BR0210060A - Heterobicycles fkbp ligands - Google Patents
Heterobicycles fkbp ligandsInfo
- Publication number
- BR0210060A BR0210060A BR0210060-6A BR0210060A BR0210060A BR 0210060 A BR0210060 A BR 0210060A BR 0210060 A BR0210060 A BR 0210060A BR 0210060 A BR0210060 A BR 0210060A
- Authority
- BR
- Brazil
- Prior art keywords
- fkbp
- heterobicycles
- fkbp ligands
- ligands
- heterobicyc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"LIGANDOS DE FKBP DE HETEROBICICLOS". Derivados de diazabiciclo[3.3.1]nonano que inibem a atividade de enzima de isomerase de peptidil-prolila associada com as proteínas de ligação de FK-506 (FKBP) são descritos para tratar distúrbios neurológicos. São também descritos compostos úteis para a preparação de tais inibidores."HETEROBICYC FKBP LINKS". Diazabicyclo [3.3.1] nonane derivatives that inhibit peptidyl prolyl isomerase enzyme activity associated with FK-506 binding proteins (FKBP) are described to treat neurological disorders. Also useful compounds for the preparation of such inhibitors are described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28982801P | 2001-05-10 | 2001-05-10 | |
PCT/US2002/014966 WO2002089806A1 (en) | 2001-05-10 | 2002-05-10 | Heterobicycles fkbp-ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0210060A true BR0210060A (en) | 2004-08-17 |
Family
ID=23113278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0210060-6A BR0210060A (en) | 2001-05-10 | 2002-05-10 | Heterobicycles fkbp ligands |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1423119A4 (en) |
JP (1) | JP2004532854A (en) |
BR (1) | BR0210060A (en) |
CA (1) | CA2446795A1 (en) |
MX (1) | MXPA03010255A (en) |
WO (1) | WO2002089806A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007024651A2 (en) * | 2005-08-19 | 2007-03-01 | Elan Pharmaceuticals, Inc. | Bridged n-bicyclic sulfonamido inhibitors of gamma secretase |
EP2690102A1 (en) * | 2012-07-24 | 2014-01-29 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Bicyclic aza-amides for treatment of psychiatric disorders |
EP2899192A1 (en) * | 2014-01-24 | 2015-07-29 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders |
US9914732B2 (en) * | 2014-01-24 | 2018-03-13 | Max-Planck-Gesellschaft Zur Forderung Der Wissensc Haften E.V. | Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders |
CA2953040A1 (en) | 2014-08-27 | 2016-03-03 | F. Hoffmann-La Roche Ag | Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders |
US10597378B2 (en) | 2017-09-08 | 2020-03-24 | National Health Research Institutes | Tetrahydroisoquinolines for use as MOR/NOP dual agonists |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3880927A (en) * | 1972-06-19 | 1975-04-29 | Lilly Co Eli | {62 -Phenyl-{62 ,{62 -difluoroethylamines |
AP2001002052A0 (en) * | 1998-07-17 | 2001-03-31 | Agouron Pharma | Compounds, compositions, and methods for stimulating neuronal growth and elongation |
US6818643B1 (en) * | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
HUP0301442A3 (en) * | 2000-10-19 | 2007-03-28 | Pfizer Prod Inc | Bridged piperazine derivatives and pharmaceutical compositions containing them |
WO2002060894A2 (en) * | 2001-01-30 | 2002-08-08 | Bristol-Myers Squibb Company | Sulfonamide lactam inhibitors of factor xa |
-
2002
- 2002-05-10 EP EP02731761A patent/EP1423119A4/en not_active Withdrawn
- 2002-05-10 BR BR0210060-6A patent/BR0210060A/en not_active IP Right Cessation
- 2002-05-10 WO PCT/US2002/014966 patent/WO2002089806A1/en active Application Filing
- 2002-05-10 CA CA002446795A patent/CA2446795A1/en not_active Abandoned
- 2002-05-10 JP JP2002586941A patent/JP2004532854A/en not_active Abandoned
- 2002-05-10 MX MXPA03010255A patent/MXPA03010255A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1423119A4 (en) | 2005-04-13 |
JP2004532854A (en) | 2004-10-28 |
EP1423119A1 (en) | 2004-06-02 |
CA2446795A1 (en) | 2002-11-14 |
WO2002089806A1 (en) | 2002-11-14 |
MXPA03010255A (en) | 2005-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2131457A1 (en) | Small molecule inhibitors of rotamase enzyme activity | |
NO20021783L (en) | Alkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase | |
ES2194596A1 (en) | Inhibitors of rotamase enzyme activity | |
MA27933A1 (en) | INHIBITORS OF AKT ACTIVITY | |
NO20021781D0 (en) | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase | |
EA199800329A1 (en) | INHIBITORS OF ROTAMIC ENZYMATIVE ACTIVITY | |
NO992960D0 (en) | Substituted nitrogen-containing heterocyclic compounds as inhibitors of p38 protein kinase | |
NZ508838A (en) | Heterocyclic compounds as inhibitors of rotamase enzymes | |
BR9611624A (en) | Cyclofilin Rotamase Activity Inhibitors | |
EA200100992A1 (en) | IMPDH ENZYME INHIBITORS | |
DK0966465T3 (en) | Inhibitors of IMPDH enzymes | |
IL165434A0 (en) | Compounds having DPP-IV inhibitory activity | |
EA200870048A1 (en) | Heteroaryl-PYRROLO [2,3-b] PYRIDINES AND PYRROLO [2,3-b] PYRMIDINES AS A INHIBITOR JANUS-KINASE INHIBITORS | |
EP0876387A4 (en) | Method to improve the biological and antiviral activity of protease inhibitors | |
EA200100588A1 (en) | PIPERIDINES AS CCR5 MODULATORS | |
WO2000043373A3 (en) | Kinase inhibitors | |
HUP0002974A2 (en) | N-linked sulfonamides of heterocyclic thioesters, process for producing them and pharmaceutical compositions containing them | |
UA66865C2 (en) | Indenopyrrolocarbazoles, pharmaceutical composition, method for inhibiting kinase activity and method for treatment (variants) | |
UY27606A1 (en) | PHOSPHARASE INHIBITORS | |
EP0313847A3 (en) | Non-peptidyl alpha-succinamidoacyl aminodiols as anti-hypertensive agents | |
BR0210060A (en) | Heterobicycles fkbp ligands | |
WO2001016300A3 (en) | Method of identifying inhibitors of cdc25 | |
AU2001271611A1 (en) | Oxindole derivatives | |
PL1628979T3 (en) | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | |
ES2170628A1 (en) | Small molecule inhibitors of rotamase enzyme activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE 7A., E 8A., ANUIDADES. |
|
B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010. |