AR120928A1 - RNA-GUIDED NUCLEASES AND THEIR ACTIVE FRAGMENTS AND VARIANTS AND METHODS OF USE - Google Patents

RNA-GUIDED NUCLEASES AND THEIR ACTIVE FRAGMENTS AND VARIANTS AND METHODS OF USE

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Publication number
AR120928A1
AR120928A1 ARP200103677A ARP200103677A AR120928A1 AR 120928 A1 AR120928 A1 AR 120928A1 AR P200103677 A ARP200103677 A AR P200103677A AR P200103677 A ARP200103677 A AR P200103677A AR 120928 A1 AR120928 A1 AR 120928A1
Authority
AR
Argentina
Prior art keywords
interest
rna
target sequence
methods
crispr
Prior art date
Application number
ARP200103677A
Other languages
Spanish (es)
Original Assignee
Lifeedit Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifeedit Inc filed Critical Lifeedit Inc
Publication of AR120928A1 publication Critical patent/AR120928A1/en

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  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se proporcionan composiciones y métodos para unirse a una secuencia diana de interés. Las composiciones se usan para escindir o modificar una secuencia diana de interés, detectar una secuencia diana de interés y modificar la expresión de una secuencia de interés. Las composiciones comprenden polipéptidos de nucleasa guiados por ARN, ARN CRISPR, ARN CRISPR trans-activadores, ARN de guía y moléculas de ácido nucleico que los codifican. También se proporcionan vectores y células huésped que comprenden las moléculas de ácido nucleico. Se proporcionan, además, sistemas CRISPR para unir una secuencia diana de interés, en los que el sistema CRISPR comprende un polipéptido nucleasa guiado por ARN y uno o más ARN de guía.Compositions and methods for binding to a target sequence of interest are provided. The compositions are used to excise or modify a target sequence of interest, detect a target sequence of interest, and modify expression of a sequence of interest. The compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding them. Vectors and host cells comprising the nucleic acid molecules are also provided. Also provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs.

ARP200103677A 2019-12-30 2020-12-29 RNA-GUIDED NUCLEASES AND THEIR ACTIVE FRAGMENTS AND VARIANTS AND METHODS OF USE AR120928A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962955014P 2019-12-30 2019-12-30

Publications (1)

Publication Number Publication Date
AR120928A1 true AR120928A1 (en) 2022-03-30

Family

ID=80995067

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200103677A AR120928A1 (en) 2019-12-30 2020-12-29 RNA-GUIDED NUCLEASES AND THEIR ACTIVE FRAGMENTS AND VARIANTS AND METHODS OF USE

Country Status (1)

Country Link
AR (1) AR120928A1 (en)

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