EA202091439A1 - POLIVALENT ANTI-Pneumococcal POLYSACCHARIDE-PROTEIN CONJUGATED COMPOSITION - Google Patents

POLIVALENT ANTI-Pneumococcal POLYSACCHARIDE-PROTEIN CONJUGATED COMPOSITION

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Publication number
EA202091439A1
EA202091439A1 EA202091439A EA202091439A EA202091439A1 EA 202091439 A1 EA202091439 A1 EA 202091439A1 EA 202091439 A EA202091439 A EA 202091439A EA 202091439 A EA202091439 A EA 202091439A EA 202091439 A1 EA202091439 A1 EA 202091439A1
Authority
EA
Eurasian Patent Office
Prior art keywords
conjugated
polivalent
pneumococcal polysaccharide
protein conjugated
capsular polysaccharides
Prior art date
Application number
EA202091439A
Other languages
Russian (ru)
Inventor
Гёнджун Ан
Донсу Хам
Хун Ким
Сонхён Ким
Джинхван Син
Роберт Хопфер
Ричард Д. Кенсингер
Мо Чжо
Филипп Талага
Original Assignee
Санофи Пастер Инк.
Ск Биосайенс Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи Пастер Инк., Ск Биосайенс Ко., Лтд. filed Critical Санофи Пастер Инк.
Priority claimed from PCT/US2019/016511 external-priority patent/WO2019152925A1/en
Publication of EA202091439A1 publication Critical patent/EA202091439A1/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Предложены поливалентные противопневмококковые конъюгированные композиции со смешанным носителем, содержащие 21 различный конъюгат пневмококковых капсульных полисахаридов-белков, причем каждый из конъюгатов включает капсульный полисахарид от отличающегося серотипа Streptococcus pneumoniae, конъюгированный либо со столбнячным анатоксином (TT), либо с CRM197, причем серотипы Streptococcus pneumoniae выбраны из 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F и 33F, причем капсульные полисахариды двух из серотипов 1, 3 и 5, и один или оба из серотипов 15B и 22F конъюгированы с TT, а остальные капсульные полисахариды конъюгированы с CRM197. Предложены также способы производства поливалентных противопневмококковых конъюгированных композиций со смешанным носителем и способы их применения для профилактики у субъекта инфекции или заболевания Streptococcus pneumoniae.Proposed are multivalent antipneumococcal conjugated compositions with a mixed carrier containing 21 different conjugates of pneumococcal capsular polysaccharides-proteins, and each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae, conjugated with either tetanus toxoid or serotype CRM197 of 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F and 33F, with capsular polysaccharides of two of serotypes 1 , 3 and 5, and one or both of serotypes 15B and 22F are conjugated to TT, and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods for the production of multivalent antipneumococcal conjugated compositions with a mixed carrier and methods of their use for the prevention of Streptococcus pneumoniae infection or disease in a subject.

EA202091439A 2018-04-18 2019-02-04 POLIVALENT ANTI-Pneumococcal POLYSACCHARIDE-PROTEIN CONJUGATED COMPOSITION EA202091439A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20180045246 2018-04-18
PCT/US2019/016511 WO2019152925A1 (en) 2018-02-05 2019-02-04 Multivalent pneumococcal polysaccharide-protein conjugate composition

Publications (1)

Publication Number Publication Date
EA202091439A1 true EA202091439A1 (en) 2020-11-26

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Application Number Title Priority Date Filing Date
EA202091439A EA202091439A1 (en) 2018-04-18 2019-02-04 POLIVALENT ANTI-Pneumococcal POLYSACCHARIDE-PROTEIN CONJUGATED COMPOSITION
EA202091440A EA202091440A1 (en) 2018-04-18 2019-02-04 POLIVALENT ANTI-Pneumococcal POLYSACCHARIDE-PROTEIN CONJUGATED COMPOSITION

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202091440A EA202091440A1 (en) 2018-04-18 2019-02-04 POLIVALENT ANTI-Pneumococcal POLYSACCHARIDE-PROTEIN CONJUGATED COMPOSITION

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EA (2) EA202091439A1 (en)

Also Published As

Publication number Publication date
EA202091440A1 (en) 2020-11-16

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