EP0000283A1 - Substituted carbamates, preparation and compositions thereof and use thereof as insecticides. - Google Patents
Substituted carbamates, preparation and compositions thereof and use thereof as insecticides. Download PDFInfo
- Publication number
- EP0000283A1 EP0000283A1 EP78300097A EP78300097A EP0000283A1 EP 0000283 A1 EP0000283 A1 EP 0000283A1 EP 78300097 A EP78300097 A EP 78300097A EP 78300097 A EP78300097 A EP 78300097A EP 0000283 A1 EP0000283 A1 EP 0000283A1
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- Prior art keywords
- compound
- methyl
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- insecticidal
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/58—Derivatives of thiocarboxylic acids, the doubly-bound oxygen atoms being replaced by nitrogen atoms, e.g. imino-thio ethers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
Definitions
- This invention relates to substituted carbamates, preparation thereof and use thereof as insecticides for the control of pestiferous insects.
- U.S. Patent 3,576,834 issued April 27, 1971, relates to insecticidal compounds having the structure: such as methomyl.
- This invention relates to compounds of Formula I, their preparation, to insecticidal compositions containing them and to the method of using said compounds as insecticides.
- Specifically preferred for its outstanding insecticidal activity is dimethyl N,N'[[l,2-ethane- diylbis[thio(methylimino)carbonyloxy]]]bis(ethaneimidothioate).
- the compounds of Formula I can be prepared, as shown in Equation A, by reacting preferably at least two moles of a substituted N-(aminocarbonyloxy)-alkanimidothioic acid ester of Formula II with one mole of an alkane disulfenyl halide of Formula III in the presence of a base: wherein R, R 1 , and R 2 are as previously defined and X is halogen.
- the reaction can be carried out in any organic solvent which is inert to the reactants and the reaction products, e.g. methylene chloride, dioxane, tetrahydrofuran, chloroform, 1,2-dichlorethane, acetonitrile, benzene, toluene, the xylenes, acetone or methyl ethyl ketone. Mixtures of such solvents can also be used.
- a base which will function as an acid acceptor can be used in synthesizing the compounds of this invention.
- the process can be carried out at a temperature of between about -20° and 60°C, preferably between about -5° and 40°C. Pressure is not critical; for convenience, atmospheric pressure is preferred.
- Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few pints to several hundred gallons per acre. High strength compositions are primarily used as intermediates for further formulation.
- the formulations broadly, contain e.g. about 1% to 99% by weight of active ingredient(s) and at least one of (a) e.g. about 0% to 20% surfactant(s) and (b) e.g. about 1% to 99% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:
- Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers," 2nd Edn., Dorland Books, Caldwell, N.J. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts.
- Typical liquid diluents and solvents are described in Marsden, “Solvents Guide,” 2nd Edn., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0°C.
- compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Patent 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques.
- the ingredients are thoroughly blended, passed through an air mill, to produce an average particle size under 15 microns, reblended, and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) before packaging.
- the ingredients are blended, coarsely hammer milled and then air milled to produce particles of active ingredient essentially all below 10 microns in diameter.
- the product is reblended before packaging
- the ingredients are thoroughly blended.
- the liquid surfactant is added by spraying upon the solid ingredients in the blender. After grinding in a hammer mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) and packaged.
- the ingredients are ground together in a ball or roller mill until the solid particles have been reduced to diameters under 10 microns.
- the ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns.
- the resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.
- a slurry of wettable powder containing 50% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.
- the ingredients are blended, hammer-milled and then moistened with about 12% water.
- the mixture is extruded as cylinders about 5 mm diameter which are cut to produce pellets about 3 mm long. These may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm opening).
- the granules held on a U.S.S. No. 40 sieve (0.42 mm opening) may be packaged for use and the fines recycled.
- the ingredients are blended and ground in a hammer mill to produce a high-strength concentrate essentially all passing a U.S.S. No. 50 sieve (0.3 mm opening). This material may then be formulated in a variety of ways.
