EA202192263A1 - Замещенные бициклические соединения в качестве регуляторов фарнезоидного х-рецептора - Google Patents
Замещенные бициклические соединения в качестве регуляторов фарнезоидного х-рецептораInfo
- Publication number
- EA202192263A1 EA202192263A1 EA202192263A EA202192263A EA202192263A1 EA 202192263 A1 EA202192263 A1 EA 202192263A1 EA 202192263 A EA202192263 A EA 202192263A EA 202192263 A EA202192263 A EA 202192263A EA 202192263 A1 EA202192263 A1 EA 202192263A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- farnesoid
- compounds
- substituted bicyclic
- bicyclic compounds
- fxr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962806402P | 2019-02-15 | 2019-02-15 | |
| PCT/US2020/018210 WO2020168148A1 (fr) | 2019-02-15 | 2020-02-14 | Composés bicycliques substitués utilisés en tant que modulateurs du récepteur farnésoïde x |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202192263A1 true EA202192263A1 (ru) | 2022-01-27 |
Family
ID=69811924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202192263A EA202192263A1 (ru) | 2019-02-15 | 2020-02-14 | Замещенные бициклические соединения в качестве регуляторов фарнезоидного х-рецептора |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU2020221370A1 (fr) |
| BR (1) | BR112021015963A2 (fr) |
| CA (1) | CA3129533A1 (fr) |
| EA (1) | EA202192263A1 (fr) |
| MX (1) | MX2021009570A (fr) |
| SG (1) | SG11202108796YA (fr) |
| WO (1) | WO2020168148A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023510274A (ja) | 2020-01-15 | 2023-03-13 | アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） | Ｄ型肝炎ウイルスによる感染を処置するためのｆｘｒアゴニストの使用 |
| EP4277622A1 (fr) | 2021-01-14 | 2023-11-22 | ENYO Pharma | Effet synergique d'un agoniste de fxr et d'ifn pour le traitement d'une infection par le virus de l'hépatite b |
| EP4329761A1 (fr) | 2021-04-28 | 2024-03-06 | ENYO Pharma | Potentialisation forte d'effets d'agonistes de tlr3 à l'aide d'agonistes de fxr en tant que traitement combiné |
| CN115340536A (zh) * | 2021-05-13 | 2022-11-15 | 华东理工大学 | 含1,2,4-恶二唑的酰胺类化合物及其盐、制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4383177B2 (ja) | 2002-03-01 | 2009-12-16 | スミスクライン ビーチャム コーポレーション | ｈＰＰＡＲ活性化剤 |
| WO2004032882A2 (fr) | 2002-10-10 | 2004-04-22 | Smithkline Beecham Corporation | Composes chimiques |
| CA2603402C (fr) | 2005-04-08 | 2017-10-31 | Ptc Therapeutics, Inc. | Compositions de 1,2,4-oxadiazole oralement actives pour un traitement de suppression de mutations non-sens |
| US20120065196A1 (en) | 2006-07-21 | 2012-03-15 | Shuji Kitamura | Amide compounds |
| WO2014071247A1 (fr) | 2012-11-02 | 2014-05-08 | Dana-Farber Cancer Institute, Inc. | Dérivés d'acide pyrrol-1-yl-benzoïque utiles en tant qu'inhibiteurs de myc |
| US9956220B2 (en) | 2014-06-19 | 2018-05-01 | Bristol-Myers Squibb Company | Imidazo-pyridazine derivatives as casein kinase 1 δ/ϵ inhibitors |
| WO2016039734A1 (fr) | 2014-09-10 | 2016-03-17 | Halliburton Energy Services, Inc. | Perforateur avec système de retenue intégré |
| JP7174709B2 (ja) * | 2017-03-15 | 2022-11-17 | メタクリン，インク． | ファルネソイドｘ受容体アゴニストおよびその使用 |
| MX2019010907A (es) * | 2017-03-15 | 2019-11-07 | Metacrine Inc | Agonistas del receptor x farnesoide, y usos de los mismos. |
-
2020
- 2020-02-14 SG SG11202108796YA patent/SG11202108796YA/en unknown
- 2020-02-14 EA EA202192263A patent/EA202192263A1/ru unknown
- 2020-02-14 WO PCT/US2020/018210 patent/WO2020168148A1/fr unknown
- 2020-02-14 AU AU2020221370A patent/AU2020221370A1/en not_active Abandoned
- 2020-02-14 MX MX2021009570A patent/MX2021009570A/es unknown
- 2020-02-14 CA CA3129533A patent/CA3129533A1/fr active Pending
- 2020-02-14 BR BR112021015963-0A patent/BR112021015963A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA3129533A1 (fr) | 2020-08-20 |
| MX2021009570A (es) | 2021-09-08 |
| BR112021015963A2 (pt) | 2021-10-05 |
| AU2020221370A1 (en) | 2021-10-07 |
| SG11202108796YA (en) | 2021-09-29 |
| WO2020168148A1 (fr) | 2020-08-20 |
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