EA202090580A3 - TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION - Google Patents
TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATIONInfo
- Publication number
- EA202090580A3 EA202090580A3 EA202090580A EA202090580A EA202090580A3 EA 202090580 A3 EA202090580 A3 EA 202090580A3 EA 202090580 A EA202090580 A EA 202090580A EA 202090580 A EA202090580 A EA 202090580A EA 202090580 A3 EA202090580 A3 EA 202090580A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- binding
- epitopes
- binding molecules
- trisspecific
- methods
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
Abstract
Настоящее изобретение относится к триспецифичным связывающим молекулам, которые представляют собой мультицепочечные полипептидные молекулы, которые обладают тремя связывающими доменами и, таким образом, способны опосредовать скоординированное связывание с тремя эпитопами. Связывающие домены могут быть выбраны таким образом, чтобы триспецифичные связывающие молекулы были способны связываться с любыми тремя различными эпитопами. Такие эпитопы могут представлять собой эпитопы одного и того же антигена или эпитопы двух или трех различных антигенов. В предпочтительном воплощении один из таких эпитопов будет способен связываться с CD3, второй из таких эпитопов будет способен связываться с CD8, а третий из таких эпитопов будет способен связываться с эпитопом антигена, ассоциированного с заболеванием. В изобретении также предлагаются новое ROR1-связывающее антитело, а также его производные и применения таких композиций.The present invention relates to trispecific binding molecules, which are multi-chain polypeptide molecules that possess three binding domains and are thus capable of mediating coordinated binding to three epitopes. Binding domains can be selected so that the trispecific binding molecules are capable of binding to any three different epitopes. Such epitopes can be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, a second of such epitopes will be capable of binding to CD8, and a third of such epitopes will be capable of binding to an epitope of a disease-associated antigen. The invention also provides a novel ROR1 binding antibody, as well as derivatives and uses for such compositions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562107824P | 2015-01-26 | 2015-01-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA202090580A2 EA202090580A2 (en) | 2020-06-30 |
EA202090580A3 true EA202090580A3 (en) | 2020-07-31 |
Family
ID=71138786
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090586A EA202090586A3 (en) | 2015-01-26 | 2015-05-29 | TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION |
EA202090580A EA202090580A3 (en) | 2015-01-26 | 2015-05-29 | TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090586A EA202090586A3 (en) | 2015-01-26 | 2015-05-29 | TRISSPECIFIC BINDING MOLECULES AND METHODS OF THEIR APPLICATION |
Country Status (1)
Country | Link |
---|---|
EA (2) | EA202090586A3 (en) |
-
2015
- 2015-05-29 EA EA202090586A patent/EA202090586A3/en unknown
- 2015-05-29 EA EA202090580A patent/EA202090580A3/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA202090580A2 (en) | 2020-06-30 |
EA202090586A2 (en) | 2020-06-30 |
EA202090586A3 (en) | 2020-07-31 |
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