- the ingredients are thoroughly blended and packaged for use.
- the ingredients are combined and stirred to. produce a solution which can be emulsified in water for application.
- the ingredients are combined and stirred with gentle warming to speed solution.
- a fine screen filter is included in packaging operation to ensure the absence of any extraneous undissolved material in the product.
- the compounds of this invention are useful for control of insects which are detrimental to agriculture.
- insects controlled by the compounds of this invention include but are not limited to: cotton bollworm (Heliothis zea), tobacco budworm (Heliothis virescens), southern armyworm (Spodoptera eridania), beet armyworm (Spodoptera exigua), soybean looper (Pseudoplusia includens), Mexican bean beetle (Epilachna varivestis), and the house fly (Musca domestica).
- insects are controlled by applying the compound to the locus of infestation, to the area to be protected, or to the pests themselves.
- a compound of Formula I is generally applied to the foliage or other plant parts which are infested or which are to be protected. Effective amounts to be applied depend upon the species to be controlled, its life stage, its size and location, the amount of rainfall, the time of year, moisture, temperature, type of application, and other variables. In general, 0.1 to 10 kg/ha may be required for insect control in agriculture with rates of .2 to 4 kg/ha usually being sufficient in many situations. In large-scale field operations, rates in the range of 1/4 to 2 kg/ha are generally used.
- the compounds of this invention will generally be used in formulation with a carrier that commonly will contain oil or water. Applications may be made with ' concentrated or dilute suspensions of the insecticide in the carrier. Low-volume applications utilizing dispersions containing about 20% of the active ingredient may be preferred by some applicators while others may prefer dilute suspensions containing only 25 ppm in high-volume applications.
- the compounds of this invention possess significant advantages over prior art compounds, e.g fewer applications are required to provide a given level of insect control due to this distinctly longer residual insecticidal action. Use of fewer applications results in greater economy to the grower and dissemination of less insecticide in the environment. An additional advantage is lower phytotoxicity to cotton.
- the compounds will be incorporated into a formulation in a known manner with incorporation of other components such as (a) surfactants, (b) diluents, (c) additives to reduce foam or corrosion, or (d) preservatives to control microbiological growth.
- other components such as (a) surfactants, (b) diluents, (c) additives to reduce foam or corrosion, or (d) preservatives to control microbiological growth.
- the compounds of this invention can be mixed with fungicides, bactericides, acaricides, nematicides, other insecticides, or other biologically active compounds in order to achieve desired results with a minimum expenditure of time, effort and material. Amounts of these biologically active materials added for each part by weight of the composition of this invention may vary from 0.05 to 25 parts by weight. Suitable agents of this type are well-known to those skilled in the art. Some are listed below:
- the foliage only of red kidney bean plants in the two-leaf stage was sprayed to run-off with aqueous dispersions of dimethyl N,N'-[[1,2-ethanediylbis[thio-(methylimino)carbonyloxy]]]bis(ethanimidothioate) (I) at the dilutions indicated.
- the sprays contained Duponol L-144-WDG (sulfonated oleyl acetate surfactant) at a concentration of 1:3000.
- SAW southern armyworm
- Example 1 The plants from the test described in Example 1 were kept in a growth room at 77 ⁇ 2°F and 53 + 5% relative himidity for 7 days. At the end of that period of time the remaining cotyledonary leaf from each bean plant was placed singly in a Petri dish with southern armyworms as previously described. Insect mortality was again read 2 days later and is set forth below.
- Cotton plants approximately 22 cm in height having 3-4 true leaves were sprayed to run-off with an aqueous dispersion of dimethyl N,N'-[[1,2-ethane- diylbis[thio(methylimino)carbonyloxy]]]bis(ethanimi- dothioate) (I) at a concentration of 0.05%.
- the spray contained Duponol L-144-WDG at a concentration of 1:3000.
