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Preparation Of Compounds By Using Micro-Organisms
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Enzymes And Modification Thereof
(AREA)
Abstract
Esta invención se refiere a tioésteres y cetonas heterocíclicos neurotróticos de bajo peso molecular y moléculas pequeñas con una afinidad por inmunofilinas de tipo FKBP y su uso como inhibidores de la actividad enzimática asociada con protínas de inmunofilina, paticularmente la actividad enzimática de la isomerasa peptidil-prolilo o rotamasa.This invention relates to low molecular weight, small molecule neurotrotic heterocyclic thioesters and ketones with an affinity for FKBP-type immunophilins and their use as inhibitors of enzyme activity associated with immunophilin protins, particularly the enzymatic activity of peptidyl-prolyl isomerase or rotamasa.
ECSP9722731997-10-011997-10-01
THIOESTERS AND HETERO CYCLIC KETONES
ECSP972273A
(en)