EA202192637A1 - Полинуклеотиды, композиции и способы для экспрессии полипептида - Google Patents

Полинуклеотиды, композиции и способы для экспрессии полипептида

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Publication number
EA202192637A1
EA202192637A1 EA202192637A EA202192637A EA202192637A1 EA 202192637 A1 EA202192637 A1 EA 202192637A1 EA 202192637 A EA202192637 A EA 202192637A EA 202192637 A EA202192637 A EA 202192637A EA 202192637 A1 EA202192637 A1 EA 202192637A1
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EA
Eurasian Patent Office
Prior art keywords
methods
compositions
polynucleotides
polypeptide expression
editing
Prior art date
Application number
EA202192637A
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English (en)
Inventor
Брэдли Эндрю Мюррей
Кристиан Домбровски
Сет С. Александер
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Интеллиа Терапьютикс, Инк.
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Application filed by Интеллиа Терапьютикс, Инк. filed Critical Интеллиа Терапьютикс, Инк.
Publication of EA202192637A1 publication Critical patent/EA202192637A1/ru

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Abstract

В данном изобретении предложены композиции и способы редактирования генов. В некоторых вариантах реализации предложен полинуклеотид, кодирующий Cas9, который может обеспечивать одно или более из улучшенной эффективности редактирования, пониженной иммуногенности или других преимуществ.
EA202192637A 2019-03-28 2020-03-27 Полинуклеотиды, композиции и способы для экспрессии полипептида EA202192637A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962825656P 2019-03-28 2019-03-28
PCT/US2020/025372 WO2020198641A2 (en) 2019-03-28 2020-03-27 Polynucleotides, compositions, and methods for polypeptide expression

Publications (1)

Publication Number Publication Date
EA202192637A1 true EA202192637A1 (ru) 2022-03-18

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EA202192637A EA202192637A1 (ru) 2019-03-28 2020-03-27 Полинуклеотиды, композиции и способы для экспрессии полипептида

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Country Link
US (1) US20230012687A1 (ru)
EP (1) EP3947670A2 (ru)
JP (1) JP2022527302A (ru)
KR (1) KR20220004649A (ru)
CN (1) CN113993994A (ru)
AU (1) AU2020248470A1 (ru)
BR (1) BR112021019224A2 (ru)
CA (1) CA3135172A1 (ru)
CO (1) CO2021014400A2 (ru)
EA (1) EA202192637A1 (ru)
IL (1) IL286579A (ru)
MA (1) MA55527A (ru)
MX (1) MX2021011757A (ru)
SG (1) SG11202110135YA (ru)
TW (1) TW202102529A (ru)
WO (1) WO2020198641A2 (ru)

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AU2022382975A1 (en) 2021-11-03 2024-05-02 Intellia Therapeutics, Inc. Polynucleotides, compositions, and methods for genome editing
WO2023133525A1 (en) * 2022-01-07 2023-07-13 Precision Biosciences, Inc. Optimized polynucleotides for protein expression
WO2023154749A2 (en) * 2022-02-09 2023-08-17 The Regents Of The University Of California In vitro and in vivo protein translation via in situ circularized rnas
WO2024044697A2 (en) * 2022-08-24 2024-02-29 Walking Fish Therapeutics, Inc. Compositions and methods for treatment of fabry disease

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US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
JPH10500310A (ja) 1994-05-19 1998-01-13 ダコ アクティーゼルスカブ 淋菌及びトラコーマ クラミジアの検出のためのｐｎａ プローブ
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Also Published As

Publication number Publication date
WO2020198641A2 (en) 2020-10-01
WO2020198641A3 (en) 2020-11-05
CO2021014400A2 (es) 2021-11-19
MX2021011757A (es) 2021-12-10
AU2020248470A1 (en) 2021-11-11
BR112021019224A2 (pt) 2021-11-30
TW202102529A (zh) 2021-01-16
CA3135172A1 (en) 2020-10-01
MA55527A (fr) 2022-02-09
EP3947670A2 (en) 2022-02-09
KR20220004649A (ko) 2022-01-11
SG11202110135YA (en) 2021-10-28
JP2022527302A (ja) 2022-06-01
IL286579A (en) 2021-10-31
US20230012687A1 (en) 2023-01-19
CN113993994A (zh) 2022-01-28

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