- Another set of plants was similarly treated with methomyl. Plant injury was evaluated 6 days after treatment and is recorded below.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
- R is branched or straight chain alkyl containing 1 to 3 carbon atoms or methoxymethyl;
- R1 is branched or straight chain alkyl containing 1 to 3 carbon atoms;
- R is -CH2CH2-,
Description
- This invention relates to substituted carbamates, preparation thereof and use thereof as insecticides for the control of pestiferous insects.
-
- R is:
- R' is alkyl containing from one to four carbon atoms. Among the numerous compounds which are included in the Belgian Patent are those wherein R2 is.alkyl, optionally substituted with one or more alkylthio groups, and wherein R3 is hydrogen alkyl or alkoxy. The patentee states, however, that while compounds according to the above formula wherein R2 is an alkylthioalkyl substituent and R3 is hydrogen exhibit good pesticidal activity, their mammalian toxicity is unacceptably high.
-
-
-
- R is a branched or straight chain alkyl group of 1-3 carbon atoms or CH2OCH3;
- R, is a branched or straight chain alkyl group of 1-3 carbon atoms;
- R2 is -CH2CH2-,
- Compounds which are preferred for their high insecticidal activity are those compounds of Formula I wherein
- R is methyl or ethyl; and
- R1 is methyl.
- More preferred for their higher insecticidal activity are those compounds of Formula I wherein
- R is methyl;
- R1 is methyl; and
- R2 is -CH2CH2-.
- Specifically preferred for its outstanding insecticidal activity is dimethyl N,N'[[l,2-ethane- diylbis[thio(methylimino)carbonyloxy]]]bis(ethaneimidothioate).
- The compounds of Formula I can be prepared, as shown in Equation A, by reacting preferably at least two moles of a substituted N-(aminocarbonyloxy)-alkanimidothioic acid ester of Formula II with one mole of an alkane disulfenyl halide of Formula III in the presence of a base:
- The reaction can be carried out in any organic solvent which is inert to the reactants and the reaction products, e.g. methylene chloride, dioxane, tetrahydrofuran, chloroform, 1,2-dichlorethane, acetonitrile, benzene, toluene, the xylenes, acetone or methyl ethyl ketone. Mixtures of such solvents can also be used. A base which will function as an acid acceptor can be used in synthesizing the compounds of this invention.
- The process can be carried out at a temperature of between about -20° and 60°C, preferably between about -5° and 40°C. Pressure is not critical; for convenience, atmospheric pressure is preferred.
- Preparation of the compounds of Formula II used as starting materials is described in U.S. Patents 3,574,736; 3,576,834 and 3,787,470.
- In the compounds of Formula III, chlorine is the preferred halogen for economic reasons, and those compounds can be prepared by a suitable modification of the methods described in the Journal of Heterocvclic Chemistry, 6, 629 (1969). Alkane sulfenyl halides, such as those of Formula III wherein X is fluorine, bromine, or iodine, are also known and may be prepared by the methods reviewed in Synthesis, 11, 561-580 (1970). In the examples which follow, which are illustrat- ive only, temperatures are given in degrees centigrade.
- To a solution of 141 g of sodium methoxide in 1 ℓ of absolute ethanol, under a dry nitrogen atmosphere, was added 200 g of thiolacetic acid dropwise with stirring over a period of 20 minutes. Ethylene dibromide (229.2 g) was then added and the reaction heated to reflux for five hours. The reaction mixture was cooled, sodium bromide was filtered off, and the ethanol was removed under vacuum. The residue was taken up in diethyl ether, washed with water, dried over anhydrous magnesium sulfate and the crude product isolated by distillation of the diethyl ether solvent. After recrystallization from hexanes, the product, ethane-1,2-bisthiolacetate, melted at 68-70°.
- Sulfuryl chloride (54 g) was added dropwise to a solution of 35.6 g of ethane-l,2-bisthiolacetate in 200 ml of methylene chloride at ambient temperature. After stirring for 45 minutes at room temperature the methylene chloride solvent and volatile by-products were removed by vacuum distillation of 0°. The yellow product, ethane-l,2-disulfenyl chloride, melted at 32-34°.
