EA202190034A1 - Вещества, ингибирующие ask1 - Google Patents

Вещества, ингибирующие ask1

Info

Publication number
EA202190034A1
EA202190034A1 EA202190034A EA202190034A EA202190034A1 EA 202190034 A1 EA202190034 A1 EA 202190034A1 EA 202190034 A EA202190034 A EA 202190034A EA 202190034 A EA202190034 A EA 202190034A EA 202190034 A1 EA202190034 A1 EA 202190034A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibiting substances
ask1
compounds
ask1 inhibiting
receipt
Prior art date
Application number
EA202190034A
Other languages
English (en)
Inventor
Феликс Гонзалес Лопез Де Турисо
Михаэль Дечантсрайтер
Чжили Синь
Джон Х. Джоунс
Мартин Химмелбауер
Original Assignee
Байоджен Ма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджен Ма Инк. filed Critical Байоджен Ма Инк.
Publication of EA202190034A1 publication Critical patent/EA202190034A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Представлены соединения формулы (I)в том числе соединения формул (II), (III) и (IV), где X, R1, R2, R3 и n являются такими, как определено в данном документе, и их фармацевтически приемлемые соли, и способы их применения и получения. Эти соединения могут быть пригодны, например, в лечении нарушений, связанных с ингибированием регулирующей апоптотические сигналы киназы 1 (ASK1).
EA202190034A 2018-06-27 2019-06-26 Вещества, ингибирующие ask1 EA202190034A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862690674P 2018-06-27 2018-06-27
PCT/US2019/039156 WO2020006031A1 (en) 2018-06-27 2019-06-26 Ask1 inhibiting agents

Publications (1)

Publication Number Publication Date
EA202190034A1 true EA202190034A1 (ru) 2021-04-08

Family

ID=67254023

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190034A EA202190034A1 (ru) 2018-06-27 2019-06-26 Вещества, ингибирующие ask1

Country Status (22)

Country Link
US (2) US11814362B2 (ru)
EP (1) EP3814333A1 (ru)
JP (1) JP2021528456A (ru)
KR (1) KR20210024532A (ru)
CN (1) CN112638896A (ru)
AR (1) AR115636A1 (ru)
AU (1) AU2019291806A1 (ru)
BR (1) BR112020026423A2 (ru)
CA (1) CA3104662A1 (ru)
CL (1) CL2020003375A1 (ru)
CO (1) CO2021000782A2 (ru)
CR (1) CR20210049A (ru)
EA (1) EA202190034A1 (ru)
IL (1) IL279709A (ru)
JO (1) JOP20200318A1 (ru)
MA (1) MA53009A (ru)
MX (1) MX2020013895A (ru)
PE (1) PE20211379A1 (ru)
SG (1) SG11202012784SA (ru)
TW (1) TW202035389A (ru)
UY (1) UY38278A (ru)
WO (1) WO2020006031A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202012972YA (en) 2018-06-27 2021-01-28 Bristol Myers Squibb Co Substituted naphthyridinone compounds useful as t cell activators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
UY35212A (es) * 2012-12-21 2014-06-30 Gilead Sciences Inc Inhibidores de la quinasa que regula la señal de la apoptosis
WO2015095059A1 (en) * 2013-12-20 2015-06-25 Gilead Sciences, Inc. Apoptosis signal-regulating kinase inhibitors
WO2018151830A1 (en) 2017-02-17 2018-08-23 Fronthera U.S. Pharmaceuticals Llc Pyridinyl based apoptosis signal-regulation kinase inhibitors

Also Published As

Publication number Publication date
JOP20200318A1 (ar) 2020-12-10
SG11202012784SA (en) 2021-01-28
WO2020006031A1 (en) 2020-01-02
JP2021528456A (ja) 2021-10-21
WO2020006031A8 (en) 2020-09-24
MA53009A (fr) 2021-05-05
CA3104662A1 (en) 2020-01-02
US20210115020A1 (en) 2021-04-22
CR20210049A (es) 2021-07-01
AR115636A1 (es) 2021-02-10
MX2020013895A (es) 2021-07-21
IL279709A (en) 2021-03-01
PE20211379A1 (es) 2021-07-27
AU2019291806A1 (en) 2021-01-07
US11814362B2 (en) 2023-11-14
US20240109867A1 (en) 2024-04-04
CL2020003375A1 (es) 2021-09-03
UY38278A (es) 2020-01-31
CO2021000782A2 (es) 2021-01-29
EP3814333A1 (en) 2021-05-05
BR112020026423A2 (pt) 2021-03-23
CN112638896A (zh) 2021-04-09
KR20210024532A (ko) 2021-03-05
TW202035389A (zh) 2020-10-01

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