ECSP22049008A - M?todos de tratamiento del c?ncer de pulm?n de c?lulas peque?as con formulaciones de lurbinectedina - Google Patents
M?todos de tratamiento del c?ncer de pulm?n de c?lulas peque?as con formulaciones de lurbinectedinaInfo
- Publication number
- ECSP22049008A ECSP22049008A ECSENADI202249008A ECDI202249008A ECSP22049008A EC SP22049008 A ECSP22049008 A EC SP22049008A EC SENADI202249008 A ECSENADI202249008 A EC SENADI202249008A EC DI202249008 A ECDI202249008 A EC DI202249008A EC SP22049008 A ECSP22049008 A EC SP22049008A
- Authority
- EC
- Ecuador
- Prior art keywords
- lurbinectedin
- methods
- formulations
- treatment
- lung cancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proporcionan m?todos para el tratamiento de pacientes con CPCP mediante la administraci?n de cantidades terap?uticas de lurbinectedina mediante infusi?n intravenosa. Tambi?n se proporcionan m?todos para tratar el c?ncer mediante la administraci?n de lurbinectedina en combinaci?n con otros f?rmacos anticancerosos, en particular inhibidores de la topoisomerasa. La invenci?n tambi?n se refiere a la administraci?n de lurbinectedina en combinaci?n con agentes antiem?ticos para el control eficaz de los s?ntomas relacionados con n?useas y v?mitos, dosis reducidas de lurbinectedina para lograr una administraci?n m?s segura y un aumento en el n?mero de ciclos de tratamiento. Tambi?n se proporcionan formulaciones liofilizadas estables de lurbinectedina.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19383025 | 2019-11-21 | ||
EP20382409 | 2020-05-14 | ||
PCT/EP2020/063734 WO2021228414A1 (en) | 2020-05-14 | 2020-05-15 | Methods of treating small cell lung cancer with lurbinectedin formulations |
PCT/EP2020/065093 WO2021098992A1 (en) | 2019-11-21 | 2020-05-29 | Methods of treating small cell lung cancer with lurbinectedin formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP22049008A true ECSP22049008A (es) | 2022-08-31 |
Family
ID=70918456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202249008A ECSP22049008A (es) | 2019-11-21 | 2022-06-20 | M?todos de tratamiento del c?ncer de pulm?n de c?lulas peque?as con formulaciones de lurbinectedina |
Country Status (17)
Country | Link |
---|---|
US (6) | US20230027502A1 (es) |
EP (1) | EP4061372A1 (es) |
JP (1) | JP2023503318A (es) |
KR (1) | KR20220119618A (es) |
CN (1) | CN115151259A (es) |
AU (1) | AU2020388196A1 (es) |
BR (1) | BR112022009283A2 (es) |
CA (1) | CA3158733A1 (es) |
CL (1) | CL2022001342A1 (es) |
CO (1) | CO2022008437A2 (es) |
CR (1) | CR20220289A (es) |
EC (1) | ECSP22049008A (es) |
IL (1) | IL293128A (es) |
JO (1) | JOP20220118A1 (es) |
MX (1) | MX2022006208A (es) |
PE (1) | PE20221338A1 (es) |
WO (1) | WO2021098992A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023079177A1 (en) * | 2021-11-08 | 2023-05-11 | Pharma Mar, S.A. | Lurbinectedin and atezolizumab combinations |
CN115304619A (zh) * | 2022-04-08 | 2022-11-08 | 上海皓元医药股份有限公司 | 一种卢比替定的晶型及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0119243D0 (en) | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
WO2005077341A1 (en) * | 2004-01-19 | 2005-08-25 | Ranbaxy Laboratories Limited | Orally disintegrating pharmaceutical compositions of ondansetron |
DK1658848T3 (da) * | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
JP6037337B2 (ja) * | 2010-05-25 | 2016-12-07 | ファルマ、マール、ソシエダード、アノニマPharma Mrs,S.A. | エクチナサイジン化合物の製造のための合成方法 |
BR122017028570B1 (pt) * | 2010-11-12 | 2022-03-03 | Pharma Mar, S.A | Uso de pm01183, ou um sal farmaceuticamente aceitável do mesmo, em combinação sinérgica com um inibidor da topoisomerase i e/ou ii e kit |
JOP20190254A1 (ar) * | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
-
2020
- 2020-05-29 CN CN202080090766.7A patent/CN115151259A/zh active Pending
- 2020-05-29 IL IL293128A patent/IL293128A/en unknown
- 2020-05-29 EP EP20729071.9A patent/EP4061372A1/en active Pending
- 2020-05-29 KR KR1020227021161A patent/KR20220119618A/ko unknown
- 2020-05-29 US US17/777,982 patent/US20230027502A1/en active Pending
- 2020-05-29 MX MX2022006208A patent/MX2022006208A/es unknown
- 2020-05-29 JO JOP/2022/0118A patent/JOP20220118A1/ar unknown
- 2020-05-29 BR BR112022009283A patent/BR112022009283A2/pt unknown
- 2020-05-29 WO PCT/EP2020/065093 patent/WO2021098992A1/en active Application Filing
- 2020-05-29 CR CR20220289A patent/CR20220289A/es unknown
- 2020-05-29 JP JP2022529896A patent/JP2023503318A/ja active Pending
- 2020-05-29 AU AU2020388196A patent/AU2020388196A1/en active Pending
- 2020-05-29 CA CA3158733A patent/CA3158733A1/en active Pending
- 2020-05-29 PE PE2022000823A patent/PE20221338A1/es unknown
-
2022
- 2022-05-20 CL CL2022001342A patent/CL2022001342A1/es unknown
- 2022-06-16 CO CONC2022/0008437A patent/CO2022008437A2/es unknown
- 2022-06-20 EC ECSENADI202249008A patent/ECSP22049008A/es unknown
-
2023
- 2023-08-10 US US18/448,122 patent/US20240041873A1/en active Pending
- 2023-08-10 US US18/448,145 patent/US20230390286A1/en active Pending
- 2023-08-10 US US18/448,124 patent/US20240041874A1/en active Pending
- 2023-08-10 US US18/448,097 patent/US20240041872A1/en active Pending
- 2023-08-10 US US18/448,144 patent/US20230390285A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CO2022008437A2 (es) | 2022-07-29 |
US20230390286A1 (en) | 2023-12-07 |
MX2022006208A (es) | 2022-07-05 |
KR20220119618A (ko) | 2022-08-30 |
BR112022009283A2 (pt) | 2022-08-02 |
WO2021098992A1 (en) | 2021-05-27 |
PE20221338A1 (es) | 2022-09-13 |
CL2022001342A1 (es) | 2023-03-17 |
US20230390285A1 (en) | 2023-12-07 |
US20240041872A1 (en) | 2024-02-08 |
EP4061372A1 (en) | 2022-09-28 |
US20230027502A1 (en) | 2023-01-26 |
US20240041874A1 (en) | 2024-02-08 |
CA3158733A1 (en) | 2021-05-27 |
JOP20220118A1 (ar) | 2023-01-30 |
IL293128A (en) | 2022-07-01 |
CR20220289A (es) | 2022-10-27 |
US20240041873A1 (en) | 2024-02-08 |
CN115151259A (zh) | 2022-10-04 |
JP2023503318A (ja) | 2023-01-27 |
AU2020388196A1 (en) | 2022-06-30 |
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