EA202091802A1 - Производные бексаротена и их применения для лечения рака - Google Patents
Производные бексаротена и их применения для лечения ракаInfo
- Publication number
- EA202091802A1 EA202091802A1 EA202091802A EA202091802A EA202091802A1 EA 202091802 A1 EA202091802 A1 EA 202091802A1 EA 202091802 A EA202091802 A EA 202091802A EA 202091802 A EA202091802 A EA 202091802A EA 202091802 A1 EA202091802 A1 EA 202091802A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bexarotene
- derivatives
- cancer treatment
- methods
- relates
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- NAVMQTYZDKMPEU-UHFFFAOYSA-N Targretin Chemical class CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C(=C)C1=CC=C(C(O)=O)C=C1 NAVMQTYZDKMPEU-UHFFFAOYSA-N 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000004976 peripheral blood cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
- C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
- C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
- C07C13/47—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing ten carbon atoms
- C07C13/48—Completely or partially hydrogenated naphthalenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
- C07C63/74—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen having unsaturation outside the aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/49—Polycyclic acids containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение относится к композициям и способам лечения рака. В частности, настоящее изобретение относится к производным бексаротена, способам для лечения рака, аутоиммунных расстройств и/или дерматита кожи, и/или способам для увеличения количества форменных элементов периферической крови и/или улучшения функции иммунной системы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862637387P | 2018-03-01 | 2018-03-01 | |
| PCT/US2019/020298 WO2019169270A1 (en) | 2018-03-01 | 2019-03-01 | Bexarotene derivatives and their use in treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202091802A1 true EA202091802A1 (ru) | 2021-02-05 |
Family
ID=67805954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202091802A EA202091802A1 (ru) | 2018-03-01 | 2019-03-01 | Производные бексаротена и их применения для лечения рака |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210363093A1 (ru) |
| EP (1) | EP3758694A4 (ru) |
| JP (1) | JP7296643B2 (ru) |
| KR (1) | KR20200128406A (ru) |
| CN (1) | CN112218629B (ru) |
| AU (1) | AU2019228634B2 (ru) |
| BR (1) | BR112020017534A2 (ru) |
| CA (1) | CA3092682A1 (ru) |
| EA (1) | EA202091802A1 (ru) |
| IL (1) | IL277038B2 (ru) |
| MX (2) | MX2020009015A (ru) |
| SA (1) | SA520420057B1 (ru) |
| WO (1) | WO2019169270A1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112479918B (zh) * | 2020-12-11 | 2023-07-14 | 成都大学 | 一种维甲酸类衍生物Am580的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2139063T3 (es) * | 1993-01-11 | 2000-02-01 | Ligand Pharm Inc | Compuestos que tienen selectividad por receptores de retinoides x. |
| EP1336600A3 (en) | 1995-10-06 | 2004-07-07 | Ligand Pharmaceuticals Incorporated | Dimer-selective RXR modulators and methods for their use |
| JP2005511516A (ja) * | 2001-09-25 | 2005-04-28 | スミスクライン ビーチャム コーポレーション | 選択的ｒｘｒリガンド |
| CA2790318A1 (en) | 2010-02-19 | 2011-08-25 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acti Ng For And On Behalf Of Arizona State University | Novel bexarotene analogs |
| BR112013009531A2 (pt) | 2010-11-11 | 2016-07-19 | Redx Pharma Ltd | derivados de fármaco |
| WO2013056232A2 (en) | 2011-10-13 | 2013-04-18 | Case Western Reserve University | Rxr agonists compounds and methods |
-
2019
- 2019-03-01 JP JP2020544954A patent/JP7296643B2/ja active Active
- 2019-03-01 US US16/971,736 patent/US20210363093A1/en active Pending
- 2019-03-01 AU AU2019228634A patent/AU2019228634B2/en active Active
- 2019-03-01 WO PCT/US2019/020298 patent/WO2019169270A1/en active Application Filing
- 2019-03-01 MX MX2020009015A patent/MX2020009015A/es unknown
- 2019-03-01 CA CA3092682A patent/CA3092682A1/en active Pending
- 2019-03-01 KR KR1020207027153A patent/KR20200128406A/ko not_active Application Discontinuation
- 2019-03-01 EA EA202091802A patent/EA202091802A1/ru unknown
- 2019-03-01 IL IL277038A patent/IL277038B2/en unknown
- 2019-03-01 CN CN201980016638.5A patent/CN112218629B/zh active Active
- 2019-03-01 EP EP19760927.4A patent/EP3758694A4/en active Pending
- 2019-03-01 BR BR112020017534-0A patent/BR112020017534A2/pt unknown
-
2020
- 2020-08-28 MX MX2022013895A patent/MX2022013895A/es unknown
- 2020-08-30 SA SA520420057A patent/SA520420057B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20210363093A1 (en) | 2021-11-25 |
| AU2019228634B2 (en) | 2024-08-01 |
| CA3092682A1 (en) | 2019-09-06 |
| KR20200128406A (ko) | 2020-11-12 |
| SA520420057B1 (ar) | 2024-05-23 |
| EP3758694A4 (en) | 2022-03-23 |
| IL277038B2 (en) | 2023-12-01 |
| MX2020009015A (es) | 2020-12-03 |
| AU2019228634A1 (en) | 2020-09-10 |
| CN112218629B (zh) | 2024-08-09 |
| WO2019169270A1 (en) | 2019-09-06 |
| IL277038B1 (en) | 2023-08-01 |
| IL277038A (en) | 2020-10-29 |
| CN112218629A (zh) | 2021-01-12 |
| EP3758694A1 (en) | 2021-01-06 |
| JP7296643B2 (ja) | 2023-06-23 |
| MX2022013895A (es) | 2022-11-30 |
| JP2021526503A (ja) | 2021-10-07 |
| BR112020017534A2 (pt) | 2020-12-22 |
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