EP0000490A1 - Naphtyridinones substituées, procédés pour leurs préparation et applications thérapeutiques - Google Patents

Naphtyridinones substituées, procédés pour leurs préparation et applications thérapeutiques Download PDF

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Publication number
EP0000490A1
EP0000490A1 EP78100341A EP78100341A EP0000490A1 EP 0000490 A1 EP0000490 A1 EP 0000490A1 EP 78100341 A EP78100341 A EP 78100341A EP 78100341 A EP78100341 A EP 78100341A EP 0000490 A1 EP0000490 A1 EP 0000490A1
Authority
EP
European Patent Office
Prior art keywords
loweralkyl
compound
formula
independently hydrogen
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP78100341A
Other languages
German (de)
English (en)
Inventor
William Alfred Bolhofer
Edward Jethro Crago Jr.
Jacob Matthew Hoffman Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0000490A1 publication Critical patent/EP0000490A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP78100341A 1977-07-18 1978-07-10 Naphtyridinones substituées, procédés pour leurs préparation et applications thérapeutiques Withdrawn EP0000490A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US816617 1977-07-18
US05/816,617 US4133885A (en) 1977-07-18 1977-07-18 Substituted naphthyridinones

Publications (1)

Publication Number Publication Date
EP0000490A1 true EP0000490A1 (fr) 1979-02-07

Family

ID=25221139

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78100341A Withdrawn EP0000490A1 (fr) 1977-07-18 1978-07-10 Naphtyridinones substituées, procédés pour leurs préparation et applications thérapeutiques

Country Status (6)

Country Link
US (1) US4133885A (fr)
EP (1) EP0000490A1 (fr)
JP (1) JPS5422394A (fr)
ES (1) ES471767A1 (fr)
IT (1) IT7850335A0 (fr)
PT (1) PT68294A (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567520A1 (fr) * 1984-07-11 1986-01-17 Carpibem Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres
FR2592652A1 (fr) * 1986-01-06 1987-07-10 Carpibem Nouvelles phenyl-naphtyridines, leur procede de preparation et les medicaments en contenant.
FR2592650A1 (fr) * 1986-01-06 1987-07-10 Carpibem Nouvelles phenyl-naphtyridines fonctionnalisees en position-3, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
FR2592649A1 (fr) * 1986-01-06 1987-07-10 Carpibem Cyano et amido phenyl-naphtyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
FR2592651A1 (fr) * 1986-01-06 1987-07-10 Carpibem Nouvelles phenyl naphtyridines comportant un substituant methyle en position 3, et les medicaments qui en contiennent.
EP0231709A2 (fr) * 1986-01-06 1987-08-12 Laboratoires Upsa Nouvelles phényl-naphtyridines fonctionnalisées en position-3, leur procédé de préparation, médicaments les contenant, notamment anti-ulcères
EP0232659A1 (fr) * 1986-01-06 1987-08-19 Laboratoires Upsa Nouvelles phényl naphtyridines comportant un substituant méthyle en position 3, et les médicaments qui en contiennent
EP0267691A2 (fr) * 1986-10-15 1988-05-18 Schering Corporation Utilisation de dérivés substitués en 1 de la naphthyridine et de la pyridopyrazine pour la préparation de médicaments utiles comme immunosuppresseurs.
US4916131A (en) * 1986-10-15 1990-04-10 Schering Corporation Naphthyridine derivatives and method for treating allergic reactions
FR2650279A1 (fr) * 1989-07-28 1991-02-01 Bellon Labor Sa Roger Nouveaux derives de benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
EP4311762A1 (fr) 2022-07-29 2024-01-31 AIRBUS HELICOPTERS DEUTSCHLAND GmbH Porte d'aéronef avec un dispositif anti-vibration

