ECSP21077614A - Compuestos de 4h-pirrolo[3,2-c]piridin-4-ona - Google Patents
Compuestos de 4h-pirrolo[3,2-c]piridin-4-onaInfo
- Publication number
- ECSP21077614A ECSP21077614A ECSENADI202177614A ECDI202177614A ECSP21077614A EC SP21077614 A ECSP21077614 A EC SP21077614A EC SENADI202177614 A ECSENADI202177614 A EC SENADI202177614A EC DI202177614 A ECDI202177614 A EC DI202177614A EC SP21077614 A ECSP21077614 A EC SP21077614A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- pyrrolo
- pyridin
- processes
- seen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos de la fórmula (I), conforme se desprende del gráfico constante en el resumen de la memoria descriptiva, procesos para su producción y uso como preparados farmacológicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962838051P | 2019-04-24 | 2019-04-24 | |
US201962940036P | 2019-11-25 | 2019-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP21077614A true ECSP21077614A (es) | 2021-11-30 |
Family
ID=70456765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202177614A ECSP21077614A (es) | 2019-04-24 | 2021-10-19 | Compuestos de 4h-pirrolo[3,2-c]piridin-4-ona |
Country Status (20)
Country | Link |
---|---|
US (1) | US20220298157A1 (es) |
EP (1) | EP3959211A1 (es) |
JP (1) | JP2022532850A (es) |
KR (1) | KR20220004103A (es) |
CN (3) | CN114127064B (es) |
AU (1) | AU2020262221A1 (es) |
BR (1) | BR112021019998B1 (es) |
CA (1) | CA3137218A1 (es) |
CL (1) | CL2021002770A1 (es) |
CO (1) | CO2021014022A2 (es) |
CR (1) | CR20210530A (es) |
EC (1) | ECSP21077614A (es) |
IL (1) | IL287390A (es) |
JO (1) | JOP20210285A1 (es) |
MA (1) | MA55751A (es) |
MX (1) | MX2021012987A (es) |
PE (1) | PE20220254A1 (es) |
SG (1) | SG11202111304UA (es) |
TW (1) | TW202106683A (es) |
WO (1) | WO2020216781A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019081486A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | 4H-PYRROLO [3,2-C] PYRIDIN-4-ONE DERIVATIVES |
WO2022033416A1 (zh) * | 2020-08-10 | 2022-02-17 | 上海和誉生物医药科技有限公司 | 作为egfr抑制剂的稠环化合物及其制备方法和应用 |
EP4217070A1 (en) * | 2020-09-23 | 2023-08-02 | Scorpion Therapeutics, Inc. | Pyrrolo[3,2-c]pyridin-4-one derivatives useful in the treatment of cancer |
WO2022094271A1 (en) * | 2020-10-30 | 2022-05-05 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
WO2022098992A1 (en) * | 2020-11-05 | 2022-05-12 | Scorpion Therapeutics, Inc. | Use of macrocyclic compounds in methods of treating cancer |
WO2022101184A1 (en) * | 2020-11-11 | 2022-05-19 | Bayer Aktiengesellschaft | N-[2-({4-[3-(anilino)-4-oxo-4,5,6,7-tetrahydro-1h-pyrrolo[3,2-c]pyridin-2-yl]pyridin-3-yl)oxy)ethyl]prop-2-enamide derivatives and similar compounds as egfr inhibitors for the treatment of cancer |
US20220387405A1 (en) * | 2021-05-06 | 2022-12-08 | Celgene Corporation | Methods of treatment with n-((r)-1-(3-chloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-((s)-2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide |
WO2023183601A1 (en) * | 2022-03-24 | 2023-09-28 | Scorpion Therapeutics, Inc. | Methods of synthesizing egfr inhibitors |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3966781A (en) | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US8299108B2 (en) | 2002-03-29 | 2012-10-30 | Novartis Ag | Substituted benzazoles and methods of their use as inhibitors of raf kinase |
US7211573B2 (en) | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
DE102006033140A1 (de) | 2006-07-18 | 2008-01-24 | Merck Patent Gmbh | Aminoindazolharnstoffderivate |
