ECSP14024753A - Métodos y composiciones para modular la actividad notch - Google Patents
Métodos y composiciones para modular la actividad notchInfo
- Publication number
- ECSP14024753A ECSP14024753A ECIEPI201424753A ECPI201424753A ECSP14024753A EC SP14024753 A ECSP14024753 A EC SP14024753A EC IEPI201424753 A ECIEPI201424753 A EC IEPI201424753A EC PI201424753 A ECPI201424753 A EC PI201424753A EC SP14024753 A ECSP14024753 A EC SP14024753A
- Authority
- EC
- Ecuador
- Prior art keywords
- polypeptides
- compositions
- methods
- modulate
- notch activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Insects & Arthropods (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En la presente se proporcionan los polipéptidos y derivados de estos que contienen secuencias de una proteína Serrate y que inhiben la función de la vía de Notch. También se proporcionan en la presente los ácidos nucleicos que codifican los polipéptidos, vectores y células para producir los polipéptidos, y las composiciones farmacéuticas y kits relacionados. Además se proporcionan los anticuerpos que se unen a la región de inhibición de Notch de una proteína Serrate. También se proporcionan métodos terapéuticos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2012/031213 WO2013147793A1 (en) | 2012-03-29 | 2012-03-29 | Methods and compositions for modulating notch activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP14024753A true ECSP14024753A (es) | 2015-09-30 |
Family
ID=49260857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECIEPI201424753A ECSP14024753A (es) | 2012-03-29 | 2014-10-28 | Métodos y composiciones para modular la actividad notch |
Country Status (10)
Country | Link |
---|---|
US (1) | US20150291681A1 (es) |
KR (1) | KR20150014439A (es) |
AU (1) | AU2012375337A1 (es) |
BR (1) | BR112014024230A8 (es) |
CA (1) | CA2868747A1 (es) |
CL (1) | CL2014002596A1 (es) |
EC (1) | ECSP14024753A (es) |
MX (1) | MX2014011608A (es) |
PH (1) | PH12014502182A1 (es) |
WO (1) | WO2013147793A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2876904C (en) | 2012-06-22 | 2019-12-03 | Cytomx Therapeutics, Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
CN111269311B (zh) * | 2019-09-30 | 2023-10-13 | 复旦大学 | 一种增强型合成Notch受体及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0861261T3 (da) * | 1995-06-28 | 2009-12-14 | Imp Cancer Res Tech | Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå |
WO2004082710A1 (en) * | 2003-03-21 | 2004-09-30 | Lorantis Limited | Treatment of allergic diseases using a modulator of the notch signaling pathway |
-
2012
- 2012-03-29 CA CA2868747A patent/CA2868747A1/en not_active Abandoned
- 2012-03-29 AU AU2012375337A patent/AU2012375337A1/en not_active Abandoned
- 2012-03-29 WO PCT/US2012/031213 patent/WO2013147793A1/en active Application Filing
- 2012-03-29 BR BR112014024230A patent/BR112014024230A8/pt not_active IP Right Cessation
- 2012-03-29 KR KR1020147030124A patent/KR20150014439A/ko not_active Application Discontinuation
- 2012-03-29 MX MX2014011608A patent/MX2014011608A/es unknown
- 2012-03-29 US US14/388,598 patent/US20150291681A1/en not_active Abandoned
-
2014
- 2014-09-29 PH PH12014502182A patent/PH12014502182A1/en unknown
- 2014-09-29 CL CL2014002596A patent/CL2014002596A1/es unknown
- 2014-10-28 EC ECIEPI201424753A patent/ECSP14024753A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2014002596A1 (es) | 2015-07-10 |
BR112014024230A2 (es) | 2017-06-20 |
AU2012375337A1 (en) | 2014-10-16 |
CA2868747A1 (en) | 2013-10-03 |
MX2014011608A (es) | 2015-05-11 |
WO2013147793A1 (en) | 2013-10-03 |
BR112014024230A8 (pt) | 2017-07-25 |
KR20150014439A (ko) | 2015-02-06 |
PH12014502182A1 (en) | 2014-12-10 |
US20150291681A1 (en) | 2015-10-15 |
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