EA202090004A1 - Биспецифические антитела против pd-1 и против tim-3 - Google Patents

Биспецифические антитела против pd-1 и против tim-3

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Publication number
EA202090004A1
EA202090004A1 EA202090004A EA202090004A EA202090004A1 EA 202090004 A1 EA202090004 A1 EA 202090004A1 EA 202090004 A EA202090004 A EA 202090004A EA 202090004 A EA202090004 A EA 202090004A EA 202090004 A1 EA202090004 A1 EA 202090004A1
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Eurasian Patent Office
Prior art keywords
tim
cell
bind
variable domain
bspecific
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EA202090004A
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English (en)
Inventor
Сесилия Анна Вильгельмина Гёин
Ринсе Клостер
Корнелис Адриан Де Крёйф
Паулус Йоханнес Таккен
Марк Тросби
Тон Логтенберг
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Мерус Н.В.
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Publication date
Application filed by Мерус Н.В. filed Critical Мерус Н.В.
Publication of EA202090004A1 publication Critical patent/EA202090004A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

В документе предложены средства и способы препятствования, опосредуемому белком, запрограммированной гибели клеток 1 (PD-1) и белком 3 Т-клеток, содержащим домен иммуноглобулина и домен муцина (TIM-3), ингибированию в PD-1-положительной и/или TIM-3-положительной клетке. Способ может включать приведение указанной клетки в контакт с антителом или его функциональной частью, производным и/или аналогом, содержащими вариабельный домен, который может связываться с внеклеточной частью PD-1, и вариабельный домен, который может связываться с внеклеточной частью TIM-3, тем самым ингибируя опосредуемую PD-1 и/или TIM-3 активность в указанной клетке. В документе также предложены антитела или их варианты, содержащие вариабельный домен, который может связываться с внеклеточной частью PD-1, и вариабельный домен, который может связываться с внеклеточной частью TIM-3.
EA202090004A 2017-07-06 2018-07-06 Биспецифические антитела против pd-1 и против tim-3 EA202090004A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17180061 2017-07-06
PCT/NL2018/050450 WO2019009727A1 (en) 2017-07-06 2018-07-06 ANTI-PD1 ANTI-TIM3 BISPECIFIC ANTIBODIES

Publications (1)

Publication Number Publication Date
EA202090004A1 true EA202090004A1 (ru) 2020-06-18

Family

ID=59366222

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090004A EA202090004A1 (ru) 2017-07-06 2018-07-06 Биспецифические антитела против pd-1 и против tim-3

Country Status (15)

Country Link
US (2) US11753470B2 (ru)
EP (1) EP3649155A1 (ru)
JP (1) JP7422655B2 (ru)
KR (1) KR20200042467A (ru)
CN (1) CN111094348A (ru)
AU (1) AU2018297058B2 (ru)
BR (1) BR112020000227A2 (ru)
CA (1) CA3068932A1 (ru)
EA (1) EA202090004A1 (ru)
IL (1) IL271832A (ru)
MX (1) MX2020000055A (ru)
PH (1) PH12020550013A1 (ru)
SG (1) SG11202000054RA (ru)
TW (1) TW201920657A (ru)
WO (1) WO2019009727A1 (ru)

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EP3649156A1 (en) * 2017-07-06 2020-05-13 Merus N.V. Antibodies that modulate a biological activity expressed by a cell
TWI804572B (zh) * 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 雙特異性抗體
MX2020010267A (es) * 2018-03-30 2020-11-06 Merus Nv Anticuerpo multivalente.
EP3966247A4 (en) * 2019-05-06 2023-01-04 Brown University B-SPECIFIC ANTIBODIES AGAINST CHI3L1 AND PD1 WITH ENHANCED T-LYMPHOCYTE-MEDIATED CYTOTOXIC EFFECTS ON TUMOR CELLS
SG11202112399PA (en) 2019-05-09 2021-12-30 Merus Nv Variant domains for multimerizing proteins and separation thereof
CN113563473A (zh) * 2020-04-29 2021-10-29 三生国健药业（上海）股份有限公司 四价双特异性抗体、其制备方法和用途
AR127714A1 (es) * 2021-11-19 2024-02-21 Merus Nv UNIDADES DE UNIÓN MULTIESPECÍFICAS QUE COMPRENDEN LOS DOMINIOS DE UNIÓN A PD-1 Y TGF-bRII

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JP4836451B2 (ja) 2002-07-18 2011-12-14 メルス ベー ヴェー 抗体混合物の組換え生産
CN109485727A (zh) 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
JP5639039B2 (ja) 2008-04-11 2014-12-10 メリマック ファーマシューティカルズ インコーポレーティッド ヒト血清アルブミンリンカーおよびそのコンジュゲート
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WO2011159877A2 (en) * 2010-06-18 2011-12-22 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
PT2838917T (pt) 2012-04-20 2019-09-12 Merus Nv Métodos e meios para a produção de moléculas similares a ig heterodiméricas
DK2900694T3 (en) 2012-09-27 2018-11-19 Merus Nv BISPECIFIC IGG ANTIBODIES AS T-CELL ACTIVATORS
WO2015130173A1 (en) * 2014-02-28 2015-09-03 Merus B.V. Antibody that binds erbb-2 and erbb-3
EP3356821B1 (en) * 2015-10-02 2019-10-23 H. Hoffnabb-La Roche Ag Cellular based fret assay for the determination of simultaneous binding
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AU2016348391A1 (en) * 2015-11-03 2018-05-17 Janssen Biotech, Inc. Antibodies specifically binding TIM-3 and their uses

Also Published As

Publication number Publication date
KR20200042467A (ko) 2020-04-23
MX2020000055A (es) 2020-08-06
US20200216539A1 (en) 2020-07-09
JP7422655B2 (ja) 2024-01-26
BR112020000227A2 (pt) 2020-09-29
CN111094348A (zh) 2020-05-01
US20230357407A1 (en) 2023-11-09
AU2018297058B2 (en) 2021-04-29
JP2020532281A (ja) 2020-11-12
SG11202000054RA (en) 2020-02-27
IL271832A (en) 2020-02-27
CA3068932A1 (en) 2019-01-10
WO2019009727A1 (en) 2019-01-10
TW201920657A (zh) 2019-06-01
EP3649155A1 (en) 2020-05-13
AU2018297058A1 (en) 2020-01-30
WO2019009727A8 (en) 2020-01-30
US11753470B2 (en) 2023-09-12
PH12020550013A1 (en) 2020-10-12

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