ECSP066507A - MODULATORS OF P-SELECTINE GLICOPROTEIN BINDING PSGL- I - Google Patents
MODULATORS OF P-SELECTINE GLICOPROTEIN BINDING PSGL- IInfo
- Publication number
- ECSP066507A ECSP066507A EC2006006507A ECSP066507A ECSP066507A EC SP066507 A ECSP066507 A EC SP066507A EC 2006006507 A EC2006006507 A EC 2006006507A EC SP066507 A ECSP066507 A EC SP066507A EC SP066507 A ECSP066507 A EC SP066507A
- Authority
- EC
- Ecuador
- Prior art keywords
- cell
- glicoprotein
- selectine
- modulators
- cells
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Los compuestos multiméricos que se uno a P-Selectina Glicoproteina 1 (PSGL-1) sobre la superficie de las células T or natural killer (NK) cells pueden ser usadas para inducir a la célula T o la agotamiento de la céula NK y/o para inducir a la célula T o la apoptosis de la célula NK. Los compuestos multiméricos y métodos de la invención pueden ser usados para controlar las células T no deseadas o las inmuno respuestas mediadas por la célula NK en condiciones, tales como enfermedades inflamatorias, enfermedades autoinmunes, rechazo de transplantes y enfermedades alérgicas.Multimeric compounds that bind P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and / or to induce T cell or NK cell apoptosis. The multimeric compounds and methods of the invention can be used to control unwanted T cells or immune responses mediated by the NK cell under conditions, such as inflammatory diseases, autoimmune diseases, transplant rejection and allergic diseases.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/662,906 US20040116333A1 (en) | 2001-08-03 | 2003-09-15 | Modulators of P-selectin glycoprotein ligand 1 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066507A true ECSP066507A (en) | 2006-10-10 |
Family
ID=36242362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006507A ECSP066507A (en) | 2003-09-15 | 2006-04-13 | MODULATORS OF P-SELECTINE GLICOPROTEIN BINDING PSGL- I |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1663290A4 (en) |
JP (1) | JP5808879B2 (en) |
KR (1) | KR101159140B1 (en) |
CN (1) | CN1852730B (en) |
AU (1) | AU2004273807B2 (en) |
BR (1) | BRPI0414402A (en) |
CA (1) | CA2538284C (en) |
EC (1) | ECSP066507A (en) |
IL (1) | IL174172A (en) |
NO (1) | NO20061306L (en) |
NZ (1) | NZ546203A (en) |
RU (1) | RU2407539C2 (en) |
SG (1) | SG146670A1 (en) |
TW (2) | TW201012472A (en) |
UA (1) | UA91004C2 (en) |
ZA (1) | ZA200602151B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1751300B1 (en) * | 2004-05-11 | 2017-11-08 | AbGenomics Coöperatief U.A. | T-cell death-inducing epitopes |
WO2009139459A1 (en) * | 2008-05-15 | 2009-11-19 | 国立大学法人 岡山大学 | Method for prevention and treatment of metabolic syndrome through the inhibition of psgl-1 |
CN108713026B (en) * | 2016-01-08 | 2023-01-06 | 美国全心医药生技股份有限公司 | Tetravalent anti-PSGL-1 antibodies and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843707A (en) | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
US6117977A (en) * | 1996-04-24 | 2000-09-12 | Genentech, Inc. | Type C lectins |
ZA973051B (en) * | 1996-04-24 | 1998-10-12 | Genentech Inc | Type c lectins |
US7744888B2 (en) * | 2001-08-03 | 2010-06-29 | Abgenomics Cooperatief U.A. | Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies |
-
2004
- 2004-09-09 RU RU2006112399/15A patent/RU2407539C2/en not_active IP Right Cessation
- 2004-09-09 AU AU2004273807A patent/AU2004273807B2/en not_active Ceased
- 2004-09-09 UA UAA200604170A patent/UA91004C2/en unknown
- 2004-09-09 JP JP2006526304A patent/JP5808879B2/en not_active Expired - Fee Related
- 2004-09-09 CN CN2004800266029A patent/CN1852730B/en not_active Expired - Fee Related
- 2004-09-09 EP EP04783669A patent/EP1663290A4/en not_active Withdrawn
- 2004-09-09 BR BRPI0414402-3A patent/BRPI0414402A/en not_active Application Discontinuation
- 2004-09-09 CA CA2538284A patent/CA2538284C/en not_active Expired - Fee Related
- 2004-09-09 SG SG200807009-6A patent/SG146670A1/en unknown
- 2004-09-09 NZ NZ546203A patent/NZ546203A/en not_active IP Right Cessation
- 2004-09-09 KR KR1020067005222A patent/KR101159140B1/en active IP Right Grant
- 2004-09-14 TW TW098143964A patent/TW201012472A/en unknown
- 2004-09-14 TW TW093127762A patent/TWI359024B/en not_active IP Right Cessation
-
2006
- 2006-03-08 IL IL174172A patent/IL174172A/en active IP Right Grant
- 2006-03-14 ZA ZA2006/02151A patent/ZA200602151B/en unknown
- 2006-03-23 NO NO20061306A patent/NO20061306L/en not_active Application Discontinuation
- 2006-04-13 EC EC2006006507A patent/ECSP066507A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO20061306L (en) | 2006-06-14 |
TW201012472A (en) | 2010-04-01 |
KR101159140B1 (en) | 2012-06-22 |
RU2006112399A (en) | 2006-08-10 |
JP5808879B2 (en) | 2015-11-10 |
JP2007533618A (en) | 2007-11-22 |
EP1663290A2 (en) | 2006-06-07 |
CA2538284A1 (en) | 2005-03-31 |
IL174172A0 (en) | 2006-08-01 |
RU2407539C2 (en) | 2010-12-27 |
TW200513262A (en) | 2005-04-16 |
ZA200602151B (en) | 2013-08-28 |
AU2004273807B2 (en) | 2011-06-09 |
AU2004273807A1 (en) | 2005-03-31 |
CA2538284C (en) | 2015-10-20 |
IL174172A (en) | 2011-12-29 |
CN1852730B (en) | 2012-05-30 |
CN1852730A (en) | 2006-10-25 |
SG146670A1 (en) | 2008-10-30 |
EP1663290A4 (en) | 2009-07-01 |
UA91004C2 (en) | 2010-06-25 |
NZ546203A (en) | 2009-05-31 |
TWI359024B (en) | 2012-03-01 |
KR20060088104A (en) | 2006-08-03 |
BRPI0414402A (en) | 2006-11-14 |
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