EA201991883A1 - Классификатор метилирования для выявления инвазивных раковых заболеваний, индуцированных впч, раковых заболеваний женских половых органов и аногенитальной области, не индуцированных впч, и их поражений-предшественников высокой степени - Google Patents
Классификатор метилирования для выявления инвазивных раковых заболеваний, индуцированных впч, раковых заболеваний женских половых органов и аногенитальной области, не индуцированных впч, и их поражений-предшественников высокой степениInfo
- Publication number
- EA201991883A1 EA201991883A1 EA201991883A EA201991883A EA201991883A1 EA 201991883 A1 EA201991883 A1 EA 201991883A1 EA 201991883 A EA201991883 A EA 201991883A EA 201991883 A EA201991883 A EA 201991883A EA 201991883 A1 EA201991883 A1 EA 201991883A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hpv
- induced
- cancer diseases
- female genital
- invasive
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 230000011987 methylation Effects 0.000 title abstract 4
- 238000007069 methylation reaction Methods 0.000 title abstract 4
- 210000001752 female genitalia Anatomy 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- 102100022142 Achaete-scute homolog 1 Human genes 0.000 abstract 3
- 101000901099 Homo sapiens Achaete-scute homolog 1 Proteins 0.000 abstract 3
- 101000619912 Homo sapiens LIM/homeobox protein Lhx8 Proteins 0.000 abstract 3
- 108010069296 ST6GalNAc V brain-specific GD1alpha synthase Proteins 0.000 abstract 3
- 102100029229 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Human genes 0.000 abstract 2
- 102100022136 LIM/homeobox protein Lhx8 Human genes 0.000 abstract 2
- 230000003902 lesion Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 238000003149 assay kit Methods 0.000 abstract 1
- 230000006607 hypermethylation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к способу выявления предраковых поражений высокой степени, индуцированных ВПЧ, инвазивных раковых заболеваний, индуцированных ВПЧ, и раковых заболеваний женских половых органов и аногенитальной области, не индуцированных ВПЧ, включающему выявление классификатора метилирования, состоящего из генов LHX8, ASCL1 и ST6GALNAC5 и их регуляторной последовательности, в клетке, причем такое гиперметилирование указывает на присутствие поражений-предшественников с инвазивным потенциалом, индуцированных ВПЧ, инвазивных раковых заболеваний, индуцированных ВПЧ, а также раковых заболеваний женских половых органов и аногенитальной области, не индуцированных ВПЧ. Настоящее изобретение также включает применение классификатора метилирования, состоящего из генов LHX8, ASCL1 и ST6GALNAC5 и их регуляторной последовательности, в таком способе и набор для анализа для выявления метилирования LHX8, ASCL1 и/или ST6GALNAC5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17160346 | 2017-03-10 | ||
| PCT/NL2018/050143 WO2018164577A1 (en) | 2017-03-10 | 2018-03-09 | A methylation classifier for detection of hpv-induced invasive cancers, nonhpv- induced gynaecological and anogenital cancers and their high-grade precursor lesions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201991883A1 true EA201991883A1 (ru) | 2020-03-06 |
Family
ID=58266967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201991883A EA201991883A1 (ru) | 2017-03-10 | 2018-03-09 | Классификатор метилирования для выявления инвазивных раковых заболеваний, индуцированных впч, раковых заболеваний женских половых органов и аногенитальной области, не индуцированных впч, и их поражений-предшественников высокой степени |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11932909B2 (ru) |
| EP (2) | EP3744861B1 (ru) |
| JP (1) | JP7299158B2 (ru) |
| KR (1) | KR102542502B1 (ru) |
| CN (1) | CN110753761A (ru) |
| AU (1) | AU2018231578B2 (ru) |
| BR (1) | BR112019018743A2 (ru) |
| CA (1) | CA3055895A1 (ru) |
| DK (1) | DK3592867T3 (ru) |
| EA (1) | EA201991883A1 (ru) |
| ES (1) | ES2928068T3 (ru) |
| MA (1) | MA47821A (ru) |
| MX (1) | MX2019010508A (ru) |
| PH (1) | PH12019550180A1 (ru) |
| PL (1) | PL3592867T3 (ru) |
| PT (1) | PT3592867T (ru) |
| SG (2) | SG11201908273PA (ru) |
| WO (1) | WO2018164577A1 (ru) |
| ZA (1) | ZA201905977B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112021010640A2 (pt) * | 2018-12-04 | 2021-09-08 | Hkg Epitherapeutics Limited | Método in-vitro para obter preditores precoces de câncer cervical, painel de biomarcadores de metilação de dna para rastreamento e detecção precoce de câncer cervical, combinação de biomarcadores de metilação de dna para rastreamento e detecção precoce de câncer cervical, kit para detecção de câncer cervical, uso de equação de regressão linear multivariável ou análise de rede neura, uso de ensaios decaracterísticas de operação do receptor (roc), e método implementado por computador para obter biomarcadores de metilação de dna candidatos para detecção precoce dediagnóstico de câncer cervical |
