critical patent/EP0021940B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

Definitions

  • the present invention relates to amino derivatives of benzothiazole, their preparation process and: their application in therapy.
  • the alcohols (IV) can be isolated and purified by the usual means (distillation, crystallization) or directly transformed into tosylates (V) by means of p chloride. toluenesulfonyl, in the presence of a tertiary base such as pyridine.

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
EP80400831A 1979-06-20 1980-06-10 Nouveaux dérivés aminés du benzothiazole, leur procédé de préparation et leur application en thérapeutique Expired EP0021940B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7915774A FR2459239A1 (fr) 1979-06-20 1979-06-20 Nouveaux derives amines du benzothiazole, leur procede de preparation et leur application en therapeutique
FR7915774 1979-06-20

Publications (2)

Publication Number Publication Date
EP0021940A1 EP0021940A1 (fr) 1981-01-07
EP0021940B1 true EP0021940B1 (fr) 1983-01-19

Family

ID=9226843

Family Applications (1)

Application Number Title Priority Date Filing Date
EP80400831A Expired EP0021940B1 (fr) 1979-06-20 1980-06-10 Nouveaux dérivés aminés du benzothiazole, leur procédé de préparation et leur application en thérapeutique

Country Status (7)

Country Link
US (2) US4337343A (cg-RX-API-DMAC10.html)
EP (1) EP0021940B1 (cg-RX-API-DMAC10.html)
JP (1) JPS567772A (cg-RX-API-DMAC10.html)
CA (1) CA1140136A (cg-RX-API-DMAC10.html)
DE (1) DE3061672D1 (cg-RX-API-DMAC10.html)
ES (1) ES8103071A1 (cg-RX-API-DMAC10.html)
FR (1) FR2459239A1 (cg-RX-API-DMAC10.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE45735T1 (de) * 1984-12-22 1989-09-15 Thomae Gmbh Dr K Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel.
JPS62292229A (ja) * 1986-06-13 1987-12-18 Toyo Seikan Kaisha Ltd 易開口性蓋の製造方法
DE3620813A1 (de) 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung
WO2008001200A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal composition having enhanced color stability
KR102505085B1 (ko) 2009-12-04 2023-02-28 선오비온 파마슈티컬스 인코포레이티드 다환형 화합물 및 이의 사용 방법
JP2019523279A (ja) 2016-07-29 2019-08-22 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 化合物および組成物ならびにそれらの使用
SG11201900689RA (en) 2016-07-29 2019-02-27 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
CA3053903A1 (en) 2017-02-16 2018-08-23 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
AU2018312559B2 (en) 2017-08-02 2022-06-02 Pgi Drug Discovery Llc Isochroman compounds and uses thereof
MY208150A (en) 2018-02-16 2025-04-18 Sunovion Pharmaceuticals Inc Salts, crystal forms, and production methods thereof
JP7703449B2 (ja) 2019-03-14 2025-07-07 スミトモ・ファーマ・アメリカ・インコーポレイテッド イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物
US11738002B2 (en) 2020-04-14 2023-08-29 Sunovion Pharmaceuticals Inc. Methods of treating neurological and psychiatric disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792402A (fr) * 1971-12-07 1973-06-07 Ciba Geigy Composes heterocycliques azotes et medicaments anthelminthiqueset antimicrobiens qui en contiennent
JPS4930360A (cg-RX-API-DMAC10.html) * 1972-03-04 1974-03-18
JPS50108261A (cg-RX-API-DMAC10.html) * 1974-02-12 1975-08-26
FR2406635A1 (fr) * 1977-10-24 1979-05-18 Logeais Labor Jacques Nouveaux derives du benzo(d)thiazole, leur procede de preparation et leurs applications en therapeutique

Also Published As

Publication number Publication date
JPS6342622B2 (cg-RX-API-DMAC10.html) 1988-08-24
FR2459239A1 (fr) 1981-01-09
JPS567772A (en) 1981-01-27
US4423056A (en) 1983-12-27
EP0021940A1 (fr) 1981-01-07
FR2459239B1 (cg-RX-API-DMAC10.html) 1982-09-10
US4337343A (en) 1982-06-29
ES492578A0 (es) 1981-02-16
ES8103071A1 (es) 1981-02-16
CA1140136A (en) 1983-01-25
DE3061672D1 (en) 1983-02-24

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