EA202090586A3 - TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION - Google Patents

TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION

Info

Publication number
EA202090586A3
EA202090586A3 EA202090586A EA202090586A EA202090586A3 EA 202090586 A3 EA202090586 A3 EA 202090586A3 EA 202090586 A EA202090586 A EA 202090586A EA 202090586 A EA202090586 A EA 202090586A EA 202090586 A3 EA202090586 A3 EA 202090586A3
Authority
EA
Eurasian Patent Office
Prior art keywords
binding
epitopes
binding molecules
trisspecific
methods
Prior art date
Application number
EA202090586A
Other languages
Russian (ru)
Other versions
EA202090586A2 (en
Inventor
Лесли С. Джонсон
Лин Хуан
Гурунад Редди Чичили
Калпана Шах
Чиа-Ин Као Лам
Стивен Джеймс Бёрк
Лицинь Лиу
Пол А. Мур
Эзио Бонвини
Бхасвати Барат
Original Assignee
Мэкроудженикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мэкроудженикс, Инк. filed Critical Мэкроудженикс, Инк.
Publication of EA202090586A2 publication Critical patent/EA202090586A2/en
Publication of EA202090586A3 publication Critical patent/EA202090586A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

Abstract

Настоящее изобретение относится к триспецифичным связывающим молекулам, которые представляют собой мультицепочечные полипептидные молекулы, которые обладают тремя связывающими доменами и, таким образом, способны опосредовать скоординированное связывание с тремя эпитопами. Связывающие домены могут быть выбраны таким образом, чтобы триспецифичные связывающие молекулы были способны связываться с любыми тремя различными эпитопами. Такие эпитопы могут представлять собой эпитопы одного и того же антигена или эпитопы двух или трех различных антигенов. В предпочтительном воплощении один из таких эпитопов будет способен связываться с CD3, второй из таких эпитопов будет способен связываться с CD8, а третий из таких эпитопов будет способен связываться с эпитопом антигена, ассоциированного с заболеванием. В изобретении также предлагаются новое ROR1-связывающее антитело, а также его производные и применения таких композиций.The present invention relates to trispecific binding molecules, which are multi-chain polypeptide molecules that possess three binding domains and are thus capable of mediating coordinated binding to three epitopes. Binding domains can be selected so that the trispecific binding molecules are capable of binding to any three different epitopes. Such epitopes can be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, a second of such epitopes will be capable of binding to CD8, and a third of such epitopes will be capable of binding to an epitope of a disease-associated antigen. The invention also provides a novel ROR1 binding antibody, as well as derivatives and uses for such compositions.

EA202090586A 2015-01-26 2015-05-29 TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION EA202090586A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562107824P 2015-01-26 2015-01-26

Publications (2)

Publication Number Publication Date
EA202090586A2 EA202090586A2 (en) 2020-06-30
EA202090586A3 true EA202090586A3 (en) 2020-07-31

Family

ID=71138786

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202090580A EA202090580A3 (en) 2015-01-26 2015-05-29 TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION
EA202090586A EA202090586A3 (en) 2015-01-26 2015-05-29 TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA202090580A EA202090580A3 (en) 2015-01-26 2015-05-29 TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION

Country Status (1)

Country Link
EA (2) EA202090580A3 (en)

Also Published As

Publication number Publication date
EA202090580A3 (en) 2020-07-31
EA202090586A2 (en) 2020-06-30
EA202090580A2 (en) 2020-06-30

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