- A solution of 6.5 g of N-(methylaminocarbonyloxy)-ethanimidothioic acid, methyl ester, in 50 ml methylene chloride and 2.0 ml of pyridine was prepared. To that solution was added dropwise 28 gm of ethane-l,2-disulfenyl chloride,dissolved in 25 ml of methylene chloride, with stirring over a period of 10 minutes. The reaction was slightly exothermic. After stirring for about 16 hours at ambient temperature, the reaction mixture was washed with water, dried over anhydrous magnesium sulfate, and the crude product isolated. by distilling off the methylene chloride solvent. After recrystallization from ethyl alcohol followed by recrystallization from acetonitrile, the product, dimethyl N,N'-[[1,2-ethanediylbis[thio(methylimino)carbonyloxy]]]bis(ethan- imidothioate), melted at 176-179°.
-
- Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few pints to several hundred gallons per acre. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain e.g. about 1% to 99% by weight of active ingredient(s) and at least one of (a) e.g. about 0% to 20% surfactant(s) and (b) e.g. about 1% to 99% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:
- Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.
- Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers," 2nd Edn., Dorland Books, Caldwell, N.J. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Edn., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0°C. "McCutcheon's Detergents and Emulsifiers Annual," McCutcheon Division, MC Publishing Co., Ridgewood, New Jersey, as well as Sisely and Wood, "Encyclopedia of Surface Active Agents," Chemical Publ. Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foam, caking, corrosion, microbiological growth, etc.
- The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Patent 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques.
- See J. E. Browning, "Agglomeration," Chemical Engineering, Dec. f, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook," 4th Edn., McGraw-Hill, N.Y., 1963, pp. 8-59ff.
- For further information regarding the art of formulation, see for example:
- J. B. Buchanan, U.S. Patent 3,576,834 April 27, 1971, Col. 5, line 36 throush Col. 7, line 70 and Exs. 1-4, 17, 106, 123-140.
- R. R. Shaffer, U.S. Patent 3,560,616, Feb. 2, 1971, Col. 3, line 48 through Col. 7, line 26 and Exs. 3-9, 11-18.
- E. Somers, "Formulation," Chapter 6 in Torgeson, "Fungicides," Vol. I, Academic Press, New York, 1967.
-
- The ingredients are thoroughly blended, passed through an air mill, to produce an average particle size under 15 microns, reblended, and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) before packaging.
- All compounds of the invention may be formulated in the same manner.
-
-
- The ingredients are thoroughly blended. The liquid surfactant is added by spraying upon the solid ingredients in the blender. After grinding in a hammer mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) and packaged.
-
- The ingredients are ground together in a ball or roller mill until the solid particles have been reduced to diameters under 10 microns.
-
- The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.
-
-
- The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 5 mm diameter which are cut to produce pellets about 3 mm long. These may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm opening). The granules held on a U.S.S. No. 40 sieve (0.42 mm opening) may be packaged for use and the fines recycled.
-
- The ingredients are blended and ground in a hammer mill to produce a high-strength concentrate essentially all passing a U.S.S. No. 50 sieve (0.3 mm opening). This material may then be formulated in a variety of ways.
-
- The ingredients are thoroughly blended and packaged for use.
-
- The ingredients are combined and stirred to. produce a solution which can be emulsified in water for application.
-
- The ingredients are combined and stirred with gentle warming to speed solution. A fine screen filter is included in packaging operation to ensure the absence of any extraneous undissolved material in the product.
- The compounds of this invention are useful for control of insects which are detrimental to agriculture.
- As demonstrated in Examples 16 to 18 below, improved residual insecticidal properties as well as decreased phytotoxicity are obtained with a formulation containing a compound of Formula I.
- The compounds readily control pestiferous insects belonging to such orders as Lepidoptera, Coleoptera, and Diptera. More specifically, insects controlled by the compounds of this invention include but are not limited to: cotton bollworm (Heliothis zea), tobacco budworm (Heliothis virescens), southern armyworm (Spodoptera eridania), beet armyworm (Spodoptera exigua), soybean looper (Pseudoplusia includens), Mexican bean beetle (Epilachna varivestis), and the house fly (Musca domestica).
