ES471767A1 - Un procedimiento para la preparacion de naftiridinonas sus- tituidas dotadas de propiedades inhibidoras de la secrecion gastrica - Google Patents

Un procedimiento para la preparacion de naftiridinonas sus- tituidas dotadas de propiedades inhibidoras de la secrecion gastrica

Info

Publication number
ES471767A1
ES471767A1 ES471767A ES471767A ES471767A1 ES 471767 A1 ES471767 A1 ES 471767A1 ES 471767 A ES471767 A ES 471767A ES 471767 A ES471767 A ES 471767A ES 471767 A1 ES471767 A1 ES 471767A1
Authority
ES
Spain
Prior art keywords
lower alkyl
preparations
processes
formula
naphthyridinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471767A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES471767A1 publication Critical patent/ES471767A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la preparación de naftiridinonas sustituidas dotadas de propiedades inhibidoras de la secreción gástrica de la fórmula: **(Fórmula)** donde n es un número entero de 2 a 6, tal que la longitud de la cadena carbonada que conecta los dos átomos de nitrógeno no es inferior a 2; R1, R2, R3, R4 y R5 son independientemente hidrógeno, alquilo inferior, alcoxi inferior, amino, haloalquilo inferior o fenilo o dos sustituyentes adyacentes cualesquiera pueden estar unidos para formar un sustituyente benzo; R6 y R7 son independientemente hidrógeno, alquilo inferior, fenialquilo inferior, N-(alquil inferior) carbamoílo, N-(alquil inferior) tiocarbamaoílo.
ES471767A 1977-07-18 1978-07-14 Un procedimiento para la preparacion de naftiridinonas sus- tituidas dotadas de propiedades inhibidoras de la secrecion gastrica Expired ES471767A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/816,617 US4133885A (en) 1977-07-18 1977-07-18 Substituted naphthyridinones

Publications (1)

Publication Number Publication Date
ES471767A1 true ES471767A1 (es) 1979-10-01

Family

ID=25221139

Family Applications (1)

Application Number Title Priority Date Filing Date
ES471767A Expired ES471767A1 (es) 1977-07-18 1978-07-14 Un procedimiento para la preparacion de naftiridinonas sus- tituidas dotadas de propiedades inhibidoras de la secrecion gastrica

Country Status (6)

Country Link
US (1) US4133885A (es)
EP (1) EP0000490A1 (es)
JP (1) JPS5422394A (es)
ES (1) ES471767A1 (es)
IT (1) IT7850335A0 (es)
PT (1) PT68294A (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229456A (en) * 1977-07-18 1980-10-21 Merck & Co., Inc. Substituted naphthyridinones and processes for their preparations
US4324893A (en) * 1979-04-18 1982-04-13 American Home Products Corporation 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
US4420615A (en) * 1981-08-24 1983-12-13 Merck & Co., Inc. Substituted pyridopyrimidines as gastric secretion inhibitors
US4551463A (en) * 1982-11-03 1985-11-05 Schering Corporation Composition containing 1-phenyl-1,8-naphthridin-2(1H)-ones and a non-steroidal anti-inflammatory drug
FR2567520B1 (fr) * 1984-07-11 1987-01-02 Carpibem Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres
NZ218773A (en) * 1986-01-06 1990-05-28 Carpibem 3-methyl-2-oxo-1-(substituted phenyl)-naphthyridines and pharmaceutical compositions
NZ218774A (en) * 1986-01-06 1990-06-26 Carpibem 3-substituted phenylnaphthyridines and pharmaceutical compositions
FR2592649B1 (fr) * 1986-01-06 1988-04-29 Carpibem Cyano et amido phenyl-naphtyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
FR2592650B1 (fr) * 1986-01-06 1988-04-29 Carpibem Nouvelles phenyl-naphtyridines fonctionnalisees en position-3, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
FR2592652B1 (fr) * 1986-01-06 1988-04-29 Carpibem Nouvelles phenyl-naphtyridines, leur procede de preparation et les medicaments en contenant.
FR2592651B1 (fr) * 1986-01-06 1988-05-13 Carpibem Nouvelles phenyl naphtyridines comportant un substituant methyle en position 3, et les medicaments qui en contiennent.
US4916131A (en) * 1986-10-15 1990-04-10 Schering Corporation Naphthyridine derivatives and method for treating allergic reactions
EP0267691A3 (en) * 1986-10-15 1989-08-23 Schering Corporation Use of 1-substituted naphthyridine and pyridopyrazine derivatives for the preparation of medicaments with immunosuppressor activity.
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
NZ232092A (en) * 1989-01-16 1992-05-26 Bellon Labor Sa Roger 8-halo-7-fluoro-4-oxo-1,4-dihydro-benzo(b)(1,8) naphthyridine-3-carboxylic acid esters and preparation thereof
NZ232091A (en) * 1989-01-16 1990-12-21 Bellon Labor Sa Roger 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof
FR2650279B1 (fr) * 1989-07-28 1991-10-18 Bellon Labor Sa Roger Nouveaux derives de benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent
AU623475B2 (en) * 1989-01-16 1992-05-14 Laboratoire Roger Bellon New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them
US5258356A (en) * 1989-03-11 1993-11-02 Basf Aktiengesellschaft Substituted 1,8-naphthyridines, their preparation and their use as antidotes
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
KR950704314A (ko) * 1992-12-01 1995-11-17 가와노 다케히코 1,8-나프티리딘-2-온 유도체 및 그 사용 방법(1,8-naphthyridin-2-one derivative and use thereof)
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) * 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
AU2013363218B2 (en) 2012-12-17 2018-03-15 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
KR20150095870A (ko) 2012-12-17 2015-08-21 패리온 사이언스 인코퍼레이티드 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
EP4311762A1 (en) 2022-07-29 2024-01-31 AIRBUS HELICOPTERS DEUTSCHLAND GmbH An aircraft door with an anti-vibration device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962262A (en) * 1973-04-11 1976-06-08 Merck & Co., Inc. 1,8-naphthyridine compounds
US4041070A (en) * 1976-07-14 1977-08-09 American Cyanamid Company Tetrahydro-4-imino-1-naphthylureas

Also Published As

Publication number Publication date
PT68294A (en) 1978-08-01
EP0000490A1 (en) 1979-02-07
US4133885A (en) 1979-01-09
JPS5422394A (en) 1979-02-20
IT7850335A0 (it) 1978-07-17

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