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229456A (en) * 1977-07-18 1980-10-21 Merck & Co., Inc. Substituted naphthyridinones and processes for their preparations
US4324893A (en) * 1979-04-18 1982-04-13 American Home Products Corporation 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
US4420615A (en) * 1981-08-24 1983-12-13 Merck & Co., Inc. Substituted pyridopyrimidines as gastric secretion inhibitors
US4551463A (en) * 1982-11-03 1985-11-05 Schering Corporation Composition containing 1-phenyl-1,8-naphthridin-2(1H)-ones and a non-steroidal anti-inflammatory drug
AU623475B2 (en) * 1989-01-16 1992-05-14 Laboratoire Roger Bellon New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them
AU623474B2 (en) * 1989-01-16 1992-05-14 Laboratoire Roger Bellon New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them
NZ232092A (en) * 1989-01-16 1992-05-26 Bellon Labor Sa Roger 8-halo-7-fluoro-4-oxo-1,4-dihydro-benzo(b)(1,8) naphthyridine-3-carboxylic acid esters and preparation thereof
US5258356A (en) * 1989-03-11 1993-11-02 Basf Aktiengesellschaft Substituted 1,8-naphthyridines, their preparation and their use as antidotes
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
EP0670320A4 (fr) * 1992-12-01 1997-05-02 Green Cross Corp Derive de 1,8-naphthyridin-2-one et utilisation de ce derive.
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) * 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
HUE032891T2 (hu) 2012-12-17 2017-11-28 Parion Sciences Inc Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962262A (en) * 1973-04-11 1976-06-08 Merck & Co., Inc. 1,8-naphthyridine compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4041070A (en) * 1976-07-14 1977-08-09 American Cyanamid Company Tetrahydro-4-imino-1-naphthylureas

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962262A (en) * 1973-04-11 1976-06-08 Merck & Co., Inc. 1,8-naphthyridine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IL FARMACO ED.Sc. 28, 722-32 (1973). *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567520A1 (fr) * 1984-07-11 1986-01-17 Carpibem Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres
EP0172058A1 (fr) * 1984-07-11 1986-02-19 Laboratoires Upsa Nouvelles phényl-naphthyridines, leur procédé de préparation, médicaments les contenant, notamment anti-ulcères
US4622328A (en) * 1984-07-11 1986-11-11 Carpibem Phenyl-naphthyridines and drugs containing them, particularly anti-ulcer drugs
EP0232659A1 (fr) * 1986-01-06 1987-08-19 Laboratoires Upsa Nouvelles phényl naphtyridines comportant un substituant méthyle en position 3, et les médicaments qui en contiennent
FR2592650A1 (fr) * 1986-01-06 1987-07-10 Carpibem Nouvelles phenyl-naphtyridines fonctionnalisees en position-3, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
FR2592649A1 (fr) * 1986-01-06 1987-07-10 Carpibem Cyano et amido phenyl-naphtyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
FR2592651A1 (fr) * 1986-01-06 1987-07-10 Carpibem Nouvelles phenyl naphtyridines comportant un substituant methyle en position 3, et les medicaments qui en contiennent.
EP0231709A2 (fr) * 1986-01-06 1987-08-12 Laboratoires Upsa Nouvelles phényl-naphtyridines fonctionnalisées en position-3, leur procédé de préparation, médicaments les contenant, notamment anti-ulcères
FR2592652A1 (fr) * 1986-01-06 1987-07-10 Carpibem Nouvelles phenyl-naphtyridines, leur procede de preparation et les medicaments en contenant.
EP0231709A3 (en) * 1986-01-06 1988-11-02 Carpibem Phenyl naphthyridines, with a functional group in position 3, process for their preparation, medicaments containing them, especially as anti-ulcers
EP0267691A2 (fr) * 1986-10-15 1988-05-18 Schering Corporation Utilisation de dérivés substitués en 1 de la naphthyridine et de la pyridopyrazine pour la préparation de médicaments utiles comme immunosuppresseurs.
EP0267691A3 (fr) * 1986-10-15 1989-08-23 Schering Corporation Utilisation de dérivés substitués en 1 de la naphthyridine et de la pyridopyrazine pour la préparation de médicaments utiles comme immunosuppresseurs.
US4916131A (en) * 1986-10-15 1990-04-10 Schering Corporation Naphthyridine derivatives and method for treating allergic reactions
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
FR2650279A1 (fr) * 1989-07-28 1991-02-01 Bellon Labor Sa Roger Nouveaux derives de benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent
EP4311762A1 (fr) 2022-07-29 2024-01-31 AIRBUS HELICOPTERS DEUTSCHLAND GmbH Porte d'aéronef avec un dispositif anti-vibration

Also Published As

Publication number Publication date
IT7850335A0 (it) 1978-07-17
ES471767A1 (es) 1979-10-01
JPS5422394A (en) 1979-02-20
PT68294A (en) 1978-08-01
US4133885A (en) 1979-01-09

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): BE CH DE FR GB NL

17P Request for examination filed
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19800722

RIN1 Information on inventor provided before grant (corrected)

Inventor name: HOFFMAN JR., JACOB MATTHEW

Inventor name: BOLHOFER, WILLIAM ALFRED

Inventor name: CRAGO JR., EDWARD JETHRO