EP2151431A4 (en) | 2007-04-27 | 2010-04-21 | Sumitomo Chemical Co | AMIDE COMPOUND AND USE THEREOF |
BRPI0814777A2 (pt) | 2007-08-08 | 2015-03-03 | Glaxosmithkline Llc | Composto, composição farmacêutica, método para tratar um neoplasma, uso de um composto, e, composição farmacêutica. |
TWI491610B (zh) | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
JP5789602B2 (ja) * | 2009-06-15 | 2015-10-07 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 置換ピリミジニルピロロピリジノン誘導体、これらの製造のための方法およびキナーゼ阻害剤としてのこれらの使用 |
EP2675440B1 (en) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
WO2015022073A1 (en) | 2013-08-13 | 2015-02-19 | Grünenthal GmbH | Annelated pyrroles and their use as crac inhibitors |
CA2952307A1 (en) | 2014-06-17 | 2015-12-23 | Bayer Pharma Aktiengesellschaft | 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones |
JP2017538697A (ja) | 2014-12-08 | 2017-12-28 | バイエル ファーマ アクチエンゲゼルシャフト | 新規なアリール−シアノグアニジン化合物 |
WO2016100166A1 (en) | 2014-12-15 | 2016-06-23 | Bristol-Myers Squibb Company | SUBSTITUTED DIHYDRO-1H-PYRROLO[3,2-c]PYRIDIN-4(5H)-ONES AS RIPK3 INHIBITORS |
AU2016212230B2 (en) | 2015-01-28 | 2019-09-19 | Bayer Pharma Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
-
2020
- 2020-04-22 EP EP20721196.2A patent/EP3959211A1/en active Pending
- 2020-04-22 MA MA055751A patent/MA55751A/fr unknown
- 2020-04-22 KR KR1020217037778A patent/KR20220004103A/ko unknown
- 2020-04-22 AU AU2020262221A patent/AU2020262221A1/en active Pending
- 2020-04-22 JO JOP/2021/0285A patent/JOP20210285A1/ar unknown
- 2020-04-22 PE PE2021001760A patent/PE20220254A1/es unknown
- 2020-04-22 CN CN202080031189.4A patent/CN114127064B/zh active Active
- 2020-04-22 US US17/605,975 patent/US20220298157A1/en active Pending
- 2020-04-22 JP JP2021563175A patent/JP2022532850A/ja active Pending
- 2020-04-22 CN CN202311714944.0A patent/CN117946100A/zh active Pending
- 2020-04-22 CR CR20210530A patent/CR20210530A/es unknown
- 2020-04-22 SG SG11202111304UA patent/SG11202111304UA/en unknown
- 2020-04-22 TW TW109113538A patent/TW202106683A/zh unknown
- 2020-04-22 CA CA3137218A patent/CA3137218A1/en active Pending
- 2020-04-22 CN CN202311716707.8A patent/CN117986251A/zh active Pending
- 2020-04-22 MX MX2021012987A patent/MX2021012987A/es unknown
- 2020-04-22 WO PCT/EP2020/061176 patent/WO2020216781A1/en active Application Filing
- 2020-04-22 BR BR112021019998-5A patent/BR112021019998B1/pt active IP Right Grant
-
2021
- 2021-10-19 IL IL287390A patent/IL287390A/en unknown
- 2021-10-19 EC ECSENADI202177614A patent/ECSP21077614A/es unknown
- 2021-10-20 CO CONC2021/0014022A patent/CO2021014022A2/es unknown
- 2021-10-21 CL CL2021002770A patent/CL2021002770A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2022532850A (ja) | 2022-07-20 |
CN117986251A (zh) | 2024-05-07 |
US20220298157A1 (en) | 2022-09-22 |
WO2020216781A1 (en) | 2020-10-29 |
EP3959211A1 (en) | 2022-03-02 |
SG11202111304UA (en) | 2021-11-29 |
CN114127064A (zh) | 2022-03-01 |
PE20220254A1 (es) | 2022-02-16 |
CR20210530A (es) | 2021-12-23 |
MX2021012987A (es) | 2022-04-01 |
CL2021002770A1 (es) | 2022-05-27 |
CA3137218A1 (en) | 2020-10-29 |
BR112021019998A2 (es) | 2021-12-07 |
AU2020262221A1 (en) | 2021-11-18 |
JOP20210285A1 (ar) | 2023-01-30 |
KR20220004103A (ko) | 2022-01-11 |
BR112021019998B1 (pt) | 2024-01-16 |
IL287390A (en) | 2021-12-01 |
CN114127064B (zh) | 2023-12-26 |
TW202106683A (zh) | 2021-02-16 |
CO2021014022A2 (es) | 2022-03-29 |
MA55751A (fr) | 2022-03-02 |
CN117946100A (zh) | 2024-04-30 |
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