| WO2021255460A1 (en) * | 2020-06-17 | 2021-12-23 | Ucl Business Ltd | Methods for detecting and predicting grade 3 cervical epithelial neoplasia (cin3) and/or cancer |
| GB202009222D0 (en) * | 2020-06-17 | 2020-07-29 | Ucl Business Plc | Methods for detecting and predicting cancer |
| GB202009220D0 (en) * | 2020-06-17 | 2020-07-29 | Ucl Business Ltd | Methods for detecting and predicting cancer |
| WO2021255459A1 (en) * | 2020-06-17 | 2021-12-23 | Ucl Business Ltd | Methods for detecting and predicting cancer and/or cin3 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8845535B2 (en) | 2008-02-22 | 2014-09-30 | Herbert Michael Pinedo | Device for detecting a medical condition or disease |
| AU2009344468B2 (en) | 2009-04-17 | 2015-02-12 | National Defense Medical Center | A method for screening cancer |
| TWI408235B (zh) | 2010-06-03 | 2013-09-11 | Univ China Medical | 用於檢測口腔癌之基因標記及方法 |
| SI2756099T1 (sl) * | 2011-09-15 | 2017-11-30 | Self-Screen B.V. | Postopek za detekcijo HPV-induciranega raka materničnega vratu |
| WO2013174432A1 (en) * | 2012-05-24 | 2013-11-28 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis |
| NZ708027A (en) | 2012-10-12 | 2019-01-25 | Self Screen Bv | Fam19a4 and hsa-mir124-2, molecular diagnostic markers for hpv-induced invasive cancers and their high-grade precursor lesions |
| CN107002136B (zh) * | 2014-09-22 | 2021-09-21 | 格罗宁根大学 | 宫颈癌的生物标记物 |
| WO2016115354A1 (en) | 2015-01-14 | 2016-07-21 | Taipei Medical University | Methods for cancer diagnosis and prognosis |
| EP3135768A1 (en) * | 2015-08-26 | 2017-03-01 | Self-screen B.V. | Zic1 and ghsr, molecular diagnostic markers for hpv-induced invasive cancers, nonhpv-induced gynaecological and anogenital cancers and their high-grade precursor lesions |
-
2018
- 2018-03-09 PT PT187105721T patent/PT3592867T/pt unknown
- 2018-03-09 AU AU2018231578A patent/AU2018231578B2/en active Active
- 2018-03-09 CN CN201880029251.9A patent/CN110753761A/zh active Pending
- 2018-03-09 DK DK18710572.1T patent/DK3592867T3/da active
- 2018-03-09 MA MA047821A patent/MA47821A/fr unknown
- 2018-03-09 BR BR112019018743A patent/BR112019018743A2/pt not_active IP Right Cessation
- 2018-03-09 EA EA201991883A patent/EA201991883A1/ru unknown
- 2018-03-09 SG SG11201908273P patent/SG11201908273PA/en unknown
- 2018-03-09 JP JP2019549400A patent/JP7299158B2/ja active Active
- 2018-03-09 SG SG10202106932YA patent/SG10202106932YA/en unknown
- 2018-03-09 KR KR1020197027973A patent/KR102542502B1/ko active IP Right Grant
- 2018-03-09 ES ES18710572T patent/ES2928068T3/es active Active
- 2018-03-09 EP EP20172435.8A patent/EP3744861B1/en active Active
- 2018-03-09 US US16/491,182 patent/US11932909B2/en active Active
- 2018-03-09 EP EP18710572.1A patent/EP3592867B1/en active Active
- 2018-03-09 CA CA3055895A patent/CA3055895A1/en active Pending
- 2018-03-09 MX MX2019010508A patent/MX2019010508A/es unknown
- 2018-03-09 WO PCT/NL2018/050143 patent/WO2018164577A1/en unknown
- 2018-03-09 PL PL18710572.1T patent/PL3592867T3/pl unknown
-
2019
- 2019-09-09 PH PH12019550180A patent/PH12019550180A1/en unknown
- 2019-09-10 ZA ZA2019/05977A patent/ZA201905977B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12019550180A1 (en) | 2020-06-29 |
| EP3744861C0 (en) | 2023-12-20 |
| MA47821A (fr) | 2020-01-15 |
| EP3744861A1 (en) | 2020-12-02 |
| CA3055895A1 (en) | 2018-09-13 |
| AU2018231578B2 (en) | 2024-01-11 |
| SG11201908273PA (en) | 2019-10-30 |
| EP3744861B1 (en) | 2023-12-20 |
| DK3592867T3 (da) | 2022-10-17 |
| EP3592867A1 (en) | 2020-01-15 |
| SG10202106932YA (en) | 2021-08-30 |
| KR102542502B1 (ko) | 2023-06-12 |
| PL3592867T3 (pl) | 2022-11-21 |
| AU2018231578A1 (en) | 2019-09-26 |
| ZA201905977B (en) | 2022-12-21 |
| MX2019010508A (es) | 2020-01-20 |
| BR112019018743A2 (pt) | 2020-05-05 |
| ES2928068T3 (es) | 2022-11-15 |
| US11932909B2 (en) | 2024-03-19 |
| US20200032348A1 (en) | 2020-01-30 |
| KR20190141130A (ko) | 2019-12-23 |
| EP3592867B1 (en) | 2022-08-17 |
| WO2018164577A1 (en) | 2018-09-13 |
| JP7299158B2 (ja) | 2023-06-27 |
| PT3592867T (pt) | 2022-10-13 |
| JP2020509758A (ja) | 2020-04-02 |
| CN110753761A (zh) | 2020-02-04 |
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