- The insects are controlled by applying the compound to the locus of infestation, to the area to be protected, or to the pests themselves. For the control of insects in agricultural crops, a compound of Formula I is generally applied to the foliage or other plant parts which are infested or which are to be protected. Effective amounts to be applied depend upon the species to be controlled, its life stage, its size and location, the amount of rainfall, the time of year, moisture, temperature, type of application, and other variables. In general, 0.1 to 10 kg/ha may be required for insect control in agriculture with rates of .2 to 4 kg/ha usually being sufficient in many situations. In large-scale field operations, rates in the range of 1/4 to 2 kg/ha are generally used.
- The compounds of this invention will generally be used in formulation with a carrier that commonly will contain oil or water. Applications may be made with' concentrated or dilute suspensions of the insecticide in the carrier. Low-volume applications utilizing dispersions containing about 20% of the active ingredient may be preferred by some applicators while others may prefer dilute suspensions containing only 25 ppm in high-volume applications.
- The compounds of this invention possess significant advantages over prior art compounds, e.g fewer applications are required to provide a given level of insect control due to this distinctly longer residual insecticidal action. Use of fewer applications results in greater economy to the grower and dissemination of less insecticide in the environment. An additional advantage is lower phytotoxicity to cotton.
- Conventionally, the compounds will be incorporated into a formulation in a known manner with incorporation of other components such as (a) surfactants, (b) diluents, (c) additives to reduce foam or corrosion, or (d) preservatives to control microbiological growth.
- The compounds of this invention can be mixed with fungicides, bactericides, acaricides, nematicides, other insecticides, or other biologically active compounds in order to achieve desired results with a minimum expenditure of time, effort and material. Amounts of these biologically active materials added for each part by weight of the composition of this invention may vary from 0.05 to 25 parts by weight. Suitable agents of this type are well-known to those skilled in the art. Some are listed below:
-
- methyl 2-benzimidazolecarbamate;
- tetramethyl thiuram disulfide (thiuram);
- n-dodecylguanidine acetate (dodine);
- manganese ethylenebisdithiocarbamate (maneb);
- 1,4-dichloro-2,5-dimethoxybenzene (chloroneb);
- methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate (benomyl);
- N-trichloromethylthiotetrahydrophthalimide (captan);
- N-trichloromethylthiophthalimide (folpet);
-
- tribasic copper sulfate;
- streptomycin sulfate;
-
- senecioic acid, ester with 2-sec-butyl-4,6-dinitrophenol (Morocide®);
- 6-methyl-l,3-dithiolo[4,5-b]quinoxalin-2-one (Morestan®); ethyl 4,4'-dichlorobenzilate (Folbex®);
- l,l-bis(p-chlorophenyl)-2,2,2-trichloroethane (Kelthane®);
- bis(pentachloro-2,4-cyclopentadien-lyl) (Pentac®); tricyclohexyl tinhydroxide (cyhexatin);
-
- S-methyl l-(dimethylcarbamoyl)-N-(methylcarbamoyloxy)-thioformimidate (oxamyl);
- S-methyl l-carbamoyl-N-(methylcarbamoyloxy)thiofor- mimidate;
- N-isopropylphosphoramidic acid, O-ethyl-O'-[4-(methyl- thio)-m-tolyl]diester (fenamiphos);
-
- methylcarbamic acid, ester with 2,3-dihydro-2,2-dimethyl-7-benzofuranol (Furadan®);
- 0-[2,4,5-trichloro-α-(chloromethyl)benzyl]phosphoric acid, O',O'-dimethyl ester (tetrachlorvinphos);
- 0-ethyl-0-(4-nitrophenyl)phenylphosphonothioate (EPN); octachlorocamphene (toxaphene);
- cyano(3-phenoxyphenyl)methyl-4-chloro-alpha-(1-methylethyl)benzeneacetate (Pydrin ™);
- (3-phenoxyphenyl)methyl(±)-cis,trans-3-(2,2-dichloro-, ethenyl)-2,2-dimethylcyclopropanecarboxylate (Ambush®);
- 3-phenoxybenzyl-dl-cis,trans-chrysanthemate (phenothrin);
- 2-mercaptosuccinic acid, diethyl ester, S-ester with thionophosphoric acid, dimethyl ester (malathion);
- phosphorothioic acid, O,O-dimethyl, O-p-nitrophenyl ester (methyl parathion);
- methylcarbamic acid, ester with α-naphthol (carbaryl);
- methyl N-(methylaminocarbonyloxy)ethaneimidothioate (methomyl);
- N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlordimeform);
- O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidylphosphoro- thioate (Diazinon®);
- O,S-dimethylacetylphosphoramidothioate (acephate);
- O,S-dimethylphosphoramidothioate (methamidophos).
