EE201400038A - Composition comprising a probiotic microorganism strain Lactobacillus plantarum Inducia DSM 21379 as hypocholesterolemic and antimicrobial agent for use in preventing cardiovascular disorders Clostridium difficile associated diarrhoea - Google Patents

Composition comprising a probiotic microorganism strain Lactobacillus plantarum Inducia DSM 21379 as hypocholesterolemic and antimicrobial agent for use in preventing cardiovascular disorders Clostridium difficile associated diarrhoea

Info

Publication number
EE201400038A
EE201400038A EEP201400038A EEP201400038A EE201400038A EE 201400038 A EE201400038 A EE 201400038A EE P201400038 A EEP201400038 A EE P201400038A EE P201400038 A EEP201400038 A EE P201400038A EE 201400038 A EE201400038 A EE 201400038A
Authority
EE
Estonia
Prior art keywords
plantarum inducia
hypocholesterolemic
oxidative
difficile
cardiovascular disorders
Prior art date
Application number
EEP201400038A
Other languages
Estonian (et)
Inventor
Marika Mikelsaar
Epp Songisepp
Merle Rätsep
Pirje Hütt
Imbi Smidt
Kai Truusalu
Epp Sepp
Raik-Hiio Mikelsaar
Kalle Kilk
Jelena Stsepetova
Siiri Kõljalg
Mirjam Vallas
Original Assignee
OÜ Tervisliku Piima Biotehnoloogiate Arenduskeskus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/244,284 external-priority patent/US20140335066A1/en
Application filed by OÜ Tervisliku Piima Biotehnoloogiate Arenduskeskus filed Critical OÜ Tervisliku Piima Biotehnoloogiate Arenduskeskus
Priority to EEP201800005A priority Critical patent/EE05809B1/en
Publication of EE201400038A publication Critical patent/EE201400038A/en
Publication of EE05799B1 publication Critical patent/EE05799B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • C12R2001/25—Lactobacillus plantarum

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention relates to a microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent. The food products and compositions comprising said strain have a cardio-protective effect. L. plantarum Inducia is used in preventing cholesterol metabolism disorders and cardiovascular disorders by reducing the level of LDL-cholesterol, and simultaneously as an anti-oxidative agent for use in enhancing anti-oxidative activity of human body by reducing the levels of oxidative stress markers - oxidized low density lipoprotein (ox-LDL) and oxidative stress index (OSI). L. plantarum Inducia can be used as an antimicrobial agent in lowering risk of Clostridium difficile associated diarrhoea (CDAD) of endogenous or exogenous origin by preventing germination of C. difficile spores and by suppressing proliferation of C. difficile vegetative cells. L. plantarum Inducia can be used simultaneously with antibiotic treatment. The compositions against C. difficile may further comprise xylitol.
EEP201400038A 2008-05-13 2014-10-31 Composition comprising hypocholesterolemic probiotic microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use in preventing cardiovascular disorders EE05799B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EEP201800005A EE05809B1 (en) 2008-05-13 2014-10-31 Composition comrising probiotic microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use in reducing risk of Clostridium difficile associated diarrhoea (CDAD)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14/244,284 US20140335066A1 (en) 2008-05-13 2014-04-03 Lactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile

Publications (2)

Publication Number Publication Date
EE201400038A true EE201400038A (en) 2015-11-16
EE05799B1 EE05799B1 (en) 2017-10-16

Family

ID=51932160

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP201400038A EE05799B1 (en) 2008-05-13 2014-10-31 Composition comprising hypocholesterolemic probiotic microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use in preventing cardiovascular disorders

Country Status (3)

Country Link
JP (1) JP2017515799A (en)
EE (1) EE05799B1 (en)
WO (1) WO2015149818A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201519326D0 (en) 2015-11-02 2015-12-16 Optibiotix Health Ltd Composition`
GB201611782D0 (en) * 2016-07-06 2016-08-17 Optibiotix Ltd Composition
CN112823015A (en) * 2018-08-01 2021-05-18 N.M.B.医学应用有限公司 Orally administered supplement and method for reducing calorie absorption and altering the nutritional value of consumed nutrients
CN109234189A (en) * 2018-08-17 2019-01-18 甘肃普诺贝康生物科技有限责任公司 One plant of lactobacillus plantarum strain BX62 and its application with oxidation resistance
WO2020171256A1 (en) * 2019-02-21 2020-08-27 서울대학교산학협력단 Lactobacillus strain having growth-inhibitory effect on clostridium difficile
WO2023132628A1 (en) * 2022-01-04 2023-07-13 주식회사 바이오뱅크힐링 Novel strain and vesicles derived therefrom, and anti-inflammatory and antibacterial uses thereof
KR102365420B1 (en) * 2022-01-04 2022-02-23 주식회사 바이오뱅크힐링 Roseburia intestinalis strain, and vesicles from thereof and anti-inflammation and anti-bacteria uses of thereof
CN116676239B (en) * 2023-07-26 2023-10-27 杭州微致生物科技有限公司 Lactobacillus plantarum VB165 and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2080519A1 (en) * 2008-01-15 2009-07-22 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Peptides having binding affinity to an antibody which recognizes an epitope on an alpha1 loop 2 or beta 2 loop 1 of an adrenoreceptor
EE05341B1 (en) * 2008-05-13 2010-08-16 O� Tervisliku Piima Biotehnoloogiate Arenduskeskus Isolated microorganism or Lactobacillus plantarum Inducia DSM 21379 as a probiotic that enhances the natural defenses of the organism, the food and the composition containing them, and the use of the microorganism in the preparation of a cell-mediated immunity
EP2311473A1 (en) 2009-10-09 2011-04-20 AB-Biotics Producciones Industriales De Microbiotas, S.L. Lactobacillus plantarum strains as probiotics

Also Published As

Publication number Publication date
JP2017515799A (en) 2017-06-15
EE05799B1 (en) 2017-10-16
WO2015149818A1 (en) 2015-10-08

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