EA202191588A1 - Замещенные ксантиновые производные - Google Patents

Замещенные ксантиновые производные

Info

Publication number
EA202191588A1
EA202191588A1 EA202191588A EA202191588A EA202191588A1 EA 202191588 A1 EA202191588 A1 EA 202191588A1 EA 202191588 A EA202191588 A EA 202191588A EA 202191588 A EA202191588 A EA 202191588A EA 202191588 A1 EA202191588 A1 EA 202191588A1
Authority
EA
Eurasian Patent Office
Prior art keywords
xanthine derivatives
substituted xanthine
substituted
trpc5
therapy
Prior art date
Application number
EA202191588A
Other languages
English (en)
Russian (ru)
Inventor
Кай Герлах
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Хайдра Байосайенсиз, Ллк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх, Хайдра Байосайенсиз, Ллк filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA202191588A1 publication Critical patent/EA202191588A1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA202191588A 2018-12-12 2019-12-10 Замещенные ксантиновые производные EA202191588A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18212060 2018-12-12
PCT/EP2019/084375 WO2020120450A1 (en) 2018-12-12 2019-12-10 Substituted xanthine derivatives

Publications (1)

Publication Number Publication Date
EA202191588A1 true EA202191588A1 (ru) 2021-10-18

Family

ID=64665184

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191588A EA202191588A1 (ru) 2018-12-12 2019-12-10 Замещенные ксантиновые производные

Country Status (18)

Country Link
US (2) US11198696B2 (https=)
EP (1) EP3894410B1 (https=)
JP (1) JP7502299B2 (https=)
KR (1) KR102877857B1 (https=)
CN (1) CN113166151B (https=)
AU (1) AU2019396499B2 (https=)
BR (1) BR112021008316A2 (https=)
CL (1) CL2021001509A1 (https=)
DK (1) DK3894410T3 (https=)
EA (1) EA202191588A1 (https=)
ES (1) ES2964630T3 (https=)
HU (1) HUE064908T2 (https=)
IL (1) IL283768B2 (https=)
MX (1) MX2021007019A (https=)
PH (1) PH12021551345A1 (https=)
PL (1) PL3894410T3 (https=)
TW (1) TWI825243B (https=)
WO (1) WO2020120450A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12064917B2 (en) 2012-11-21 2024-08-20 Stratasys, Inc. Method for printing three-dimensional parts with cyrstallization kinetics control
HUE064908T2 (hu) * 2018-12-12 2024-04-28 Boehringer Ingelheim Int Szubsztituált xantinszármazékok
WO2024164818A1 (zh) * 2023-02-08 2024-08-15 中国科学院上海药物研究所 黄嘌呤类化合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107082782B (zh) 2013-03-15 2020-03-20 海德拉生物科学有限责任公司 取代的黄嘌呤及其使用方法
WO2016023830A1 (en) 2014-08-11 2016-02-18 Hydra Biosciences, Inc. Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives
GB201702160D0 (en) 2017-02-09 2017-03-29 Univ Leeds Innovations Ltd Inhibitors for use in therapy
DK3652176T3 (da) * 2017-07-11 2022-01-17 Boehringer Ingelheim Int Substituerede xanthinderivater
HUE064908T2 (hu) * 2018-12-12 2024-04-28 Boehringer Ingelheim Int Szubsztituált xantinszármazékok

Also Published As

Publication number Publication date
IL283768A (en) 2021-07-29
IL283768B2 (en) 2024-05-01
HUE064908T2 (hu) 2024-04-28
US11198696B2 (en) 2021-12-14
DK3894410T3 (da) 2023-11-27
TWI825243B (zh) 2023-12-11
AU2019396499B2 (en) 2024-10-10
WO2020120450A1 (en) 2020-06-18
KR102877857B1 (ko) 2025-10-29
CA3119229A1 (en) 2020-06-18
CL2021001509A1 (es) 2021-12-17
KR20210102955A (ko) 2021-08-20
BR112021008316A2 (pt) 2021-08-03
CN113166151B (zh) 2023-12-01
EP3894410A1 (en) 2021-10-20
PH12021551345A1 (en) 2022-05-11
JP2022512373A (ja) 2022-02-03
CN113166151A (zh) 2021-07-23
US20200190093A1 (en) 2020-06-18
MX2021007019A (es) 2021-09-10
ES2964630T3 (es) 2024-04-08
PL3894410T3 (pl) 2024-03-18
US20220177479A1 (en) 2022-06-09
JP7502299B2 (ja) 2024-06-18
EP3894410B1 (en) 2023-10-11
IL283768B1 (en) 2024-01-01
AU2019396499A1 (en) 2021-05-27
TW202039495A (zh) 2020-11-01

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