- The foliage only of red kidney bean plants in the two-leaf stage was sprayed to run-off with aqueous dispersions of dimethyl N,N'-[[1,2-ethanediylbis[thio-(methylimino)carbonyloxy]]]bis(ethanimidothioate) (I) at the dilutions indicated. The sprays contained Duponol L-144-WDG (sulfonated oleyl acetate surfactant) at a concentration of 1:3000. After drying, a single leaf from each treated plant was excised and placed in a covered 20 x 100 mm Petri dish containing a moistened filter paper and 10 southern armyworm (SAW) larvae approximately 13 mm in length. The test was conducted in duplicate. Insect mortality was evaluated two days later and is recorded below.
- The plants from the test described in Example 1 were kept in a growth room at 77 ± 2°F and 53 + 5% relative himidity for 7 days. At the end of that period of time the remaining cotyledonary leaf from each bean plant was placed singly in a Petri dish with southern armyworms as previously described. Insect mortality was again read 2 days later and is set forth below.
- Cotton plants approximately 22 cm in height having 3-4 true leaves were sprayed to run-off with an aqueous dispersion of dimethyl N,N'-[[1,2-ethane- diylbis[thio(methylimino)carbonyloxy]]]bis(ethanimi- dothioate) (I) at a concentration of 0.05%. The spray contained Duponol L-144-WDG at a concentration of 1:3000. Another set of plants was similarly treated with methomyl. Plant injury was evaluated 6 days after treatment and is recorded below.
Claims (10)
that said insecticidal compound is a compound of any of claims 1-4.
that said insecticidal compound is a compound of any of claims 1-4.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81231677A | 1977-07-01 | 1977-07-01 | |
US812316 | 1977-07-01 | ||
US05/885,251 US4160034A (en) | 1977-07-01 | 1978-03-10 | Substituted carbamates |
US885251 | 1978-03-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0000283A1 true EP0000283A1 (en) | 1979-01-10 |
EP0000283B1 EP0000283B1 (en) | 1981-10-14 |
Family
ID=27123592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP78300097A Expired EP0000283B1 (en) | 1977-07-01 | 1978-06-28 | Substituted carbamates, preparation and compositions thereof and use thereof as insecticides. |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0000283B1 (en) |
JP (1) | JPS5444614A (en) |
AR (1) | AR220138A1 (en) |
AU (1) | AU515983B2 (en) |
BR (1) | BR7804185A (en) |
CA (1) | CA1107292A (en) |
CS (1) | CS199213B2 (en) |
DE (1) | DE2861154D1 (en) |
DK (1) | DK254378A (en) |
EG (1) | EG13741A (en) |
ES (1) | ES471280A1 (en) |
GB (1) | GB2001628B (en) |
GR (1) | GR64548B (en) |
IE (1) | IE47205B1 (en) |
IL (1) | IL55050A (en) |
IT (1) | IT1158872B (en) |
MX (1) | MX5138E (en) |
OA (1) | OA05999A (en) |
PH (1) | PH13803A (en) |
PL (1) | PL114208B1 (en) |
TR (1) | TR19962A (en) |
