EA201992149A1 - Комбинация активных ингредиентов, содержащие ее композиции и их применение в лечении саркопении - Google Patents
Комбинация активных ингредиентов, содержащие ее композиции и их применение в лечении саркопенииInfo
- Publication number
- EA201992149A1 EA201992149A1 EA201992149A EA201992149A EA201992149A1 EA 201992149 A1 EA201992149 A1 EA 201992149A1 EA 201992149 A EA201992149 A EA 201992149A EA 201992149 A EA201992149 A EA 201992149A EA 201992149 A1 EA201992149 A1 EA 201992149A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- combination
- sarcopenia
- treatment
- active ingredients
- compositions
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000001076 sarcopenia Diseases 0.000 title abstract 2
- AXFYFNCPONWUHW-UHFFFAOYSA-N 3-hydroxyisovaleric acid Chemical compound CC(C)(O)CC(O)=O AXFYFNCPONWUHW-UHFFFAOYSA-N 0.000 abstract 2
- SLPUVFBNQHVEEU-WCCKRBBISA-N (2s)-2,5-diaminopentanoic acid;2-oxopentanedioic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CCC(=O)C(O)=O SLPUVFBNQHVEEU-WCCKRBBISA-N 0.000 abstract 1
- 229940124325 anabolic agent Drugs 0.000 abstract 1
- 239000003263 anabolic agent Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 229940087603 grape seed extract Drugs 0.000 abstract 1
- 235000002532 grape seed extract Nutrition 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 239000002417 nutraceutical Substances 0.000 abstract 1
- 235000021436 nutraceutical agent Nutrition 0.000 abstract 1
- 229940075858 ornithine alpha-ketoglutarate Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000001717 vitis vinifera seed extract Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Объектом настоящего изобретения является новая комбинация активных ингредиентов, в частности комбинация 3-гидрокси-3-метилбутановой кислоты или ее фармакологически приемлемой соли, экстракта виноградных косточек, экстракта витании и необязательно орнитин-альфа-кетоглутарата. Комбинация по изобретению является полезной в лечении саркопении и в целом заболеваний, вызывающих потерю мышечной массы, и в качестве анаболического агента. Еще одним объектом изобретения является фармацевтическая или нутрицевтическая композиция, содержащая комбинацию, упомянутую выше, вместе с общепринятыми вспомогательными веществами и носителями.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102017000028228A IT201700028228A1 (it) | 2017-03-14 | 2017-03-14 | Associazione di principi attivi e loro uso nel trattamento della sarcopenia |
PCT/IB2018/051656 WO2018167661A1 (en) | 2017-03-14 | 2018-03-13 | Combination of active ingredients, compositions comprising it and their use in the treatment of sarcopenia |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201992149A1 true EA201992149A1 (ru) | 2020-03-05 |
Family
ID=59521445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201992149A EA201992149A1 (ru) | 2017-03-14 | 2018-03-13 | Комбинация активных ингредиентов, содержащие ее композиции и их применение в лечении саркопении |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP3595637B1 (ru) |
CN (1) | CN110621304A (ru) |
EA (1) | EA201992149A1 (ru) |
ES (1) | ES2899252T3 (ru) |
IT (1) | IT201700028228A1 (ru) |
WO (1) | WO2018167661A1 (ru) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110064712A1 (en) * | 2009-09-16 | 2011-03-17 | Daniel Moses Amato | Dietary Supplement Compositions and Methods of Making and Using the Same |
WO2011056549A1 (en) * | 2009-10-27 | 2011-05-12 | Access Business Group International Llc | Molecular targets and dietary modulators of exercise-induced muscle damage |
WO2013188258A1 (en) * | 2012-06-11 | 2013-12-19 | Abbott Laboratories | Use of hmb to improve health outcomes for hospitalized patients |
WO2015099842A1 (en) * | 2013-12-23 | 2015-07-02 | Abbott Laboratories | Hot beverage fortifier |
CN105031530A (zh) * | 2015-05-18 | 2015-11-11 | 简茗 | 一种抗衰老组合物 |
-
2017
- 2017-03-14 IT IT102017000028228A patent/IT201700028228A1/it unknown
-
2018
- 2018-03-13 CN CN201880031812.9A patent/CN110621304A/zh active Pending
- 2018-03-13 ES ES18715811T patent/ES2899252T3/es active Active
- 2018-03-13 EP EP18715811.8A patent/EP3595637B1/en active Active
- 2018-03-13 WO PCT/IB2018/051656 patent/WO2018167661A1/en unknown
- 2018-03-13 EA EA201992149A patent/EA201992149A1/ru unknown
Also Published As
Publication number | Publication date |
---|---|
IT201700028228A1 (it) | 2018-09-14 |
EP3595637B1 (en) | 2021-08-18 |
CN110621304A (zh) | 2019-12-27 |
EP3595637A1 (en) | 2020-01-22 |
WO2018167661A1 (en) | 2018-09-20 |
ES2899252T3 (es) | 2022-03-10 |
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