EA202092929A1 - RNA-CONTROLLED NUCLEASES AND ACTIVE FRAGMENTS AND THEIR VARIANTS AND METHODS OF APPLICATION - Google Patents

RNA-CONTROLLED NUCLEASES AND ACTIVE FRAGMENTS AND THEIR VARIANTS AND METHODS OF APPLICATION

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Publication number
EA202092929A1
EA202092929A1 EA202092929A EA202092929A EA202092929A1 EA 202092929 A1 EA202092929 A1 EA 202092929A1 EA 202092929 A EA202092929 A EA 202092929A EA 202092929 A EA202092929 A EA 202092929A EA 202092929 A1 EA202092929 A1 EA 202092929A1
Authority
EA
Eurasian Patent Office
Prior art keywords
interest
target sequence
rnas
rna
crispr
Prior art date
Application number
EA202092929A
Other languages
Russian (ru)
Inventor
Тайсон Д. Боуэн
Тедд Д. Элич
Александра Брайнер Кроли
Родольф Баррангу
Майкл Койл
Original Assignee
Лайфэдит, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лайфэдит, Инк. filed Critical Лайфэдит, Инк.
Priority claimed from PCT/US2019/035373 external-priority patent/WO2019236566A1/en
Publication of EA202092929A1 publication Critical patent/EA202092929A1/en

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Abstract

Предлагаются композиции и способы связывания с представляющей интерес целевой последовательностью. Композиции находят применение при расщеплении или модификации представляющей интерес целевой последовательности, визуализации представляющей интерес целевой последовательности и модификации экспрессии представляющей интерес последовательности. Композиции включают полипептиды нуклеаз, управляемых РНК, CRISPR РНК, трансактивирующие CRISPR РНК, управляющие РНК и молекулы нуклеиновых кислот, кодирующие их. Также предлагаются векторы и клетки-хозяева, содержащие молекулы нуклеиновых кислот. Кроме того, предусмотрены системы CRISPR для связывания представляющей интерес целевой последовательности, при этом система CRISPR включает полипептид нуклеазы, управляемой РНК, и одну или несколько управляющих РНК.Compositions and methods of linking to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualizing a target sequence of interest, and modifying the expression of a sequence of interest. The compositions include RNA guided nuclease polypeptides, CRISPR RNAs, CRISPR transactivating RNAs, guiding RNAs, and nucleic acid molecules encoding them. Also provided are vectors and host cells containing nucleic acid molecules. In addition, CRISPR systems are provided for binding a target sequence of interest, the CRISPR system comprising a guided RNA nuclease polypeptide and one or more guiding RNAs.

EA202092929A 2019-02-13 2019-06-04 RNA-CONTROLLED NUCLEASES AND ACTIVE FRAGMENTS AND THEIR VARIANTS AND METHODS OF APPLICATION EA202092929A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962805045P 2019-02-13 2019-02-13
PCT/US2019/035373 WO2019236566A1 (en) 2018-06-05 2019-06-04 Rna-guided nucleases and active fragments and variants thereof and methods of use

Publications (1)

Publication Number Publication Date
EA202092929A1 true EA202092929A1 (en) 2021-05-28

Family

ID=76160102

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092929A EA202092929A1 (en) 2019-02-13 2019-06-04 RNA-CONTROLLED NUCLEASES AND ACTIVE FRAGMENTS AND THEIR VARIANTS AND METHODS OF APPLICATION

Country Status (1)

Country Link
EA (1) EA202092929A1 (en)

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