EA202192637A1 - Полинуклеотиды, композиции и способы для экспрессии полипептида - Google Patents

Полинуклеотиды, композиции и способы для экспрессии полипептида

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Publication number
EA202192637A1
EA202192637A1 EA202192637A EA202192637A EA202192637A1 EA 202192637 A1 EA202192637 A1 EA 202192637A1 EA 202192637 A EA202192637 A EA 202192637A EA 202192637 A EA202192637 A EA 202192637A EA 202192637 A1 EA202192637 A1 EA 202192637A1
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EA
Eurasian Patent Office
Prior art keywords
methods
compositions
polynucleotides
polypeptide expression
editing
Prior art date
Application number
EA202192637A
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English (en)
Inventor
Брэдли Эндрю Мюррей
Кристиан Домбровски
Сет С. Александер
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Интеллиа Терапьютикс, Инк.
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Publication date
Application filed by Интеллиа Терапьютикс, Инк. filed Critical Интеллиа Терапьютикс, Инк.
Publication of EA202192637A1 publication Critical patent/EA202192637A1/ru

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    • C12P19/00—Preparation of compounds containing saccharide radicals
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    • C12N2800/00—Nucleic acids vectors
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

В данном изобретении предложены композиции и способы редактирования генов. В некоторых вариантах реализации предложен полинуклеотид, кодирующий Cas9, который может обеспечивать одно или более из улучшенной эффективности редактирования, пониженной иммуногенности или других преимуществ.
EA202192637A 2019-03-28 2020-03-27 Полинуклеотиды, композиции и способы для экспрессии полипептида EA202192637A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962825656P 2019-03-28 2019-03-28
PCT/US2020/025372 WO2020198641A2 (en) 2019-03-28 2020-03-27 Polynucleotides, compositions, and methods for polypeptide expression

Publications (1)

Publication Number Publication Date
EA202192637A1 true EA202192637A1 (ru) 2022-03-18

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EA202192637A EA202192637A1 (ru) 2019-03-28 2020-03-27 Полинуклеотиды, композиции и способы для экспрессии полипептида

Country Status (16)

Country Link
US (1) US20230012687A1 (ru)
EP (1) EP3947670A2 (ru)
JP (1) JP2022527302A (ru)
KR (1) KR20220004649A (ru)
CN (1) CN113993994A (ru)
AU (1) AU2020248470A1 (ru)
BR (1) BR112021019224A2 (ru)
CA (1) CA3135172A1 (ru)
CO (1) CO2021014400A2 (ru)
EA (1) EA202192637A1 (ru)
IL (1) IL286579A (ru)
MA (1) MA55527A (ru)
MX (1) MX2021011757A (ru)
SG (1) SG11202110135YA (ru)
TW (1) TW202102529A (ru)
WO (1) WO2020198641A2 (ru)

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JP7423521B2 (ja) 2017-11-22 2024-01-29 モダーナティエックス・インコーポレイテッド フェニルケトン尿症の治療用のフェニルアラニンヒドロキシラーゼをコードするポリヌクレオチド
CA3237303A1 (en) 2021-11-03 2023-05-11 Intellia Therapeutics, Inc. Polynucleotides, compositions, and methods for genome editing
WO2023133525A1 (en) * 2022-01-07 2023-07-13 Precision Biosciences, Inc. Optimized polynucleotides for protein expression
WO2023154749A2 (en) * 2022-02-09 2023-08-17 The Regents Of The University Of California In vitro and in vivo protein translation via in situ circularized rnas
TW202423959A (zh) * 2022-08-24 2024-06-16 美商步行魚醫療公司 用於治療法布瑞氏症(fabry disease)之組成物及方法

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US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
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Publication number Publication date
KR20220004649A (ko) 2022-01-11
BR112021019224A2 (pt) 2021-11-30
MX2021011757A (es) 2021-12-10
MA55527A (fr) 2022-02-09
CN113993994A (zh) 2022-01-28
AU2020248470A1 (en) 2021-11-11
CA3135172A1 (en) 2020-10-01
JP2022527302A (ja) 2022-06-01
IL286579A (en) 2021-10-31
CO2021014400A2 (es) 2021-11-19
EP3947670A2 (en) 2022-02-09
US20230012687A1 (en) 2023-01-19
WO2020198641A2 (en) 2020-10-01
SG11202110135YA (en) 2021-10-28
WO2020198641A3 (en) 2020-11-05
TW202102529A (zh) 2021-01-16

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