EA202190842A1 - Антагонисты 2-адренорецептора подтипа с (альфа-2с адренорецепторов) для лечения апноэ во сне - Google Patents
Антагонисты 2-адренорецептора подтипа с (альфа-2с адренорецепторов) для лечения апноэ во снеInfo
- Publication number
- EA202190842A1 EA202190842A1 EA202190842A EA202190842A EA202190842A1 EA 202190842 A1 EA202190842 A1 EA 202190842A1 EA 202190842 A EA202190842 A EA 202190842A EA 202190842 A EA202190842 A EA 202190842A EA 202190842 A1 EA202190842 A1 EA 202190842A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- adrenoreceptor
- antagonists
- alpha
- sleep
- apnea
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102100025983 Alpha-2C adrenergic receptor Human genes 0.000 title 1
- 101710149275 Alpha-2C adrenergic receptor Proteins 0.000 title 1
- 208000008784 apnea Diseases 0.000 title 1
- 208000003417 Central Sleep Apnea Diseases 0.000 abstract 1
- 206010041235 Snoring Diseases 0.000 abstract 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 abstract 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 208000001797 obstructive sleep apnea Diseases 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к антагонистам 2-адренорецепторов подтипа С (альфа-2С адренорецепторов), в частности к арилпиперазинам формулы (I) для применения в способе лечения и/или профилактики связанных со сном расстройств дыхания, предпочтительно обструктивного и центрального апноэ во сне и храпа.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18196686 | 2018-09-25 | ||
| PCT/EP2019/075102 WO2020064479A1 (en) | 2018-09-25 | 2019-09-19 | α2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190842A1 true EA202190842A1 (ru) | 2021-07-02 |
Family
ID=63685606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190842A EA202190842A1 (ru) | 2018-09-25 | 2019-09-19 | Антагонисты 2-адренорецептора подтипа с (альфа-2с адренорецепторов) для лечения апноэ во сне |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20210338662A1 (ru) |
| EP (1) | EP3856183A1 (ru) |
| JP (1) | JP2022502374A (ru) |
| KR (1) | KR20210065948A (ru) |
| CN (1) | CN112714647A (ru) |
| AU (1) | AU2019350264A1 (ru) |
| BR (1) | BR112021003340A2 (ru) |
| CA (1) | CA3113700A1 (ru) |
| CL (1) | CL2021000707A1 (ru) |
| EA (1) | EA202190842A1 (ru) |
| IL (1) | IL281645A (ru) |
| JO (1) | JOP20210059A1 (ru) |
| MA (1) | MA53711A (ru) |
| MX (1) | MX2021003428A (ru) |
| SG (1) | SG11202101821TA (ru) |
| TW (1) | TW202034920A (ru) |
| UA (1) | UA128095C2 (ru) |
| WO (1) | WO2020064479A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3965766A1 (en) * | 2019-05-09 | 2022-03-16 | Bayer Aktiengesellschaft | Combination of an ?2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea |
| TW202342011A (zh) * | 2021-12-22 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α２－腎上腺素受體亞型Ｃ（α－２Ｃ）拮抗劑與蕈毒鹼受體拮抗劑之組合 |
| WO2023131638A1 (en) * | 2022-01-07 | 2023-07-13 | Bayer Aktiengesellschaft | 2,3-dihydrobenzo [b][1, 4]dioxin-2-ylmethyl)piperazin-1-yl derivates for the treatment of sleep apnea |
| WO2023249924A1 (en) * | 2022-06-21 | 2023-12-28 | Apnimed, Inc. (Delaware) | Methods of treating sleep apnea with a combination of a cannabinoid and a carbonic anhydrase inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7103449A (ru) * | 1971-03-15 | 1972-09-19 | ||
| TW201024282A (en) | 2008-11-20 | 2010-07-01 | Orion Corp | New pharmaceutical compounds |
| WO2017031319A1 (en) * | 2015-08-18 | 2017-02-23 | Massachusetts Institute Of Technology | Noradrenergic drug treatment of obstructive sleep apnea |
-
2019
- 2019-09-19 MA MA053711A patent/MA53711A/fr unknown
- 2019-09-19 JP JP2021516568A patent/JP2022502374A/ja active Pending
- 2019-09-19 BR BR112021003340-8A patent/BR112021003340A2/pt unknown
- 2019-09-19 JO JOP/2021/0059A patent/JOP20210059A1/ar unknown
- 2019-09-19 MX MX2021003428A patent/MX2021003428A/es unknown
- 2019-09-19 WO PCT/EP2019/075102 patent/WO2020064479A1/en unknown
- 2019-09-19 SG SG11202101821TA patent/SG11202101821TA/en unknown
- 2019-09-19 EP EP19769177.7A patent/EP3856183A1/en active Pending
- 2019-09-19 EA EA202190842A patent/EA202190842A1/ru unknown
- 2019-09-19 KR KR1020217008388A patent/KR20210065948A/ko unknown
- 2019-09-19 AU AU2019350264A patent/AU2019350264A1/en active Pending
- 2019-09-19 US US17/279,536 patent/US20210338662A1/en active Pending
- 2019-09-19 CA CA3113700A patent/CA3113700A1/en active Pending
- 2019-09-19 UA UAA202102170A patent/UA128095C2/uk unknown
- 2019-09-19 CN CN201980061267.2A patent/CN112714647A/zh active Pending
- 2019-09-23 TW TW108134163A patent/TW202034920A/zh unknown
-
2021
- 2021-03-18 IL IL281645A patent/IL281645A/en unknown
- 2021-03-22 CL CL2021000707A patent/CL2021000707A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2021000707A1 (es) | 2021-08-20 |
| US20210338662A1 (en) | 2021-11-04 |
| MA53711A (fr) | 2021-12-29 |
| KR20210065948A (ko) | 2021-06-04 |
| JOP20210059A1 (ar) | 2023-01-30 |
| SG11202101821TA (en) | 2021-03-30 |
| IL281645A (en) | 2021-05-31 |
| AU2019350264A1 (en) | 2021-03-25 |
| CN112714647A (zh) | 2021-04-27 |
| CA3113700A1 (en) | 2020-04-02 |
| TW202034920A (zh) | 2020-10-01 |
| EP3856183A1 (en) | 2021-08-04 |
| JP2022502374A (ja) | 2022-01-11 |
| UA128095C2 (uk) | 2024-04-03 |
| MX2021003428A (es) | 2021-06-15 |
| WO2020064479A1 (en) | 2020-04-02 |
| BR112021003340A2 (pt) | 2021-05-11 |
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