YU (1) | YU154178A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2485882A1 (en) * | 1980-07-03 | 1982-01-08 | Du Pont | CARBAMATES SUBSTITUTED TO FIGHT TICK |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3856972A (en) * | 1970-09-24 | 1974-12-24 | M Hirano | Carbamate pesticides |
-
1978
- 1978-06-08 DK DK254378A patent/DK254378A/en not_active Application Discontinuation
- 1978-06-23 PH PH21318A patent/PH13803A/en unknown
- 1978-06-28 EP EP78300097A patent/EP0000283B1/en not_active Expired
- 1978-06-28 DE DE7878300097T patent/DE2861154D1/en not_active Expired
- 1978-06-28 GB GB787828116A patent/GB2001628B/en not_active Expired
- 1978-06-28 AU AU37526/78A patent/AU515983B2/en not_active Expired
- 1978-06-28 EG EG406/78A patent/EG13741A/en active
- 1978-06-28 MX MX787191U patent/MX5138E/en unknown
- 1978-06-28 TR TR19962A patent/TR19962A/en unknown
- 1978-06-29 YU YU01541/78A patent/YU154178A/en unknown
- 1978-06-29 CS CS784303A patent/CS199213B2/en unknown
- 1978-06-29 ES ES471280A patent/ES471280A1/en not_active Expired
- 1978-06-29 JP JP7812978A patent/JPS5444614A/en active Pending
- 1978-06-30 IL IL55050A patent/IL55050A/en unknown
- 1978-06-30 PL PL1978208044A patent/PL114208B1/en unknown
- 1978-06-30 OA OA56548A patent/OA05999A/en unknown
- 1978-06-30 AR AR272767A patent/AR220138A1/en active
- 1978-06-30 CA CA306,631A patent/CA1107292A/en not_active Expired
- 1978-06-30 IE IE1324/78A patent/IE47205B1/en unknown
- 1978-06-30 BR BR7804185A patent/BR7804185A/en unknown
- 1978-06-30 GR GR56643A patent/GR64548B/en unknown
- 1978-06-30 IT IT25229/78A patent/IT1158872B/en active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3856972A (en) * | 1970-09-24 | 1974-12-24 | M Hirano | Carbamate pesticides |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2485882A1 (en) * | 1980-07-03 | 1982-01-08 | Du Pont | CARBAMATES SUBSTITUTED TO FIGHT TICK |
Also Published As
Publication number | Publication date |
---|---|
DE2861154D1 (en) | 1981-12-24 |
ES471280A1 (en) | 1979-10-01 |
EP0000283B1 (en) | 1981-10-14 |
OA05999A (en) | 1981-06-30 |
GR64548B (en) | 1980-04-12 |
IL55050A (en) | 1983-03-31 |
GB2001628A (en) | 1979-02-07 |
PL114208B1 (en) | 1981-01-31 |
CA1107292A (en) | 1981-08-18 |
EG13741A (en) | 1982-09-30 |
BR7804185A (en) | 1979-03-20 |
IE47205B1 (en) | 1984-01-11 |
PH13803A (en) | 1980-10-01 |
IT1158872B (en) | 1987-02-25 |
IT7825229A0 (en) | 1978-06-30 |
AR220138A1 (en) | 1980-10-15 |
MX5138E (en) | 1983-03-28 |
TR19962A (en) | 1980-05-16 |
AU515983B2 (en) | 1981-05-14 |
JPS5444614A (en) | 1979-04-09 |
PL208044A1 (en) | 1979-12-03 |
CS199213B2 (en) | 1980-07-31 |
IE781324L (en) | 1979-01-01 |
DK254378A (en) | 1979-01-02 |
AU3752678A (en) | 1980-01-03 |
YU154178A (en) | 1983-01-21 |
GB2001628B (en) | 1982-01-13 |
IL55050A0 (en) | 1978-08-31 |
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